• Special Issue Topic

    Chronic Inflammation and Autoimmunity

    Submission Deadline: April 30, 2024

    Guest Editor

    Prof. Margherita Sisto E-Mail

    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, Laboratory of Cell Biology, University of Bari Medical School, Bari 70124, Italy

    About the Special Issue

    Dear Colleagues, inflammation is an integral part of many physiological functions triggered in response to pathogen infection or tissue damage. Recently, increasing evidences have shown that the abnormal inflammatory response is closely linked to many autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus and sjögren's disease.  In these diseases, onset as well as disease course dependent on interactions between different genetic/epigenetic/immunological, and environmental factors. Since that, the pathogenesis of inflammatory dysfunction in autoimmune conditions is also elusive and the knowledge of the mechanisms of inflammation regulation will lead to significant clinical benefits for the treatment of autoimmune diseases. Research results open up new strategies for early diagnosis, prevention and treatment of a wide range of autoimmune disorders associated with systemic chronic inflammation.

    The purpose of this special issue is to bring together experts in the field of chronic inflammation and autoimmune diseases to investigate precise molecular and cellular mechanisms. In addition, studies that investigate the link between autoimmune disorders and immune regulatory processes controlling chronic inflammation in order to identify novel ideas for diagnosis and treatment in these diseases.

    Keywords: Autoimmunity, chronic inflammation, immune regulatory process, epigenetic factors

    Call for Papers

    Published Articles

    Open Access
    Rheumatoid arthritis: a complex tale of autoimmune hypersensitivity
    Rheumatoid arthritis (RA) is a complex autoimmune disorder characterized by a spectrum of hypersensitivity reactions, encompassing Type II, Type III, and Type IV responses. Firstly, RA is marked by  [...] Read more.
    Jihye Heo ... Jea-Hyun Baek
    Published: June 20, 2024 Explor Immunol. 2024;4:358–375
    DOI: https://doi.org/10.37349/ei.2024.00146
    Times Cited: 0
    Open Access
    Original Article
    Myelitis associated with COVID-19: clinical, radiological, and laboratory characteristics
    Aim: The current study aimed to describe various types of myelitis associated with a novel coronavirus infection [coronavirus disease 2019 (COVID-19)] as well as to analyze cytokine profiles and cerebrospinal fluid (CSF) parameter [...] Read more.
    Aleksandra Kozlova ... Maria Zakharova
    Published: February 29, 2024 Explor Immunol. 2024;4:115–128
    DOI: https://doi.org/10.37349/ei.2024.00132
    Times Cited: 0
    Open Access
    Potential therapeutic applications of targeting signal-transducing adaptor protein-2 in autoimmune diseases
    Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical dom [...] Read more.
    Yuto Sasaki ... Tadashi Matsuda
    Published: December 28, 2023 Explor Immunol. 2023;3:604–612
    DOI: https://doi.org/10.37349/ei.2023.00125
    Times Cited: 0