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    Therapeutic Targets for Neuroprotection in Ischemic Stroke

    Submission Deadline: July 31, 2023

    Guest Editor

    Dr. Silvia Fischer E-Mail

    Institute of Biochemistry, medicine, Justus-Liebig-University, Giessen, Germany

    Research Keywords: Endothelial cells; angiogenesis; endothelium; innate immunity; inflammatory responses


    About the Special Issue

    Stroke still belongs to the leading causes of death worldwide, accounting for 7.08 million deaths in 2020. Ischemic stroke is responsible for approximately 87% of all strokes, while hemorrhagic stroke accounts for 13%. Ischemic stroke, caused for example by thrombosis, embolism or systemic hypoperfusion, results in impaired blood flow and cell death, especially of neurons. Clinically, only intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and mechanical thrombectomy are administered for acute ischemic stroke to restore the blood flow. Unfortunately, both treatments are limited because of a very short therapeutic window and numerous contra-indications. Therefore, more knowledge about pathological cellular and molecular mechanisms in ischemic stroke is necessary to develop new strategies of neuroprotection. Some of the molecular events that can be targeted by neuroprotectants include glutamate release, glutamate receptor activation, intracellular Ca2+ increase, mitochondrial dysfunction, activation of several intracellular enzymes, generation of free radicals, apoptosis, blood-brain barrier disruption, and inflammation. Furthermore, ischemic stroke results in the release of danger associated molecular patterns (DAMPs) from dying cells such as heat shock proteins, histones, thioredoxin, adenosine triphosphate, high mobility group box protein 1, and numerous self-nucleic acids. These DAMPs can orchestrate innate and adaptive immune responses in the injured regions of the brain by glial cell activation, leading to the release of cytokines and chemokines, and the recruitment of leukocytes. Activated neutrophils further release neutrophil extracellular traps (NETs) which have been identified in infarcted lesions in specimens from ischemic stroke patients. Thus, inhibitory targeting of these events might provide promising therapeutic interventions to treat ischemic stroke.

    This special issue summarizes new knowledge about cellular and molecular mechanisms in ischemic stroke and treatment modalities.

    Keywords: Ischemic stroke; neuroprotection; neurons; glial cells; danger-associated molecular patterns; inflammation

    Call for Papers

    Published Articles

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    • Ongoing Special Issues
      Neuroprotective Nitric Oxide and Its Metabolites (Nitrite and Nitrate)
      Cognitive Alterations in Psychiatry
      Glia and Neuroprotection
      The Future of Biomarkers in CNS Diseases
      Biomarkers in Amyotrophic Lateral Sclerosis
      Molecular Mechanisms of Ischemic Tolerance in the Brain
      Recent Advances in Neurochemistry and Genetics of Late-onset Alzheimer's Disease
      The Search for Biomarkers: from Diagnosis to Progression Assessment
      Parkinson's Disease: Principal Targets and Interventional Mechanisms
      Intervention of Neuroimmune Responses
      Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
      The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
      New Advances in Imaging Techniques for the Evaluation of Neurological Disorders
      Natural Products in Neurotherapeutic Applications
      Penetrance and Metabolism of Brain Drugs
      Therapeutic Targets for Neuroprotection in Ischemic Stroke
      Neuroinvasion, Neuropathogenesis and Neuroprotective Agents in the Pathophysiology of SARS-CoV-2
      Empower Yourself - Physical Activity as Prevention and Rehabilitation of Neurological and Psychiatric Diseases
      Neuro-Inflammation as a Target in the Design of Multifunctional Drug Candidates for Neurodegenerative Diseases
      Dry Needling for Neurological Disorders
      Peripheral Nerve Regeneration
      Defending the Brain and the Mind: Exploring Neuroprotective Therapies for Mental Health Disorders
      Synaptic Pruning and Autophagy: from Physiology to Pathology
    • Completed Special Issues
      Cholesterol Dyshomeostasis in Neurological Diseases
      Emerging Concepts in Subarachnoid Hemorrhage
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