• Special Issue Topic

    Immunosenescence: Mechanisms and Its Impact

    Submission Deadline: February 28, 2023

    Guest Editors

    Dr. Roberto Paganelli E-Mail

    Professor of Internal Medicine (MED 09) at the School of Medicine and Surgery of the G. d’Annunzio University, Chieti, Italy

    Research Keywords: Aging, autoimmunity, autoantibody, antibodies, immunoglobulin, rheumatic diseases, allergy

    Dr. Tamas Fulop E-Mail

    Full professor, Department of Medicine, Geriatric Division and Department of Radiology and Nuclear Medicine, Université de Sherbrooke, Sherbrooke, Canada

    Research Keywords: Aging, geriatrics, immunology, neurosceinces, nutrition

    About the Special Issue

    Aging is both a chronological as well as a functional phenomenon, Certain aspects of aging may begin early in life, but at a different rate in different organs and different individuals, Studies on longevity have dissected both genetic and environmental determinants of aging, The aging of the immune system is a multifaceted process which is thought to underlie most aspects of organ and individual aging. Confrontation with the exome shapes immunological responses and our immune repertoire. Among external cues, infectious agents (especially viral ones) and local microbiota have emerged as major factors affecting both our responses and tissue inflammation. Since low level inflammatory milieu has been proposed to underlie immunosenescence (inflamm-aging), this special issue is welcoming research articles and reviews and opinions on the definition of the mechanisms of the immune system aging, its biomarkers for innate and adaptive immunity in various districts, and the impact of immunosenescence on the function of different systems (neurological, musculoskeletal, cardiovascular, gastrointestinal)) and organs (kidney, liver, eye, others)  and their diseases in the elderly.

    Keywords: Aging, immunosenescence, immune system, mechanisms, impact, organ

    Call for Papers

    Published Articles

    Open Access
    Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages
    Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk. Macrophages are key in [...] Read more.
    Rafael Moura Maurmann ... Brandt D. Pence
    Published: October 11, 2023 Explor Immunol. 2023;3:442–452
    DOI: https://doi.org/10.37349/ei.2023.00112
    Times Cited: 0
    Open Access
    Vitamin D, ageing, and the immune system
    Changes occurring in the immune system along the ageing process increase the risk of infection, susceptibility to tumor development, and autoimmunity. Interventions such as physical exercise, supple [...] Read more.
    Valquiria Bueno
    Published: August 31, 2023 Explor Immunol. 2023;3:341–360
    DOI: https://doi.org/10.37349/ei.2023.00106
    Times Cited: 0
    Open Access
    Immune system rejuvenation—approaches and real achievements
    Interest in the mechanisms of aging of the immune system has not faded over the past 100 years, and it is caused by the immune-mediated development of age-related pathology, including autoimmune org [...] Read more.
    Iryna Pishel
    Published: August 31, 2023 Explor Immunol. 2023;3:325–340
    DOI: https://doi.org/10.37349/ei.2023.00105
    Times Cited: 0
    Open Access
    The aging process and its relation to periodontal conditions
    Periodontal tissue destruction can cause complaints for sufferers. Inflammatory conditions of the gingiva, bleeding gums, and even tooth loss are clinical features of the destruction of the periodon [...] Read more.
    Pitu Wulandari
    Published: June 30, 2023 Explor Immunol. 2023;3:207–216
    DOI: https://doi.org/10.37349/ei.2023.00098
    Times Cited: 0
    Open Access
    Cytomegalovirus at the crossroads of immunosenescence and oncogenesis
    Human cytomegalovirus (HCMV), whose genome is around 235 kb, is a ubiquitous human herpesvirus that infects between 40% and 95% of the population. Though HCMV infection is co [...] Read more.
    Fidaa Bouezzedine ... Georges Herbein
    Published: February 24, 2023 Explor Immunol. 2023;3:17–27
    DOI: https://doi.org/10.37349/ei.2023.00086