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    Breakthroughs in Mechanisms and Treatments for Neurodegenerative Diseases

    Submission Deadline: September 30, 2025

    Guest Editors

    Dr. Rong Ma E-Mail

    Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

    Research Keywords: pathogenic mechanisms of neurodegenerative diseases; Alzheimer's disease; Parkinson’s disease


    Dr. Guoku Hu E-Mail

    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Research Keywords: neurodegenerative diseases; drugs of abuse; brain aging


    About the Special Issue

    Conditions such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and Huntington's disease affect millions globally. The complex interplay of genetic, environmental, and lifestyle factors is crucial in the onset and progression of these debilitating conditions, highlighting the urgent need for comprehensive research to uncover the underlying mechanisms and develop effective therapeutic strategies.

    This special issue features groundbreaking research and innovative approaches that enhance our understanding of neurodegenerative disease mechanisms and explore novel therapeutic interventions. Contributions span a diverse range of topics, including molecular pathways, protein aggregation dynamics, cellular signaling cascades, neuroinflammation mechanisms, synaptic dysfunction, immunotherapy, and neuronal regeneration strategies. Additionally, we explore emerging technologies such as extracellular vesicle therapy, gene editing techniques, advanced neuroimaging modalities, and biomarker discovery for early diagnosis and treatment monitoring.

    Our aim is to foster interdisciplinary collaboration, facilitate knowledge exchange, and drive scientific advancements in the field of neurodegenerative diseases. By bringing together diverse perspectives and pioneering research findings, we hope to inspire further investigation, accelerate translational efforts, and enhance clinical applications, ultimately contributing to the development of innovative therapies and improved patient outcomes.

    Keywords: neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis (ALS); neuroinflammation; biomarker discovery; immunotherapy; extracellular vesicle

    Call for Papers

    Published Articles

    Open Access
    Review
    Advancements in extracellular vesicle therapy for neurodegenerative diseases
    Neurodegenerative diseases represent a significant and growing challenge to public health worldwide. Current therapeutic strategies often fall short in halting or reversing disease progression, high [...] Read more.
    Ningyun Hu ... Rong Ma
    Published: May 06, 2025 Explor Neuroprot Ther. 2025;5:1004104
    DOI: https://doi.org/10.37349/ent.2025.1004104
    View:229
    Download:6
    Times Cited: 0