Andrea Borghini E-Mail
Institute of Clinical Physiology - National Research Council (IFC-CNR), Pisa, Italy
Research Keywords: cardiovascular genetics and epigenetics; molecular epidemiology; radiobiology
Cardiovascular aging is a process of functional and structural changes which can progress to cardiovascular disease. Age-related vascular damage can be also accelerated by environmental insults, such as air pollution and radiation exposure. Therefore, it is crucial to understand the molecular mechanisms of cardiovascular aging as well as to better define how environmental stressors impact this process.
Over the last few years, extensive research has emphasized the importance of several pathways involved in the pathophysiology of vascular aging. Intrinsic and extrinsic changes, including oxidative stress, inflammation, mitochondrial dysfunction, genomic instability, epigenetic alterations, and cellular senescence represent key cellular and molecular mechanisms of vascular aging. However, a more in-depth comprehension of these mechanisms is needed to identify novel diagnostic and/or prognostic indicators as well as potential new actionable therapeutic targets of cardiovascular aging. Considering the burden of cardiovascular disease with aging, this is, without a doubt, a strategic topic for future cardiology research.
For this Special Issue, we invite investigators to contribute with original research and review papers. In particular, experimental, translational, and clinical studies which emphasize the understanding of the biological mechanisms of cardiovascular aging are welcome.
Dr. Andrea Borghini,
Keywords: cardiovascular aging; molecular mechanisms; therapeutic targets; diagnostic and prognostic indicators