• Special Issue Topic

    Natural Products in Health and Disease

    Submission Deadline: May 31, 2024

    Guest Editor

    Marcello Iriti E-Mail

    Plant Biology and Pathology at the Department of Biomedical, Surgical and Dental Sciences, Milan State University, Milan, Italy

    Research Keywords: functional foods; nutraceuticals; mediterranean diet; nutritional therapy; pharmaconutrients; phytotherapeutics; bioactive phytochemicals; medicinal and food plants; food security


    About the Special Issue

    Plant organisms represent an unlimited source of bioactive secondary metabolites. In recent decades, an enormous amount of preclinical (i.e. in vitro and in vivo) studies have indicated that phytochemicals exert a plethora of biological and pharmacological activities in cell cultures and animal models, although the evidence in humans is less substantiated and still fragmentary. Nowadays, we know that bioactive phytochemicals possess antimicrobial, anti-inflammatory, antioxidant/prooxidant, cytotoxic and immunomodulating activities, among others, which make them promising antibiotic, cardioprotective, neuroprotective, anticancer, antidiabetic, anti-obesity and antiaging agents. In general, phytochemicals exert a multi-target mechanism of action which makes them suitable drugs for the prevention and treatment of both communicable and non-communicable diseases, although phytochemicals appear to be more effective in the prevention than in the treatment of chronic-degenerative diseases, as demonstrated by healthy diets rich in plant foods. Furthermore, phytochemicals can be developed as adjuvant and sensitizing agents in association with conventional antibiotic and anticancer therapies to improve their efficacy, decrease their adverse effects, reduce the risk of selecting resistant microbial strains or cancer cells, or even reverse resistance. However, the preclinical pharmacological activities of phytochemicals need to be further substantiated by clinical studies in healthy and unhealthy subjects on their effective dose, route of administration, possible adverse effects and drug interactions.

    In this very wide context, we invite investigators to submit both original research and review articles that explore all these aspects.

    Keywords: medicinal plants; botanicals; plant extracts; essential oils; marine drugs; nutraceuticals; herbal remedies; antimicrobials; antimicrobial resistance; anticancer drugs; antineoplastic resistance; cardioprotection; neuroprotection; antidiabetic agents; anti-obesity agents; antioxidant activity; ethnopharmacology; one health

    Call for Papers

    Published Articles

    Open Access
    Original Article
    Assessment of the health benefits of phytochemicals in Cynometra cauliflora based on an in silico study against Alzheimer’s disease
    Aim: Cynometra cauliflora (namnam) belongs to the family Fabaceae and is native to eastern Peninsular Malaysia. It grows well with an annual rainfall of 1,500–2,000 mm. Even though a consider [...] Read more.
    Jagath Illangasinghe ... Viduranga Yashasvi Waisundara
    Published: January 23, 2024 Explor Foods Foodomics. 2024;2:1–29
    DOI: https://doi.org/10.37349/eff.2024.00023
    View:279
    Download:27
    Times Cited: 0
    Open Access
    Original Article
    Broccoli by-product extract as a functional ingredient: food application
    Aim: Food production demand has been promoting an increase in the generation of agro-industrial waste. Food industry waste can contain compounds with added value that, if properly extracted and u [...] Read more.
    David Q. Martínez ... Presentación García
    Published: October 31, 2023 Explor Foods Foodomics. 2023;1:235–243
    DOI: https://doi.org/10.37349/eff.2023.00018
    View:559
    Download:36
    Times Cited: 0
    Open Access
    Review
    Olive oil, fruit and leaves in diabetes mellitus type 2 treatment
    The Mediterranean dietary pattern, where extra virgin olive oil (EVOO) takes the central spot, is related to longer life expectancy and lower risk of a number of non-communicable diseases, including [...] Read more.
    Mario Nosić ... Ines Banjari
    Published: October 29, 2023 Explor Foods Foodomics. 2023;1:192–205
    DOI: https://doi.org/10.37349/eff.2023.00015
    View:637
    Download:18
    Times Cited: 0
    Open Access
    Original Article
    Isolation, characterization, and encapsulation of a lupeol-rich fraction obtained from the hexanic extract of Coccoloba uvifera L. leaves
    Aim: This study aimed to isolate, characterize, and encapsulate a lupeol-rich fraction obtained from the hexanic extract of Coccoloba uvifera L. leaves to evaluate its potential use in nutraceuti [...] Read more.
    Carla N. Cruz-Salas ... Juan A. Ragazzo-Sánchez
    Published: August 28, 2023 Explor Foods Foodomics. 2023;1:115–129
    DOI: https://doi.org/10.37349/eff.2023.00010
    View:414
    Download:19
    Times Cited: 0