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  • Open Access
    Editorial
    Exploration of Targeted Anti-tumor Therapy: a contribution to the development of targeted therapies
    Nicola Normanno, Graham Packham
    Published: February 29, 2020 Explor Target Antitumor Ther. 2020;1:1–2
    DOI: https://doi.org/10.37349/etat.2020.00001
    View:1331
    Download:19
    Times Cited: 0
    Open Access
    Review
    Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms
    Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins. Thus, t..11.
    Joe Taylor ... Graham Packham
    Published: February 29, 2020 Explor Target Antitumor Ther. 2020;1:3–25
    DOI: https://doi.org/10.37349/etat.2020.00002
    View:5029
    Download:116
    Open Access
    Review
    Inhibitors of the Fanconi anaemia pathway as potential antitumour agents for ovarian cancer
    The Fanconi anaemia (FA) pathway is an important mechanism for cellular DNA damage repair, which functions to remove toxic DNA interstrand crosslinks. This is particularly relevant in the context of..11.
    Sarah J Taylor ... Simon P Langdon
    Published: February 29, 2020 Explor Target Antitumor Ther. 2020;1:26–52
    DOI: https://doi.org/10.37349/etat.2020.00003
    View:6201
    Download:179
    Times Cited: 0
    Open Access
    Review
    Colorectal cancer genomic biomarkers in the clinical management of patients with metastatic colorectal carcinoma
    Colorectal carcinoma (CRC) is an heterogeneous disease in which different genetic alterations play a role in its pathogenesis and progression and offer potential for therapeutic intervention. The re..11.
    Anna Maria Rachiglio ... Nicola Normanno
    Published: February 29, 2020 Explor Target Antitumor Ther. 2020;1:53–70
    DOI: https://doi.org/10.37349/etat.2020.00004
    View:4645
    Download:136
    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP displays a range of severity, though even mild disease may result in life-long visual impairment. ..11.
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. 2020;1:4–26
    DOI: https://doi.org/10.37349/emed.2020.00002
    View:3637
    Download:116
    Open Access
    Original Article
    Identifying factors associated with opioid cessation in a biracial sample using machine learning
    Aim: Racial disparities in opioid use disorder (OUD) management exist, however, and there is limited research on factors that influence opioid cessation in different population groups. Methods: We employed multiple machine learning prediction algorithms least absolute shrinkage and selection operator, random forest, deep neural network, and support vector machine to assess factors associated with ceasing opioid use in a sample of 1,192 African Americans (AAs) and 2,557 individuals of European ancestry (EAs) who met Diagnostic and Statistical Manual of Mental Disorders, 5th Edition criteria for OUD. ..11.
    Jiayi W. Cox ... Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:27–41
    DOI: https://doi.org/10.37349/emed.2020.00003
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:4150
    Download:86
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause, values of glomerular filtration rate and albuminuria category. Seeing that CKD is closely linked to the development of end-stage renal disease and other comorbidities, the determination of additional independent predictors for CKD is clinically necessary. ..11.
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42–50
    DOI: https://doi.org/10.37349/emed.2020.00004
    View:3019
    Download:63
    Open Access
    Editorial
    Welcome message from the Editor-in-Chief
    Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:1–3
    DOI: https://doi.org/10.37349/emed.2020.00001
    View:1627
    Download:38
    Times Cited: 0
    Open Access
    Original Article
    Implementation of an NGS panel for clinical practice in paraffin-embedded tissue samples from locally advanced and metastatic melanoma patients
    Aim: Single biomarker diagnostic test of BRAFV600 locus in metastatic melanoma is mandatory for treatment decision; however, multiple-gene based techniques, such as targeted next-generation sequenc ..11.
    Paola Castillo ... Cristina Teixido
    Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:101–108
    DOI: https://doi.org/10.37349/etat.2020.00006
    View:2902
    Download:53
    Open Access
    Review
    The impact of tumour pH on cancer progression: strategies for clinical intervention
    Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasi..11.
    Carol Ward ... Simon P Langdon
    Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:71–100
    DOI: https://doi.org/10.37349/etat.2020.00005
    View:13978
    Download:662
    Open Access
    Case Report
    Multiple adverse drug reactions during all-trans retinoic acid treatment for acute promyelocytic leukemia: differentiation syndrome, bradycardia, intestinal necrosis
    All-trans retinoic acid (ATRA) induces complete remission in a high proportion of acute promyelocytic leukemia (APL). Nevertheless it is be associated with adverse drug reactions that might be life-..11.
    Valeria Ferla ... Nicola Stefano Fracchiolla
    Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:109–116
    DOI: https://doi.org/10.37349/etat.2020.00007
    View:2221
    Download:23
    Open Access
    Review
    Angiogenesis and epidermal growth factor receptor inhibitors in non-small cell lung cancer
    Several preclinical studies suggested a potential benefit from combined treatment with inhibitors of epidermal growth factor receptor (EGFR) and angiogenesis, both effective in patients with advance..11.
    Giuliano Palumbo ... Alessandro Morabito
    Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:117–130
    DOI: https://doi.org/10.37349/etat.2020.00008
    View:2320
    Download:60
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals toward effective diagnosis and management. Recently, it has been shown that sex differences play a role in the prevalence and progression of NAFLD...11.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:9385
    Download:210
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a composite of arterial and ventricular elastances, but not intrinsic contractility. The clinician should be aware of its numerous limitations when measuring and reporting it. ..11.
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. 2020;1:75–84
    DOI: https://doi.org/10.37349/emed.2020.00006
    View:5788
    Download:144
    Times Cited: 0
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusion of competing causes of liver disease must be addressed. Here we propose a novel taxonomic classification of NAFLD based on hepatic, pathogenic and systemic features of disease in the individual patient. The variable course of disease in any given patient remains a clinical enigma. ..11.
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85–107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    View:5631
    Download:124
    Open Access
    Review
    Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors
    Chronic lymphocytic leukemia is a common form of leukemia and is dependent on growth-promoting signaling via the B-cell receptor. The Bruton tyrosine kinase (BTK) is an important mediator of B-cell ..11.
    Rachael Arthur ... Graham Packham
    Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:131–152
    DOI: https://doi.org/10.37349/etat.2020.00009
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
    View:6858
    Download:277
    Open Access
    Original Article
    Reduction of endoglin receptor impairs mononuclear cell-migration
    Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell surface and oxidative stress. Methods: MNCs of HHT patients and normal controls were subjected to migration assay. Fractions of MNCs were pre-incubated with antibodies specific to HHT causative genes ENG [hereditary hemorrhagic telangiectasia type 1 (HHT1)] or activin receptor-like kinase 1 [ALK1, hereditary hemorrhagic telangiectasia type 2 (HHT2)], AMD3100 or Diprotin-A to block ENG, ALK1 C-X-C chemokine receptor 4 (CXCR4) or CD26 (increased in HHT1 MNCs) before migration assay. ..11.
    Zhenying Han ... Hua Su
    Published: June 29, 2020 Explor Med. 2020;1:136–148
    DOI: https://doi.org/10.37349/emed.2020.00010
    View:2370
    Download:27
    Open Access
    Original Article
    Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study
    Aim: Epigenetic variation of DNA methylation of the mu-opioid receptor gene (OPRM1) has been identified in the blood and saliva of individuals with opioid use disorder (OUD) and infants with neonatal opioid withdrawal syndrome (NOWS). It is unknown whether epigenetic variation in OPRM1 exists within placental tissue in women with OUD and whether it is associated with NOWS outcomes. ..11.
    Elisha M. Wachman ... Huiping Zhang
    Published: June 29, 2020 Explor Med. 2020;1:124–135
    DOI: https://doi.org/10.37349/emed.2020.00009
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:3202
    Download:44
    Open Access
    Meta-Analysis
    GLP-1 receptor agonists for NAFLD treatment in patients with and without type 2 diabetes: an updated meta-analysis
    Aim: Recent randomized controlled trials (RCTs) have tested the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RA) to specifically treat non-alcoholic fatty liver disease (NAFLD). We performed a meta-analysis of RCTs to investigate the efficacy of GLP-1 RAs for treatment of NAFLD or non-alcoholic steatohepatitis (NASH). Methods: We systematically searched PubMed and ClinicalTrials.Gov databases utilizing specific terms to identify placebo-controlled or head-to-head RCTs (last research on March 1, 2020) involving NAFLD patients with the aim of evaluating the efficacy of GLP-1 RAs to treat NAFLD/NASH...11.
    Alessandro Mantovani ... Giovanni Targher
    Published: June 29, 2020 Explor Med. 2020;1:108–123
    DOI: https://doi.org/10.37349/emed.2020.00008
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:2647
    Download:83
    Open Access
    Review
    An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
    Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone..11.
    Irum Naz ... Kwang Seok Ahn
    Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:153–170
    DOI: https://doi.org/10.37349/etat.2020.00010
    This article belongs to the special issue Targeting Transcription Factors for Cancer Therapy
    View:3820
    Download:83
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from portal hypertension primarily caused by advanced fibrosis and erratic tissue remodeling. However, elevated portal venous pressure has also been detected in experimental models of fatty liver and in human NAFLD when fibrosis is far less advanced and cirrhosis is absent. ..11.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:5604
    Download:103
    Open Access
    Review
    Role of liquid biopsy for thoracic cancers immunotherapy
    Immunotherapy has shifted the therapeutic landscape in thoracic cancers. However, assessment of biomarkers for patient selection and disease monitoring remain challenging, especially considering the..11.
    Raimondo Di Liello ... Paloma Martín-Martorell
    Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:183–199
    DOI: https://doi.org/10.37349/etat.2020.00012
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:3241
    Download:58
    Open Access
    Review
    Integration of PARP-inhibitors in ovarian cancer therapy
    Poly-ADP-ribose polymerase inhibitors (PARP-I) represent one of the most attractive and promising class of biological agents studied both in relapsed ovarian cancer (OC) and in the advanced setting...11.
    Antonella Pietragalla ... Gennaro Daniele
    Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:171–182
    DOI: https://doi.org/10.37349/etat.2020.00011
    View:2146
    Download:36
    Open Access
    Review
    The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis
    Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity and mortality, without having to-date any licensed treatment. C-C chemokine receptor (CCR) antagonists have been investigated as candidates for the treatment of NASH. Inhibition of CCR2 is expected to mitigate hepatic inflammation, through reducing the activation of Kupffer cells, as well as the infiltration of monocytes and macrophages into the liver. ..11.
    Michael Doulberis ... Stergios A. Polyzos
    Published: August 31, 2020 Explor Med. 2020;1:170–183
    DOI: https://doi.org/10.37349/emed.2020.00012
    This article belongs to the special issue Exploring NAFLD/NASH
    View:3753
    Download:68
    Open Access
    Perspective
    Visual communication and learning from COVID-19 to advance preparedness for pandemics
    The currently ongoing coronavirus disease 19 (COVID-19) pandemic has affected globally human health and economy. Research in progress has shown facts associated with this disease and raised questions relevant for disease control and prevention. In this perspective, the collaboration between science and art in visual communication using the artwork “Enseñanza” (“Teaching”) contributes to the representation of the lessons ..11.
    José de la Fuente ... Christian Gortázar
    Published: August 31, 2020 Explor Med. 2020;1:244–247
    DOI: https://doi.org/10.37349/emed.2020.00016
    View:3833
    Download:67
    Open Access
    Review
    A brief overview of antitumoral actions of bruceine D
    Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually a..11.
    Zi Wayne Sin ... Manoj Garg
    Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:200–217
    DOI: https://doi.org/10.37349/etat.2020.00013
    This article belongs to the special issue Targeting Transcription Factors for Cancer Therapy
    View:2872
    Download:62
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity and heterogeneity of these pathologies but also for the lack of standardised clinical guidelines. The diagnosis of cancer is traumatizing and monopolizes the attention of both patients and caregivers. Thus, pre-existent or new-onset diabetes can be overshadowed thus increasing the risk for short- and long-term adverse events. ..11.
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184–204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:6343
    Download:136
    Open Access
    Review
    Genetic and metabolic factors: the perfect combination to treat metabolic associated fatty liver disease
    The prevalence of nonalcoholic or more recently re-defined metabolic associated fatty liver disease (MAFLD) is rapidly growing worldwide. It is characterized by hepatic fat accumulation exceeding 5% of liver weight not attributable to alcohol consumption. MAFLD refers to an umbrella of conditions ranging from simple steatosis to nonalcoholic steatohepatitis which may finally progress to cirrhosis and hepatocellular carcinoma. MAFLD is closely related to components of the metabolic syndrome and to environmental factors. ..11.
    Marica Meroni ... Paola Dongiovanni
    Published: August 31, 2020 Explor Med. 2020;1:218–243
    DOI: https://doi.org/10.37349/emed.2020.00015
    This article belongs to the special issue Exploring NAFLD/NASH
    View:4025
    Download:96
    Open Access
    Review
    Future directions and management of liquid biopsy in non-small cell lung cancer
    Lung cancer represents the world’s most common cause of cancer death. In recent years, we moved from a generic therapeutic strategy to a personalized approach, based on the molecular char..11.
    Alessia Maria Cossu ... Marco Bocchetti
    Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:239–252
    DOI: https://doi.org/10.37349/etat.2020.00015
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:2698
    Download:59
    Open Access
    Commentary
    Circulating cancer stem cells: an interesting niche to explore
    Federica Papaccio
    Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:253–258
    DOI: https://doi.org/10.37349/etat.2020.00016
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:2471
    Download:81
    Open Access
    Review
    PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors
    BCL-XL is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance. More recently, BCL-XL has also been identified..11.
    Peiyi Zhang ... Guangrong Zheng
    Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:259–272
    DOI: https://doi.org/10.37349/etat.2020.00017
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
    View:5314
    Download:279
    Open Access
    Review
    Non-alcoholic fatty liver disease and transient elastography
    Nonalcoholic fatty liver disease (NAFLD) is a serious condition that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD is associated with metabolic syndrome (MetS) and all of its components. According to data, around 25–30% of population has NAFLD. Giving the growing incidence of MetS, obesity and diabetes mellitus type 2, NAFLD related terminal-stage liver disease is becoming prevailing indication for liver transplantation. In order to prevent terminal stage of this disease, it is crucial to determine those that are in risk group, to modify their risk factors and monitor their potential progression. ..11.
    Ivana Mikolasevic ... Sandra Milic
    Published: August 31, 2020 Explor Med. 2020;1:205–217
    DOI: https://doi.org/10.37349/emed.2020.00014
    This article belongs to the special issue Exploring NAFLD/NASH
    View:4748
    Download:68
    Open Access
    Review
    Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
    Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways. Posttranslational modifications of proteins (PMPs) added another layer of complexity to the pathogenesis of NAFLD. PMPs change protein properties and regulate many biological functions, including cellular localization, stability, intracellular signaling, and protein function...11.
    Fatiha Nassir
    Published: August 31, 2020 Explor Med. 2020;1:248–258
    DOI: https://doi.org/10.37349/emed.2020.00017
    This article belongs to the special issue Exploring NAFLD/NASH
    View:4018
    Download:101
    Open Access
    Review
    Possible applications of salvianolic acid B against different cancers
    Cancer is the second death causing disease worldwide after cardiovascular abnormalities. The difficulty in treating tumor cells with more precise targeted interventions and recurrence of cancer afte..11.
    Iram Shahzadi ... Reza Mohammadinejad
    Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:218–238
    DOI: https://doi.org/10.37349/etat.2020.00014
    This article belongs to the special issue Targeting Transcription Factors for Cancer Therapy
    View:2800
    Download:37
    Open Access
    Review
    The diagnostic conundrum in non-alcoholic fatty liver disease
    Non-alcoholic fatty liver disease (NAFLD) has become the most common liver alteration worldwide. It encompasses a spectrum of disorders that range from simple steatosis to a progressive form, defined non-alcoholic steatohepatitis (NASH), that can lead to advanced fibrosis and eventually cirrhosis and hepatocellular carcinoma. On liver histology, NASH is characterized by the concomitant presence of significant fat accumulation and inflammatory reaction with hepatocellular injury. ..11.
    Valerio Rosato ... Marcello Persico
    Published: October 30, 2020 Explor Med. 2020;1:259–286
    DOI: https://doi.org/10.37349/emed.2020.00018
    This article belongs to the special issue Exploring NAFLD/NASH
    View:5151
    Download:167
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was to review the current knowledge of these mechanisms in a unified manner. Subjects with NAFLD and T2DM have established insulin resistance (IR), which exacerbates the two comorbidities...11.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:5878
    Download:245
    Open Access
    Commentary
    Country rankings on the scientific production in endocrinology and diabetology
    Alessandro Mantovani ... Chiara Zusi
    Published: October 30, 2020 Explor Med. 2020;1:307–313
    DOI: https://doi.org/10.37349/emed.2020.00020
    View:1803
    Download:19
    Open Access
    Review
    Diagnostic and prognostic role of liquid biopsy in non-small cell lung cancer: evaluation of circulating biomarkers
    Lung cancer is still one of the main causes of cancer-related death, together with prostate and colorectal cancers in males and breast and colorectal cancers in females. The prognosis for non-small ..11.
    Giovanni Vicidomini ... Mario Santini
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:343–354
    DOI: https://doi.org/10.37349/etat.2020.00020
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:2062
    Download:33
    Open Access
    Review
    Current strategies for the design of PROTAC linkers: a critical review
    PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead” ..11.
    Robert I. Troup ... Matthias G. J. Baud
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:273–312
    DOI: https://doi.org/10.37349/etat.2020.00018
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
    View:22617
    Download:2882
    Open Access
    Original Article
    Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer
    Aim: Tamoxifen (TAM) resistance remains a clinical issue in breast cancer. The authors previously reported that 15-hydroxyprostaglandin dehydrogenase (HPGD) was significantly downregulated in tamox..11.
    Milene Volpato ... Valerie Speirs
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:355–371
    DOI: https://doi.org/10.37349/etat.2020.00021
    View:2648
    Download:40
    Open Access
    Case Report
    Pseudoprogression in lung cancer: a case report
    Immunotherapy dramatically changed the management of several malignancies including non-small cell lung cancer (NSCLC). Since immune checkpoint inhibitors have a different mechanism of action from c..11.
    Giulia Meoni ... Angela Stefania Ribecco
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:372–380
    DOI: https://doi.org/10.37349/etat.2020.00022
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:2534
    Download:43
    Times Cited: 0
    Open Access
    Review
    Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
    Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains..11.
    Sosmitha Girisa ... Ajaikumar B. Kunnumakkara
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:313–342
    DOI: https://doi.org/10.37349/etat.2020.00019
    This article belongs to the special issue Targeting Transcription Factors for Cancer Therapy
    View:3432
    Download:69
    Open Access
    Review
    Novel approaches for the rational design of PROTAC linkers
    Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent molecules that facilitate ubiquitination of a target protein by simultaneously binding and bringing together b..11.
    Almaz Zagidullin ... Emil Bulatov
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:381–390
    DOI: https://doi.org/10.37349/etat.2020.00023
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
    View:5170
    Download:367
    Open Access
    Review
    Insulin pump therapy and continuous glucose monitoring in adults with type 2 diabetes: where are we now?
    Technology in diabetes is rapidly evolving, with the aim of helping affected people to safely optimize their blood glucose control. New technologies are now considered as an essential tool for managing glycemia predominantly in people with type 1 diabetes, and clinical trials have demonstrated that in these subjects the use of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) systems are associated with improved glycemic control along with a better quality of life. ..11.
    Erika Pedone ... Amelia Caretto
    Published: October 30, 2020 Explor Med. 2020;1:314–330
    DOI: https://doi.org/10.37349/emed.2020.00021
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:3487
    Download:57
    Open Access
    Perspective
    High-performance computing will assist experiments in recovery from COVID-19
    Bhushan Dharmadhikari ... Prabir Patra
    Published: October 30, 2020 Explor Med. 2020;1:355–358
    DOI: https://doi.org/10.37349/emed.2020.00023
    View:1917
    Download:22
    Times Cited: 0
    Open Access
    Original Article
    Going against the norm: validation of a novel alternative to brain SPECT normative datasets
    Aim: Quantitative analysis of brain single photon emission computed tomography (SPECT) perfusion imaging is dependent on normative datasets that are challenging to produce. This study investigated the combination of SPECT neuroimaging from a large clinical population rather than small numbers of controls. The authors hypothesized this “population template” would demonstrate noninferiority to a control dataset, providing a viable alternative for quantifying perfusion abnormalities in SPECT neuroimaging. Methods: A total of 2, 068 clinical SPECT scans were averaged to form the “population template”. Validation was three-fold. First, the template was imported into SPECT brain analysis software, MIMneuro®, and compared against its control dataset of 90 individuals through its region and cluster analysis tools. ..11.
    Lindsay M. Quandt, Cyrus A. Raji
    Published: October 30, 2020 Explor Med. 2020;1:331–354
    DOI: https://doi.org/10.37349/emed.2020.00022
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
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    Open Access
    Commentary
    The need for a harmonized speech dataset for Alzheimer’s disease biomarker development
    This commentary is the product of a concerted effort to understand the needs, barriers, and gaps in the field of speech and language biomarkers for Alzheimer’s disease (AD). It distills interviews, surveys, and extensive correspondence with global leaders in the areas of dementia research, clinical trials, linguistics, and data analytics into an idealized clinical-study design for the harmonized collection of voice recordings...11.
    Nicole L. Bjorklund ... Lampros Kourtis
    Published: December 31, 2020 Explor Med. 2020;1:359–363
    DOI: https://doi.org/10.37349/emed.2020.00024
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:3196
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    Open Access
    Review
    Use of liquid biopsy in monitoring therapeutic resistance in EGFR oncogene addicted NSCLC
    Liquid biopsy has emerged as a minimally invasive alternative to tumor tissue analysis for the management of lung cancer patients, especially for epidermal growth factor receptor (EGFR) oncogene add..11.
    Marialucia Iacovino ... Francesca Sparano
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:391–400
    DOI: https://doi.org/10.37349/etat.2020.00024
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:2249
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    Open Access
    Editorial
    Exploration of Immunology: challenging knowledge, developing curiosity and transforming passion into discovery
    Dominique J Charron, Reem Al-Daccak
    Published: April 30, 2021 Explor Immunol. 2021;1:1–3
    DOI: https://doi.org/10.37349/ei.2021.00001
    View:2937
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    Times Cited: 0
    Open Access
    Review
    Targeting transcription factors in cancer drug discovery
    Cancer drug discovery is currently dominated by clinical trials or clinical research. Several potential drug candidates have been brought into the pipeline of drug discovery after showing very promi..11.
    Partha Mitra
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:401–412
    DOI: https://doi.org/10.37349/etat.2020.00025
    This article belongs to the special issue Targeting Transcription Factors for Cancer Therapy
    View:3876
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    Open Access
    Original Article
    Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity
    Aim: Research suggests that Alzheimer’s disease (AD) is heterogeneous with numerous subtypes. Through a proprietary interactive ML system, several underlying biological mechanisms associated with AD pathology were uncovered. This paper is an introduction to emerging analytic efforts that can more precisely elucidate the heterogeneity of AD. Methods: A public AD data set (GSE84422) consisting of transcriptomic data of postmortem brain samples from healthy controls (n = 121) and AD (n = 380) subjects was analyzed. ..11.
    Bessi Qorri ... Joseph Geraci
    Published: December 31, 2020 Explor Med. 2020;1:377–395
    DOI: https://doi.org/10.37349/emed.2020.00026
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:3059
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    Open Access
    Review
    The entero-insular axis: a journey in the physiopathology of diabetes
    Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role. The discovery of the hormone insulin and the description of its function for glycemic control made fundamental scientific progress in this field. However, since then our view of the problem has been deeply influenced only in terms of glucose and insulin (in an insulin-centric and glucose-centric way). ..11.
    Roberta Malaguarnera ... Salvatore Piro
    Published: December 31, 2020 Explor Med. 2020;1:364–376
    DOI: https://doi.org/10.37349/emed.2020.00025
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:2604
    Download:59
    Open Access
    Review
    An overview of the potential anticancer properties of cardamonin
    Cancer is one of the leading causes of mortality, contributing to 9.6 million deaths globally in 2018 alone. Although several cancer treatments exist, they are often associated with severe side effe..11.
    Shanaya Ramchandani ... Manoj Garg
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:413–426
    DOI: https://doi.org/10.37349/etat.2020.00026
    This article belongs to the special issue Targeting Transcription Factors for Cancer Therapy
    View:3314
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    Open Access
    Letter to the Editor
    Is hyperprogressive disease a specific phenomenom of immunotherapy?
    Hyperprogressive disease (HPD) is a novel pattern of response during immunotherapy treatment. Several retrospective studies have evaluated its prevalence among various cancer types and, in particula..11.
    Marta Brambilla ... Mario Occhipinti
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:427–433
    DOI: https://doi.org/10.37349/etat.2020.00027
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:1954
    Download:29
    Open Access
    Review
    Circulating biomarkers in malignant pleural mesothelioma
    Malignant pleural mesothelioma (MPM) is an aggressive tumor strictly connected to asbestos exposure. Prognosis is dismal as diagnosis commonly occurs in advanced stage. Radiological screenings have ..11.
    Giuseppe Viscardi ... Giulia Galli
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:434–451
    DOI: https://doi.org/10.37349/etat.2020.00028
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:2672
    Download:64
    Open Access
    Review
    An overview of immune checkpoint inhibitors in breast cancer
    Although breast cancer is not traditionally considered an immunogenic type of tumor, the combination of immunotherapy and chemotherapy has recently emerged as a novel treatment option in triple-nega..11.
    Federica Miglietta ... Nicla La Verde
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:452–472
    DOI: https://doi.org/10.37349/etat.2020.00029
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:3374
    Download:110
    Open Access
    Original Article
    Detection of mild traumatic brain injury in pediatric populations using BrainCheck, a tablet-based cognitive testing software: a preliminary study
    Aim: Despite its high frequency of occurrence, mild traumatic brain injury (mTBI), or concussion, is difficult to recognize and diagnose, particularly in pediatric populations. Conventional methods to diagnose mTBI primarily rely on clinical questionnaires and sometimes include neuroimaging or pencil and paper neuropsychological testing. However, these methods are time consuming, require administration/interpretation from health professionals, and lack adequate test sensitivity and specificity. ..11.
    Siao Ye ... Reza Hosseini Ghomi
    Published: December 31, 2020 Explor Med. 2020;1:396–405
    DOI: https://doi.org/10.37349/emed.2020.00027
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:2502
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    Times Cited: 0
    Open Access
    Original Article
    Identification of digital voice biomarkers for cognitive health
    Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identify voice biomarkers that are predictive of future dementia. Methods: Participants were recruited from the Framingham Heart Study. The vocal responses to neuropsychological tests were recorded,..11.
    Honghuang Lin ... Rhoda Au
    Published: December 31, 2020 Explor Med. 2020;1:406–417
    DOI: https://doi.org/10.37349/emed.2020.00028
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:2872
    Download:81
    Open Access
    Review
    Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies
    Silent coronary artery disease (CAD) is one of the manifestations of heart disease that particularly affects subjects with type 2 diabetes mellitus (T2DM). From a clinical point of view, silent CAD represents a constant challenge for the diabetologist, who has to decide whether a patient could or could not be screened for this disease. In the present narrative review, several aspects of silent CAD are considered: the epidemiology of the disease, the associated risk factors, and main studies conducted, in the last 20 years, especially aimed to demonstrate the usefulness of the screening of silent CAD, to improve cardiovascular outcomes in type 2 diabetes...11.
    Saula Vigili de Kreutzenberg
    Published: February 28, 2021 Explor Med. 2021;2:1–19
    DOI: https://doi.org/10.37349/emed.2021.00029
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:2345
    Download:53
    Times Cited: 0
    Open Access
    Editorial
    Science plus technology to address challenges in determining the efficacy of neuroprotective/neurorestorative therapies
    Rafael Franco
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:1–6
    DOI: https://doi.org/10.37349/ent.2021.00001
    View:1745
    Download:33
    Open Access
    Review
    Old but gold: the role of drug combinations in improving response to immune check-point inhibitors in thoracic malignancies beyond NSCLC
    The introduction of immune checkpoint inhibitors (ICIs) in non-oncogene addicted non-small cell lung cancer (NSCLC) has revolutionized the treatment scenario and led to a meaningful improvement in p..11.
    Luca Cantini ... Rossana Berardi
    Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:1–25
    DOI: https://doi.org/10.37349/etat.2021.00030
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:1988
    Download:36
    Times Cited: 0
    Open Access
    Review
    Cardiovascular involvement after liver transplantation: role of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    Patients submitted to liver transplantation (LT) are exposed to high risk of cardiovascular (CV) complications which are the main determinants of both short-term and long-term morbidity and mortality in LT. Non-alcoholic fatty liver disease (NAFLD) is a very frequent condition in general population and is associated with a high risk of cardiovascular disease (CVD) which represents the first cause of death of these patients. NAFLD is predicted to become the first indication to LT and nowadays is also frequently detected in patients submitted to LT for other indications...11.
    Rosa Lombardi ... Anna Ludovica Fracanzani
    Published: February 28, 2021 Explor Med 2021;2:20–38
    DOI: https://doi.org/10.37349/emed.2021.00030
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2054
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    Times Cited: 0
    Open Access
    Review
    Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
    Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer facto..11.
    Honey Pavithran, Ranjith Kumavath
    Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:26–35
    DOI: https://doi.org/10.37349/etat.2021.00031
    This article belongs to the special issue Targeting Transcription Factors for Cancer Therapy
    View:2455
    Download:59
    Open Access
    Review
    Immunotherapy in gynecological cancers
    Immunotherapy has changed the natural history of several malignancies that, a decade ago, had a very poor prognosis, such as lung cancer and melanoma. Consequently, many attempts have been done to e..11.
    Domenica Lorusso ... Giovanni Scambia
    Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:48–64
    DOI: https://doi.org/10.37349/etat.2021.00033
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:1795
    Download:41
    Times Cited: 0
    Open Access
    Review
    Non-invasive detection of epithelial mesenchymal transition phenotype and metastatic dissemination of lung cancer by liquid biopsy
    The occurrence of phenotype switch from an epithelial to a mesenchymal cell state during the activation of the epithelial mesenchymal transition (EMT) program in cancer cells has been closely associ..11.
    Viviana De Rosa ... Francesca Iommelli
    Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:36–47
    DOI: https://doi.org/10.37349/etat.2021.00032
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:1620
    Download:32
    Times Cited: 0
    Open Access
    Review
    Cell-derived vesicles for delivery of cancer immunotherapy
    In recent years, cancer immunotherapy has received unprecedented attention due to the clinical achievements. The applications of biomedical engineering and materials science to cancer immunotherapy have solved the challenges caused by immunotherapy to a certain extent. Among them, cell-derived vesicles are natural biomaterials chosen as carriers or immune-engineering in view of their many unique advantages. This review will briefly introduce the recent applications of cell-derived vesicles for cancer immunotherapy...11.
    Jialu Xu, Chao Wang
    Published: February 28, 2021 Explor Med. 2021;2:39–59
    DOI: https://doi.org/10.37349/emed.2021.00031
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:2985
    Download:74
    Open Access
    Original Article
    Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes
    Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite their high heritability, few genetic risk loci have been identified for either opioid or cocaine dependence (OD or CD, respectively). A genome-wide association study of OD and CD related phenotypes reflecting the time between first self-reported use of these substances and a first DSM-IV dependence diagnosis was conducted. ..11.
    Richard Sherva ... Lindsay A. Farrer
    Published: February 28, 2021 Explor Med. 2021;2:60–73
    DOI: https://doi.org/10.37349/emed.2021.00032
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:2920
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    Times Cited: 0
    Open Access
    Review
    Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma
    Multiple myeloma (MM), the second most common hematologic cancer, is caused by accumulation of aberrant plasma cells in the bone marrow. Its molecular causes are not fully understood and its great h..11.
    Sara Ovejero, Jerome Moreaux
    Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:65–106
    DOI: https://doi.org/10.37349/etat.2021.00034
    This article belongs to the special issue Off-Label Drugs and -Omics Data in Cancer Treatment
    View:2949
    Download:57
    Times Cited: 0
    Open Access
    Review
    Aptamers and antibodies: rivals or allies in cancer targeted therapy?
    The goal of an efficacious cancer therapy is to specifically target diseased cells at high accuracy while sparing normal, healthy cells. Over the past three decades, immunotherapy, based on the use ..11.
    Lisa Agnello ... Laura Cerchia
    Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:107–121
    DOI: https://doi.org/10.37349/etat.2021.00035
    View:2787
    Download:104
    Open Access
    Review
    The role of interleukin-24 in atopic dermatitis
    Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl ..11.
    Yen Hai Vu ... Gaku Tsuji
    Published: April 30, 2021 Explor Immunol. 2021;1:4–15
    DOI: https://doi.org/10.37349/ei.2021.00002
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:5517
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    Times Cited: 0
    Open Access
    Original Article
    A machine learning approach to identify correlates of current e-cigarette use in Canada
    Aim: Popularity of electronic cigarettes (i.e. e-cigarettes) is soaring in Canada. Understanding person-level correlates of current e-cigarette use (vaping) is crucial to guide tobacco policy, but prior studies have not fully identified these correlates due to model overfitting caused by multicollinearity. This study addressed this issue by using classification tree, a machine learning algorithm. ..11.
    Rui Fu ... Michael Chaiton
    Published: February 28, 2021 Explor Med. 2021;2:74–85
    DOI: https://doi.org/10.37349/emed.2021.00033
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:2335
    Download:34
    Times Cited: 0
    Open Access
    Original Article
    Assessing the capacity for mental manipulation in patients with statically-determined mild cognitive impairment using digital technology
    Aims: Prior research employing a standard backward digit span test has been successful in operationally defining neurocognitive constructs associated with the Fuster’s model of executive attention. The current research sought to test if similar behavior could be obtained using a cross-modal mental manipulation test. ..11.
    Sheina Emrani ... David J. Libon
    Published: February 28, 2021 Explor Med. 2021;2:86–97
    DOI: https://doi.org/10.37349/emed.2021.00034
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:2522
    Download:29
    Open Access
    Original Article
    Risk factors in acute diabetic foot syndrome: analysis of 75 consecutive patients referred to a tertiary center in Modena, Italy
    Aim: Diabetic foot syndrome (DFS) is a complication of diabetes in which the presence of infections, ulceration and/or destruction of deep tissue associated with neuropathy, peripheral atherosclerosis and comorbidity affect the prognosis, the need for limb amputation and quality of life. Purpose of the present study is to report the features of patients with acute DFS admitted to our Diabetic Foot Unit tertiary Center in 2019. ..11.
    Mauro Maurantonio ... Luca Roncucci
    Published: February 28, 2021 Explor Med. 2021;2:98–109
    DOI: https://doi.org/10.37349/emed.2021.00035
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1990
    Download:28
    Times Cited: 0
    Open Access
    Review
    Potential benefit of β-glucans as adjuvant therapy in immuno-oncology: a review
    Fungal compounds have long been used for centuries as food supplements. β-glucans have been identified as the most interesting molecules with beneficial effects in several chronic diseas..11.
    Valeria Cognigni ... Rossana Berardi
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:122–138
    DOI: https://doi.org/10.37349/etat.2021.00036
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:3607
    Download:152
    Open Access
    Original Article
    Proof of concept: digital clock drawing behaviors prior to transcatheter aortic valve replacement may predict length of hospital stay and cost of care
    Aims: Reduced pre-operative cognitive functioning in older adults is a risk factor for postoperative complications, but it is unknown if preoperative digitally-acquired clock drawing test (CDT) cognitive screening variables, which allow for more nuanced examination of patient performance, may predict lengthier hospital stay and greater cost of hospital care. ..11.
    Margaret Ellenora Wiggins ... Catherine C. Price
    Published: March 05, 2021 Explor Med. 2021;2:110–121
    DOI: https://doi.org/10.37349/emed.2021.00036
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:3004
    Download:38
    Open Access
    Review
    Targeting HER2 in breast cancer: new drugs and paradigms on the horizon
    About 15–20% of all breast cancers (BCs) are defined human epidermal growth factor receptor 2 (HER2)-positive, based on the overexpression of HER2 protein and/or amplification..11.
    Paolo Tarantino ... Giuseppe Curigliano
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:139–155
    DOI: https://doi.org/10.37349/etat.2021.00037
    View:4491
    Download:198
    Open Access
    Original Article
    In silico investigation of binding affinities between human leukocyte antigen class I molecules and SARS-CoV-2 virus spike and ORF1ab proteins
    Aim: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019, a global pandemic. There is hence an urgent need for effective approaches to..11.
    Spyros A. Charonis ... Apostolos P. Georgopoulos
    Published: April 30, 2021 Explor Immunol. 2021;1:16–26
    DOI: https://doi.org/10.37349/ei.2021.00003
    View:2212
    Download:50
    Times Cited: 0
    Open Access
    Review
    Liquid biopsy in NSCLC: a new challenge in radiation therapy
    Lung cancer is the most common cancer and the leading cause of cancer mortality worldwide. To date, tissue biopsy has been the gold standard for the diagnosis and the identification of specific mole..11.
    Annarita Perillo ... Ida Rosalia Scognamiglio
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:156–173
    DOI: https://doi.org/10.37349/etat.2021.00038
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:1941
    Download:41
    Times Cited: 0
    Open Access
    Review
    Gastrointestinal disorders as immune-related adverse events
    Immune checkpoint inhibitors, such as cytotoxic T-lymphocyte antigen 4 inhibitors, programmed cell death 1 inhibitors and programmed cell death-ligand 1 inhibitors, have recently emerged as novel dr..11.
    Daniele Balducci ... Luca Maroni
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:174–186
    DOI: https://doi.org/10.37349/etat.2021.00039
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:1691
    Download:28
    Open Access
    Original Article
    Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition
    Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect a..11.
    Buyong Ma
    Published: April 30, 2021 Explor Immunol. 2021;1:27–36
    DOI: https://doi.org/10.37349/ei.2021.00004
    View:1589
    Download:31
    Open Access
    Letter to the Editor
    P2X7 receptor involvement in COVID-19 disease
    Peter Illes
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:7–9
    DOI: https://doi.org/10.37349/ent.2021.00002
    View:1176
    Download:39
    Times Cited: 0
    Open Access
    Original Article
    Nuclear factor erythroid 2-related factor 2 modulates HER4 receptor in ovarian cancer cells to influence their sensitivity to tyrosine kinase inhibitors
    Aim: Nuclear factor erythroid 2-related factor 2 (NRF2) is a key component in the cell’s response to oxidative and electrophilic stress and is a transcription factor regulating the expre..11.
    Ibrahim H. Kankia ... Yusuf Y. Deeni
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:187–203
    DOI: https://doi.org/10.37349/etat.2021.00040
    View:1413
    Download:56
    Times Cited: 0
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    Editorial
    Analysis of DNA from liquid biopsy: new genetic biomarkers for cancer immunotherapy?
    Carminia Maria Della Corte ... Floriana Morgillo
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:204–207
    DOI: https://doi.org/10.37349/etat.2021.00041
    This article belongs to the special issue Liquid Biopsy in Thoracic Cancer
    View:1343
    Download:20
    Times Cited: 0
    Open Access
    Review
    Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
    Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 rece..11.
    Masutaka Furue, Mihoko Furue
    Published: April 30, 2021 Explor Immunol. 2021;1:37–47
    DOI: https://doi.org/10.37349/ei.2021.00005
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:3022
    Download:124
    Open Access
    Case Report
    Hepatic manifestations of drug reaction with eosinophilia and systemic symptoms syndrome
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening drug reaction, which can affect multiple organs. Patients with DRESS syndrome and hepatic manifestations may present alterations ranging from mild hepatitis to acute liver failure. The diagnosis might be difficult, and the management of these patients is challenging. This report analyzes a series of five cases reporting the clinical presentation, which ranged from acute hepatitis to liver failure, and discussed their treatment...11.
    Maria Gabriela Delgado ... Jean François Dufour
    Published: April 30, 2021 Explor Med. 2021;2:122–134
    DOI: https://doi.org/10.37349/emed.2021.00037
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:3413
    Download:61
    Times Cited: 0
    Open Access
    Original Article
    Angiotensin-(3-4) modulates the overweight- and undernutrition-induced ACE2 downregulation in renal proximal tubule cells: implications for COVID-19?
    Aim: The renal lesions–including severe acute kidney injury–are severe outcomes in severe acute respiratory syndrome coronavirus 2 infections. There are no reports regarding the influence of the nutritional status on the severity and progress of these lesions. Ageing is also an important risk factor. Methods: In the present study we compared the influence of overweight and undernutrition on the levels of renal angiotensin converting enzymes 1 and 2 (ACE and ACE2), which were evaluated by Western blotting. Since the renin-angiotensin-aldosterone system (RAAS) has been implicated in the progress of kidney failure during coronavirus disease 2019, the influence of Angiotensin-(3-4) [Ang-(3-4)] was investigated. Ang-(3-4) is the shortest angiotensin-derived peptide, which is considered the physiological antagonist of several Ang II effects...11.
    Rafael Luzes ... Adalberto Vieyra
    Published: April 30, 2021 Explor Med. 2021;2:135–145
    DOI: https://doi.org/10.37349/emed.2021.00038
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:2161
    Download:103
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    Original Article
    Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: an in silico study
    Aim: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high heterogeneity, rapid progression, and paucity of treatment options. The most effective chemotherape..11.
    Garhima Arora ... Samrat Chatterjee
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:208–226
    DOI: https://doi.org/10.37349/etat.2021.00042
    This article belongs to the special issue Calcium Signaling Apparatus in Cancers
    View:2307
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    Times Cited: 0
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    Review
    AS1411-functionalized delivery nanosystems for targeted cancer therapy
    Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal target for the treatment of various cancers. AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells. ..11.
    Pooria Safarzadeh Kozani ... Mohammad Tariq Malik
    Published: April 30, 2021 Explor Med. 2021;2:146–166
    DOI: https://doi.org/10.37349/emed.2021.00039
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:2741
    Download:71
    Open Access
    Review
    Nanomedicine in cancer therapy: promises and hurdles of polymeric nanoparticles
    The limitations of current cancer treatments have stimulated the application of nanotechnology to develop more effective and safer cancer therapies. Remarkable progress has been made in the development of nanomedicine to overcome issues associated with conventional cancer treatment, including low drug solubility, insufficient targeting, and drug resistance. ..11.
    Carmen Paus ... Alessandra Cambi
    Published: April 30, 2021 Explor Med. 2021;2:167–185
    DOI: https://doi.org/10.37349/emed.2021.00040
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:2474
    Download:69
    Open Access
    Review
    Immunology of biodegradable nanoparticles: a brief overview on a wide growing field
    Immunity is continuously evolving by evolutionary mechanisms shaped by pathogenic stimuli of different kinds. Man-made nanomaterials (NMs) have been developed in the last decades and represent a nov..11.
    Anissa Pisani, Giuseppe Bardi
    Published: April 30, 2021 Explor Immunol. 2021;1:48–60
    DOI: https://doi.org/10.37349/ei.2021.00006
    View:3883
    Download:221
    Open Access
    Perspective
    Vascular aging, the vascular cytoskeleton and aortic stiffness
    Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth muscle cell (VSMC). This review will highlight the mechanisms by which the VSMC contributes to disorders of vascular aging. Distinct functional sub-components of the vascular cell and the molecular mechanisms of the protein-protein interactions, signaling mechanisms and intracellular trafficking processes in the setting of the aging aorta will be detailed...11.
    Lova Prasadareddy Kajuluri ... Kathleen G Morgan
    Published: June 30, 2021 Explor Med. 2021;2:186–197
    DOI: https://doi.org/10.37349/emed.2021.00041
    This article belongs to the special issue Exploring Aortic Disease
    View:2046
    Download:70
    Open Access
    Original Article
    Tumor burden as possible biomarker of outcome in advanced NSCLC patients treated with immunotherapy: a single center, retrospective, real-world analysis
    Aim: The role of tumor burden (TB) for patients with non-small cell lung cancer (NSCLC) receiving immunotherapy is still unknown. The aim of this analysis was to analyze the prognostic value of T..11.
    Edoardo Lenci ... Rossana Berardi
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:227–239
    DOI: https://doi.org/10.37349/etat.2021.00043
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:2044
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    Open Access
    Case Report
    Lynch syndrome-associated lung cancer: pitfalls of an immunotherapy-based treatment strategy in an unusual tumor type
    Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline alterations in mismatch repair (MMR) genes leading to increased risk of colon cancer as well as other cancer types. N..11.
    Elena Maccaroni ... Rossana Berardi
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:240–248
    DOI: https://doi.org/10.37349/etat.2021.00044
    View:2142
    Download:57
    Open Access
    Review
    Overview of Ca2+ signaling in lung cancer progression and metastatic lung cancer with bone metastasis
    Intracellular Ca2+ ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of funda..11.
    Manh Tien Tran
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:249–265
    DOI: https://doi.org/10.37349/etat.2021.00045
    This article belongs to the special issue Calcium Signaling Apparatus in Cancers
    View:2047
    Download:49
    Open Access
    Review
    Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets
    Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transit..11.
    Chaochu Cui ... Xianwei Wang
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:266–291
    DOI: https://doi.org/10.37349/etat.2021.00046
    This article belongs to the special issue Calcium Signaling Apparatus in Cancers
    View:2529
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    Times Cited: 0
    Open Access
    Review
    Cholesterol in autism spectrum disorders
    The autism spectrum disorder (ASD) comprises a series of neurological diseases that share serious alterations of the development of the central nervous system. The degree of disability may vary so t..11.
    Rafael Franco ... Irene Reyes-Resina
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:10–18
    DOI: https://doi.org/10.37349/ent.2021.00003
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3376
    Download:99
    Times Cited: 0
    Open Access
    Review
    Targeting cytoskeletal phosphorylation in cancer
    Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to m..11.
    Clara Llorente-González ... Miguel Vicente-Manzanares
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:292–308
    DOI: https://doi.org/10.37349/etat.2021.00047
    View:1657
    Download:69
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef..11.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:3968
    Download:211
    Open Access
    Review
    Immunopathogenesis of severe acute respiratory syndrome coronavirus-2: evolving knowledge and its current status
    As the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is a new virus, the current knowledge on the immunopathogenesis of this newly emerged SARS-CoV-2 is beginning to unravel with intens..11.
    Nitin Saksena ... Monica Miranda-Saksena
    Published: June 30, 2021 Explor Immunol. 2021;1:61–79
    DOI: https://doi.org/10.37349/ei.2021.00007
    View:2466
    Download:77
    Open Access
    Review
    L-arginine as a novel target for clinical intervention in inflammatory bowel disease
    Arginase-1 (Arg1) and the inducible nitric oxide synthase 2 (NOS2) compete for the common substrate L-arginine, semi-essential amino acid, and central intestinal metabolite. Both enzymes exhibit var..11.
    Björn Nüse, Jochen Mattner
    Published: June 30, 2021 Explor Immunol. 2021;1:80–89
    DOI: https://doi.org/10.37349/ei.2021.00008
    View:2768
    Download:95
    Open Access
    Review
    Wave propagation and reflection in the aorta and implications of the aortic Windkessel
    Some have said that it is inappropriate and perhaps impossible to consider wave and Windkessel phenomena simultaneously. For 50 years, arterial hemodynamics has been dominated by the frequency-domain “impedance analysis” in which it was assumed that all variations in aortic pressure and flow were caused only by forward- and backward-going waves. ..11.
    John V. Tyberg
    Published: June 30, 2021 Explor Med. 2021;2:198–207
    DOI: https://doi.org/10.37349/emed.2021.00042
    This article belongs to the special issue Exploring Aortic Disease
    View:1505
    Download:54
    Times Cited: 0
    Open Access
    Review
    Emerging nanomaterials for cancer immunotherapy
    Immunotherapy is a unique approach to treat cancer that targets tumours besides triggering the immune cells. It attempts to harness the supremacy and specificity of immune cells for the regression of malignancy. The key strategy of immunotherapy is that it boosts the natural defence and manipulates the immune system at both cellular and molecular levels. ..11.
    Sureshbabu Ram Kumar Pandian ... Krishnan Sundar
    Published: June 30, 2021 Explor Med. 2021;2:208–231
    DOI: https://doi.org/10.37349/emed.2021.00043
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:2059
    Download:73
    Open Access
    Original Article
    Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort
    Aim: Although clinicians primarily diagnose dementia based on a combination of metrics such as medical history and formal neuropsychological tests, recent work using linguistic analysis of narrative speech to identify dementia has shown promising results. We aim to build upon research by Thomas JA & Burkardt HA et al. (J Alzheimers Dis. 2020;76:905–2) and Alhanai et al. (arXiv:1710.07551v1. 2020) on the Framingham Heart Study (FHS) Cognitive Aging Cohort by 1) demonstrating the predictive capability of linguistic analysis in differentiating cognitively normal from cognitively impaired participants and 2) comparing the performance of the original linguistic features with the performance of expanded features...11.
    Larry Zhang ... Reza Hosseini Ghomi
    Published: June 30, 2021 Explor Med. 2021;2:232–252
    DOI: https://doi.org/10.37349/emed.2021.00044
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:2127
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    Open Access
    Original Article
    Digital sleep measures and white matter health in the Framingham Heart Study
    Aim: Impaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort. Methods: The target population was the Framingham Heart Study Generation-2/Omni-1 Cohorts. Magnetic resonance imaging (diffusion tensor imaging) was used to assess WM integrity. Wearable digital devices were used to assess sleep quality: the (M1-SleepImageTM system) and the Nonin WristOx for nocturnal oxygenation. The M1 device collects trunk actigraphy and the electrocardiogram (ECG); sleep stability indices were computed using cardiopulmonary coupling using the ECG. Two nights of recording were averaged...11.
    Robert Joseph Thomas ... Rhoda Au
    Published: June 30, 2021 Explor Med. 2021;2:253–267
    DOI: https://doi.org/10.37349/emed.2021.00045
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:2127
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    Open Access
    Review
    Angiotensin-(1-7) and Mas receptor in the brain
    The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher brain functions, including cognition, memory, depression and anxiety. For many years, angiotensin II (Ang II) has been considered the major bioactive component of the RAS. However, the existence of many other biologically active RAS components has currently been recognized, with similar, opposite, or distinct effects to those exerted by Ang II. ..11.
    Natalia L. Rukavina Mikusic ... Mariela M. Gironacci
    Published: June 30, 2021 Explor Med. 2021;2:268–293
    DOI: https://doi.org/10.37349/emed.2021.00046
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:3941
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    Open Access
    Review
    Angiotensin peptides in the regulation of adrenal cortical function
    The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones. Evidence exists that angiotensin II regulates adrenocortical function and it has been contended that angiotensin peptides of the non-canonical branch of the renin angiotensin system (RAS) might also modulate steroidogenesis in adrenals. Thus, the aim of this review is to examine the role of the RAS, and particularly of the angiotensin peptides and their receptors, in the regulation of adrenocortical hormones with particular focus on aldosterone production...11.
    Gian Paolo Rossi ... Teresa Maria Seccia
    Published: June 30, 2021 Explor Med. 2021;2:294–304
    DOI: https://doi.org/10.37349/emed.2021.00047
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:2260
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    Open Access
    Review
    Vitamin D and immunomodulation in the skin: a useful affirmative nexus
    Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune r..11.
    Saptadip Samanta
    Published: June 30, 2021 Explor Immunol. 2021;1:90–111
    DOI: https://doi.org/10.37349/ei.2021.00009
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:3095
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    Times Cited: 0
    Open Access
    Review
    Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
    Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regene..11.
    Panagiotis Mallis ... Catherine Stavropoulos Giokas
    Published: June 30, 2021 Explor Immunol. 2021;1:112–139
    DOI: https://doi.org/10.37349/ei.2021.00010
    View:3663
    Download:78
    Open Access
    Commentary
    An engineered mayhem: YAP/TAZ mechanosignaling and hepatocarcinogenesis in NAFLD
    Gyorgy Baffy
    Published: August 31, 2021 Explor Med. 2021;2:305–310
    DOI: https://doi.org/10.37349/emed.2021.00048
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1582
    Download:48
    Times Cited: 0
    Open Access
    Review
    Sex hormones abnormalities in non-alcoholic fatty liver disease: pathophysiological and clinical implications
    Obesity and metabolic syndrome are conditions at high risk for the development of complications such as type 2 diabetes mellitus, atherosclerotic cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). The growing prevalence of NAFLD has recently raised attention in the clinical practice, due to the worsening prognosis observed in the affected patients. Sex hormones abnormalities, commonly found in subjects suffering from obesity and metabolic syndrome, have been recently hypothesized to be directly involved in the physiopathology of obesity-related comorbidites;..11.
    Angelo Di Vincenzo ... Marco Rossato
    Published: August 31, 2021 Explor Med. 2021;2:311–323
    DOI: https://doi.org/10.37349/emed.2021.00049
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2342
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    Times Cited: 0
    Open Access
    Review
    Gut microbial imbalance and neurodegenerative proteinopathies: from molecular mechanisms to prospects of clinical applications
    The pathogenic basis behind some of the most prevalent neurodegenerative diseases in advanced societies, known as proteinopathies, deals with alterations in protein homeostasis. Despite the broad di..11.
    Paula Alonso-García ... Eva Martínez-Pinilla
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:33–54
    DOI: https://doi.org/10.37349/ent.2021.00005
    View:2317
    Download:90
    Times Cited: 0
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    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered ..11.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:4054
    Download:210
    Open Access
    Original Article
    The effect of iron on the expression levels of calcium related gene in cisplatin resistant epithelial ovarian cancer cells
    Aim: Anticancer drugs (chemotherapeutics) used in cancer treatment (chemotherapy) lead to drug resistance. This study was conducted to investigate the possible effect of iron on calcium homeostasis..11.
    Bahire Kucukkaya ... Leman Yalcintepe
    Published: August 30, 2021 Explor Target Antitumor Ther. 2021;2:309–322
    DOI: https://doi.org/10.37349/etat.2021.00048
    View:1210
    Download:39
    Times Cited: 0
    Open Access
    Case Report
    Central pontine myelinolysis secondary to glycemic variability in type 1 diabetes: a case report and a systematic review of the literature
    Central pontine myelinolysis (CPM) is a rare manifestation of osmotic demyelination syndrome (ODS) which involves the pons and causes significant morbidity and mortality. CPM usually occurs in the setting of rapid correction of severe chronic hyponatremia. A rare case of CPM due to hyperglycemia in a 27-year-old man with type 1 diabetes is reported...11.
    Stefania Di Agostino ... Mauro Maurantonio
    Published: August 31, 2021 Explor Med. 2021;2:324–332
    DOI: https://doi.org/10.37349/emed.2021.00050
    View:1630
    Download:46
    Times Cited: 0
    Open Access
    Review
    The promising potential of piperlongumine as an emerging therapeutics for cancer
    In spite of the immense advancement in the diagnostic and treatment modalities, cancer continues to be one of the leading causes of mortality across the globe, responsible for the death of around 10..11.
    Dey Parama ... Ajaikumar B. Kunnumakkara
    Published: August 30, 2021 Explor Target Antitumor Ther. 2021;2:323–354
    DOI: https://doi.org/10.37349/etat.2021.00049
    View:3769
    Download:147
    Open Access
    Review
    Pediatric vs. adult NAFLD to MAFLD transition: a welcome but tangled path
    The term non-alcoholic fatty liver disease (NAFLD) appears unfitting both in adults and in children. As obesity and metabolic syndrome play a relevant pathogenic role, an international group of adults’ liver disease experts has proposed to rename this condition metabolic (dysfunction)-associated fatty liver disease (MAFLD). While this new more appropriate and useful definition has mostly been met with good reactions in adults, it may present a tangled path in pediatrics. ..11.
    Angelo Colucci ... Claudia Mandato
    Published: August 31, 2021 Explor Med. 2021;2:333–342
    DOI: https://doi.org/10.37349/emed.2021.00051
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2011
    Download:80
    Open Access
    Case Report
    Submucosal esophageal hematomas in a critically ill patient on anticoagulation
    Submucosal esophageal hematoma is an uncommon clinical complication of anticoagulation. Current literature is scarce regarding presentation and management in acute submucosal hematomas in critically ill patients. Patients often present with retrosternal chest pain, making the diagnosis challenging due to overlap with common presentations of cardiopulmonary disorders. ..11.
    Hassam Ali, Maliha Naseer
    Published: August 31, 2021 Explor Med. 2021;2:343–347
    DOI: https://doi.org/10.37349/emed.2021.00052
    View:1102
    Download:23
    Times Cited: 0
    Open Access
    Review
    The evolving role and utility of off-label drug use in multiple myeloma
    The treatment landscape for multiple myeloma (MM) has dramatically changed over the last three decades, moving from no US Food and Drug Administration approvals and two active drug classes to over 1..11.
    James H Stoeckle ... Gareth J Morgan
    Published: August 30, 2021 Explor Target Antitumor Ther. 2021;2:355–373
    DOI: https://doi.org/10.37349/etat.2021.00050
    This article belongs to the special issue Off-Label Drugs and -Omics Data in Cancer Treatment
    View:2930
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    Times Cited: 0
    Open Access
    Review
    Does the gut microbiome environment influence response to systemic breast cancer treatment?
    The gut microbiome is a novel player in the pathogenesis and treatment of breast cancer. The term “microbiome” is used to describe the diverse community of micro-organisms exis..11.
    Eilidh Bruce ... Beatrix Elsberger
    Published: August 30, 2021 Explor Target Antitumor Ther. 2021;2:374–384
    DOI: https://doi.org/10.37349/etat.2021.00051
    View:1845
    Download:55
    Open Access
    Review
    Role of estrogen receptor coregulators in endocrine resistant breast cancer
    Breast cancer (BC) is the most ubiquitous cancer in women. Approximately 70–80% of BC diagnoses are positive for estrogen receptor (ER) alpha (ERα). The steroid ho..11.
    Kristin A. Altwegg, Ratna K. Vadlamudi
    Published: August 30, 2021 Explor Target Antitumor Ther. 2021;2:385–400
    DOI: https://doi.org/10.37349/etat.2021.00052
    This article belongs to the special issue Endocrine Resistant Breast Cancer
    View:3027
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    Open Access
    Review
    Role of angiotensin II in the development of subcellular remodeling in heart failure
    The development of heart failure under various pathological conditions such as myocardial infarction (MI), hypertension and diabetes are accompanied by adverse cardiac remodeling and cardiac dysfunction. Since heart function is mainly determined by coordinated activities of different subcellular organelles including sarcolemma, sarcoplasmic reticulum, mitochondria and myofibrils for regulating the intracellular concentration of Ca2+, it has been suggested that the occurrence of heart failure is a consequence of subcellular remodeling, metabolic alterations and Ca2+-handling abnormalities in cardiomyocytes. ..11.
    Sukhwinder K. Bhullar ... Naranjan S. Dhalla
    Published: August 31, 2021 Explor Med. 2021;2:352–371
    DOI: https://doi.org/10.37349/emed.2021.00054
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:2061
    Download:53
    Open Access
    Original Article
    High prevalence of false positive SARS-CoV2 serology in a cohort of patients with liver autoimmune diseases
    Aim: Monitoring the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) immunization in patients with autoimmune diseases is of particular concern to understand their response to the infection and to the vaccine. In fact, the immunological disorder and the immunosuppressive therapies could affect the serological response...11.
    Maria Giulia Cornacchia ... Gaetano Serviddio
    Published: August 31, 2021 Explor Med. 2021;2:372–377
    DOI: https://doi.org/10.37349/emed.2021.00055
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1996
    Download:42
    Open Access
    Perspective
    Why the aortic dissection detection risk score is problematic in emergency departments
    Acute aortic syndromes, including aortic dissection (AD), are rare. The AD detection risk score (ADDRS) and associated investigation pathway were developed to reduce missed diagnosis of AD. The methodology for its development was sub-optimal and it has not been robustly validated in the emergency department chest pain population...11.
    Anne-Maree Kelly
    Published: August 31, 2021 Explor Med. 2021;2:348–351
    DOI: https://doi.org/10.37349/emed.2021.00053
    This article belongs to the special issue Exploring Aortic Disease
    View:1711
    Download:33
    Open Access
    Review
    Severe acute respiratory syndrome coronavirus 2 targeted antibodies cocktail and B cell receptor interplay: interventions to trigger vaccine development
    Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 spread globally and creates an alarming situation. Following the SARS-CoV-2 paradigm, therape..11.
    Kabeer Haneef ... Zainab Fatima
    Published: August 31, 2021 Explor Immunol. 2021;1:140–154
    DOI: https://doi.org/10.37349/ei.2021.00011
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:1812
    Download:69
    Times Cited: 0
    Open Access
    Review
    Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
    Head and neck squamous cell carcinoma (HNSCC) is a relatively widespread cancer with high mortality rates. Many patients with locally advanced disease are treated with combinations of surgery, radia..11.
    Shalini K. Sureshbabu ... Shubhada V. Chiplunkar
    Published: August 31, 2021 Explor Immunol. 2021;1:166–198
    DOI: https://doi.org/10.37349/ei.2021.00013
    View:2469
    Download:110
    Open Access
    Review
    The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
    Understanding the interactions of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with humans is deeply grounded in immunology, from the diagnosis to pathogenesis, from the clinical pre..11.
    Eduardo Tosta
    Published: August 31, 2021 Explor Immunol. 2021;1:199–225
    DOI: https://doi.org/10.37349/ei.2021.00014
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:2556
    Download:57
    Open Access
    Original Article
    Conserved envelope protein of nCoV2 as the possible target to design polytope vaccine
    Aim: The envelope protein of novel coronavirus 2 (nCoV2) was reported to be highly conserved compared to its spike (S) protein which was shown to undergo several alterations in their amino acid seq..11.
    Krupanidhi Sreerama
    Published: August 31, 2021 Explor Immunol. 2021;1:155–165
    DOI: https://doi.org/10.37349/ei.2021.00012
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:1603
    Download:25
    Times Cited: 0
    Open Access
    Review
    Macrophages and fibroblasts underpin skin immune responses
    There are various types of skin immune responses including inflammatory skin diseases and skin malignancy. Macrophages and fibroblasts are skin resident cells that had been overlooked in terms of im..11.
    Makoto Sugaya
    Published: August 31, 2021 Explor Immunol. 2021;1:226–242
    DOI: https://doi.org/10.37349/ei.2021.00015
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:2393
    Download:120
    Times Cited: 0
    Open Access
    Commentary
    Breastfeeding duration and reduced risk of NAFLD in midlife of parous women
    Alessandro Mantovani ... Andrea Dalbeni
    Published: October 31, 2021 Explor Med. 2021;2:378–381
    DOI: https://doi.org/10.37349/emed.2021.00056
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1119
    Download:15
    Open Access
    Review
    A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression
    Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process. Although Ca2+ signaling, re..11.
    Wen-Li Hsu ... Etsuro Ito
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:401–415
    DOI: https://doi.org/10.37349/etat.2021.00053
    This article belongs to the special issue Calcium Signaling Apparatus in Cancers
    View:2034
    Download:66
    Times Cited: 0
    Open Access
    Original Article
    Objective measurement of sleep by smartphone application: comparison with actigraphy and relation to self-reported sleep
    Aim: Smartphone technology is increasingly used by the public to assess sleep. Specific features of some sleep-tracking applications are comparable to actigraphy in objectively monitoring sleep. The clinical utility of smartphone apps should be investigated further to increase access to convenient means of monitoring sleep...11.
    Taylor Maynard ... Sandy Neargarder
    Published: October 31, 2021 Explor Med. 2021;2:382–391
    DOI: https://doi.org/10.37349/emed.2021.00057
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1808
    Download:43
    Open Access
    Review
    Exploring evidence-based innovative therapy for the treatment of chronic HBV infection: experimental and clinical
    With the advent of various vaccines and antimicrobial agents during the 20th century, the control and containment of infectious diseases appeared to be a matter of time. However, studies unveiled the diverse natures of microbes, their lifestyle, and pathogenetic potentials. Since the ground-breaking discovery of the hepatitis B virus (HBV) by Baruch Blumberg and the subsequent development of a vaccine in the early 1980s, the main task of the scientific community has been to develop a proper management strategy for HBV-induced chronic liver diseases. In the early 1980’s, standard interferon (IFN) induced a reduction of HBV DNA levels, followed by the normalization of serum transaminases (alanine aminotransferase, ALT), in some chronic hepatitis B (CHB) patients. ..11.
    Sheikh Mohammad Fazle Akbar ... Yoichi Hiasa
    Published: October 31, 2021 Explor Med. 2021;2:392–409
    DOI: https://doi.org/10.37349/emed.2021.00058
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1189
    Download:26
    Times Cited: 0
    Open Access
    Original Article
    Serum profiles of tryptophan-kynurenine pathway metabolites in psoriasis
    Aim: Chronic inflammation is closely associated with tryptophan (TRP)-kynurenine (KYN) metabolic pathway. However, TRP-KYN pathway has not been fully elucidated in psoriasis, a systemic inflammator..11.
    Mariko Seishima ... Kuniaki Saito
    Published: October 31, 2021 Explor Immunol. 2021;1:258–268
    DOI: https://doi.org/10.37349/ei.2021.00017
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:1574
    Download:60
    Open Access
    Review
    Immune responses induced by different vaccine platforms against coronavirus disease-19
    There have been significant developments in the design of nanostructured scaffolds for eliciting robust immune responses named vaccine. The technique is to produce strong immune responses is to mani..11.
    Eknath D. Ahire, Sanjay J. Kshirsagar
    Published: October 31, 2021 Explor Immunol. 2021;1:243–257
    DOI: https://doi.org/10.37349/ei.2021.00016
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:4024
    Download:126
    Open Access
    Review
    T-cell based immunotherapies for Parkinson’s disease
    Current evidence indicates that neurodegeneration of dopaminergic neurons of the substantia nigra associated to Parkinson’s disease is a consequence of a neuroinflammatory process in whic..11.
    Rodrigo Pacheco
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:72–85
    DOI: https://doi.org/10.37349/ent.2021.00007
    View:2353
    Download:113
    Open Access
    Review
    Immunization with neural-derived peptides as a neuroprotective therapy for spinal cord injury
    Spinal cord injury (SCI) induces several destructive events that develop immediately after the primary insult. These phenomena increase tissue damage; that is why, numerous therapeutic approaches ar..11.
    Andrea Paola Ibarra-García, Antonio Ibarra
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:111–120
    DOI: https://doi.org/10.37349/ent.2021.00009
    View:1392
    Download:49
    Times Cited: 0
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo..11.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:5668
    Download:269
    Open Access
    Original Article
    The two faces of mast cells in vitiligo pathogenesis
    Aim: Previously, we reported increased number of T helper 17 (Th17) cells in vitiligo. However, in our recent study, tryptase and interleukin (IL)17 double positive cells which identified by polycl..11.
    Ichiro Katayama ... Mari Wataya-Kaneda
    Published: October 31, 2021 Explor Immunol. 2021;1:269–284
    DOI: https://doi.org/10.37349/ei.2021.00018
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:1699
    Download:73
    Times Cited: 0
    Open Access
    Review
    Current options and future directions of systemic therapy for advanced biliary tract cancer
    Biliary tract cancers (BTCs) are aggressive tumors arising from different portions of the biliary tree and classified according to the anatomical location in intrahepatic (i) cholangiocarcinoma (CCA..11.
    Maria Giuseppina Prete ... Lorenza Rimassa
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:416–433
    DOI: https://doi.org/10.37349/etat.2021.00054
    This article belongs to the special issue Precision Medicine for Cholangiocarcinoma
    View:2692
    Download:79
    Open Access
    Review
    Targeting protein kinase CK2 in the treatment of cholangiocarcinoma
    Cholangiocarcinoma (CCA) is a disease with a very poor prognosis and limited treatment options. Although targeted therapies directed towards specific mutations found in CCA are becoming available an..11.
    Padma-Sheela Jayaraman, Kevin Gaston
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:434–447
    DOI: https://doi.org/10.37349/etat.2021.00055
    This article belongs to the special issue Precision Medicine for Cholangiocarcinoma
    View:1891
    Download:65
    Open Access
    Meta-Analysis
    A review of aortic thrombosis in COVID-19 infection
    Aim: As the novel coronavirus disease 2019 (COVID-19) pandemic impacts the global healthcare system, evolving data show increased frequency of arterial and venous thromboembolism among patients with COVID-19 infection. Aortic thrombus is a rare thrombotic event with a wide spectrum of clinical manifestations and potential catastrophic complications. This study aimed to elucidate the clinical manifestations, diagnosis and treatment dilemmas of aortic thrombus with COVID-19 infection and raise awareness among frontline medical providers. Aortic thrombosis is rare, but if not considered early in the course of COVID-19 infection, the data suggest that the diagnosis will probably not be made until potentially serious complications arise. ..11.
    Korin Karabulut ... James Morgan
    Published: October 31, 2021 Explor Med. 2021;2:410–422
    DOI: https://doi.org/10.37349/emed.2021.00059
    This article belongs to the special issue Exploring Aortic Disease
    View:1718
    Download:29
    Open Access
    Review
    Skin and immune cells crosstalk via circadian regulations
    Both innate and adaptive immune cells exist in the skin, predominantly in the dermis layer. Recent studies have focused on how and which circadian rhythms contribute to maintain good health. Over re..11.
    Kanami Orihara
    Published: October 31, 2021 Explor Immunol. 2021;1:285–294
    DOI: https://doi.org/10.37349/ei.2021.00019
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:2320
    Download:116
    Open Access
    Review
    Aortic complications in pregnancy: the less remembered chapter—a narrative review
    Pregnancy increases the risk of common vascular events and also the rarer events like aortic dissection (AD)/aortic rupture and this is even more pronounced in patients with predisposing aortopathies. AD was found to occur in 0.0004% of all pregnancies, and it is more pronounced in patients with underlying connective tissue disorders. The normal hemodynamic changes on a weak aorta will lead to AD and/or rupture, more so with increase in the period of gestation...11.
    Preetha Rajasekaran ... Bashi V. Velayudhan
    Published: October 31, 2021 Explor Med. 2021;2:423–434
    DOI: https://doi.org/10.37349/emed.2021.00060
    This article belongs to the special issue Exploring Aortic Disease
    View:1339
    Download:60
    Times Cited: 0
    Open Access
    Commentary
    Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
    Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone publication clearly and exhaustively explains the multitude of pathogenic pathways involved in the development and progression of disease eventually conducive to heterogeneous clinical phenotypes and different disease outcomes. ..11.
    Amedeo Lonardo
    Published: October 31, 2021 Explor Med. 2021;2:435–442
    DOI: https://doi.org/10.37349/emed.2021.00061
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1327
    Download:74
    Open Access
    Review
    A review of molecularly targeted therapy in biliary tract carcinoma: what is the next step?
    Patients with unresectable biliary tract carcinomas (BTCs) have a poor prognosis with a median overall survival of fewer than 12 months following systemic chemotherapy. In recent years, the identifi..11.
    Giacomo Aimar ... Massimo Di Maio
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:448–464
    DOI: https://doi.org/10.37349/etat.2021.00056
    This article belongs to the special issue Precision Medicine for Cholangiocarcinoma
    View:1823
    Download:79
    Open Access
    Review
    Targeted therapy of multiple myeloma
    Multiple myeloma (MM) is a malignant proliferative disease of monoclonal plasma cells (PCs) and is characterized by uncontrolled proliferation of PCs and excessive production of specific types of im..11.
    Shan Zhou, Renxi Wang
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:465–480
    DOI: https://doi.org/10.37349/etat.2021.00057
    View:1589
    Download:52
    Times Cited: 0
    Open Access
    Original Article
    Performing oncological procedures during COVID-19 outbreak: a picture from an Italian cancer center
    Aim: Since SARS-CoV-2 infection rapidly spread around the world, Italy has quickly become one of the most affected countries. Healthcare systems introduced strict infection control measures to ensu..11.
    Maristella Bungaro ... Silvia Novello
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:481–489
    DOI: https://doi.org/10.37349/etat.2021.00058
    This article belongs to the special issue COVID-19 and Cancer
    View:1222
    Download:34
    Times Cited: 0
    Open Access
    Perspective
    Maternal imprinting, mitochondrial DNA, nuclear DNA and Alzheimer’s disease
    Familial early-onset Alzheimer’s disease (AD) is more probable in individuals coming from mothers diagnosed with AD than from fathers diagnosed with AD. Studies in animal models have show..11.
    Alberto Pérez-Mediavilla, Marta Zamarbide
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:121–126
    DOI: https://doi.org/10.37349/ent.2021.00010
    View:1131
    Download:35
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    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is even necessary to support cellular functions as a second messenger for homeostasis under physiological conditions. Therefore, redox medicine could develop as a new therapeutic concept for human health-benefits. ..11.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443–454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:4438
    Download:1784
    Open Access
    Review
    Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
    Adjuvant hormonal therapy is one of the most important treatments of hormone-receptor-positive breast cancer and includes selective estrogen receptor modulators, aromatase inhibitors, and luteinizin..11.
    Alfredo Rossi ... Marta Carlesimo
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:490–495
    DOI: https://doi.org/10.37349/etat.2021.00059
    This article belongs to the special issue Endocrine Resistant Breast Cancer
    View:1494
    Download:32
    Open Access
    Review
    Viral vector-based vaccines against SARS-CoV-2
    Viral vectors have been frequently applied for vaccine development. It has also been the case for vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to tackle the coronavi..11.
    Kenneth Lundstrom
    Published: October 31, 2021 Explor Immunol. 2021;1:295–308
    DOI: https://doi.org/10.37349/ei.2021.00020
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:3672
    Download:93
    Open Access
    Review
    Proteolysis-targeting chimeras and their implications in breast cancer
    Breast cancer (BC) is a highly heterogeneous neoplasm of the mammary tissue, causing the deaths of a large number of women worldwide. Nearly 70% and 20% of BC cases are estro..11.
    Angeles C. Tecalco-Cruz ... Alberto Rojas-Ochoa
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:496–510
    DOI: https://doi.org/10.37349/etat.2021.00060
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
    View:2212
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    Open Access
    Review
    Future incidence and mortality of colorectal carcinoma in the United States: an updated overview of risk factors and preventative measures
    According to the Global Cancer Observatory (GLOBOCAN) 2020, colorectal carcinoma (CRC) was the second leading cause of cancer death globally. Current literature utilizes reported databases such as Surveillance, Epidemiology, and End Results (SEER) to better understand the epidemiology of CRC. The global cancer observatory’s “Cancer Tomorrow” data visualization tools were used to predict the future incidence and mortality of colorectal cancers until 2030 as a guided tool to look over ways to reduce incidence by controlling risk factors of CRC. The total number of CRC is expected to rise by 2030, with a percent change of 17.3%. ..11.
    Hassam Ali
    Published: December 31, 2021 Explor Med. 2021;2:455–467
    DOI: https://doi.org/10.37349/emed.2021.00063
    View:1138
    Download:36
    Open Access
    Review
    Obstetric implications of maternal chronic hepatitis B virus infection
    Antenatal screening for hepatitis B surface antigen seropositivity is widely adopted to identify pregnant women with chronic hepatitis B virus (HBV) infection in order to target their newborn infants for combined passive-active neonatal immunization to prevent the maternal-to-child transmission of HBV. It is less certain whether the presence of chronic HBV infection in these largely asymptomatic women could impact their pregnancy outcome. There is now gathering ..11.
    Terence T. Lao
    Published: December 31, 2021 Explor Med. 2021;2:468–482
    DOI: https://doi.org/10.37349/emed.2021.00064
    View:1169
    Download:39
    Times Cited: 0
    Open Access
    Review
    The clinical advances of proteolysis targeting chimeras in oncology
    Proteolysis targeting chimeras (PROTACs) are a class of small molecules designed to target proteins for degradation. Their novel and unique modes of action provide PROTACs with the potential for the..11.
    Hao Xie ... Jason B. Fleming
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:511–521
    DOI: https://doi.org/10.37349/etat.2021.00061
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
    View:3959
    Download:212
    Open Access
    Review
    COVID-19 vaccine and immune response
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; βCoV), the causative agent of coronavirus disease 2019 (COVID-19), causes severe lower respiratory tract infections and acute ..11.
    Sevilay Hintistan, Hatice Demirağ
    Published: December 31, 2021 Explor Immunol. 2021;1:341–355
    DOI: https://doi.org/10.37349/ei.2021.00023
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:17014
    Download:46
    Times Cited: 0
    Open Access
    Original Article
    Cross-cultural adaptation of Delphi definitions of low back pain prevalence in French (Delphi DOLBaPP-F)
    Aim: The high heterogeneity in the definitions of low back pain encountered in the literature has led to the development of standardized definitions of this condition called “Delphi definitions of low back pain prevalence (Delphi DOLBaPP)” by a group of international researchers. In order to be widely used, these definitions need to be adapted according to the cultural and linguistic context. The aim of this work was to perform the cross-cultural adaptation of the Delphi DOLBaPP definitions in Quebec French and to pre-test them among French-speaking adults. ..11.
    Antarou Ly ... Clermont E. Dionne
    Published: December 31, 2021 Explor Med. 2021;2:483–493
    DOI: https://doi.org/10.37349/emed.2021.00065
    View:995
    Download:44
    Open Access
    Review
    Immunotherapy in head and neck squamous cell carcinoma and rare head and neck malignancies
    The dismal prognosis of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) prompted recent advances in the field of therapeutic approaches beyond cytotoxic cancer therapy. In r..11.
    Stefano Cavalieri ... Laura D. Locati
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:522–542
    DOI: https://doi.org/10.37349/etat.2021.00062
    This article belongs to the special issue Immunotherapy in Cancer Patients
    View:2187
    Download:95
    Open Access
    Review
    Peroxisomes in intracellular cholesterol transport: from basic physiology to brain pathology
    Peroxisomes are actively involved in the metabolism of various lipids including fatty acids, ether phospholipids, bile acids as well as the processing of reactive oxygen and nitrogen species. Recent..11.
    Jian Xiao ... Jie Luo
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:127–145
    DOI: https://doi.org/10.37349/ent.2021.00011
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2800
    Download:125
    Open Access
    Review
    Preeclampsia—an immune disease? An epidemiologic narrative
    The maternal syndrome preeclampsia is triggered by syncytiotrophoblast (STB) stress; the heterogeneity of the syndrome is caused by the different pathways leading to this STB stress. Inflammation pl..11.
    Gustaaf Albert Dekker, Pierre Yves Robillard
    Published: December 31, 2021 Explor Immunol. 2021;1:325–340
    DOI: https://doi.org/10.37349/ei.2021.00022
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    View:1740
    Download:33
    Times Cited: 0
    Open Access
    Review
    Immunoregulation in the testis and its implication in fertility and infections
    The testis is designated as one of the immune previleged sites in the body and harbours a unique immunoregulatory environment, which is important for preventing an immune response against sperm anti..11.
    Kushaan Khambata ... Satish K. Gupta
    Published: December 31, 2021 Explor Immunol. 2021;1:309–324
    DOI: https://doi.org/10.37349/ei.2021.00021
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    View:2161
    Download:59
    Times Cited: 0
    Open Access
    Review
    Molecular targets regulating endoplasmic reticulum-mitochondria crosstalk for NAFLD treatment
    Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease poses a significant impact on public healthcare and economic risk worldwide. As a multifactorial disease, NAFLD is usually associated with many comorbidities such as obesity, insulin resistance, hypertension, hyperlipidemia, diabetes, and cardiovascular disease. Without effectively preventive intervention, the advanced stage of NAFLD, non-alcoholic steatohepatitis (NASH), can progress to cirrhosis and hepatocellular carcinoma (HCC). ..11.
    Chunye Zhang, Ming Yang
    Published: December 31, 2021 Explor Med. 2021;2:494–510
    DOI: https://doi.org/10.37349/emed.2021.00066
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1462
    Download:65
    Times Cited: 0
    Open Access
    Review
    Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
    Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the het..11.
    Xuntian Jiang, Daniel S. Ory
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
    DOI: https://doi.org/10.37349/ent.2021.00012
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1928
    Download:86
    Open Access
    Original Article
    Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma
    Aim: To investigate alterations in transcription of genes, encoding Ca2+ toolkit proteins, in oesophageal adenocarcinoma (OAC) and to assess associations between gene expression, tumor ..11.
    Alana L. Cutliffe ... John J. Mackrill
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:543–575
    DOI: https://doi.org/10.37349/etat.2021.00063
    This article belongs to the special issue Calcium Signaling Apparatus in Cancers
    View:1833
    Download:50
    Open Access
    Review
    Vaccine-induced immune responses against SARS-CoV-2 infections
    Vaccination against coronavirus disease 2019 (COVID-19) is one of the most effective tools to curb the pandemic. Multiple vaccine candidates based on different platforms are available for emergency ..11.
    Mandeep Garg ... Suruchi Garg
    Published: December 31, 2021 Explor Immunol. 2021;1:356–373
    DOI: https://doi.org/10.37349/ei.2021.00024
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:1471
    Download:29
    Times Cited: 0
    Open Access
    Review
    Activation of mucosal immunity and novel prophylactic and therapeutic strategy in combating COVID-19
    Coronavirus disease 2019 (COVID-19) emerges as an expeditiously growing pandemic, in the human population caused by the highly transmissible RNA virus severe acute respiratory syndrome of coronaviru..11.
    Swapan K. Chatterjee ... Maria Nilda M. Munoz
    Published: December 31, 2021 Explor Immunol. 2021;1:374–397
    DOI: https://doi.org/10.37349/ei.2021.00025
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:2592
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    Open Access
    Commentary
    Functions of two distinct Kupffer cells in the liver
    Tissue-resident macrophages play critically important roles in host homeostasis and pathogenesis of diseases, with the functions of phagocytosis, metabolism, and immune modulation. Recently, two research studies accomplished by a collaborated group of researchers showed that there are two populations of liver resident Kupffer cells (KCs), including a major cluster of differentiation 206 low expression (CD206low)endothelial cell-selective adhesion molecule negative (ESAM−) population (KC1) and a minor CD206highESAM+ population (KC2). ..11.
    Chunye Zhang ... Ming Yang
    Published: December 31, 2021 Explor Med. 2021;2:511–515
    DOI: https://doi.org/10.37349/emed.2021.00067
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:2113
    Download:111
    Open Access
    Review
    A unique vaccine for birth control and treatment of advanced stage cancers secreting ectopically human chorionic gonadotropin
    This article is a tribute and homage to Gerard Chaouat who invited me to contribute this article. My years in France have remained very memorable to me. Reviewed briefly is the vaccine that was made..11.
    Gursaran P. Talwar ... Krishna M. Ella
    Published: December 31, 2021 Explor Immunol. 2021;1:398–405
    DOI: https://doi.org/10.37349/ei.2021.00026
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    View:1971
    Download:36
    Times Cited: 0
    Open Access
    Review
    Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases
    The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by cytochrome P450 46A1 (CYP46A1). ..11.
    Irina A. Pikuleva
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:159–172
    DOI: https://doi.org/10.37349/ent.2021.00013
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2139
    Download:86
    Open Access
    Review
    Progesterone induced blocking factor in health and disease
    The foetus expressing paternal antigens ought to be “rejected” by the maternal immune system. However, the immunological relationship of the mother and the foetus does not follow the rules of transplantation immunology. Maternal immune functions are re-adjusted during pregnancy, to create a tolerant environment for the developing foetus. Progesterone and its downstream mediator; the progesterone induced blocking factor (PIBF) are important in this process. The mRNA transcribed from the PIBF1 gene contains 18 exons, and codes for a 90 kDa protein. The 90 kDa form is associated with the centrosome and plays a role in cell cycle regulation, while smaller isoforms produced by alternative spicing are secreted, and bind to the glycosylphosphatidylinositol (GPI) anchored PIBF receptor. Upon ligation, the former forms a heterodimer with the alpha chain of the interleukin-4 (IL-4) receptor and activates the Janus kinase/signal transducers and activators of transcription (Jak/STAT) pathway, via which, PIBF induces increased production of T helper2 (Th2) cytokines. PIBF regulates natural killer (NK) cytotoxicity, by inhibiting perforin release from the cytoplasmic granules of NK cells. During normal human pregnancy, the serum concentrations of PIBF increase with gestational age, and lower than normal serum levels predict spontaneous pregnancy termination. Depletion of PIBF during the peri-implantation period in mice, results in lower implantation and increased resorption rates, together with increased decidual and peripheral NK activity, downregulation of the genes implicated in T cell activation in CD4+ cells, and Th1 differentiation of the T cells. PIBF is expressed in rapidly proliferating immature cells as well as several tumours, and regulates invasion. The PIBF gene has been identified in the chromosomal region 13q21-q22—which is a common site for somatic deletions in a variety of malignant tumours. These data suggest that PIBF might be involved in tumorigenesis..11.
    Julia Szekeres-Bartho
    Published: December 31, 2021 Explor Immunol. 2021;1:406–417
    DOI: https://doi.org/10.37349/ei.2021.00027
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    View:1527
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    Open Access
    Original Article
    Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates
    Aim: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. Methods: Four different analytical methods [AlogP calculation, reverse phase (RP) high-performance liquid chromatography (HPLC; RP-HPLC), size exclusion chromatography HPLC (SEC-HPLC), and differential scanning calorimetry (DSC)] were tested for this comparison...11.
    Tomohiro Fujii ... Yutaka Matsuda
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:576–585
    DOI: https://doi.org/10.37349/etat.2021.00064
    This article belongs to the special issue Antibody-Drug Conjugates
    View:2323
    Download:151
    Open Access
    Review
    Key roles of CCCTC-binding factor in cancer evolution and development
    The processes of cancer and embryonic development have a partially overlapping effect. Several transcription factor families, which are highly conserved in the evolutionary history of biology, play a key role in the development of cancer and are often responsible for the pivotal developmental processes such as cell survival, expansion, senescence, and differentiation. As an evolutionary conserved and ubiquitously expression protein, CCCTC-binding factor (CTCF) has diverse regulatory functions, including gene regulation, imprinting, insulation, X chromosome inactivation, and the establishment of three-dimensional (3D) chromatin structure during human embryogenesis. ..11.
    Zishuai Li ... Guangwen Cao
    Published: December 31, 2021 Explor Med. 2021;2:516–526
    DOI: https://doi.org/10.37349/emed.2021.00068
    View:1256
    Download:37
    Times Cited: 0
    Open Access
    Review
    Crosstalk between keratinocytes and immune cells in inflammatory skin diseases
    Cutaneous homeostasis is maintained by dynamic cellular communications between different cell types in the skin through interactions with various mediators, including cytokines, chemokines and antim..11.
    Xinhui Ni, Yuping Lai
    Published: December 31, 2021 Explor Immunol. 2021;1:418–431
    DOI: https://doi.org/10.37349/ei.2021.00028
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:2313
    Download:146
    Open Access
    Review
    A global genetic epidemiological review of pseudoexfoliation syndrome
    Pseudoexfoliation (PXF) syndrome is an important public health concern requiring individual population level analysis. Disease prevalence differs by geographic location and ethnicity, and has environmental, demographic, genetic, and molecular risk factors have been demonstrated. Epidemiological factors that have been associated with PXF include age, sex, environmental factors, and diet. Genetic and molecular components have also been identified that are associated with PXF...11.
    Patrice M. Hicks ... Margaret M. DeAngelis
    Published: December 31, 2021 Explor Med. 2021;2:527–543
    DOI: https://doi.org/10.37349/emed.2021.00069
    View:1671
    Download:62
    Times Cited: 0
    Open Access
    Review
    Antioxidant enzymes and vascular diseases
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in regulating endothelial function and vascular tone in the physiological conditions of a vascular system. However, oxidative stress has detrimental effects on human health, and numerous studies confirmed that high ROS/RNS production contributes to the initiation and progression of cardiovascular diseases. The antioxidant defense has an essential role in the homeostatic functioning of the vascular endothelial system. Endogenous antioxidative defense includes various molecules and enzymes such as superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase. ..11.
    Jelena Radovanovic ... Esma R. Isenovic
    Published: December 31, 2021 Explor Med. 2021;2:544–555
    DOI: https://doi.org/10.37349/emed.2021.00070
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1753
    Download:68
    Open Access
    Review
    Interface between obesity with dysfunctional metabolism and inflammation, and the triple-negative breast cancer in African American women
    Obesity has dramatically increased over the past fifty years. In the last decade, it has been noted that augmented body mass, metabolic abnormalities, and the relevant “obese”..11.
    Katarzyna Rygiel
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:602–616
    DOI: https://doi.org/10.37349/etat.2021.00066
    This article belongs to the special issue Endocrine Resistant Breast Cancer
    View:1398
    Download:55
    Open Access
    Review
    Blocking cholesterol storage to treat Alzheimer’s disease
    Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltr..11.
    Ta Yuan Chang ... James G. Gow
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
    DOI: https://doi.org/10.37349/ent.2021.00014
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2587
    Download:87
    Open Access
    Review
    New variants of SARS-CoV-2, vaccine immune response and the Brazilian reality
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly pathogenic β-coronavirus, is the etiologic agent of coronavirus disease 2019 (COVID-19), which gave rise to a diffi..11.
    Marileia Chaves Andrade ... Hellen Oliveira Rosa
    Published: December 31, 2021 Explor Immunol. 2021;1:432–439
    DOI: https://doi.org/10.37349/ei.2021.00029
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:1092
    Download:40
    Times Cited: 0
    Open Access
    Original Article
    The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type
    Aim: Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that play a fundamental role in transcription regulation. Preclinical and early clinical evidence sustain BET targ..11.
    Chiara Tarantelli ... Francesco Bertoni
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:586–601
    DOI: https://doi.org/10.37349/etat.2021.00065
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
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    Open Access
    Review
    State-of-the-art preclinical evaluation of COVID-19 vaccine candidates
    The coronavirus disease 2019 (COVID-19) results from the infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and primarily affects the respiratory tissue. Since first reported ..11.
    Devlina Ghosh ... Abhishek Saxena
    Published: December 31, 2021 Explor Immunol. 2021;1:440–460
    DOI: https://doi.org/10.37349/ei.2021.00030
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:1620
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    Times Cited: 0
    Open Access
    Review
    Pregnancy depends on a delicate balance of immune activation and regulation
    It is well recognized that immune tolerance is important to prevent semiallografted fetuses from rejection by maternal immunocompetent cells; however, immune activation also plays an important role ..11.
    Shigeru Saito ... Sayaka Tsuda
    Published: December 31, 2021 Explor Immunol. 2021;1:461–478
    DOI: https://doi.org/10.37349/ei.2021.00031
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    View:1403
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    Times Cited: 0
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the ..11.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
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    Open Access
    Review
    Antibody-drug conjugate therapies in multiple myeloma—what’s next on the horizon?
    Targeted immunotherapy has arisen over the past decade to the forefront of cancer care. Notably, targeted therapies such as antibody-drug conjugates (ADCs) are becoming more recognized for a novel a..11.
    Monique Hartley-Brown, Paul Richardson
    Published: January 14, 2022 Explor Target Antitumor Ther. 2022;3:1–10
    DOI: https://doi.org/10.37349/etat.2022.00067
    This article belongs to the special issue Antibody-Drug Conjugates
    View:2655
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    Open Access
    Original Article
    Preclinical toxicity test results of a new antiviral–immune-modulator compound consisting of flavonoid molecules (COVID-19 clinical trial preliminary data)
    Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of bioavailability and molecular concentrations. The specific formula is then tested..11.
    Gürer G. Budak ... Orkun Tarkun
    Published: January 18, 2022 Explor Med. 2022;3:1–21
    DOI: https://doi.org/10.37349/emed.2022.00071
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    Open Access
    Perspective
    Fertility and COVID-19 vaccination
    One of the most troubling developments of 2021 has been the number of fertile-age women who have been led to believe that mRNA vaccines against severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2, coronavirus disease 2019 (COVID-19)] can cause infertility via cross-reactivity of immune response. Specifically, cross-reactivity of developed antibodies to syncytin-1, a protein found in human cell fusion, placentation and recently identified in the envelope gene of a human endogenous defective retrovirus, HERV-W (see “Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis”. Nature.2000;403:785–9. doi: 10.1038/35001608). The mechanism, evidence, and evaluation of the claim is presented concluding in a rejection due to lack of evidence...11.
    Iosif M. Gershteyn
    Published: February 11, 2022 Explor Immunol. 2022;2:1–8
    DOI: https://doi.org/10.37349/ei.2022.00032
    View:1338
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    Times Cited: 0
    Open Access
    Original Article
    Bcl-2-like protein-10 increases aggressive features of melanoma cells
    Aim: B-cell lymphoma-2 (Bcl-2)-like protein-10 (Bcl2L10) is the less studied member of Bcl-2 family proteins, with the controversial role in different cancer histotypes. Very recently, Bcl2L10 ex..11.
    Donatella Del Bufalo ... Simona D’Aguanno
    Published: January 30, 2022 Explor Target Antitumor Ther. 2022;3:11–26
    DOI: https://doi.org/10.37349/etat.2022.00068
    This article belongs to the special issue The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy
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    Times Cited: 0
    Open Access
    Review
    Immune titers of protection against severe acute respiratory syndrome coronavirus 2: are we there yet?
    A few pieces of research exist about the protective titer against severe acute respiratory syndrome (SARS) coronavirus 2 (CoV-2; SARS-CoV-2) in monkeys and humans in which the protection could be sh..11.
    Yoanna Slabakova ... Tsvetelina Velikova
    Published: February 11, 2022 Explor Immunol. 2022;2:9–24
    DOI: https://doi.org/10.37349/ei.2022.00033
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:1383
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    Open Access
    Perspective
    Endometriosis and autoimmunity
    Endometriosis is an inflammatory oestrogen-dependent chronic disease and is mainly expressed by pain and increased infertility. Several studies showed an increased prevalence of autoimmune systemic ..11.
    Noémie Abisror ... Arsene Mekinian
    Published: February 16, 2022 Explor Immunol. 2022;2:25–31
    DOI: https://doi.org/10.37349/ei.2022.00034
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    View:1139
    Download:27
    Times Cited: 0
    Open Access
    Review
    Nano-immunotherapeutics: targeting approach as strategic regulation at tumor microenvironment for cancer treatment
    Cancer is the leading cause of mortality worldwide, which necessitates our consideration related to novel treatment approach. Tumor cells at the tumor microenvironment (TME), regulate a plethora of ..11.
    Priyanka Singh ... Anita Kamra Verma
    Published: February 16, 2022 Explor Med. 2022;3:22–42
    DOI: https://doi.org/10.37349/emed.2022.00072
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:1668
    Download:46
    Open Access
    Review
    γδT cells: alternative treasure in antitumor immunity
    In recent decades, abundant methods for targeted tumor cell immunotherapy have been developed. It was recently discovered that excellent curative effects observed in hematological tumors cannot be achieved in solid tumors, as serious side effects will occur...11.
    Xiangjin Zhang ... Wei He
    Published: February 17, 2022 Explor Immunol. 2022;2:32–47
    DOI: https://doi.org/10.37349/ei.2022.00035
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
    View:1175
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    Times Cited: 0
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole..11.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:4418
    Download:195
    Open Access
    Review
    Dry needling in stroke
    Stroke causes acute neurological deficit which is an important cause of morbidity and mortality. Neurorehabilitation is an important dimension in the management of post-stroke deficits. Spasticity, ..11.
    Nirmal Surya, Guhan Ramamurthy
    Published: February 17, 2022 Explor Neuroprot Ther. 2022;2:28–35
    DOI: https://doi.org/10.37349/ent.2022.00016
    This article belongs to the special issue Dry Needling for Neurological Disorders
    View:2870
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    Times Cited: 0
    Open Access
    Review
    The microbiota is a potential mediator of the crosstalk between γδ T cells and tumors
    γδ T cells are one of the immune cell types that express antigen receptors. γδ T cells are able to recognize pathogens or cancer cells independently o..11.
    Huidi Wang ... Jia Yin
    Published: February 18, 2022 Explor Immunol. 2022;2:48–63
    DOI: https://doi.org/10.37349/ei.2022.00036
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
    View:1224
    Download:30
    Open Access
    Review
    Tumor-associated protein ligands recognized by human γδ T cell receptor and their implications in cancer therapy
    In recent years, immunologists have been working to utilize the functional mechanism of the immune system to research new tumor treatment methods and achieved a major breakthrough in 2013, which was..11.
    Chang Liu ... Wei He
    Published: February 22, 2022 Explor Immunol. 2022;2:64–78
    DOI: https://doi.org/10.37349/ei.2022.00037
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
    View:1262
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    Times Cited: 0
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra..11.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:3779
    Download:145
    Open Access
    Review
    Oxidative stress in obesity and insulin resistance
    Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published lite..11.
    Anastasija Panic ... Esma R. Isenovic
    Published: February 23, 2022 Explor Med. 2022;3:58–70
    DOI: https://doi.org/10.37349/emed.2022.00074
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:2701
    Download:128
    Open Access
    Review
    γδ T cell costimulatory ligands in antitumor immunity
    Antitumor immunity relies on the ability of T cells to recognize and kill tumor targets. γδ T cells are a specialized subset of T cells that predominantly localizes to non-ly..11.
    Joseph M. McGraw, Deborah A. Witherden
    Published: February 24, 2022 Explor Immunol. 2022;2:79–97
    DOI: https://doi.org/10.37349/ei.2022.00038
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
    View:2023
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    Open Access
    Review
    Novel insights based on the plasticity of γδ T cells in the tumor microenvironment
    γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner,..11.
    Yue Wang ... Wei He
    Published: February 24, 2022 Explor Immunol. 2022;2:98–132
    DOI: https://doi.org/10.37349/ei.2022.00039
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
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    Open Access
    Editorial
    Elimination of hepatitis C virus infection in Europe: targeting the obstacles
    Dante Romagnoli
    Published: February 24, 2022 Explor Med. 2022;3:71–76
    DOI: https://doi.org/10.37349/emed.2022.00075
    This article belongs to the special issue Exploring Chronic Liver Disease
    Open Access
    Review
    Multi-faced roles of reactive oxygen species in anti-tumor T cell immune responses and combination immunotherapy
    T cells play a central role in anti-tumor immunity, and reactive oxygen species (ROS) lie at the crossroad on the anti-tumor T cell responses. To activate efficient T cell immunity, a moderate level..11.
    Tao Wang, Haiyan Xu
    Published: February 25, 2022 Explor Med. 2022;3:77–98
    DOI: https://doi.org/10.37349/emed.2022.00076
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1832
    Download:65
    Open Access
    Review
    New antibody-drug conjugates (ADCs) in breast cancer—an overview of ADCs recently approved and in later stages of development
    Antibody-drug conjugates (ADCs) have changed the treatment of breast cancer (BC) in more recent years. BC is a heterogenous group of malignancies with a broad range of histopathological characterist..11.
    Kira-Lee Koster ... Markus Joerger
    Published: February 24, 2022 Explor Target Antitumor Ther. 2022;3:27–36
    DOI: https://doi.org/10.37349/etat.2022.00069
    This article belongs to the special issue Antibody-Drug Conjugates
    View:3025
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    Open Access
    Original Article
    B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells
    Aim: T-helper cells could play an important role in the pathogenesis of chronic lymphocytic leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble antigens targeted from..11.
    Annabel R. Minton ... Graham Packham
    Published: February 25, 2022 Explor Target Antitumor Ther. 2022;3:37–49
    DOI: https://doi.org/10.37349/etat.2022.00070
    View:1927
    Download:68
    Open Access
    Original Article
    Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia
    Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously..11.
    Kristin E. Reeve ... Babbette LaMarca
    Published: February 25, 2022 Explor Med. 2022;3:99–111
    DOI: https://doi.org/10.37349/emed.2022.00077
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1402
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