• Special Issue Topic

    Exploring Aortic Disease

    Submission Deadline: January 01, 2023

    Guest Editor

    Dr. Kathleen G. Morgan E-Mail

    Professor, Boston University School of Medicine, USA

    Research Keywords: precursors of cardiovascular disease; vascular dementia; aging-induced aortic stiffness; trafficking of cytoskeleton and signaling proteins; mechanisms of pre-term labor

    About the Special Issue

    We welcome submissions on all aspects of Aortic Disease. For example, Aortic Stiffness and Blood Pressure are known to be interrelated (G.F Mitchell Hypertension, 2014); but, although the quantity of research on hypertension is vast, investigation is less often focused on aortic stiffness and other diseases of the aorta that may cause the hypertension. Similarly, although aortic stiffness often precedes and is well known as an important risk factor for high blood pressure, stroke, and other incident cardiovascular diseases, we have essentially no accepted therapeutics to directly treat aortic stiffness. The aorta is also subject to calcification, aneurysms, rupture, and other disorders for which little is available therapeutically, short of emergency surgery.

    This special issue will cover recent advances in our understanding of the molecular, cellular and integral etiology of aortic diseases as well as the state of the art on prototypic therapeutic approaches to aortic diseases.

    Keywords: aortic stiffness; aortic aneurysms; aortic calcification; aortic dissection; aortic stenosis; Marfan syndrome; aortic regurgitation

    Published Articles

    Open Access
    Original Article
    Type 2 diabetes mellitus and coronary artery stenosis: a risk pattern association study
    Aim: Cardiovascular diseases (CVD) are the leading cause of death globally. In the condition of type 2 diabetes mellitus (T2DM), the prevalence of CVD increase parallel with the rise of metabolic [...] Read more.
    Dharmsheel Shrivastav ... Vimal Mehta
    Published: June 28, 2023 Explor Med. 2023;4:336–342
    DOI: https://doi.org/10.37349/emed.2023.00145
    Open Access
    Case Report
    Right atrial thrombus, junctional tachycardia, and critical lower limb ischemia: three rare complications of severe acute respiratory syndrome coronavirus 2 infection
    In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and [...] Read more.
    Said Makani ... Youssef Tijani
    Published: December 29, 2022 Explor Med. 2022;3:583–591
    DOI: https://doi.org/10.37349/emed.2022.00115
    Times Cited: 0
    Open Access
    Aortic complications in pregnancy: the less remembered chapter—a narrative review
    Pregnancy increases the risk of common vascular events and also the rarer events like aortic dissection (AD)/aortic rupture and this is even more pronounced in patients with predisposing aortopathies. AD was found to occur in 0.00 [...] Read more.
    Preetha Rajasekaran ... Bashi V. Velayudhan
    Published: October 31, 2021 Explor Med. 2021;2:423–434
    DOI: https://doi.org/10.37349/emed.2021.00060
    Times Cited: 0
    Open Access
    A review of aortic thrombosis in COVID-19 infection
    Aim: As the novel coronavirus disease 2019 (COVID-19) pandemic impacts the global healthcare system, evolving data show increased frequency of arterial and venous thromboembolism among patients with COVID-19 infection. Aortic t [...] Read more.
    Korin Karabulut ... James Morgan
    Published: October 31, 2021 Explor Med. 2021;2:410–422
    DOI: https://doi.org/10.37349/emed.2021.00059
    Open Access
    Why the aortic dissection detection risk score is problematic in emergency departments
    Acute aortic syndromes, including aortic dissection (AD), are rare. The AD detection risk score (ADDRS) and associated investigation pathway were developed to reduce missed diagnosis of AD. The methodology for its development was  [...] Read more.
    Anne-Maree Kelly
    Published: August 31, 2021 Explor Med. 2021;2:348–351
    DOI: https://doi.org/10.37349/emed.2021.00053
    Open Access
    Wave propagation and reflection in the aorta and implications of the aortic Windkessel
    Some have said that it is inappropriate and perhaps impossible to consider wave and Windkessel phenomena simultaneously. For 50 years, arterial hemodynamics has been dominated by the frequency-domain “impedance analysis” in wh [...] Read more.
    John V. Tyberg
    Published: June 30, 2021 Explor Med. 2021;2:198–207
    DOI: https://doi.org/10.37349/emed.2021.00042
    Times Cited: 0
    Open Access
    Vascular aging, the vascular cytoskeleton and aortic stiffness
    Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth m [...] Read more.
    Lova Prasadareddy Kajuluri ... Kathleen G Morgan
    Published: June 30, 2021 Explor Med. 2021;2:186–197
    DOI: https://doi.org/10.37349/emed.2021.00041