• Special Issue Topic
    Calcium Signaling Apparatus in Cancers
    Submission Deadline: May 31, 2021

    Guest Editor

    Dr. Zui Pan E-Mail

    College of Nursing and Health Innovation, The University of Texas at Arlington, TX, USA

    Research Keywords: esophageal cancer; calcium signaling; store-operated calcium entry; live cell imaging; chemotherapy

    About the Special Issue

    Dysregulated intracellular Ca2+ signaling is associated with the development of malignant phenotypes. Cancer cells remodel their Ca2+ signaling apparatus to enhance proliferation, to increase cell motility and invasion, to resist apoptosis, to escape from immune-attack, or to have neovascularization. There has been an increasing awareness that tumorigenic pathways are associated with altered expression or abnormal activation of Ca2+ channels, transporters or Ca2+-pumps. Targeting the altered Ca2+ signaling apparatus to develop new anti-cancer drugs is emerging, yet many challenges remains. Intracellular Ca2+ homeostasis plays important role in normal physiology and cell functions; thus, it is important to identify the cancer specific properties of the Ca2+ apparatus. Different cancers or different stages during tumor development may present distinct different alteration in Ca2+ signaling apparatus. More specific, more potent and less off-target compounds targeting Ca2+ channels/transporters/pumps are urgently needed.
    This special issue will highlight the current state of diverse molecular mechanisms of intracellular Ca2+ involved in cell proliferation, apoptosis, migration, invasion, or angiogenesis in different cancers. It will also discuss developing effective novel cancer treatment targeting Ca2+ channels, transporters or Ca2+-pumps.

    Keywords: calcium channels; cell proliferation; apoptosis; migration; metastasis; transcription factors; chemotherapy

    Call for Papers

    Published Articles

    Open Access
    A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression
    Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process. Although Ca2+ signaling, re...
    Wen-Li Hsu ... Etsuro Ito
    Online First: September 26, 2021 Explor Target Antitumor Ther. 2021;2:Online First
    DOI: https://doi.org/10.37349/etat.2021.00053
    Times Cited: 0
    Open Access
    Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets
    Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transit...
    Chaochu Cui ... Xianwei Wang
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:266-291
    DOI: https://doi.org/10.37349/etat.2021.00046
    Times Cited: 0
    Open Access
    Overview of Ca2+ signaling in lung cancer progression and metastatic lung cancer with bone metastasis
    Intracellular Ca2+ ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of funda...
    Manh Tien Tran
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:249-265
    DOI: https://doi.org/10.37349/etat.2021.00045
    Times Cited: 0
    Open Access
    Original Article
    Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: an in silico study
    Aim: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high heterogeneity, rapid progression, and paucity of treatment options. The most effective chemotherape...
    Garhima Arora ... Samrat Chatterjee
    Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:208-226
    DOI: https://doi.org/10.37349/etat.2021.00042
    Times Cited: 0