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    The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases

    Submission Deadline: May 20, 2022

    Guest Editors

    Dr. Feng Tian E-Mail

    Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University; Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China


    Dr. Changqing Jing E-Mail

    Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University; Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China


    About the Special Issue

    Gut Microbiota (GM) is known as the second human genome. It is not only related to nutrition and metabolism, intestinal dysfunction, intestinal inflammation and immunity, and gastrointestinal tumors, but also can regulate the function of remote organs. The cross-talk between Gut Microbiota itself or its metabolites and intestinal cells plays an important role in the occurrence and development of gastrointestinal diseases. Although more and more diseases are confirmed to be related to Gut Microbiota, there are still many unknown areas worth exploring, including new discoveries of diseases, exploration of regulatory mechanisms, and evaluation of clinical interventions. Thus, we would like this special issue to focus on this area of Gut Microbiota and gastrointestinal diseases which remains under-appreciated.

    This special issue will include primary research papers and reviews. The content will range from a phenomenon description to their role in disease mechanism, with a primary focus on gastrointestinal diseases, and potential intervention evaluation in ameliorating human suffering.

    Keywords: gut microbiota, bacterial strain, gastrointestinal dysfunction, intestinal motility, nutrition and metabolism, gastrointestinal tumors

    Call for Papers

    Published Articles

    Open Access
    Review
    Gastrointestinal microbiome and coronavirus disease: evidence of a bidirectional association
    The gastrointestinal (GI) microbiome remains an emerging topic of study and the characterization and impact on human health and disease continue to be an area of great interest. Similarly, the coron [...] Read more.

    The gastrointestinal (GI) microbiome remains an emerging topic of study and the characterization and impact on human health and disease continue to be an area of great interest. Similarly, the coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the healthcare system with active disease, lasting effects, and complications with the full impact yet to be determined. The most current evidence of the interaction between COVID-19 and the GI microbiome is reviewed, with a focus on key mediators and the microbiome changes associated with acute disease and post-acute COVID-19 syndrome (PACS).

    Kevin V. Houston ... David A. Johnson
    Published: April 25, 2023 Explor Med. 2023;4:157–165
    DOI: https://doi.org/10.37349/emed.2023.00130
    Full Text
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    Times Cited: 0

    The gastrointestinal (GI) microbiome remains an emerging topic of study and the characterization and impact on human health and disease continue to be an area of great interest. Similarly, the coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the healthcare system with active disease, lasting effects, and complications with the full impact yet to be determined. The most current evidence of the interaction between COVID-19 and the GI microbiome is reviewed, with a focus on key mediators and the microbiome changes associated with acute disease and post-acute COVID-19 syndrome (PACS).

    Open Access
    Review
    Immunomodulation strategies against COVID-19 evidence: key nutrients and dietary approaches
    The novel coronavirus disease-2019 (COVID-19) has created a major public health crisis. Various dietary factors may enhance immunological activity against COVID-19 and serve as a method to combat se [...] Read more.

    The novel coronavirus disease-2019 (COVID-19) has created a major public health crisis. Various dietary factors may enhance immunological activity against COVID-19 and serve as a method to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dietary factors that are responsible for boosting immunity may provide a therapeutic advantage in patients with COVID-19. Investigators have demonstrated that vitamins B6, B12, C, D, E, and K, and trace elements like zinc, copper, selenium, and iron may serve as important tools for immunomodulation. Herein this is a review the peer-reviewed literature pertaining to dietary immunomodulation strategies against COVID-19. This review is intended to better define the evidence that dietary modifications and supplementation could positively influence the proinflammatory state in patients with COVID-19 and improve clinical outcomes. With appropriate insight, therapeutic interventions are discussed and directed to potentially modulate host immunity to mitigate the disease mechanisms of COVID-19.

    Lindsey B. Cundra ... David A. Johnson
    Published: April 25, 2023 Explor Med. 2023;4:189–206
    DOI: https://doi.org/10.37349/emed.2023.00133
    Full Text
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    View:147
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    Times Cited: 0

    The novel coronavirus disease-2019 (COVID-19) has created a major public health crisis. Various dietary factors may enhance immunological activity against COVID-19 and serve as a method to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dietary factors that are responsible for boosting immunity may provide a therapeutic advantage in patients with COVID-19. Investigators have demonstrated that vitamins B6, B12, C, D, E, and K, and trace elements like zinc, copper, selenium, and iron may serve as important tools for immunomodulation. Herein this is a review the peer-reviewed literature pertaining to dietary immunomodulation strategies against COVID-19. This review is intended to better define the evidence that dietary modifications and supplementation could positively influence the proinflammatory state in patients with COVID-19 and improve clinical outcomes. With appropriate insight, therapeutic interventions are discussed and directed to potentially modulate host immunity to mitigate the disease mechanisms of COVID-19.

    Open Access
    Perspective
    A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exer [...] Read more.

    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exert a role of engrams for making the condition of specific inflammation in the gut. Dysregulation of immune cells induced by the command of engrams might be crucial in the pathogenesis of damages in gut epithelium. The anti-proliferative (APRO) family of anti-proliferative proteins characterized by immediate early responsive gene-products that might be involved in the machinery of the carcinogenesis in IBD. Herein, it is suggested that some probiotics with specific bacteria could prevent the development and/or progression of the IBD related tumors. In addition, consideration regarding the application of studying APRO family proteins for the comprehension of IBD related tumors has been presented. It is hypothesized that overexpression of Tob1, a member of APRO family proteins, in the epithelium of IBD could suppress the function of adjacent cytotoxic immune cells possibly via the paracrine signaling.

    Yuka Ikeda ... Satoru Matsuda
    Published: October 27, 2022 Explor Med. 2022;3:468–478
    DOI: https://doi.org/10.37349/emed.2022.00108
    Full Text
    PDF
    View:928
    Download:549
    Times Cited: 0

    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exert a role of engrams for making the condition of specific inflammation in the gut. Dysregulation of immune cells induced by the command of engrams might be crucial in the pathogenesis of damages in gut epithelium. The anti-proliferative (APRO) family of anti-proliferative proteins characterized by immediate early responsive gene-products that might be involved in the machinery of the carcinogenesis in IBD. Herein, it is suggested that some probiotics with specific bacteria could prevent the development and/or progression of the IBD related tumors. In addition, consideration regarding the application of studying APRO family proteins for the comprehension of IBD related tumors has been presented. It is hypothesized that overexpression of Tob1, a member of APRO family proteins, in the epithelium of IBD could suppress the function of adjacent cytotoxic immune cells possibly via the paracrine signaling.

    Open Access
    Review
    Feed your microbiome and improve sleep, stress resilience, and cognition
    The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagu [...] Read more.

    The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagus nerve, and the gut microbiome. It can influence brain function and even behavior, suggesting that dietary interventions may help enhance and protect mental health and cognitive performance. This review focuses on the role of the microbiome and its metabolites in sleep regulation, neurodegenerative disorders, mechanisms of stress, and mood. It also provides examples of nutritional interventions which can restore healthy gut microbiota and aid with risk reduction and management of many disorders related to mental and cognitive health. Evidence suggests a shift in the gut microbiota towards a balanced composition could be a target to maintain brain health, reduce stress and improve quality of life.

    Maciej Chichlowski ... Neeraj Pandey
    Published: August 29, 2022 Explor Med. 2022;3:331–344
    DOI: https://doi.org/10.37349/emed.2022.00097
    Full Text
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    View:900
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    Times Cited: 1

    The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagus nerve, and the gut microbiome. It can influence brain function and even behavior, suggesting that dietary interventions may help enhance and protect mental health and cognitive performance. This review focuses on the role of the microbiome and its metabolites in sleep regulation, neurodegenerative disorders, mechanisms of stress, and mood. It also provides examples of nutritional interventions which can restore healthy gut microbiota and aid with risk reduction and management of many disorders related to mental and cognitive health. Evidence suggests a shift in the gut microbiota towards a balanced composition could be a target to maintain brain health, reduce stress and improve quality of life.

    Open Access
    Editorial
    Does our microbiota eat with or without gluten?
    Giuseppe Merra ... Marco Marchetti
    Published: June 24, 2022 Explor Med. 2022;3:275–279
    DOI: https://doi.org/10.37349/emed.2022.00091
    Full Text
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    View:523
    Download:27
    Times Cited: 0
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      The Role of Repetitive DNA Elements in the Development and Progression of Human Disease
      Colon Controlled Microbiome Function: Role, Impact, Structure, Pathogenetic Significance, Therapeutic and Diagnostic Management
      The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
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      Emerging Infectious Diseases
      Applications of Radiomics in Precision Medicine
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