Our site uses cookies to offer you a better user experience. By continuing to use this site, you agree to our use of cookies. To find out more, read our Privacy and Cookies policies.
  • Open Access
    Original Article
    Insights into the binding selectivity of harzianoic acids A and B to tetraspanin CD81
    Aim: Harzianoic acids A and B (Hz-A/B) are two rare cyclobutene-containing sesquiterpenes isolated from a marine strain of the sponge-associated fungus Trichoderma harzianum. They display antican..11.
    Gérard Vergoten, Christian Bailly
    Online First: November 01, 2023 Explor Drug Sci. 2023;1:405–419
    DOI: https://doi.org/10.37349/eds.2023.00027
    View:35
    Download:5
    Times Cited: 0
    Open Access
    Meta-Analysis
    Efficacy and safety of CDP-choline, cerebrolysin, MLC601, and edaravone in recovery of patients with acute ischemic strokes: a meta-analysis
    Aim: Stroke is the second most common cause of mortality and disability worldwide with ischemic strokes being the predominant type. The advent of neuroprotectants brought hope of improved outcome..11.
    Shafiq Dexter B. Abou Zaki, Johnny K. Lokin
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:398–408
    DOI: https://doi.org/10.37349/ent.2023.00057
    This article belongs to the special issue Therapeutic Targets for Neuroprotection in Ischemic Stroke
    View:38
    Download:2
    Times Cited: 0
    Open Access
    Original Article
    Figuring the characteristics of the Delta variant SARS-CoV-2 gene mutations in an Indonesian hospital: a descriptive study
    Aim: Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 has undergone several mutations, and ult..11.
    Phey Liana ... Tungki Pratama Umar
    Published: October 31, 2023 Explor Med. 2023;4:839–846
    DOI: https://doi.org/10.37349/emed.2023.00181
    This article belongs to the special issue Emerging Infectious Diseases
    View:69
    Download:6
    Times Cited: 0
    Open Access
    Review
    Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing
    Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford..11.
    Naoko Suga ... Satoru Matsuda
    Published: October 31, 2023 Explor Med. 2023;4:822–838
    DOI: https://doi.org/10.37349/emed.2023.00180
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:65
    Download:7
    Times Cited: 0
    Open Access
    Original Article
    Broccoli by-product extract as a functional ingredient: food application
    Aim: Food production demand has been promoting an increase in the generation of agro-industrial waste. Food industry waste can contain compounds with added value that, if properly extracted and u..11.
    David Q. Martínez ... Presentación García
    Published: October 31, 2023 Explor Foods Foodomics. 2023;1:235–243
    DOI: https://doi.org/10.37349/eff.2023.00018
    This article belongs to the special issue Natural Products in Health and Disease
    View:55
    Download:4
    Times Cited: 0
    Open Access
    Perspective
    A U.S. Food and Drug Administration perspective on cannabis research and drug development
    Since the early 1970s, the U.S. Food and Drug Administration (FDA) has received over 800 investigational new drug applications (INDs) for, and pre-INDs pertaining to, research of cannabis or cannabi..11.
    Cassandra L. Taylor, Schuyler A. Pruyn
    Published: October 31, 2023 Explor Med. 2023;4:813–821
    DOI: https://doi.org/10.37349/emed.2023.00179
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:663
    Download:76
    Times Cited: 0
    Open Access
    Commentary
    A decade of CD4+ chimeric antigen receptor T-cell evolution in two chronic lymphocytic leukemia patients: were chronic lymphocytic leukemia cells present?
    On Feb 2, 2022, Nature published the paper titled “Decade-long leukemia remissions with the persistence of CD4+ CAR T-cells” (Nature. 2022;602:503–9. doi: 10.1038/s41586-021-04390-6). Accordin..11.
    Dimitrios Bouzianas, Stella Bouziana
    Published: October 31, 2023 Explor Target Antitumor Ther. 2023;4:1128–1135
    DOI: https://doi.org/10.37349/etat.2023.00186
    This article belongs to the special issue Novel Strategies and Targets for Immunotherapy of Cancer
    View:52
    Download:4
    Times Cited: 0
    Open Access
    Original Article
    Exploring green extraction methods to obtain polyphenols from partially defatted chia (Salvia hispanica L.) flour
    Aim: The extraction of polyphenols is commonly accomplished using conventional techniques such as solid-liquid and liquid-liquid extraction, which are associated with the use of high quantities o..11.
    Micaela Antón ... Rafael Borneo
    Published: October 31, 2023 Explor Foods Foodomics. 2023;1:221–234
    DOI: https://doi.org/10.37349/eff.2023.00017
    This article belongs to the special issue The food (r)evolution towards food quality/security and human nutrition
    View:58
    Download:8
    Times Cited: 0
    Open Access
    Review
    Recent advancements in skin cancer treatment: a critical review
    The prevalence of skin cancer has increased hastily in the recent decade for both kinds of melanoma and non-melanoma skin cancer. Skin cancers mostly encompass keratinocyte cancers: cutaneous squamo..11.
    Rajat Goyal ... Rohit Sharma
    Published: October 31, 2023 Explor Med. 2023;4:782–812
    DOI: https://doi.org/10.37349/emed.2023.00178
    View:221
    Download:7
    Times Cited: 0
    Open Access
    Review
    Exploration of transcutaneous vagus nerve stimulation as a treatment option for adjuvant cancer and heart failure therapy
    Vagus nerve stimulation (VNS) has gained prominence in the treatment of various clinical disorders such as migraine, depression, and tinnitus. Based on increased scientific knowledge of the VNS and ..11.
    Niklas Frank ... Carola Y. Förster
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:363–397
    DOI: https://doi.org/10.37349/ent.2023.00056
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:64
    Download:8
    Times Cited: 0
    Open Access
    Review
    Stem cell therapy in neurological disorders: promises and concerns
    Self-neuronal regeneration is often limited or nonexistent after neuronal cell damage, making new technologies necessary for treating neurological damage. Although the brain can partially compensate..11.
    Said Hachimi-Idrissi
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:346–362
    DOI: https://doi.org/10.37349/ent.2023.00055
    This article belongs to the special issue Therapeutic Targets for Neuroprotection in Ischemic Stroke
    View:49
    Download:3
    Times Cited: 0
    Open Access
    Mini Review
    Small airway dysfunction and impulse oscillometry in adult patients with asthma: recent findings
    Asthma is a respiratory disease affecting more than 300 million people around the world. Airflow obstruction and inflammation due to asthma usually involve large airways, but recently small airway i..11.
    Marcello Cottini ... Alvise Berti
    Published: October 31, 2023 Explor Asthma Allergy. 2023;1:163–173
    DOI: https://doi.org/10.37349/eaa.2023.00017
    This article belongs to the special issue Small Airways Disease Across the Ages
    View:76
    Download:7
    Times Cited: 0
    Open Access
    Review
    Precision medicine: how to approach the adolescent asthmatic
    It is well known that adolescent patients often have less than optimal outcomes. Adolescence is a time of much transition, physically, emotionally, and socially all of which have effects on asthma m..11.
    Alan Kaplan
    Published: October 31, 2023 Explor Asthma Allergy. 2023;1:153–162
    DOI: https://doi.org/10.37349/eaa.2023.00016
    This article belongs to the special issue Precision Medicine in Allergy and Rhinology
    View:45
    Download:6
    Times Cited: 0
    Open Access
    Original Article
    Safety of 2-day rush induction protocol in sublingual immunotherapy with Pru p 3
    Aim: Allergy to lipid transfer proteins (LTPs) clinically manifests from oral allergy syndrome (OAS) to anaphylaxis. The risk of systemic symptoms and cross-reactivity make it an important target..11.
    Maria Inês T. Silva ... Célia Costa
    Published: October 31, 2023 Explor Asthma Allergy. 2023;1:142–152
    DOI: https://doi.org/10.37349/eaa.2023.00015
    View:50
    Download:8
    Times Cited: 0
    Open Access
    Review
    Contemporary review: recognition, management, and screening for radiation-induced heart disease
    Radiation is a primary therapy in the treatment of thoracic malignancies with clear survival benefits. Consequently, patients with cancer are living longer but may be subject to a wide array of card..11.
    Chirag Mehta ... Jess Brar
    Published: October 30, 2023 Explor Med. 2023;4:772–781
    DOI: https://doi.org/10.37349/emed.2023.00177
    View:91
    Download:8
    Times Cited: 0
    Open Access
    Original Article
    Coronary external diameter index for assessing coronary artery involvement in Kawasaki disease
    Aim: Transthoracic echocardiography is commonly used to assess coronary artery dilatation in Kawasaki disease (KD). However, existing criteria often miss early abnormalities. This study examines ..11.
    Andrea Azzarelli ... Francesco Vierucci
    Published: October 31, 2023 Explor Cardiol. 2023;1:103–113
    DOI: https://doi.org/10.37349/ec.2023.00011
    View:128
    Download:14
    Times Cited: 0
    Open Access
    Review
    Echocardiographic predictors of outcomes in hypertrophic cardiomyopathy
    The use of echocardiography, a straightforward and widely available technique, allows for a comprehensive assessment of the patient with hypertrophic cardiomyopathy (HCM) under both resting and stre..11.
    Annamaria Del Franco ... Iacopo Olivotto
    View:101
    Download:7
    Times Cited: 0
    Open Access
    Perspective
    Cholesterol esterification and p53-mediated tumor suppression
    Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53’s product, p53 regulates many biological processes, including cell metabolism..11.
    Youjun Li ... Edward V. Prochownik
    Published: October 31, 2023 Explor Target Antitumor Ther. 2023;4:1122–1127
    DOI: https://doi.org/10.37349/etat.2023.00185
    This article belongs to the special issue Therapeutic Targeting of the Tumor Microenvironment
    View:51
    Download:3
    Times Cited: 0
    Open Access
    Perspective
    Immune-based, multifaceted inactivation of pathogenic T lymphocytes in treating autoimmune diseases
    Immunotherapeutic treatment of autoimmune diseases should aim to inactivate autoaggressive memory T-cells and restore immune tolerance. It is envisaged that three approaches could be used to achieve..11.
    Victor Ivanovich Seledtsov ... Alexei A. von Delwig
    Published: October 30, 2023 Explor Immunol. 2023;3:506–512
    DOI: https://doi.org/10.37349/ei.2023.00117
    This article belongs to the special issue Cell Biology and Treatment of Autoimmune Diseases
    View:122
    Download:8
    Times Cited: 0
    Open Access
    Original Article
    Creation and interpretation of machine learning models for aqueous solubility prediction
    Aim: Solubility prediction is an essential factor in rational drug design and many models have been developed with machine learning (ML) methods to enhance the predictive ability. However, most o..11.
    Minyi Su, Enric Herrero
    Published: October 30, 2023 Explor Drug Sci. 2023;1:388–404
    DOI: https://doi.org/10.37349/eds.2023.00026
    This article belongs to the special issue Machine Learning for Drug Science
    View:46
    Download:5
    Times Cited: 0
    Open Access
    Review
    Determinants of human longevity: input of environment, nutrition, physical activity, eustress, heredity, health care, motivation, and mental state
    The paper aims to review the possibilities of a complex transdisciplinary approach to forming health and longevity. Determinants of productive longevity (DPL) and health culture are reviewed; defini..11.
    Renad I. Zhdanov ... Alexey S. Sozinov
    Published: October 30, 2023 Explor Med. 2023;4:755–771
    DOI: https://doi.org/10.37349/emed.2023.00176
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:92
    Download:8
    Times Cited: 0
    Open Access
    Mini Review
    Nutritional treatment with the ketogenic diet in children with refractory epilepsy: a narrative review
    The two mainstays of therapy for refractory epilepsy are medication and surgery. Child behavioral and cognitive aspects of epilepsy can be improved by using a specialized dietary regimen such as the..11.
    Srilaxmi Vityala ... Swathi Nenavath
    Published: October 30, 2023 Explor Neurosci. 2023;2:245–250
    DOI: https://doi.org/10.37349/en.2023.00025
    This article belongs to the special issue Epilepsy
    View:79
    Download:12
    Times Cited: 0
    Open Access
    Review
    Mitral valve prolapse—arrhythmic faces of the valve disease
    Mitral valve prolapse (MVP) is a relatively common mitral valvulopathy and the most common cause of isolated primary mitral regurgitation (MR) requiring surgical repair. It affects about 1–3% of t..11.
    Maria Możdżan ... Karina Wierzbowska-Drabik
    View:50
    Download:7
    Times Cited: 0
    Open Access
    Review
    Neuroprotective astroglial response to neural damage and its relevance to affective disorders
    Astrocytes not only support neuronal function with essential roles in synaptic neurotransmission, action potential propagation, metabolic support, or neuroplastic and developmental adaptations. They..11.
    José Javier Miguel-Hidalgo
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:328–345
    DOI: https://doi.org/10.37349/ent.2023.00054
    This article belongs to the special issue Glia and Neuroprotection
    View:56
    Download:9
    Times Cited: 0
    Open Access
    Original Article
    Acryl-3,5-bis(2,4-difluorobenzylidene)-4-piperidone targeting cellular JUN proto-oncogene, AP-1 transcription factor subunit inhibits head and neck squamous cell carcinoma progression
    Aim: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with a survival rate below fifty percent. Addressing meager therapeutic options, a series of small m..11.
    Levi Arnold ... Sufi Mary Thomas
    Published: October 31, 2023 Explor Target Antitumor Ther. 2023;4:1104–1121
    DOI: https://doi.org/10.37349/etat.2023.00184
    This article belongs to the special issue Therapeutic Targeting of the Tumor Microenvironment
    View:73
    Download:7
    Times Cited: 0
    Open Access
    Systematic Review
    Impact of coronavirus disease 2019 pandemic on good clinical practice trials in oncology
    Aim: Coronavirus disease 2019 (COVID-19) became pandemic on 11th March 2020 and it deeply stressed the healthcare system. Cancer patients represent a vulnerable population, so many recommendation..11.
    Veronica Agostinelli ... Rossana Berardi
    Published: October 30, 2023 Explor Target Antitumor Ther. 2023;4:1095–1103
    DOI: https://doi.org/10.37349/etat.2023.00183
    This article belongs to the special issue COVID-19 and Cancer
    View:63
    Download:3
    Times Cited: 0
    Open Access
    Review
    Coronavirus disease 2019 and lung cancer: where are we?
    Oncology patients are more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection due to hospital contact and an immunological system that can be compromised by antine..11.
    Abrahams Ocanto ... Felipe Couñago
    Published: October 30, 2023 Explor Target Antitumor Ther. 2023;4:1082–1094
    DOI: https://doi.org/10.37349/etat.2023.00182
    This article belongs to the special issue COVID-19 and Cancer
    View:79
    Download:3
    Times Cited: 0
    Open Access
    Review
    Cardiovascular imaging in COVID-19: insights into features and complications
    The clinical manifestations of COVID-19 which mainly involve the respiratory system may however affect also cardiovascular system. There are a lot and still increasing numbers of reports revealing c..11.
    Iwona Duraj ... Karina Wierzbowska-Drabik
    Published: October 30, 2023 Explor Cardiol. 2023;1:59–71
    DOI: https://doi.org/10.37349/ec.2023.00008
    View:57
    Download:7
    Times Cited: 0
    Open Access
    Review
    Overcoming phenotypic switching: targeting protein-protein interactions in cancer
    Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative ..11.
    Christos Ladias ... Nikolaos A. Papanikolaou
    Published: October 30, 2023 Explor Target Antitumor Ther. 2023;4:1071–1081
    DOI: https://doi.org/10.37349/etat.2023.00181
    This article belongs to the special issue Off-label drugs and -omics data in cancer treatment
    View:66
    Download:6
    Times Cited: 0
    Open Access
    Original Article
    Effect of vitamin D supplementation on inflammatory markers and total antioxidant capacity in breast cancer women using a machine learning technique
    Aim: This study aimed to establish a learning system using an artificial neural network (ANN) to predict the effects of vitamin D supplementation on the serum levels of vitamin D, inflammatory fa..11.
    Marzieh Tahmasebi ... Amir Jamshidnezhad
    Published: October 30, 2023 Explor Target Antitumor Ther. 2023;4:1059–1070
    DOI: https://doi.org/10.37349/etat.2023.00180
    View:74
    Download:7
    Times Cited: 0
    Open Access
    Original Article
    Association of mutations in hemochromatosis genes with clinical severity of calcium pyrophosphate arthritis
    Aims: To study factors associated with the development of calcium pyrophosphate (CPP) arthritis and the severity phenotype. Methods: Transversal case-control study. Cases had to be confirme..11.
    Joana Atxotegi-Saenz de Buruaga ... Fernando Perez-Ruiz
    Published: October 31, 2023 Explor Musculoskeletal Dis. 2023;1:186–193
    DOI: https://doi.org/10.37349/emd.2023.00021
    View:59
    Download:9
    Times Cited: 0
    Open Access
    Perspective
    Nutritional problems in rheumatoid arthritis patients with temporomandibular joint involvement
    Rheumatoid arthritis (RA) is an inflammatory arthritis that affects synovial joints, and it is not surprising that the temporomandibular joint (TMJ), a synovial joint, is also affected. However, TMJ..11.
    Manolya Ilhanli, Ilker Ilhanli
    Published: October 31, 2023 Explor Musculoskeletal Dis. 2023;1:180–185
    DOI: https://doi.org/10.37349/emd.2023.00020
    This article belongs to the special issue Comorbidities in rheumatoid arthritis
    View:49
    Download:7
    Times Cited: 0
    Open Access
    Original Article
    Development of soy whey fortified orange juice beverages: their physicochemical, rheological, antioxidant, and sensory properties
    Aim: Soy whey is a byproduct of tofu production and is being discarded after tofu preparation. However, soy whey is a rich source of phytochemicals, minerals, and protein. The present study was c..11.
    Hilal Ahmad Punoo ... Andleeb Muzaffar
    Published: October 29, 2023 Explor Foods Foodomics. 2023;1:206–220
    DOI: https://doi.org/10.37349/eff.2023.00016
    View:73
    Download:7
    Times Cited: 0
    Open Access
    Perspective
    Antiseptic pyolytics and warming wet compresses improve the prospect of healing chronic wounds
    Infection and suppuration of chronic wounds reduce the effectiveness of their treatment with a course of antibiotics and antiseptics combined with frequently renewed dressings. Therefore, daily shor..11.
    Aleksandr Urakov ... Marina Zavarzina
    Published: October 27, 2023 Explor Med. 2023;4:747–754
    DOI: https://doi.org/10.37349/emed.2023.00175
    This article belongs to the special issue Advances in Wound Healing
    View:76
    Download:12
    Times Cited: 0
    Open Access
    Case Report
    Cheiro-oral-pedal syndrome of the pons and the role of imaging in diagnosis and management
    The patient is a 58-year-old male who presented with chief complaints of right-sided numbness, tingling, and loss of temperature sensation in the upper and lower extremities. The patient’s symptom..11.
    Zachary I. Merhavy ... Thomas C. Varkey
    Published: October 27, 2023 Explor Med. 2023;4:739–746
    DOI: https://doi.org/10.37349/emed.2023.00174
    This article belongs to the special issue Applications of Radiomics in Precision Medicine
    View:288
    Download:6
    Times Cited: 0
    Open Access
    Original Article
    Aldh1a1 and additional markers of dopamine cell heterogeneity in substantia nigra and ventral tegmental area identified as preserved in two transgenic α-synuclein mouse models of neurodegenerative disease
    Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)]. The correlation between αSyn patho..11.
    Bianca Vlcek ... Åsa Wallén-Mackenzie
    Published: October 30, 2023 Explor Neuroprot Ther. 2023;3:299–327
    DOI: https://doi.org/10.37349/ent.2023.00053
    This article belongs to the special issue Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinsons Disease
    View:191
    Download:9
    Times Cited: 0
    Open Access
    Editorial
    The concept and assessment of immune fitness
    Joris C. Verster ... Johan Garssen
    Published: October 27, 2023 Explor Immunol. 2023;3:500–505
    DOI: https://doi.org/10.37349/ei.2023.00116
    This article belongs to the special issue Immune Fitness in Health, Disease, and Longevity
    View:81
    Download:9
    Times Cited: 0
    Open Access
    Case Report
    A successful case of maturogenesis by stepwise excavation using calcium-enriched mixture cement
    This case report demonstrates the successful induction of apexogenesis in an extensively carious lower right first molar with immature roots through the use of stepwise excavation and calcium-enrich..11.
    Saeed Asgary, Laleh Alim Marvasti
    Published: October 27, 2023 Explor Med. 2023;4:733–738
    DOI: https://doi.org/10.37349/emed.2023.00173
    This article belongs to the special issue Biomaterials and Biomarkers in Dentistry: Up to Date
    View:66
    Download:5
    Times Cited: 0
    Open Access
    Review
    Association of oral bacteriome and oral squamous cell carcinoma
    Oral cancer is the most common carcinoma of head and neck cancers. The majority of oral cancers are oral squamous cell carcinoma (OSCC). Among the various etiological factors, oral microbes—bacter..11.
    Karthika Panneerselvam ... Mathan Mohan
    Published: October 27, 2023 Explor Med. 2023;4:720–732
    DOI: https://doi.org/10.37349/emed.2023.00172
    View:64
    Download:4
    Times Cited: 0
    Open Access
    Review
    Olive oil, fruit and leaves in diabetes mellitus type 2 treatment
    The Mediterranean dietary pattern, where extra virgin olive oil (EVOO) takes the central spot, is related to longer life expectancy and lower risk of a number of non-communicable diseases, including..11.
    Mario Nosić ... Ines Banjari
    Published: October 29, 2023 Explor Foods Foodomics. 2023;1:192–205
    DOI: https://doi.org/10.37349/eff.2023.00015
    This article belongs to the special issue Natural Products in Health and Disease
    View:117
    Download:10
    Times Cited: 0
    Open Access
    Review
    Male obesity secondary hypogonadism: effectiveness of ketogenic diet on testicular function
    Epidemiological studies have reported an association between obesity/metabolic syndrome (MetS) and male reproductive disorders. Endocrine dysfunctions, direct testicular damage, chronic low-grade in..11.
    Giulia Izzo ... Mario Vitale
    Published: October 29, 2023 Explor Foods Foodomics. 2023;1:178–191
    DOI: https://doi.org/10.37349/eff.2023.00014
    This article belongs to the special issue Ketogenic Diet as Medical Nutrition Therapy
    View:84
    Download:4
    Times Cited: 0
    Open Access
    Review
    Therapeutic proteins immunogenicity: a peptide point of view
    Protein therapeutics are extensively used in the treatment of autoimmune diseases, but a subset of patients appears to be refractory to these treatments, mainly due to the development of an immune r..11.
    Feliciana Real-Fernandez ... Paolo Rovero
    Published: October 26, 2023 Explor Drug Sci. 2023;1:377–387
    DOI: https://doi.org/10.37349/eds.2023.00025
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:102
    Download:10
    Times Cited: 0
    Open Access
    Original Article
    Familial achalasia isolated or syndromic: about 18 families
    Aim: Familial achalasia (FA) is a very rare condition. This work aims to evaluate its prevalence, characterize its clinical profile in a large series, and assess the efficacy and safety of pneuma..11.
    Amar Tebaibia ... Nadia Oumnia
    Published: October 26, 2023 Explor Dig Dis. 2023;2:276–281
    DOI: https://doi.org/10.37349/edd.2023.00030
    This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
    View:90
    Download:4
    Times Cited: 0
    Open Access
    Original Article
    Lessons to be learned from real life data based on 98 gout patients using benzbromarone
    Aim: This study aims to analyze the efficacy and safety of benzbromarone as uricosuric, in a real-life clinical setting of a retrospective hospital-based gout cohort. Methods: Data from gou..11.
    Ioana Hotea ... Tim L. Jansen
    Published: October 30, 2023 Explor Musculoskeletal Dis. 2023;1:171–179
    DOI: https://doi.org/10.37349/emd.2023.00019
    View:63
    Download:8
    Times Cited: 0
    Open Access
    Systematic Review
    Effect of coronavirus disease 2019 on diagnosis and treatment of hepatocellular carcinoma: a systematic review
    Aim: Changes in strategies in the coronavirus disease 2019 (COVID-19) crisis and the imposing of restrictions have isolated many vulnerable patients including those with hepatocellular carcinoma ..11.
    Afrooz Mazidimoradi ... Hamid Salehiniya
    Published: October 26, 2023 Explor Target Antitumor Ther. 2023;4:1039–1058
    DOI: https://doi.org/10.37349/etat.2023.00179
    This article belongs to the special issue COVID-19 and Cancer
    View:85
    Download:8
    Times Cited: 0
    Open Access
    Original Article
    A large-scale survey of cannabis use for sleep: preferred products and perceived effects in comparison to over-the-counter and prescription sleep aids
    Aim: Cannabis use for sleep-related problems is on the rise; however, little is known about the cannabis products people are using for sleep or the perceived effects of cannabis in comparison to ..11.
    Amanda Stueber, Carrie Cuttler
    Published: October 25, 2023 Explor Med. 2023;4:709–719
    DOI: https://doi.org/10.37349/emed.2023.00171
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:140
    Download:4
    Times Cited: 0
    Open Access
    Review
    The effects of post-translational modifications on alpha-synuclein aggregation and immune cell activation in Parkinson’s disease
    Post-translational modifications (PTMs) of alpha-synuclein (α-syn) can alter protein aggregation propensity to affect α-syn oligomer and fibril formation. The inflammatory response in Parkinson’..11.
    Zaina Khan, Yoo Jin Jung
    Published: October 26, 2023 Explor Neuroprot Ther. 2023;3:281–298
    DOI: https://doi.org/10.37349/ent.2023.00052
    This article belongs to the special issue Parkinson’s Disease: Principal Targets and Interventional Mechanisms
    View:80
    Download:6
    Times Cited: 0
    Open Access
    Review
    Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in December 2019 quickly escalated to pandemic levels and had a severe impact on public health. There are 761 m..11.
    Atri Das ... Shantanabha Das
    Published: October 24, 2023 Explor Drug Sci. 2023;1:336–376
    DOI: https://doi.org/10.37349/eds.2023.00024
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:157
    Download:9
    Times Cited: 0
    Open Access
    Review
    Integration of signaling pathway and bromodomain and extra-terminal domain inhibition for the treatment of mutant Kirsten rat sarcoma viral oncogene homolog cancer
    Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) is now a drugable oncogenic driver and the KRAS G12C variant responds clinically to sotorasib and adagrasib that covalently block the cystein..11.
    Gerhard Hamilton ... Barbara Rath
    Published: October 26, 2023 Explor Target Antitumor Ther. 2023;4:1027–1038
    DOI: https://doi.org/10.37349/etat.2023.00178
    This article belongs to the special issue Integrated Approaches for Non-Small-Cell Lung Cancer
    View:77
    Download:6
    Times Cited: 0
    Open Access
    Review
    A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors
    The present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challe..11.
    Babak Sokouti
    Published: October 26, 2023 Explor Target Antitumor Ther. 2023;4:994–1026
    DOI: https://doi.org/10.37349/etat.2023.00177
    This article belongs to the special issue Emerging Screening Technologies in Drug Discovery
    View:107
    Download:7
    Times Cited: 0
    Open Access
    Review
    Molecular mechanisms of metabolic disease-associated hepatic inflammation in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide, with a progressive form of non-alcoholic steatohepatitis (NASH). It may progress to advanced liver diseases,..11.
    Chunye Zhang ... Ming Yang
    Published: October 25, 2023 Explor Dig Dis. 2023;2:246–275
    DOI: https://doi.org/10.37349/edd.2023.00029
    This article belongs to the special issue Cellular and Molecular Targets for NAFLD or MAFLD Treatments and Their Functions in Liver Fibrosis, Cirrhosis, and Cancer
    View:113
    Download:10
    Times Cited: 0
    Open Access
    Review
    Melatonin, BAG-1 and cortisol circadian interactions in tumor pathogenesis and patterned immune responses
    A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in many studies..11.
    George Anderson
    Published: October 25, 2023 Explor Target Antitumor Ther. 2023;4:962–993
    DOI: https://doi.org/10.37349/etat.2023.00176
    This article belongs to the special issue Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
    View:90
    Download:6
    Times Cited: 0
    Open Access
    Original Article
    Modelling α-synuclein processing in primary patient cells for pharmacological intervention
    Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the di..11.
    Jessica K. Smith ... Alex M. Sykes
    Published: October 25, 2023 Explor Med. 2023;4:695–708
    DOI: https://doi.org/10.37349/emed.2023.00170
    View:139
    Download:6
    Times Cited: 0
    Open Access
    Review
    Biologic drugs and allergen immunotherapy: potential allies
    Allergen-specific immunotherapy (AIT) is a proven efficacy treatment for allergic rhinitis (AR), asthma, and Hymenoptera venom allergy, but its use in food allergy (FA) is still under investigation...11.
    Palma Carlucci ... Danilo Di Bona
    Published: October 20, 2023 Explor Asthma Allergy. 2023;1:126–141
    DOI: https://doi.org/10.37349/eaa.2023.00014
    This article belongs to the special issue The Era of Biologics in Allergy
    View:138
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Cognitive recovery in psychiatric disorders: transdiagnostic interdisciplinary intervention in a high intensity partial psychiatric in-patient unit
    Aim: The present study aims to analyze the impact on cognitive recovery of an interdisciplinary treatment for acute and severe psychiatric patients. Methods: The present research is a natur..11.
    Ana Isabel De Santiago-Díaz ... Elsa Gómez-Ruiz
    Published: October 26, 2023 Explor Neuroprot Ther. 2023;3:268–280
    DOI: https://doi.org/10.37349/ent.2023.00051
    This article belongs to the special issue Cognitive Alterations in Psychiatry
    View:96
    Download:11
    Times Cited: 0
    Open Access
    Case Report
    Cranial nerve VII on gadolinium contrast-enhanced magnetic resonance imaging in the case of Bell’s palsy
    Bell’s palsy is a rapid unilateral peripheral paralysis of cranial nerve VII whose etiology is varied, most commonly associated with an acute infectious or inflammatory demyelinating process. Nerv..11.
    Alvaro Alvarez ... Avtar Singh
    Published: October 23, 2023 Explor Med. 2023;4:688–694
    DOI: https://doi.org/10.37349/emed.2023.00169
    This article belongs to the special issue Applications of Radiomics in Precision Medicine
    View:127
    Download:13
    Times Cited: 0
    Open Access
    Review
    Biomarkers in renal cell carcinoma and their targeted therapies: a review
    Renal cell carcinoma (RCC) is one of the most life-threatening urinary malignancies displaying poor response to radiotherapy and chemotherapy. Although in the recent past there have been tremendous ..11.
    Shruti Gupta, Shamsher Singh Kanwar
    Published: October 25, 2023 Explor Target Antitumor Ther. 2023;4:941–961
    DOI: https://doi.org/10.37349/etat.2023.00175
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
    View:96
    Download:7
    Times Cited: 0
    Open Access
    Original Article
    Cannabinoid CB2 receptor ligands disrupt the sequential regulation of p-MEK1/2 to p-ERK1/2 in mouse brain cortex
    Aim The sequential phosphorylation of mitogen-activated protein (MAP) kinases MEK-ERK is the most relevant cellular signaling pathway. This study quantified the parallel in vivo regulation of bra..11.
    Glòria Salort ... Jesús A. García-Sevilla
    Published: October 24, 2023 Explor Neuroprot Ther. 2023;3:258–267
    DOI: https://doi.org/10.37349/ent.2023.00050
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
    View:164
    Download:18
    Times Cited: 0
    Open Access
    Original Article
    Estimation of the allelic status of apolipoprotein E4 isoforms with fully automated LUMIPULSE® assays
    Aim: Apolipoprotein E (ApoE) isoforms, especially the ApoE4 isoform, are genetic risk factors for Alzheimer’s disease (AD). Moreover, the APOE ε4 haplotype has a dose-dependent association wit..11.
    Tatsushi Yuri ... Hisashi Nojima
    Published: October 16, 2023 Explor Neurosci. 2023;2:238–244
    DOI: https://doi.org/10.37349/en.2023.00024
    This article belongs to the special issue Alzheimer’s Disease
    View:162
    Download:18
    Times Cited: 0
    Open Access
    Review
    Investigation into the vascular contributors to dementia and the associated treatments
    As the average lifespan has increased, memory disorders have become a more pressing public health concern. However, dementia in the elderly population is often neglected in light of other health pri..11.
    Caroline Grace Davidson ... Brandon Lucke-Wold
    Published: October 15, 2023 Explor Neurosci. 2023;2:224–237
    DOI: https://doi.org/10.37349/en.2023.00023
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:130
    Download:9
    Times Cited: 0
    Open Access
    Review
    Interplay of autophagy, apoptosis, and senescence in primary biliary cholangitis
    The pathogenesis of primary biliary cholangitis (PBC) is particularly complicated as both intrinsic and extrinsic factors are implicated. Several forms of cellular death, both programmable and non-p..11.
    Elias Kouroumalis ... Argyro Voumvouraki
    Published: October 16, 2023 Explor Dig Dis. 2023;2:223–245
    DOI: https://doi.org/10.37349/edd.2023.00028
    This article belongs to the special issue CHOLESTASIS
    View:121
    Download:6
    Times Cited: 0
    Open Access
    Review
    Loss of regulation of T helper 17 cells: a definitive factor for critical cases of coronavirus disease 2019
    One of the greatest challenges in the study of coronavirus disease 2019 (COVID-19) has been to establish the determining factors in the severity of the disease. Through extensive research efforts, a..11.
    Miguel Angel Pardiño-Vega, Norma Estela Herrera-González
    Published: October 16, 2023 Explor Immunol. 2023;3:490–499
    DOI: https://doi.org/10.37349/ei.2023.00115
    View:147
    Download:12
    Times Cited: 0
    Open Access
    Review
    Genetic basis for skeletal new bone formation
    Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, includi..11.
    Bruna Parreira ... Jácome Bruges-Armas
    Published: October 23, 2023 Explor Musculoskeletal Dis. 2023;1:143–170
    DOI: https://doi.org/10.37349/emd.2023.00018
    This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease
    View:110
    Download:14
    Times Cited: 0
    Open Access
    Review
    Interstitial lung disease in patients with rheumatoid arthritis: a narrative review
    Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease of unknown origin. Although it mainly affects joints, it can have extra-articular manifestations, with the lung being one ..11.
    Gloria Candelas Rodríguez, Virginia Villaverde
    Published: October 20, 2023 Explor Musculoskeletal Dis. 2023;1:128–142
    DOI: https://doi.org/10.37349/emd.2023.00017
    This article belongs to the special issue Comorbidities in rheumatoid arthritis
    View:133
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Risk factors and recurrent thrombosis in primary antiphospholipid syndrome
    Aim: The study aims to evaluate the incidence of recurrent thromboses in patients with primary antiphospholipid syndrome (PAPS) and its association with the presence of different antiphospholipid..11.
    Fariza A. Cheldieva ... Tatiana M. Reshetnyak
    Published: October 12, 2023 Explor Immunol. 2023;3:475–489
    DOI: https://doi.org/10.37349/ei.2023.00114
    This article belongs to the special issue Autoantibodies Associated to Thrombosis and Hemostasis
    View:145
    Download:15
    Times Cited: 0
    Open Access
    Review
    Research progress of immune balance and genetic polymorphism in unexplained recurrent abortion
    The etiology of recurrent spontaneous abortion (RSA) is extremely complex, as there are 40–50% of patients with unexplained miscarriages, known as unexplained RSA (URSA). URSA affects approximatel..11.
    Yafei Kang ... Donghui Huang
    Published: October 12, 2023 Explor Immunol. 2023;3:453–474
    DOI: https://doi.org/10.37349/ei.2023.00113
    View:119
    Download:7
    Times Cited: 0
    Open Access
    Review
    Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages
    Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk. Macrophages are key in..11.
    Rafael Moura Maurmann ... Brandt D. Pence
    Published: October 11, 2023 Explor Immunol. 2023;3:442–452
    DOI: https://doi.org/10.37349/ei.2023.00112
    This article belongs to the special issue Immunosenescence: Mechanisms and Its Impact
    View:134
    Download:11
    Times Cited: 0
    Open Access
    Review
    Effect of coronavirus disease 2019 on the vaccine development paradigm
    Vaccines are prophylactic medical products effectively used against infectious diseases. Although a high amount of vaccine studies are conducted at the preclinical stage, the number of approved vacc..11.
    Sezer Okay
    Published: October 10, 2023 Explor Immunol. 2023;3:433–441
    DOI: https://doi.org/10.37349/ei.2023.00111
    This article belongs to the special issue Old and New Paradigms in Viral Vaccinology
    View:127
    Download:10
    Times Cited: 0
    Open Access
    Review
    Impact of the GINA asthma guidelines 2019 revolution on local asthma guidelines and challenges: special attention to the GCC countries
    The Global Initiative for Asthma (GINA) provides the most comprehensive and frequently updated guidelines for the management of asthma. The primary aim of guidelines is to bridge the gap between res..11.
    Riyad Allehebi, Hamdan AL-Jahdali
    Published: October 10, 2023 Explor Asthma Allergy. 2023;1:115–125
    DOI: https://doi.org/10.37349/eaa.2023.00013
    This article belongs to the special issue The Global Picture of Asthma after Guideline Changes and the COVID Pandemics
    View:148
    Download:11
    Times Cited: 0
    Open Access
    Original Article
    Late-stage diversification strategy for the synthesis of peptide acids and amides using hydrazides
    Aim: Modification of the C-terminus of a peptide to improve its properties, particularly after constructing the peptide chain, has great promise in the development of peptide therapeutics. This s..11.
    Shoko Tanaka ... Kohei Sato
    Published: October 09, 2023 Explor Drug Sci. 2023;1:322–335
    DOI: https://doi.org/10.37349/eds.2023.00023
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:154
    Download:16
    Times Cited: 0
    Open Access
    Review
    Sleep disorders contribute to the development of dementia and Alzheimer’s disease
    Life is the highest form of adaptation to the environment which is based on energy metabolism. To maintain life, the neuromuscular system must constantly interact with the environment. The striatal ..11.
    Janusz Wiesław Błaszczyk
    Published: October 08, 2023 Explor Neurosci. 2023;2:212–223
    DOI: https://doi.org/10.37349/en.2023.00022
    This article belongs to the special issue Alzheimer’s Disease
    View:159
    Download:10
    Times Cited: 0
    Open Access
    Review
    Self-replicating RNA viruses in vaccine development
    Self-replicating RNA viruses such as alphaviruses, flaviviruses, paramyxoviruses, and rhabdoviruses have been engineered as expression vectors for vaccine development. The prominent feature of self-..11.
    Kenneth Lundstrom
    Published: October 10, 2023 Explor Med. 2023;4:670–687
    DOI: https://doi.org/10.37349/emed.2023.00168
    View:156
    Download:14
    Times Cited: 0
    Open Access
    Perspective
    Diabetes and substance use: a perspective within drug rehabilitation
    Diabetes mellitus has become increasingly more common and diagnosed within the global population. Coupled with the continued prevalence of substance use, there are some distinct considerations for u..11.
    Abuelgasim Elrasheed A. Alhassan ... Simon Elliott
    Published: October 08, 2023 Explor Med. 2023;4:664–669
    DOI: https://doi.org/10.37349/emed.2023.00167
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:140
    Download:7
    Times Cited: 0
    Open Access
    Case Report
    Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel
    Green propolis is collected by Apis mellifera from the flowers and buds of Baccharis dracunculifolia. It has several chemical compounds that confer anti-inflammatory, antimicrobial, healing, and ant..11.
    Diogo Alvarenga Silva ... Vagner Rodrigues Santos
    Published: October 9, 2023 Explor Drug Sci. 2023;1:312–321
    DOI: https://doi.org/10.37349/eds.2023.00022
    View:613
    Download:17
    Times Cited: 0
    Open Access
    Protocol
    Envisioning urban environments resilient to vector-borne diseases: a protocol to study dengue in Vietnam
    Transmitted primarily by Aedes aegypti (Ae. aegypti) and Aedes albopictus (Ae. albopictus), arboviral diseases pose a major global public health threat. Dengue, chikungunya, and Zika are increasingl..11.
    Praveen Kumar ... Andrew W. Taylor-Robinson
    Online First: September 27, 2023 Explor Digit Health Technol. 2023;1:17–27
    DOI: https://doi.org/10.37349/edht.2023.00004
    View:244
    Download:26
    Times Cited: 0
    Open Access
    Review
    Negative environmental influences on the developing brain mediated by epigenetic modifications
    Brain development, a complex process, consisting of several phases, starting as early as two weeks after conception, and continuing through childhood till early adolescence, is crucial for the devel..11.
    Maya Komar-Fletcher ... Joanna Michalina Jurek
    Published: September 28, 2023 Explor Neurosci. 2023;2:193–211
    DOI: https://doi.org/10.37349/en.2023.00021
    View:195
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Prevalence and factors associated to diffuse idiopathic skeletal hyperostosis in gout
    Aim: To evaluate the prevalence, associated factors, and the impact of diffuse idiopathic skeletal hyperostosis (DISH) in patients with gout. Methods: Patients with gout entering into an in..11.
    Fernando Pérez-Ruiz ... Ana María Herrero-Beites
    Published: September 27, 2023 Explor Musculoskeletal Dis. 2023;1:121–127
    DOI: https://doi.org/10.37349/emd.2023.00016
    This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease
    View:161
    Download:15
    Times Cited: 0
    Open Access
    Systematic Review
    Current role of artificial intelligence in head and neck cancer surgery: a systematic review of literature
    Aim: Artificial intelligence (AI) is a new field of science in which computers will provide decisions-supporting tools to help doctors make difficult clinical choices. Recent AI applications in o..11.
    Antonella Loperfido ... Gianluca Bellocchi
    Published: October 24, 2023 Explor Target Antitumor Ther. 2023;4:933–940
    DOI: https://doi.org/10.37349/etat.2023.00174
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    View:89
    Download:8
    Times Cited: 0
    Open Access
    Review
    Update on laboratory practice for the diagnosis of lupus anticoagulant and the antiphospholipid syndrome
    Antiphospholipid syndrome (APS) is defined as an autoimmune and prothrombotic disorder in patients with the persistent presence of antiphospholipid antibodies (aPLs). In the classification criteria,..11.
    Osamu Kumano ... Jean Amiral
    Published: October 08, 2023 Explor Immunol. 2023;3:416–432
    DOI: https://doi.org/10.37349/ei.2023.00110
    This article belongs to the special issue Autoantibodies Associated to Thrombosis and Hemostasis
    View:149
    Download:11
    Times Cited: 0
    Open Access
    Review
    Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
    Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis sup..11.
    Sathammai Sathappa Supuramanian ... Sitaram Harihar
    Published: October 11, 2023 Explor Target Antitumor Ther. 2023;4:912–932
    DOI: https://doi.org/10.37349/etat.2023.00173
    This article belongs to the special issue Therapeutic Targeting of the Tumor Microenvironment
    View:336
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Exploring the implications of modified advanced lung cancer inflammation index on outcomes in patients with advanced non-small cell lung cancer
    Aim: Sarcopenia and skeletal muscle density (SMD) have been shown to be both predictive and prognostic marker in oncology. Advanced lung cancer inflammation index (ALI) has been shown to predict ..11.
    Abhishek Mahajan ... Kumar Prabhash
    Published: October 11, 2023 Explor Target Antitumor Ther. 2023;4:896–911
    DOI: https://doi.org/10.37349/etat.2023.00172
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
    View:176
    Download:12
    Times Cited: 0
    Open Access
    Review
    Understanding the feasibility of chemotherapeutic and immunotherapeutic targets against non-small cell lung cancers: an update of resistant responses and recent combinatorial therapies
    Despite consistent progress in prompt diagnosis and curative therapies in the last decade, lung cancer (LC) continues to threaten mankind, accounting for nearly twice the casualties compared to pros..11.
    Parth Malik ... Tapan Kumar Mukherjee
    Published: October 10, 2023 Explor Target Antitumor Ther. 2023;4:850–895
    DOI: https://doi.org/10.37349/etat.2023.00171
    This article belongs to the special issue Integrated Approaches for Non-Small-Cell Lung Cancer
    View:134
    Download:12
    Times Cited: 0
    Open Access
    Review
    AGEs and RAGE: metabolic and molecular signatures of the glycation-inflammation axis in malignant or metastatic cancers
    From attributing mutations to cancers with the advent of cutting-edge genetic technology in recent decades, to re-searching the age-old theory of intrinsic metabolic shift of cancers (Warburg’s gl..11.
    Gowri Palanissami, Solomon F.D. Paul
    Published: September 28, 2023 Explor Target Antitumor Ther. 2023;4:812–849
    DOI: https://doi.org/10.37349/etat.2023.00170
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
    View:271
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Electrochemical properties of hydroxyapatite immobilization material for potential cytosensor fabrication
    Aim: The biorecognition unit of an electrochemical biosensor requires molecules that are immobilised to serve as a bridge between the recognition unit and the transducing surface. Unique material..11.
    Dennis Adusei ... Elvis K. Tiburu
    Published: September 21, 2023 Explor Drug Sci. 2023;1:299–311
    DOI: https://doi.org/10.37349/eds.2023.00021
    View:140
    Download:14
    Times Cited: 0
    Open Access
    Original Article
    Ejection fraction, B-lines, and global longitudinal strain evaluated with rest transthoracic echocardiography to assess prognosis in patients with chronic coronary syndromes
    Aim: Transthoracic echocardiography (TTE) is the first-line imaging test for patients with chronic coronary syndrome (CCS) and the cornerstone of risk stratification is left ventricular (LV) ejec..11.
    Lauro Cortigiani ... Francesco Bovenzi
    Published: September 18, 2023 Explor Cardiol. 2023;1:49–58
    DOI: https://doi.org/10.37349/ec.2023.00007
    View:136
    Download:8
    Times Cited: 0
    Open Access
    Review
    Drug-induced cholestasis: causative agents and challenges in diagnosis and management
    Drug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominan..11.
    Jose M. Pinazo-Bandera ... Miren García-Cortés
    Published: September 18, 2023 Explor Dig Dis. 2023;2:202–222
    DOI: https://doi.org/10.37349/edd.2023.00027
    This article belongs to the special issue CHOLESTASIS
    View:204
    Download:18
    Times Cited: 0
    Open Access
    Review
    Malignant tumors of the external auditory canal: diagnosis, treatment, genetic landscape, biomarkers, and clinical outcome
    Malignant tumors of the external auditory canal (EAC) are rare neoplasms that appear in the head and neck area. A common feature of these malignancies is their rarity, as well as their delayed diagn..11.
    Pinelopi Samara ... Ioannis Athanasopoulos
    Published: September 21, 2023 Explor Target Antitumor Ther. 2023;4:801–811
    DOI: https://doi.org/10.37349/etat.2023.00169
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
    View:205
    Download:15
    Times Cited: 0
    Open Access
    Review
    Mechanistic insights on anticancer drugs with specific biological targets and signalling pathways
    Complex enzyme interactions play a role in the spread of cancer, a process fueled by unregulated cell proliferation. DNA topoisomerases, which are important for fixing DNA topological problems, have..11.
    Mohsina Patwekar ... Rohit Sharma
    Published: September 15, 2023 Explor Med. 2023;4:637–663
    DOI: https://doi.org/10.37349/emed.2023.00166
    View:330
    Download:17
    Times Cited: 0
    Open Access
    Original Article
    Body mass, blood pressure, and cognitive functioning among octogenarians and centenarians
    Aim: The purpose of this study was to examine the association among body mass, blood pressure (BP), and cognitive functioning for octogenarians and centenarians. Methods: A total of 300 par..11.
    Peter Martin ... Leonard W. Poon
    Published: September 15, 2023 Explor Med. 2023;4:625–636
    DOI: https://doi.org/10.37349/emed.2023.00165
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:216
    Download:20
    Times Cited: 0
    Open Access
    Original Article
    A single experience in the conduction of clinical trial during COronaVIrusDisease-2019 pandemic
    Aim: From the start of the pandemic, several aspects of healthcare policies changed, not least the clinical trials management from recruiting capabilities to the protocol compliance in terms of s..11.
    Zelmira Ballatore ... Rossana Berardi
    Published: September 07, 2023 Explor Target Antitumor Ther. 2023;4:793–800
    DOI: https://doi.org/10.37349/etat.2023.00168
    This article belongs to the special issue COVID-19 and Cancer
    View:257
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Comparison of eating habits and gut microbiota of preschool children with obesity
    Aim: Childhood obesity is a global health concern that affects the daily life of children. It has a complex pathogenesis that involves genetic and nutritional factors among others. Moreover, the ..11.
    Shymaa M. Al-Jabri ... Awatif A. Al-Judaibi
    Published: September 04, 2023 Explor Med. 2023;4:612–624
    DOI: https://doi.org/10.37349/emed.2023.00164
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:252
    Download:25
    Times Cited: 0
    Open Access
    Review
    Unveiling the role of artificial intelligence for wound assessment and wound healing prediction
    Wound healing is a very dynamic and complex process as it involves the patient, wound-level parameters, as well as biological, environmental, and socioeconomic factors. Its process includes hemostas..11.
    Dinh T. P. Le, Tuan D. Pham
    Published: August 31, 2023 Explor Med. 2023;4:589–611
    DOI: https://doi.org/10.37349/emed.2023.00163
    This article belongs to the special issue Advances in Wound Healing
    View:342
    Download:14
    Times Cited: 0
    Open Access
    Review
    Autophagy and diabetes
    The current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medici..11.
    Milan Obradovic ... Esma R. Isenovic
    Published: August 31, 2023 Explor Med. 2023;4:576–588
    DOI: https://doi.org/10.37349/emed.2023.00162
    This article belongs to the special issue Genetic and Epigenetic Control of Autophagy in Human Diseases
    View:277
    Download:12
    Times Cited: 0
    Open Access
    Review
    An overview of current advances and pharmaceutical uses of 3D and 4D printing
    The development of patient-specific prosthetics, medication administration, the manufacture of tissues and organs, and surgical planning have all benefited significantly from the use of three-dimens..11.
    Pankaj Sharma, Vinay Jain
    Published: August 31, 2023 Explor Med. 2023;4:560–575
    DOI: https://doi.org/10.37349/emed.2023.00161
    This article belongs to the special issue Exploration of 3D and 4D Printing in the Biomedical and Personalized Medicine Fields: Merits and Challenges
    View:288
    Download:17
    Times Cited: 0
    Open Access
    Original Article
    Inflammatory immune mediators and Plasmodium falciparum infection: a cross-sectional study among Sudanese patients with severe and uncomplicated malaria
    Aim: A number of questions remain unanswered concerning how infected individuals regulate their immune response to Plasmodium falciparum (P. falciparum) parasites at varying levels of exposure. D..11.
    Dia Aldeen Alfaki ... Mohamed Mubarak Elbasheir
    Published: August 31, 2023 Explor Immunol. 2023;3:406–415
    DOI: https://doi.org/10.37349/ei.2023.00109
    View:312
    Download:15
    Times Cited: 0
    Open Access
    Review
    Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target
    Abnormal energy metabolism is one of the ten hallmarks of tumors, and tumor cell metabolism provides energy and a suitable microenvironment for tumorigenesis and metastasis. Tumor cells can consume ..11.
    Weimei Xing ... Mingyue Zhu
    Published: August 31, 2023 Explor Med. 2023;4:541–559
    DOI: https://doi.org/10.37349/emed.2023.00160
    View:243
    Download:20
    Times Cited: 0
    Open Access
    Review
    RNA-RNA competitive interactions: a molecular civil war ruling cell physiology and diseases
    The idea that proteins are the main determining factors in the functioning of cells and organisms, and their dysfunctions are the first cause of pathologies, has been predominant in biology and biom..11.
    Cristina Barbagallo ... Marco Ragusa
    Published: August 31, 2023 Explor Med. 2023;4:504–540
    DOI: https://doi.org/10.37349/emed.2023.00159
    This article belongs to the special issue RNA World in Health and Disease
    View:234
    Download:16
    Times Cited: 0
    Open Access
    Review
    Cannabis-based medicinal products (CBMPs) for the treatment of Long COVID symptoms: current and potential applications
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can result in a range of persistent symptoms impacting everyday functioning for a considerable proportion of patients, a condit..11.
    Hannah Thurgur ... David J. Nutt
    Published: August 31, 2023 Explor Med. 2023;4:487–503
    DOI: https://doi.org/10.37349/emed.2023.00158
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:1147
    Download:23
    Times Cited: 0
    Open Access
    Review
    Autophagy in ischemic stroke: role of circular RNAs
    Stroke, a central nervous system (CNS) injury, is responsible for the second leading cause of death in the world, bringing a great burden on the world. Stroke is normally divided into ischemic and h..11.
    Yiting Hong ... Honghong Yao
    Published: August 31, 2023 Explor Med. 2023;4:471–486
    DOI: https://doi.org/10.37349/emed.2023.00157
    This article belongs to the special issue Genetic and Epigenetic Control of Autophagy in Human Diseases
    View:226
    Download:10
    Times Cited: 0
    Open Access
    Perspective
    Utility of fibroblasts derived from broncho-alveolar lavage of patients with idiopathic pulmonary fibrosis or related disorders to develop in vitro models
    Broncho-alveolar lavage (BAL) represents a safe tool for the differential diagnosis of various pulmonary fibrotic diseases. Idiopathic pulmonary fibrosis (IPF) belongs to a heterogeneous group of di..11.
    Paolo Giannoni ... Daniela de Totero
    Published: August 31, 2023 Explor Med. 2023;4:461–470
    DOI: https://doi.org/10.37349/emed.2023.00156
    This article belongs to the special issue Lung Fibrosis—Models and Mechanisms
    View:209
    Download:10
    Times Cited: 0
    Open Access
    Original Article
    Aflatoxin B1-DNA adducts modify the effects of post-operative adjuvant transarterial chemoembolization improving hepatocellular carcinoma prognosis
    Aim: DNA damage involves in the carcinogenesis of some cancer and may act as a target for therapeutic intervention of cancers. However, it is unclear whether aflatoxin B1 (AFB1)-DNA adducts (ADAs)..11.
    Liyan Huang ... Xidai Long
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:780–792
    DOI: https://doi.org/10.37349/etat.2023.00167
    This article belongs to the special issue DNA Damage as Target for Therapeutic Intervention
    View:289
    Download:16
    Times Cited: 0
    Open Access
    Review
    Medicinal chemistry advances in targeting class I histone deacetylases
    Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gen..11.
    Diaaeldin I. Abdallah ... Patrick T. Gunning
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:757–779
    DOI: https://doi.org/10.37349/etat.2023.00166
    This article belongs to the special issue Posttranslational Modifications in Health and Disease
    View:606
    Download:35
    Times Cited: 0
    Open Access
    Review
    Immune evasion by cancer stem cells ensures tumor initiation and failure of immunotherapy
    Cancer stem cells (CSCs) are a small subpopulation of cells that drive the formation and progression of tumors. However, during tumor initiation, how CSCs communicate with neighbouring immune cells ..11.
    Sourio Chakraborty ... Tanya Das
    Published: August 31, 2023 Explor Immunol. 2023;3:384–405
    DOI: https://doi.org/10.37349/ei.2023.00108
    This article belongs to the special issue Interplay of Stem Cells and Immunology in Regenerative Medicine
    View:263
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity
    Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistan..11.
    Melissa Bersanelli ... Luca Ampollini
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:743–756
    DOI: https://doi.org/10.37349/etat.2023.00165
    View:262
    Download:9
    Times Cited: 0
    Open Access
    Original Article
    In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancer
    Aim: Delineate structure-based inhibition of colony-stimulating factor-1 receptor (CSF1R) by small molecule CSF1R inhibitors in clinical development for target identification and potential lead o..11.
    Zahra Azhar ... Zohaib Raza
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:727–742
    DOI: https://doi.org/10.37349/etat.2023.00164
    View:265
    Download:15
    Times Cited: 0
    Open Access
    Review
    Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature
    Over the past decade, knowledge of the pathophysiology and immunology of multiple sclerosis (MS) and depression, and the complex links to vitamin D (VitD) balance, has increased rapidly. Both diseas..11.
    Hans-Klaus Goischke
    Published: August 31, 2023 Explor Neurosci. 2023;2:160–192
    DOI: https://doi.org/10.37349/en.2023.00020
    This article belongs to the special issue Novel Therapeutic Approaches for the Treatment of Depression
    View:245
    Download:17
    Times Cited: 0
    Open Access
    Original Article
    An easy and safe method of subconjunctival injection of antimetabolites in glaucoma surgery
    Aim: The use of 5-fluorouracil in glaucoma surgery is associated with a high risk of corneal complications, as even minimal doses of the drug at the ocular surface inhibit corneal epithelial cell..11.
    Sergey N. Svetozarskiy ... Anna N. Sporysheva
    Published: August 30, 2023 Explor Med. 2023;4:453–460
    DOI: https://doi.org/10.37349/emed.2023.00155
    View:221
    Download:10
    Times Cited: 0
    Open Access
    Review
    Premature mortality with gout and hyperuricemia may be reduced by early resolution of comorbid obstructive sleep apnea
    Hyperuricemia is known to be a necessary and causal condition for gout, but much more prevalent than gout. Medicine has standardized treatments for gout, but has no such determination for asymptomat..11.
    Burton Abrams
    Published: August 31, 2023 Explor Musculoskeletal Dis. 2023;1:106–120
    DOI: https://doi.org/10.37349/emd.2023.00015
    This article belongs to the special issue Hyperuricemia current state and prospects
    View:257
    Download:20
    Times Cited: 0
    Open Access
    Review
    The emergence of nanovaccines as a new paradigm in virological vaccinology: a review
    Vaccination has made an enormous contribution to global health. Treatment resistance for infectious diseases is growing quickly, and chemotherapeutic toxicity in cancer means that vaccines must be m..11.
    Chittaranjan Baruah ... Bhabesh Deka
    Published: August 31, 2023 Explor Immunol. 2023;3:361–383
    DOI: https://doi.org/10.37349/ei.2023.00107
    This article belongs to the special issue Old and New Paradigms in Viral Vaccinology
    View:354
    Download:10
    Times Cited: 0
    Open Access
    Review
    Vitamin D, ageing, and the immune system
    Changes occurring in the immune system along the ageing process increase the risk of infection, susceptibility to tumor development, and autoimmunity. Interventions such as physical exercise, supple..11.
    Valquiria Bueno
    Published: August 31, 2023 Explor Immunol. 2023;3:341–360
    DOI: https://doi.org/10.37349/ei.2023.00106
    This article belongs to the special issue Immunosenescence: Mechanisms and Its Impact
    View:407
    Download:20
    Times Cited: 0
    Open Access
    Original Article
    Investigation the spatial distribution of polyphenols and metabolomic profiling of apple
    Aim: In this study, Polyphenol and chemical profiles in core, pulp, and peel of 7 apple varieties [Fuji (FS), Qinguan (QG), Qingping (QP), Jinshuai (JS), Gala (GL), Changmiou (CMO), and Huahong (..11.
    Xuan Li ... Jinfeng Bi
    Published: August 31, 2023 Explor Foods Foodomics. 2023;1:162–177
    DOI: https://doi.org/10.37349/eff.2023.00013
    View:225
    Download:22
    Times Cited: 0
    Open Access
    Review
    Intelligent point of care test for food safety via a smartphone
    The on-site, rapid, and intelligence detection methods are the wave in food safety. Recently, intelligent point-of-care test (iPOCT) methods serve as a promising alternative for advanced monitoring ..11.
    Le Zhang ... Zhaowei Zhang
    Published: August 30, 2023 Explor Foods Foodomics. 2023;1:143–161
    DOI: https://doi.org/10.37349/eff.2023.00012
    View:234
    Download:17
    Open Access
    Original Article
    Clinical and mutational profile of AT-rich interaction domain 1A-mutated cancers
    Aim: AT-rich interaction domain 1A (ARID1A) encodes a key component of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex that participates in gene expression. ARID1A alter..11.
    Rosa Falcone ... Gennaro Daniele
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:716–726
    DOI: https://doi.org/10.37349/etat.2023.00163
    View:234
    Download:15
    Times Cited: 0
    Open Access
    Review
    Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
    Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational..11.
    Angeles C. Tecalco-Cruz, Jesús Zepeda-Cervantes
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:699–715
    DOI: https://doi.org/10.37349/etat.2023.00162
    This article belongs to the special issue Posttranslational Modifications in Health and Disease
    View:266
    Download:16
    Times Cited: 0
    Open Access
    Review
    Immune system rejuvenation—approaches and real achievements
    Interest in the mechanisms of aging of the immune system has not faded over the past 100 years, and it is caused by the immune-mediated development of age-related pathology, including autoimmune org..11.
    Iryna Pishel
    Published: August 31, 2023 Explor Immunol. 2023;3:325–340
    DOI: https://doi.org/10.37349/ei.2023.00105
    This article belongs to the special issue Immunosenescence: Mechanisms and Its Impact
    View:383
    Download:9
    Times Cited: 0
    Open Access
    Case Report
    Covered stent graft for treatment of carotid artery stenosis with post-stenotic aneurysm
    Several bare metals, self-expanding stents have been approved by the Food and Drug Administration (FDA) to treat carotid stenosis, but no covered stents have been particularly examined or approved f..11.
    Mosaad Soliman ... Reem Soliman
    Published: August 31, 2023 Explor Neurosci. 2023;2:153–159
    DOI: https://doi.org/10.37349/en.2023.00019
    View:201
    Download:13
    Times Cited: 0
    Open Access
    Original Article
    The brain activities of individuals with or without motivation to change: a preliminary study among cigarette smokers
    Aim: Cigarette smoking is an addictive behavior that requires high motivation to change, a phenotype related to the functional activity of the brain. The study aims to examine motiv..11.
    Rasmon Kalayasiri ... Witaya Sungkarat
    Published: August 30, 2023 Explor Med. 2023;4:441–452
    DOI: https://doi.org/10.37349/emed.2023.00154
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:212
    Download:8
    Times Cited: 0
    Open Access
    Review
    Modify gut microbiome in autism: a promising strategy?
    The gut microbiota and dysbiosis have been implicated in various metabolic diseases and gastrointestinal disorders. Recently, there has been growing evidence suggesting the influence of gut microbio..11.
    Jean Demarquoy ... Caroline Demarquoy
    Published: August 31, 2023 Explor Neurosci. 2023;2:140–152
    DOI: https://doi.org/10.37349/en.2023.00018
    View:190
    Download:9
    Times Cited: 0
    Open Access
    Case Report
    Single or multiple treatments with lusutrombopag in subjects with thrombocytopenia and chronic liver disease needing an invasive procedure
    Thrombocytopenia is one of the most frequent implications of liver cirrhosis. This condition, when present in the severe form [platelet count (PLT) less than 50 × 109/L] correlates, with an increas..11.
    Davide Scalabrini ... Pietro Andreone
    Published: August 30, 2023 Explor Drug Sci. 2023;1:292–298
    DOI: https://doi.org/10.37349/eds.2023.00020
    This article belongs to the special issue Innovative Therapeutics in Hepato-Gastroenterology
    View:167
    Download:14
    Times Cited: 0
    Open Access
    Review
    Principles of risk stratification in nonalcoholic fatty liver disease. A narrative review emphasizing non-invasive strategies
    Nonalcoholic fatty liver disease (NAFLD) is an umbrella definition that describes the ectopic deposition of fat within the liver that occurs in the absence of inciting factors other than the metabol..11.
    Amedeo Lonardo
    Published: August 30, 2023 Explor Dig Dis. 2023;2:188–201
    DOI: https://doi.org/10.37349/edd.2023.00026
    This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
    View:258
    Download:31
    Times Cited: 0
    Open Access
    Original Article
    Human liver stem cell-derived extracellular vesicles modulate long non-coding RNA expression profile in an in vivo model of non-alcoholic steatohepatitis
    Aim: Modifications in long non-coding RNA (lncRNA) expression are associated with inflammation and fibrosis in chronic liver diseases. It has been recently demonstrated that human liver stem cell..11.
    Giulia Chiabotto ... Stefania Bruno
    View:227
    Download:34
    Times Cited: 0
    Open Access
    Original Article
    Normal physiologic coronary flow velocity gradient across the left anterior descending artery in healthy asymptomatic subjects
    Aim: Coronary flow velocity (CFV) can be obtained with transthoracic echocardiography (TTE) in the left anterior descending coronary artery (LAD). The physiologic flow velocity gradient across th..11.
    Fausto Rigo ... Maurizio Agnoletto
    Published: August 31, 2023 Explor Cardiol. 2023;1:42–48
    DOI: https://doi.org/10.37349/ec.2023.00006
    View:226
    Download:10
    Times Cited: 0
    Open Access
    Original Article
    Real-life results of urate-driven pharmacotherapy with three urate lowering drugs in gout: allopurinol, febuxostat and benzbromarone
    Aim: This study aims to assess outcomes of gout patients from the treat to target (T2T) perspective at 6 months and 12 months while using urate lowering therapy (ULT): allopurinol, febuxostat, an..11.
    Ioana Hotea ... Tim L. Jansen
    Published: August 30, 2023 Explor Musculoskeletal Dis. 2023;1:97–105
    DOI: https://doi.org/10.37349/emd.2023.00014
    View:177
    Download:14
    Times Cited: 0
    Open Access
    Perspective
    Alcohol zero: the end, the beginning of the end, or just the end of the beginning?
    Alcohol drinks, especially wine, have been described since 6,000 B.C. For many years in modern medicine, wine in moderation has been considered healthy for cardiovascular prevention, i.e., recommend..11.
    Miodrag Ostojic ... Dusko Vulic
    Published: August 31, 2023 Explor Cardiol. 2023;1:35–41
    DOI: https://doi.org/10.37349/ec.2023.00005
    View:179
    Download:16
    Times Cited: 0
    Open Access
    Review
    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
    One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergen..11.
    Priyanka S. Lande ... Leena P. Joge
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:690–698
    DOI: https://doi.org/10.37349/etat.2023.00161
    This article belongs to the special issue Plant Extracts as an Infinite Resource for New Anticancer Agents
    View:295
    Download:14
    Times Cited: 0
    Open Access
    Original Article
    Left ventricular systolic function and initial exercise capacity—their importance for results of cardiac rehabilitation after acute coronary syndrome
    Aim: The aim of this study was to compare initial and final exercise tolerance and to evaluate the determinants of exercise capacity improvement—after three weeks of inpatient cardiac rehabilit..11.
    Barbara Uznańska-Loch ... Tomasz Rechciński
    View:204
    Download:9
    Times Cited: 0
    Open Access
    Perspective
    Artificial intelligence ethics in precision oncology: balancing advancements in technology with patient privacy and autonomy
    Precision oncology is a rapidly evolving field that uses advanced technologies to deliver personalized cancer care based on a patient’s unique genetic and clinical profile. The use of artificial i..11.
    Bahareh Farasati Far
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:685–689
    DOI: https://doi.org/10.37349/etat.2023.00160
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    View:224
    Download:12
    Times Cited: 0
    Open Access
    Original Article
    Azadirachta indica A. Juss (neem) phenolic extract inhibits human B-lymphoblastoid cells growth via cell cycle arrest, apoptosis induction, and DNA damage
    Aim: As far as is known, the pharmaceutical effects of neem on human B-lymphoblastoid (TK6) cells have not been studied until now. Hence, the present study aimed to obtain neem phenolic extracts ..11.
    Klebson Silva Santos ... Maria Beatriz Pinto Prior Oliveira
    Published: August 29, 2023 Explor Foods Foodomics. 2023;1:130–142
    DOI: https://doi.org/10.37349/eff.2023.00011
    View:183
    Download:19
    Times Cited: 0
    Open Access
    Review
    Analytical dilemmas in lupus anticoagulant detection
    Accurate lupus anticoagulant (LA) detection is crucial to antiphospholipid syndrome (APS) diagnosis. Detection is based on LA functional behavior in coagulation assays irrespective of epitope specif..11.
    Gary W. Moore
    Published: August 31, 2023 Explor Immunol. 2023;3:300–324
    DOI: https://doi.org/10.37349/ei.2023.00104
    This article belongs to the special issue Autoantibodies Associated to Thrombosis and Hemostasis
    View:255
    Download:13
    Times Cited: 0
    Open Access
    Commentary
    Could flavonoid aglycones prevent the absorption of flavonoid glycosides by inhibiting sodium-dependent glucose transporter-1 in the small intestine?
    Flavonoids present a large group of natural polyphenols with numerous important health benefits for preventing and treating a diverse variety of pathological conditions. However, the actual therapeu..11.
    Katrin Sak
    Published: August 30, 2023 Explor Drug Sci. 2023;1:287–291
    DOI: https://doi.org/10.37349/eds.2023.00019
    This article belongs to the special issue Preventive and Therapeutic Potential of Nutraceuticals in Non-communicable Diseases
    View:150
    Download:12
    Times Cited: 0
    Open Access
    Review
    Perioperative management, operative techniques, and pitfalls in the surgical treatment of patients with diffuse idiopathic skeletal hyperostosis: a narrative review
    Diffuse idiopathic skeletal hyperostosis (DISH) can lead to dysphagia, airway obstruction, and unstable vertebral fractures. Surgery can be performed to relieve cervical compression or stabilize fra..11.
    Netanja I. Harlianto ... Jorrit-Jan Verlaan
    Published: August 29, 2023 Explor Musculoskeletal Dis. 2023;1:84–96
    DOI: https://doi.org/10.37349/emd.2023.00013
    This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease
    View:177
    Download:12
    Times Cited: 0
    Open Access
    Original Article
    In silico study about β-amyloid’s role in Alzheimer’s disease and glaucoma and prediction of its interactions with glaucoma related proteins
    Aim: The significance of β-amyloid protein as a key player in neuro-degenerative disorders viz. Alzheimer’s disease (AD), Parkinson’s disease (PD) has been extensively researched and reporte..11.
    Nancy Maurya
    Published: August 29, 2023 Explor Drug Sci. 2023;1:276–286
    DOI: https://doi.org/10.37349/eds.2023.00018
    This article belongs to the special issue Machine Learning for Drug Science
    View:179
    Download:14
    Times Cited: 0
    Open Access
    Letter to the Editor
    Impact of the standardization unit’s definition on the in vitro biological potency of allergen extracts
    In Europe, allergen products from different manufacturers can be labeled using the same unit with yet different definitions of that unit, which may cause confusion, as is the case for the index of r..11.
    Thierry Batard ... Laurent Mascarell
    Published: August 27, 2023 Explor Asthma Allergy. 2023;1:107–114
    DOI: https://doi.org/10.37349/eaa.2023.00012
    View:296
    Download:28
    Times Cited: 0
    Open Access
    Original Article
    Isolation, characterization, and encapsulation of a lupeol-rich fraction obtained from the hexanic extract of Coccoloba uvifera L. leaves
    Aim: This study aimed to isolate, characterize, and encapsulate a lupeol-rich fraction obtained from the hexanic extract of Coccoloba uvifera L. leaves to evaluate its potential use in nutraceuti..11.
    Carla N. Cruz-Salas ... Juan A. Ragazzo-Sánchez
    Published: August 28, 2023 Explor Foods Foodomics. 2023;1:115–129
    DOI: https://doi.org/10.37349/eff.2023.00010
    This article belongs to the special issue Natural Products in Health and Disease
    View:207
    Download:12
    Times Cited: 0
    Open Access
    Review
    Pathophysiology of biochemical signs of primary biliary cholangitis
    Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a rare chronic autoimmune cholestatic liver disease, affecting mostly females. With PBС develops chronic cholang..11.
    Vasiliy Ivanovich Reshetnyak, Igor Veniaminovich Maev
    Published: August 27, 2023 Explor Dig Dis. 2023;2:149–171
    DOI: https://doi.org/10.37349/edd.2023.00024
    This article belongs to the special issue CHOLESTASIS
    View:194
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    Deep learning based clinico-radiological model for paediatric brain tumor detection and subtype prediction
    Aim: Early diagnosis of paediatric brain tumors significantly improves the outcome. The aim is to study magnetic resonance imaging (MRI) features of paediatric brain tumors and to develop an auto..11.
    Abhishek Mahajan ... Aliasgar Moiyadi
    Published: August 30, 2023 Explor Target Antitumor Ther. 2023;4:669–684
    DOI: https://doi.org/10.37349/etat.2023.00159
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
    View:284
    Download:16
    Times Cited: 0
    Open Access
    Review
    Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant
    In patients with autoimmune coagulation factor deficiency (AiCFD), the production of autoantibodies that inhibit coagulation factors in the blood reduces the activity of those relevant coagulation f..11.
    Masahiro Ieko ... Akitada Ichinose
    Published: August 30, 2023 Explor Immunol. 2023;3:286–299
    DOI: https://doi.org/10.37349/ei.2023.00103
    This article belongs to the special issue Autoantibodies Associated to Thrombosis and Hemostasis
    View:168
    Download:11
    Times Cited: 0
    Open Access
    Review
    Rehabilitation for non-motor symptoms for patients with Parkinson’s disease from an α-synuclein perspective: a narrative review
    Parkinson’s disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbr..11.
    Zhaoyang Liu ... Wen Liu
    Published: August 27, 2023 Explor Neuroprot Ther. 2023;3:235–257
    DOI: https://doi.org/10.37349/ent.2023.00049
    This article belongs to the special issue Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
    View:320
    Download:24
    Times Cited: 0
    Open Access
    Review
    Trained-immunity and cross-reactivity for protection: insights from the coronavirus disease 2019 and monkeypox emergencies for vaccine development
    The emergence and re-emergence of pathogens is a public-health concern, which has become more evident after the coronavirus disease 2019 (COVID-19) pandemic and the monkeypox outbreaks in early 2022..11.
    Amanda Izeli Portilho, Elizabeth De Gaspari
    Published: August 24, 2023 Explor Immunol. 2023;3:276–285
    DOI: https://doi.org/10.37349/ei.2023.00102
    This article belongs to the special issue Mucosal Immune Cells - Border Protection or Entrance Gate?
    View:218
    Download:9
    Times Cited: 0
    Open Access
    Original Article
    Deep learning based automated epidermal growth factor receptor and anaplastic lymphoma kinase status prediction of brain metastasis in non-small cell lung cancer
    Aim: The aim of this study was to investigate the feasibility of developing a deep learning (DL) algorithm for classifying brain metastases from non-small cell lung cancer (NSCLC) into epidermal ..11.
    Abhishek Mahajan ... Kumar Prabhash
    Published: August 30, 2023 Explor Target Antitumor Ther. 2023;4:657–668
    DOI: https://doi.org/10.37349/etat.2023.00158
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
    View:341
    Download:13
    Times Cited: 0
    Open Access
    Original Article
    1H NMR-based metabolomics of cacao pod husk: profile comparison of three drying treatments
    Aim: The aim of this study is to apply untargeted proton nuclear magnetic resonance (1H NMR) and chemometric analysis to obtain the cacao pod husk (CPH) fingerprint and evaluate the effect of deh..11.
    Demelza Nayelli Villalón-López ... Lourdes Valadez-Carmona
    Published: August 23, 2023 Explor Foods Foodomics. 2023;1:101–114
    DOI: https://doi.org/10.37349/eff.2023.00009
    View:196
    Download:8
    Times Cited: 0
    Open Access
    Review
    Targeting α-synuclein aggregation with immunotherapy: a promising therapeutic approach for Parkinson’s disease
    Parkinson’s disease (PD) is a prevalent neurodegenerative disease (NDD) affecting millions of individuals. The pathogenesis of PD centers around α-synuclein (α-Syn), a pivotal protein whose aggr..11.
    Gabriela Henriquez, Mahesh Narayan
    Published: August 25, 2023 Explor Neuroprot Ther. 2023;3:207–234
    DOI: https://doi.org/10.37349/ent.2023.00048
    This article belongs to the special issue Parkinsons Disease: Principal Targets and Interventional Mechanisms
    View:340
    Download:21
    Times Cited: 0
    Open Access
    Review
    Diffusion magnetic resonance imaging-based surrogate marker in amyotrophic lateral sclerosis
    Amyotrophic lateral sclerosis (ALS) is the most prevalent type of motor neuron disease (MND) and is diagnosed with a delay from the first appearance of symptoms. Surrogate markers that may be used t..11.
    Yuya Saito
    Published: August 25, 2023 Explor Neuroprot Ther. 2023;3:186–206
    DOI: https://doi.org/10.37349/ent.2023.00047
    This article belongs to the special issue Biomarkers in Amyotrophic Lateral Sclerosis
    View:255
    Download:11
    Open Access
    Case Report
    Tension pneumocephalus as a complication of surgical evacuation of chronic subdural hematoma: case report and literature review
    The management of symptomatic chronic subdural hematoma (CSDH) is surgical evacuation and prognosis in most cases is good. Tension pneumocephalus is the presence of air under pressure in the intracr..11.
    Mohammed A. Azab ... Brandon Lucke-Wold
    Published: August 23, 2023 Explor Neuroprot Ther. 2023;3:177–185
    DOI: https://doi.org/10.37349/ent.2023.00046
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:278
    Download:19
    Times Cited: 0
    Open Access
    Review
    Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease—What are the proposed mechanisms?
    A high consumption of ultra-processed food (UPF) is a hallmark of Western diets that has been related to increased risk of non-communicable diseases. As an underlying mechanism, UPF may promote non-..11.
    Franziska A. Hägele ... Anja Bosy-Westphal
    Published: August 24, 2023 Explor Dig Dis. 2023;2:133–148
    DOI: https://doi.org/10.37349/edd.2023.00023
    This article belongs to the special issue Nutrition, Intestinal Barrier and Metabolic Liver Disease
    View:195
    Download:13
    Times Cited: 0
    Open Access
    Review
    Can we apply biomarkers in the management of non-steroidal anti-inflammatory drug exacerbated respiratory disease?
    Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is characterized by adult-onset asthma, chronic rhinosinusitis with nasal polyps (CRSwNPs), and aspirin/NSAID hype..11.
    Hyo-In Rhyou ... Hae-Sim Park
    Published: August 24, 2023 Explor Asthma Allergy. 2023;1:89–106
    DOI: https://doi.org/10.37349/eaa.2023.00011
    View:167
    Download:19
    Times Cited: 0
    Open Access
    Review
    Nanomedicine strategies to counteract cancer stemness and chemoresistance
    Cancer stem-like cells (CSCs) identified by self-renewal ability and tumor-initiating potential are responsible for tumor recurrence and metastasis in many cancers. Conventional chemotherapy fails t..11.
    Huayu Liu ... Ran Mo
    Published: August 30, 2023 Explor Target Antitumor Ther. 2023;4:630–656
    DOI: https://doi.org/10.37349/etat.2023.00157
    This article belongs to the special issue Cancer Stem Cell Targeting Therapy
    View:204
    Download:15
    Times Cited: 0
    Open Access
    Review
    Nuclear epidermal growth factor receptor as a therapeutic target
    Epidermal growth factor receptor (EGFR) is one of the most well-studied oncogenes with roles in proliferation, growth, metastasis, and therapeutic resistance. This intense study has led to the devel..11.
    Benjamin Atwell ... Joyce Schroeder
    Published: August 30, 2023 Explor Target Antitumor Ther. 2023;4:616–629
    DOI: https://doi.org/10.37349/etat.2023.00156
    This article belongs to the special issue Innovative Strategies to Target Triple-negative Breast Cancer
    View:291
    Download:18
    Times Cited: 0
    Open Access
    Review
    Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer
    Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has a recognized role in cancer prevention as well as evidence to support its use as an adjuvant for cancer treatment. Import..11.
    Ashley J. Hoskin ... Emma E. Vincent
    Published: August 28, 2023 Explor Target Antitumor Ther. 2023;4:600–615
    DOI: https://doi.org/10.37349/etat.2023.00155
    View:332
    Download:16
    Times Cited: 0
    Open Access
    Review
    B-cell lymphoma 2 family members and sarcomas: a promising target in a heterogeneous disease
    Targeting the B-cell lymphoma 2 (Bcl-2) family proteins has been the backbone for hematological malignancies with overall survival improvements. The Bcl-2 family is a major player in apoptosis regul..11.
    Rui Caetano Oliveira ... José Casanova
    Published: August 24, 2023 Explor Target Antitumor Ther. 2023;4:583–599
    DOI: https://doi.org/10.37349/etat.2023.00154
    This article belongs to the special issue The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy
    View:220
    Download:22
    Times Cited: 0
    Open Access
    Review
    Small airway dysfunction and obesity in asthmatic patients: a dangerous liaison?
    Asthma is a chronic condition characterized by inflammation throughout the entire bronchial airways. Recent findings suggest that ventilation inhomogeneity and small airway dysfunction (SAD) play a ..11.
    Jack Pepys ... Marcello Cottini
    Published: August 15, 2023 Explor Asthma Allergy. 2023;1:73–88
    DOI: https://doi.org/10.37349/eaa.2023.00010
    This article belongs to the special issue Small Airways Disease Across the Ages
    View:343
    Download:23
    Times Cited: 0
    Open Access
    Review
    Emerging role of quantitative imaging (radiomics) and artificial intelligence in precision oncology
    Cancer is a fatal disease and the second most cause of death worldwide. Treatment of cancer is a complex process and requires a multi-modality-based approach. Cancer detection and treatment starts w..11.
    Ashish Kumar Jha ... Andre Dekker
    Published: August 24, 2023 Explor Target Antitumor Ther. 2023;4:569–582
    DOI: https://doi.org/10.37349/etat.2023.00153
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    View:338
    Download:19
    Open Access
    Perspective
    Potential tactics with certain gut microbiota for the treatment of unresectable hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) constitutes an extremely malignant form of primary liver cancer. Intricate connections linking to the immune system might be associated with the pathogenesis of HCC. M..11.
    Sayuri Yoshikawa ... Satoru Matsuda
    Published: August 24, 2023 Explor Target Antitumor Ther. 2023;4:556–568
    DOI: https://doi.org/10.37349/etat.2023.00152
    This article belongs to the special issue Cancer Immunotherapy and Tumor Microenvironment
    View:527
    Download:191
    Times Cited: 0
    Open Access
    Review
    Alcohol—dose question and the weakest link in a chemical interplay
    The deleterious consequences of alcohol consumption are extensively documented across various dimensions of human health, encompassing somatic disorders such as nervous system impairments, digestive..11.
    Piotr Hamala, Karina Wierzbowska-Drabik
    View:231
    Download:9
    Open Access
    Review
    Natural compounds from medicinal plants against COVID-19
    The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), known to cause the coronavirus disease 2019 (COVID-19), was declared a pandemic in early 2020. During the past time, several infecti..11.
    Anton Kolodnitsky ... Vladimir Poroikov
    Published: August 28, 2023 Explor Drug Sci. 2023;1:253–275
    DOI: https://doi.org/10.37349/eds.2023.00017
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:203
    Download:19
    Times Cited: 0
    Open Access
    Letter to the Editor
    Harnessing the untapped potential of digital twin technology in digital public health interventions
    Digital technologies have garnered more attention in this epoch of public health emergencies like coronavirus disease 2019 (COVID-19) and monkeypox (mpox). Digital twin (DT) is the virtual cyberneti..11.
    Salman Khan ... ArunSundar MohanaSundaram
    Online First: August 07, 2023 Explor Digit Health Technol. 2023;1:11–16
    DOI: https://doi.org/10.37349/edht.2023.00003
    This article belongs to the special issue Social media applications in biomedical research
    View:396
    Download:49
    Times Cited: 0
    Open Access
    Review
    COVID-19 induced ARDS: immunopathology and therapeutics
    The coronavirus disease-2019 (COVID-19) pandemic is a significant threat in the modern era. Clinical studies show that the most common symptom of severe COVID-19 is viral pneumonia-induced acute res..11.
    Sneha Das ... Rupesh K. Srivastava
    Published: August 04, 2023 Explor Immunol. 2023;3:255–275
    DOI: https://doi.org/10.37349/ei.2023.00101
    This article belongs to the special issue Immunology, Immunopathology and Genomics of SARS-COV-2
    View:281
    Download:28
    Times Cited: 0
    Open Access
    Review
    Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes
    Nonalcoholic fatty liver disease (NAFLD), its more rapidly progressive steatohepatitic variant [nonalcoholic steatohepatitis, (NASH)], and the recently defined metabolic dysfunction-associated fatty..11.
    Amedeo Lonardo
    Published: August 28, 2023 Explor Drug Sci. 2023;1:239–252
    DOI: https://doi.org/10.37349/eds.2023.00016
    This article belongs to the special issue Innovative Therapeutics in Hepato-Gastroenterology
    View:177
    Download:11
    Times Cited: 0
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po..11.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:292
    Download:20
    Times Cited: 0
    Open Access
    Original Article
    Small patient datasets reveal genetic drivers of non-small cell lung cancer subtypes using machine learning for hypothesis generation
    Aim: Many small datasets of significant value exist in the medical space that are being underutilized. Due to the heterogeneity of complex disorders found in oncology, systems capable of discover..11.
    Moses Cook ... Joseph Geraci
    Published: July 26, 2023 Explor Med. 2023;4:428–440
    DOI: https://doi.org/10.37349/emed.2023.00153
    View:744
    Download:49
    Times Cited: 0
    Open Access
    Review
    Current role of machine learning and radiogenomics in precision neuro-oncology
    In the past few years, artificial intelligence (AI) has been increasingly used to create tools that can enhance workflow in medicine. In particular, neuro-oncology has benefited from the use of AI a..11.
    Teresa Perillo ... Andrea Manto
    Published: July 19, 2023 Explor Target Antitumor Ther. 2023;4:545–555
    DOI: https://doi.org/10.37349/etat.2023.00151
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    View:338
    Download:32
    Times Cited: 0
    Open Access
    Review
    Significance of autoantibodies in diagnostics of systemic vasculitis
    Systemic vasculitis is a heterogeneous group of disorders characterized by inflammation and necrosis in the vessel wall. Patients usually present a quite broad spectrum of manifestations which vary ..11.
    Katarzyna Fischer, Marek Brzosko
    Published: July 17, 2023 Explor Musculoskeletal Dis. 2023;1:77–83
    DOI: https://doi.org/10.37349/emd.2023.00012
    View:197
    Download:19
    Times Cited: 0
    Open Access
    Original Article
    In search of heart barometer—advantage of left atrial dimension over electrocardiographic indices of left ventricular hypertrophy in arterial hypertension
    Aim: Left ventricular (LV) hypertrophy (LVH) is a common and relevant complication of arterial hypertension (AH) and 12-lead electrocardiogram (ECG) is widely used for its preliminary assessment...11.
    Bogusława Nowak ... Karina Wierzbowska-Drabik
    View:278
    Download:15
    Times Cited: 0
    Open Access
    Case Report
    Conservative approach in adult right-sided Bochdalek hernia with an intrathoracic ectopic kidney
    Bochdalek hernia (BH) is a congenital diaphragmatic defect primarily diagnosed in neonates and is usually left-sided. Adult diagnosis, especially of right-sided BH is exceedingly rare and usually pr..11.
    Husam El Sharu ... Ahmed Hebishy
    Published: July 12, 2023 Explor Med. 2023;4:421–427
    DOI: https://doi.org/10.37349/emed.2023.00152
    View:396
    Download:30
    Times Cited: 0
    Open Access
    Review
    Eosinophilic gastrointestinal disorders: new perspectives and the emerging role of biological therapies
    The advent of biological drugs has opened up new therapeutic possibilities in the field of eosinophilic gastro-intestinal diseases (EGIDs). EGIDs are chronic inflammatory diseases of the gastrointes..11.
    Francesca Losa, Arianna Cingolani
    Published: June 30, 2023 Explor Asthma Allergy. 2023;1:60–72
    DOI: https://doi.org/10.37349/eaa.2023.00009
    This article belongs to the special issue The Era of Biologics in Allergy
    View:264
    Download:21
    Times Cited: 0
    Open Access
    Original Article
    Morphological variations at the knee associated with osteoarthritis: a case-control study using data from the GOAL study
    Aim: To identify constitutional morphological features at the knee that associate with knee osteoarthritis (OA, KOA). Methods: This was a case-control study using data from the Genetics of ..11.
    Anand Ramachandran Nair ... Abhishek Abhishek
    Published: June 30, 2023 Explor Musculoskeletal Dis. 2023;1:68–76
    DOI: https://doi.org/10.37349/emd.2023.00011
    View:248
    Download:23
    Times Cited: 0
    Open Access
    Original Article
    Untargeted lipidomics for evaluating fish authenticity: the case of wild-caught and farmed species of Sparus aurata
    Aim: This study aims to develop sensitive and reliable analytical technologies to enable the distinction between wild-caught and farmed fish through appropriate molecular markers to protect consu..11.
    Sara Granafei ... Tommaso R.I. Cataldi
    Published: June 30, 2023 Explor Foods Foodomics. 2023;1:83–100
    DOI: https://doi.org/10.37349/eff.2023.00008
    View:418
    Download:37
    Times Cited: 0
    Open Access
    Original Article
    A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli
    Aim: This study aims to report an engineered peptide zp39 with favorable bioactivity against enterohemorrhagic Escherichia coli (E. coli, EHEC). Its antibacterial mechanisms and application in a ..11.
    Ping Zeng ... Lanhua Yi
    Published: June 30, 2023 Explor Drug Sci. 2023;1:210–220
    DOI: https://doi.org/10.37349/eds.2023.00014
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:247
    Download:17
    Times Cited: 0
    Open Access
    Original Article
    Untargeted and quantitative analyses of amine and phenol compounds in Baijiu via chemical isotope labeling
    Aim: The aim of this study is to comprehensively investigate the distribution of amine and phenol compounds in different flavors of Baijiu. Methods: 12C-/13C-dansyl chloride labeling was ..11.
    Xiaoyu Xie ... Guowang Xu
    Published: June 30, 2023 Explor Foods Foodomics. 2023;1:72–82
    DOI: https://doi.org/10.37349/eff.2023.00007
    View:513
    Download:84
    Times Cited: 0
    Open Access
    Review
    Approved antibacterial drugs in the last 10 years: from the bench to the clinic
    Bacterial infections constitute one of the major cases of primary medical incidences worldwide. Historically, the fight against bacterial infections in humans has been an ongoing battle, due to the ..11.
    Miguel García-Castro ... Juan Manuel López-Romero
    Published: June 30, 2023 Explor Drug Sci. 2023;1:180–209
    DOI: https://doi.org/10.37349/eds.2023.00013
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:271
    Download:20
    Times Cited: 0
    Open Access
    Review
    Alcohol-related liver disease: also a question of what you drink?
    Excessive alcohol intake is still among the leading causes of chronic liver diseases. Epidemiological studies suggest that per capita consumption of alcohol from various alcohol beverages e.g., beer..11.
    Finn Jung ... Ina Bergheim
    Published: June 30, 2023 Explor Dig Dis. 2023;2:118–132
    DOI: https://doi.org/10.37349/edd.2023.00022
    This article belongs to the special issue Nutrition, Intestinal Barrier and Metabolic Liver Disease
    View:419
    Download:40
    Times Cited: 0
    Open Access
    Review
    Circadian regulation of the immune-hematopoietic system
    Earth’s rotation generates the basic circadian rhythm of day and night to which all living organisms must adapt to survive. In mammals, this happens thanks to a central clock located in the suprac..11.
    Georges Maestroni
    Published: June 30, 2023 Explor Neurosci. 2023;2:123–139
    DOI: https://doi.org/10.37349/en.2023.00017
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:453
    Download:31
    Times Cited: 0
    Open Access
    Case Report
    Food fish allergy as a result of occupational exposure to fish collagen
    A case report of fish allergy is exposed. The responsible allergen was fish collagen, and there was no sensitization to parvalbumin (main fish allergen). The patient acquired collagen sensitization ..11.
    Felipe Santos Vicente ... Borja Bartolomé Zavala
    Published: June 30, 2023 Explor Asthma Allergy. 2023;1:55–59
    DOI: https://doi.org/10.37349/eaa.2023.00008
    View:244
    Download:22
    Times Cited: 0
    Open Access
    Review
    An introductory review of post-resection chemotherapeutics for primary brain tumors
    The treatment of central nervous system (CNS) tumors is complicated by high rates of recurrence and treatment resistance that contribute to high morbidity and mortality (Nat Rev Neurol. 2022;18:221..11.
    Meaghan McGovern ... Brandon Lucke-Wold
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:537–544
    DOI: https://doi.org/10.37349/etat.2023.00150
    View:446
    Download:33
    Times Cited: 0
    Open Access
    Review
    Glucose metabolism reprogramming promotes immune escape of hepatocellular carcinoma cells
    Hepatocellular carcinoma (HCC) is a complex process that plays an important role in its progression. Abnormal glucose metabolism in HCC cells can meet the nutrients required for the occurrence and d..11.
    Qiuyue Zhang ... Mengsen Li
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:519–536
    DOI: https://doi.org/10.37349/etat.2023.00149
    This article belongs to the special issue Therapeutic Targeting of the Tumor Microenvironment
    View:399
    Download:20
    Times Cited: 0
    Open Access
    Review
    Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
    Besides trauma, several pathological conditions which directly affect the normal functioning of organs, require new therapeutic strategies to repair damaged or diseased tissues. Tissue regeneration ..11.
    Cláudia S. Oliveira, Freni K. Tavaria
    Published: June 30, 2023 Explor Immunol. 2023;3:233–254
    DOI: https://doi.org/10.37349/ei.2023.00100
    This article belongs to the special issue Interplay of Stem Cells and Immunology in Regenerative Medicine
    View:551
    Download:40
    Times Cited: 0
    Open Access
    Case Report
    Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
    Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive th..11.
    Mikhail V. Kiselevskiy ... Irina Zh. Shubina
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:511–518
    DOI: https://doi.org/10.37349/etat.2023.00148
    View:304
    Download:13
    Times Cited: 0
    Open Access
    Letter to the Editor
    Patient self-sampling for remote human leucocyte antigen-B27 analysis
    Hannah Labinsky ... Johannes Knitza
    Published: June 30, 2023 Explor Musculoskeletal Dis. 2023;1:64–67
    DOI: https://doi.org/10.37349/emd.2023.00010
    This article belongs to the special issue Digital health technologies in rheumatology: emerging evidence and innovation
    View:346
    Download:26
    Times Cited: 0
    Open Access
    Review
    Muscle fatigue and exercise-related biomarkers in amyotrophic lateral sclerosis
    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder affecting motor neurons. The complex etiopathogenetic mechanism of ALS can lead to extensive alterations, including co..11.
    Francesca Bianchi ... Gabriele Siciliano
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:164–176
    DOI: https://doi.org/10.37349/ent.2023.00045
    This article belongs to the special issue Biomarkers in Amyotrophic Lateral Sclerosis
    View:356
    Download:20
    Times Cited: 0
    Open Access
    Review
    Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy
    Currently, the predominant targets for the treatment of Alzheimer’s disease (AD) are the main components of the two pathological structures: senile plaques (composed of amyloid beta peptide aggreg..11.
    Jesús Avila ... Félix Hernández
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:151–163
    DOI: https://doi.org/10.37349/ent.2023.00044
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
    View:349
    Download:28
    Times Cited: 0
    Open Access
    Review
    Conformational and functional regulation of the chicken tumor virus number 10 (CT10) regulator of kinase II (CrkII) adaptor protein by cyclophilin A
    The Src homology 2 (SH2) and SH3 domain-containing chicken tumor virus number 10 (CT10) regulator of kinase (Crk) adaptor proteins include three cellular members that serve as integral constituents ..11.
    Noah Isakov
    Published: June 30, 2023 Explor Immunol. 2023;3:217–232
    DOI: https://doi.org/10.37349/ei.2023.00099
    This article belongs to the special issue The Role of Adaptor Proteins in Lymphoid Cell Signaling
    View:339
    Download:14
    Times Cited: 0
    Open Access
    Review
    Therapeutic potential of extracellular vesicles in Parkinson’s disease
    Globally, the incidence of Parkinson’s disease (PD) is increasing faster than other neurodegenerative disorders. Neuropathologically, PD is characterized by the loss of dopaminergic neurons in the..11.
    Michelli Ramires Teixeira ... Rodrigo Pinheiro Araldi
    Published: June 29, 2023 Explor Neurosci. 2023;2:106–122
    DOI: https://doi.org/10.37349/en.2023.00016
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:416
    Download:31
    Times Cited: 0
    Open Access
    Review
    Increasing differential diagnosis between lipoma and liposarcoma through radiomics: a narrative review
    Soft tissue sarcomas (STSs) are rare, heterogeneous, and very often asymptomatic diseases. Their diagnosis is fundamental, as is the identification of the degree of malignancy, which may be high, me..11.
    Raffaele Natella ... Antonella Santone
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:498–510
    DOI: https://doi.org/10.37349/etat.2023.00147
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    View:351
    Download:16
    Times Cited: 0
    Open Access
    Original Article
    An analysis on the clinical features and risk factors associated with the prognosis of patients with drug-induced liver injury
    Aim: This is a Chinese population-based study aimed to determine the causes and clinical features of drug-induced liver injury (DILI) from traditional Chinese medicines (TCMs) and current Western m..11.
    Qian Wei ... Jinsheng Guo
    Published: June 30, 2023 Explor Dig Dis. 2023;2:100–117
    DOI: https://doi.org/10.37349/edd.2023.00021
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:295
    Download:39
    Times Cited: 0
    Open Access
    Original Article
    Quantitative magnetic resonance spectroscopy and imaging analysis of the lipid content in the psoas major and its association with intervertebral disc degeneration: a cross-sectional study
    Aim: It is shown that the diminished function of the psoas major is mainly associated with increased lipid content; nonetheless, whether the fat content of the psoas major is associated with inte..11.
    Izaya Ogon ... Atsushi Teramoto
    Published: June 29, 2023 Explor Musculoskeletal Dis. 2023;1:54–63
    DOI: https://doi.org/10.37349/emd.2023.00009
    View:225
    Download:10
    Times Cited: 0
    Open Access
    Original Article
    Alzheimer’s disease detection from magnetic resonance imaging: a deep learning perspective
    Aim: Up to date many successful attempts to identify various types of lesions with machine learning (ML) were made, however, the recognition of Alzheimer’s disease (AD) from brain images and inter..11.
    Karolina Armonaite ... Luigi Laura
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:139–150
    DOI: https://doi.org/10.37349/ent.2023.00043
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
    View:389
    Download:23
    Times Cited: 0
    Open Access
    Review
    Type 1 and type 2 cytokine-mediated immune orchestration in the tumour microenvironment and their therapeutic potential
    Cancer remains the second leading cause of death worldwide despite modern breakthroughs in medicine, and novel treatments are urgently needed. The revolutionary success of immune checkpoint inhibito..11.
    Eric Jou
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:474–497
    DOI: https://doi.org/10.37349/etat.2023.00146
    This article belongs to the special issue Therapeutic Targeting of the Tumor Microenvironment
    View:396
    Download:17
    Times Cited: 0
    Open Access
    Perspective
    Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies
    Immunotherapy strategies targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) are revolutionizing oncology. However, ..11.
    Ai Tsuji ... Satoru Matsuda
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:460–473
    DOI: https://doi.org/10.37349/etat.2023.00145
    This article belongs to the special issue Cancer Immunotherapy and Tumor Microenvironment
    View:766
    Download:335
    Times Cited: 0
    Open Access
    Original Article
    Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors
    Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several clas..11.
    Markus Schweipert ... Franz-Josef Meyer-Almes
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:447–459
    DOI: https://doi.org/10.37349/etat.2023.00144
    This article belongs to the special issue Emerging Screening Technologies in Drug Discovery
    View:282
    Download:21
    Times Cited: 0
    Open Access
    Original Article
    Associations between methamphetamine and alcohol use disorder, suicidal ideation, and lowered quality of life in methamphetamine users
    Aim: There is a strong comorbidity between methamphetamine (MA) and alcohol use whereby MA use may contribute to increased alcohol consumption. This study aims to determine the associations betwe..11.
    Ketsupar Jirakran ... Rasmon Kalayasiri
    Published: June 30, 2023 Explor Med. 2023;4:409–420
    DOI: https://doi.org/10.37349/emed.2023.00151
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:336
    Download:30
    Times Cited: 0
    Open Access
    Original Article
    Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers
    Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets..11.
    Lisa T. Huber ... Cornelia Brunner
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:422–446
    DOI: https://doi.org/10.37349/etat.2023.00143
    This article belongs to the special issue The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
    View:359
    Download:14
    Times Cited: 0
    Open Access
    Perspective
    Mesenchymal stem cell stroke therapy: current limitations in its clinical translation
    For more than a decade now, research studies, proof of concept work, and clinical trials have endeavored to understand how mesenchymal stem cells might be used to help protect, repair, and/or regene..11.
    Ylenia Pastorello, Mark Slevin
    Published: June 28, 2023 Explor Neurosci. 2023;2:98–105
    DOI: https://doi.org/10.37349/en.2023.00015
    This article belongs to the special issue Neuroinflammation in the Ageing and the Injured Brain
    View:348
    Download:19
    Times Cited: 0
    Open Access
    Original Article
    Exploring medical cannabis use in individuals with a traumatic brain injury
    Aim: Traumatic brain injury (TBI) is a common neurological condition, which can present with a wide range of neuropsychological symptoms. Treating this broad spectrum of symptoms represents a sig..11.
    Elizabeth N. R. Schjelderup ... Alasdair M. Barr
    Published: June 30, 2023 Explor Med. 2023;4:393–408
    DOI: https://doi.org/10.37349/emed.2023.00150
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:415
    Download:26
    Times Cited: 0
    Open Access
    Review
    Molecular mechanism of electroacupuncture for improving perioperative complications with the guidance of enhanced recovery after surgery
    Enhanced recovery after surgery (ERAS) is a recommended surgical strategy at present, the core content is to reduce perioperative stress response and postoperative complications through perioperativ..11.
    Yu Mao, Lifang Yang
    Published: June 30, 2023 Explor Med. 2023;4:380–392
    DOI: https://doi.org/10.37349/emed.2023.00149
    View:290
    Download:21
    Times Cited: 0
    Open Access
    Original Article
    Cannabinoid-based medicines in clinical care of chronic non-cancer pain: an analysis of pain mechanism and cannabinoid profile
    Aim: Among treatments for chronic non-cancer pain (CNCP), cannabinoid-based medicines (CBMs) have become extremely popular. Evidence remains modest and limited primarily to delta-9-tetrahydrocann..11.
    Lucile Rapin ... Michael Dworkind
    Published: June 30, 2023 Explor Med. 2023;4:363–379
    DOI: https://doi.org/10.37349/emed.2023.00148
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:418
    Download:19
    Times Cited: 0
    Open Access
    Review
    The impact of COVID-19 pandemic on diagnosis and management of gastrointestinal cancers
    Gastrointestinal (GI) cancer is one of the leading causes of death that affect many patients around the world. The coronavirus disease 2019 (COVID-19) pandemic significantly impacted our healthcare ..11.
    Byung Soo Yoo ... David A. Johnson
    Published: June 28, 2023 Explor Med. 2023;4:356–362
    DOI: https://doi.org/10.37349/emed.2023.00147
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:331
    Download:8
    Times Cited: 0
    Open Access
    Original Article
    Association between coronavirus 2019 disease and pseudoneurological complaints: analysis of case-control data
    Aim: Pseudoneurological complaints (PNCs) are highly prevalent among the general population. Coronavirus disease 2019 (COVID-19) adversely influences such complaints in individuals who recovered ..11.
    Mohammad Ali ... Tajnuva Mehjabin
    Published: June 28, 2023 Explor Med. 2023;4:343–355
    DOI: https://doi.org/10.37349/emed.2023.00146
    View:221
    Download:13
    Times Cited: 0
    Open Access
    Original Article
    Type 2 diabetes mellitus and coronary artery stenosis: a risk pattern association study
    Aim: Cardiovascular diseases (CVD) are the leading cause of death globally. In the condition of type 2 diabetes mellitus (T2DM), the prevalence of CVD increase parallel with the rise of metabolic..11.
    Dharmsheel Shrivastav ... Vimal Mehta
    Published: June 28, 2023 Explor Med. 2023;4:336–342
    DOI: https://doi.org/10.37349/emed.2023.00145
    This article belongs to the special issue Exploring Aortic Disease
    View:281
    Download:10
    Times Cited: 0
    Open Access
    Original Article
    Identification of an inter-cysteine loop potentially involved in the activity of Opisthorchis viverrini-granulin-1
    Aim: Identification of small bioactive regions in proteins and peptides can be useful information in drug design studies. The current study has shown that an inter-cysteine loop of the N-terminal..11.
    Rozita Takjoo ... Norelle L. Daly
    Published: June 30, 2023 Explor Drug Sci. 2023;1:172–179
    DOI: https://doi.org/10.37349/eds.2023.00012
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:252
    Download:10
    Times Cited: 0
    Open Access
    Review
    Artificial intelligence and radiomics in magnetic resonance imaging of rectal cancer: a review
    Rectal cancer (RC) is one of the most common tumours worldwide in both males and females, with significant morbidity and mortality rates, and it accounts for approximately one-third of colorectal ca..11.
    Giuseppe Di Costanzo ... Enrico Cavaglià
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:406–421
    DOI: https://doi.org/10.37349/etat.2023.00142
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    View:349
    Download:19
    Times Cited: 0
    Open Access
    Review
    Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
    The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a..11.
    Hanghang Wu ... Francisco Javier Cubero
    Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
    DOI: https://doi.org/10.37349/edd.2023.00020
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:430
    Download:31
    Times Cited: 0
    Open Access
    Review
    Liver injury related to Japanese herbal medicines: clinical features and diagnosis
    The word “Kampo medicine” means the traditional Japanese herbal medicine. Even “natural herb” can cause drug-induced liver injury (DILI). In this review, the characteristics of Kampo medicin..11.
    Naoki Mantani
    Published: June 27, 2023 Explor Dig Dis. 2023;2:77–82
    DOI: https://doi.org/10.37349/edd.2023.00019
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:253
    Download:11
    Times Cited: 0
    Open Access
    Original Article
    Real world outcomes in patients with neuroendocrine tumor receiving peptide receptor radionucleotide therapy
    Aim: 177Lu-Dotatate (Lu-177), a form of peptide receptor radionuclide therapy (PRRT), was approved by Food and Drug Administration (FDA) for the treatment of somatostatin-receptor-positive neur..11.
    Stijn Hentzen ... Anup Kasi
    Published: June 29, 2023 Explor Target Antitumor Ther. 2023;4:396–405
    DOI: https://doi.org/10.37349/etat.2023.00141
    View:353
    Download:12
    Times Cited: 0