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  • Special Issue Topic

    The Complement System in Health and Disease

    Submission Deadline: April 30, 2023

    Guest Editors

    Dr. Roberta Bulla E-Mail

    Associate Professor of Immunology at the Medical Faculty and Department of Life Sciences, University of Trieste, Italy

    Research Keywords: signal transduction T cell activation, Kinases Phosphatases Proto-oncogenes Adaptor proteins


    Dr. Uday Kishore E-Mail

    University of Delhi, Salk Institute, University of Oxford, Brunel University London, London, United Kingdom

    Research Keywords: innate immunity, complement, pregnancy, cancer, neuroinflammation, infection, allergy


    About the Special Issue

    The complement system is considered crucial for maintaining cellular integrity and tissue homeostasis, acting as pattern recognition receptors (PRRs) and providing protection from pathogens and self-derived components. It is a tightly regulated cascade monitored by surface bound molecules and soluble proteins present in plasma and other biological fluids, which interact with each other connecting both innate and adaptive immunity. The split components of complement system act as potent anaphylatoxins, which are capable of recruiting immune cells that secrete a range of cytokines and chemokines, providing an effective anti-microbial defence system, clearing immune complex and also triggering an inflammatory response.

    The complement regulators control over-activation of complement pathways and inflammatory responses. Thus, dysregulation of complement system can disturb normal physiological activities and could lead to several pathological conditions such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G), paroxysmal nocturnal hemoglobinuria (PNH), Alzheimer's syndrome, schizophrenia, macular degeneration, Crohn's disease and also adverse pregnancy cases such as Preeclampsia. Overactivation of the complement system has been characterized in severe COVID-19 cases. Recent studies have also highlighted the association between genetic variations in complement components and regulators, and chronic and infectious diseases.

    This special issue will highlight various aspects of complement mediated human diseases and the mechanisms of complement regulation which are crucial for understanding disease pathology and its related therapies.

    Keywords: the complement system, diseases pathology and therapies, innate and adaptive immunity

    Call for Papers

    Published Articles

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    • Aims and Scope
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    • Ongoing Special Issues
      New insights in cancer immunology: the role of microbiota from immunosurveillance to immunotherapy
      Immunology, Immunopathology and Genomics of SARS-COV-2
      Interplay of Stem Cells and Immunology in Regenerative Medicine
      Cytokines and Skin Diseases
      DNA Sensing in Lung Inflammation
      The Role of Adaptor Proteins in Lymphoid Cell Signaling
      Nanomaterials interaction with chemokines: perspectives for applied immunology
      Old and New Paradigms in Viral Vaccinology
      Autoantibodies Associated to Thrombosis and Hemostasis
      Immunosenescence: Mechanisms and Its Impact
      The Complement System in Health and Disease
      Chronic Inflammation and Autoimmunity
      Bioinformatics, Big Data, AI: Exploring Immunology
      Role of NK cells, Chemokines, and Pyroptosis in Melanoma Development or Treatment
      Immunoregulatory Function of Mesenchymal Stem Cells in Tissue Repair and Regeneration
      The Immune Signature of Microgravity
      Cell Biology and Treatment of Autoimmune Diseases
      Mucosal Immune Cells - Border Protection or Entrance Gate?
      Immunobiology of Dendritic Cells
      Neuroimmunology of Multiple Sclerosis: Exploring New Perspectives
      Physical Activity and Immune System in Chronic Diseases : Mechanisms and Insights
      Immunobiology and Inflammation in the Male Reproductive System
    • Completed Special Issues
      Cross Talk Among Skin Cells and Immune Cells
      Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
      Human Reproduction: Involvement of the Immune System
      Interplay of γδ T cells and Tumor Cells
      The‌ ‌Sepsis‌ ‌induced‌ ‌Immune‌ ‌Conundrum
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