• Special Issue Topic

    Molecular Mechanisms of Cardiovascular Aging

    Submission Deadline: May 31, 2023

    Guest Editor

    Andrea Borghini E-Mail

    Institute of Clinical Physiology - National Research Council (IFC-CNR), Pisa, Italy

    Research Keywords: cardiovascular genetics and epigenetics; molecular epidemiology; radiobiology

    About the Special Issue

    Cardiovascular aging is a process of functional and structural changes which can progress to cardiovascular disease. Age-related vascular damage can be also accelerated by environmental insults, such as air pollution and radiation exposure. Therefore, it is crucial to understand the molecular mechanisms of cardiovascular aging as well as to better define how environmental stressors impact this process.

    Over the last few years, extensive research has emphasized the importance of several pathways involved in the pathophysiology of vascular aging. Intrinsic and extrinsic changes, including oxidative stress, inflammation, mitochondrial dysfunction, genomic instability, epigenetic alterations, and cellular senescence represent key cellular and molecular mechanisms of vascular aging. However, a more in-depth comprehension of these mechanisms is needed to identify novel diagnostic and/or prognostic indicators as well as potential new actionable therapeutic targets of cardiovascular aging. Considering the burden of cardiovascular disease with aging, this is, without a doubt, a strategic topic for future cardiology research.

    For this Special Issue, we invite investigators to contribute with original research and review papers. In particular, experimental, translational, and clinical studies which emphasize the understanding of the biological mechanisms of cardiovascular aging are welcome.


    Dr. Andrea Borghini,

    Associate Editor 

    Keywords: cardiovascular aging; molecular mechanisms; therapeutic targets; diagnostic and prognostic indicators

    Call for Papers

    Published Articles