• Special Issue Topic

    Calcium Signaling Apparatus in Cancers

    Submission Deadline: May 31, 2021

    Guest Editor

    Dr. Zui Pan E-Mail

    College of Nursing and Health Innovation, The University of Texas at Arlington, TX, USA

    Research Keywords: esophageal cancer; calcium signaling; store-operated calcium entry; live cell imaging; chemotherapy

    About the Special Issue

    Dysregulated intracellular Ca2+ signaling is associated with the development of malignant phenotypes. Cancer cells remodel their Ca2+ signaling apparatus to enhance proliferation, to increase cell motility and invasion, to resist apoptosis, to escape from immune-attack, or to have neovascularization. There has been an increasing awareness that tumorigenic pathways are associated with altered expression or abnormal activation of Ca2+ channels, transporters or Ca2+-pumps. Targeting the altered Ca2+ signaling apparatus to develop new anti-cancer drugs is emerging, yet many challenges remains. Intracellular Ca2+ homeostasis plays important role in normal physiology and cell functions; thus, it is important to identify the cancer specific properties of the Ca2+ apparatus. Different cancers or different stages during tumor development may present distinct different alteration in Ca2+ signaling apparatus. More specific, more potent and less off-target compounds targeting Ca2+ channels/transporters/pumps are urgently needed.
    This special issue will highlight the current state of diverse molecular mechanisms of intracellular Ca2+ involved in cell proliferation, apoptosis, migration, invasion, or angiogenesis in different cancers. It will also discuss developing effective novel cancer treatment targeting Ca2+ channels, transporters or Ca2+-pumps.

    Keywords: calcium channels; cell proliferation; apoptosis; migration; metastasis; transcription factors; chemotherapy

    Published Articles

    Open Access
    Roles of calcium signaling in cancer metastasis to bone
    Bone metastasis is a frequent complication for cancers and an important reason for the mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life-threatening hyp [...] Read more.
    Tianying Xie ... Jianru Xiao
    Published: August 31, 2022 Explor Target Antitumor Ther. 2022;3:445–462
    DOI: https://doi.org/10.37349/etat.2022.00094
    Times Cited: 0
    Open Access
    Targeting the two-pore channel 2 in cancer progression and metastasis
    The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of  [...] Read more.
    Kathryn A. Skelding ... Lisa F. Lincz
    Published: February 28, 2022 Explor Target Antitumor Ther. 2022;3:62–89
    DOI: https://doi.org/10.37349/etat.2022.00072
    Open Access
    Original Article
    Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma
    Aim: To investigate alterations in transcription of genes, encoding Ca2+ toolkit proteins, in oesophageal adenocarcinoma (OAC) and to assess associations between gene expression, tumor  [...] Read more.
    Alana L. Cutliffe ... John J. Mackrill
    Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:543–575
    DOI: https://doi.org/10.37349/etat.2021.00063
    Open Access
    A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression
    Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process. Although Ca2+ signaling, re [...] Read more.
    Wen-Li Hsu ... Etsuro Ito
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:401–415
    DOI: https://doi.org/10.37349/etat.2021.00053
    Times Cited: 0
    Open Access
    Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets
    Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transit [...] Read more.
    Chaochu Cui ... Xianwei Wang
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:266–291
    DOI: https://doi.org/10.37349/etat.2021.00046
    Times Cited: 0
    Open Access
    Overview of Ca2+ signaling in lung cancer progression and metastatic lung cancer with bone metastasis
    Intracellular Ca2+ ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of funda [...] Read more.
    Manh Tien Tran
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:249–265
    DOI: https://doi.org/10.37349/etat.2021.00045
    Open Access
    Original Article
    Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: an in silico study
    Aim: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high heterogeneity, rapid progression, and paucity of treatment options. The most effective chemotherape [...] Read more.
    Garhima Arora ... Samrat Chatterjee
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:208–226
    DOI: https://doi.org/10.37349/etat.2021.00042
    Times Cited: 0