• Special Issue Topic

    Exploring Type 2 Diabetes Mellitus

    Submission Deadline: July 31, 2020

    Guest Editors

    Dr. Alessandro Mantovani E-Mail

    Assistant Professor, Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy

    Research Keywords: type 2 diabetes and risk of cardiovascular complications; type 2 diabetes and risk of diabetic foot complications

    Dr. Giovanni Targher E-Mail

    Associate Professor, Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy

    Research Keywords: type 2 diabetes and risk of chronic vascular complications of diabetes; role of nonalcoholic fatty liver disease in diabetes

    About the Special Issue

    Type 2 diabetes mellitus is a major public health problem that has reached epidemic proportions worldwide. Type 2 diabetes mellitus is also strongly associated with serious chronic complications, including ischemic heart disease, stroke, blindness, kidney disease and lower-extremity amputations leading to disability and early mortality. From 1980 to 2014, the number of people affected by type 2 diabetes mellitus almost quadrupled from 108 million to 422 million worldwide, showing a growth in the global prevalence from 4.7% to 8.5%. This growth trend is not estimated to slow in the near future. Indeed, according to the recent estimates from the International Diabetes Federation, the prevalence of the disease is expected to further increase to 9.9% by the year 2045 with an estimated population of around 640 million people with diabetes worldwide. This undoubtedly represents a potential future healthcare crisis for patients and providers alike. Areas of ongoing research include all aspects of type 2 diabetes mellitus, including epidemiology, physiopathology, risk factors, complications, management and treatment.

    Keywords: type 2 diabetes; chronic complications; epidemiology; management; pharmacologic treatment; risk factors

    Published Articles

    Open Access
    Original Article
    Risk factors in acute diabetic foot syndrome: analysis of 75 consecutive patients referred to a tertiary center in Modena, Italy
    Aim: Diabetic foot syndrome (DFS) is a complication of diabetes in which the presence of infections, ulceration and/or destruction of deep tissue associated with neuropathy, peripheral atherosclerosis and comorbidity affect the pr [...] Read more.
    Mauro Maurantonio ... Luca Roncucci
    Published: February 28, 2021 Explor Med. 2021;2:98–109
    DOI: https://doi.org/10.37349/emed.2021.00035
    Times Cited: 0
    Open Access
    Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies
    Silent coronary artery disease (CAD) is one of the manifestations of heart disease that particularly affects subjects with type 2 diabetes mellitus (T2DM). From a clinical point of view, silent CAD represents a constant challenge  [...] Read more.
    Saula Vigili de Kreutzenberg
    Published: February 28, 2021 Explor Med. 2021;2:1–19
    DOI: https://doi.org/10.37349/emed.2021.00029
    Times Cited: 0
    Open Access
    The entero-insular axis: a journey in the physiopathology of diabetes
    Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role. The discovery of the hormone insulin and the description of its [...] Read more.
    Roberta Malaguarnera ... Salvatore Piro
    Published: December 31, 2020 Explor Med. 2020;1:364–376
    DOI: https://doi.org/10.37349/emed.2020.00025
    Open Access
    Insulin pump therapy and continuous glucose monitoring in adults with type 2 diabetes: where are we now?
    Technology in diabetes is rapidly evolving, with the aim of helping affected people to safely optimize their blood glucose control. New technologies are now considered as an essential tool for managing glycemia predominantly in pe [...] Read more.
    Erika Pedone ... Amelia Caretto
    Published: October 30, 2020 Explor Med. 2020;1:314–330
    DOI: https://doi.org/10.37349/emed.2020.00021
    Open Access
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184–204
    DOI: https://doi.org/10.37349/emed.2020.00013
    Open Access
    GLP-1 receptor agonists for NAFLD treatment in patients with and without type 2 diabetes: an updated meta-analysis
    Aim: Recent randomized controlled trials (RCTs) have tested the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RA) to specifically treat non-alcoholic fatty liver disease (NAFLD). We performed a meta-analysis of R [...] Read more.
    Alessandro Mantovani ... Giovanni Targher
    Published: June 29, 2020 Explor Med. 2020;1:108–123
    DOI: https://doi.org/10.37349/emed.2020.00008