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    Lung Fibrosis—Models and Mechanisms

    Submission Deadline: July 31, 2023

    Guest Editor

    Prof. Bernhard Ryffel E-Mail

    Professor, INEM, UMR7355, CNRS, University of Orleans, Orleans, France

    Research Keywords: mechanisms of inflammation, innate immune danger sensing, inflammasome activation, IL-33 and Th17/Th22 differentiation


    About the Special Issue

    The lung is a critical organ for the gas exchange and health. Chronic environmental exposures may cause injury of the respiratory barrier leading to inflammation, emphysema and progressive interstitial fibrosis leading respiratory failure. We will start with an overview of human fibrotic diseases and then address the following issues:

    ● Aerosol and systemic exposure to particles, smoke, allergens, chemicals, ozone, radiation viral, bacterial, parasite and helminth infection

    ● The clinical perspectives of COPD, rodent and in vitro models, predictive for COPD?

    ● Idiopathic pulmonary fibrosis IPF and preclinical models

    ● Molecular mechanisms of fibrosis progression and cell death pathways

    ● Role of TLR, Inflammasome, DNA sensing and cross-talk of pathways

    ● InflammAging, senescence and autophagy

    ● Inflammatory cytokine such TNF and IL-1 family member, growth factors…

    ● Contribution of intestinal microbiota and metabolism such as SCFA, tryptophan serotonin…

    ● Prevention and therapy, new therapeutic targets and drug candidates

    Keywords: TNF, IL-1, growth factors, NLRP, TLR, autophagy, senescence, pollution, microbiome, metabolites, disease models

    Call for Papers

    Published Articles

    Open Access
    Original Article
    Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D
    Aim: To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but t [...] Read more.

    Aim:

    To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but treated with high doses of vitamin D (vitD).

    Methods:

    From the 218 patients recruited (ClinicalTrials.gov NCT04411446), 16 participated in this sub-study and were randomized to a single oral dose of 500,000 IU vitD (n = 10) or placebo (n = 6). Plasmatic Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and tumor necrosis factor alpha (TNF-α) by enzyme-linked immunosorbent assay before and after treatment. Parallel, serum 25-hydroxyvitamin D3 (25-OH vitD) concentrations as vitD status was measured by a chemiluminescence immunoassay.

    Results:

    A trend towards an increase in Ang-(1-7) and a decrease in Ang II levels were observed in placebo- and vitD-treated COVID-19 patients compared to baseline values. There was no difference in Ang II and Ang-(1-7) levels between placebo- and vitD-treated COVID-19 patients. Similar results were obtained with ILs profile. COVID-19 patients showed an increase in the protective component of the RAS which was not improved by vitD treatment.

    Conclusions:

    VitD did not improve RAS disbalance in COVID-19. Notwithstanding, the authors visualize that acute treatment with high doses of vitD may show a trend to a decline in inflammatory ILs and an increase in protective markers. Finally, the authors would like to highlight the limitations of this preliminary study, namely the small number of patients and the use of a large single bolus dose of vitD rather than lower daily doses for extended periods with prolonged follow-up times. All these factors need special consideration in the designs of new vitD supplementation trials. All these factors need special consideration in the designs of new vitD supplementation trials (ClinicalTrials.gov identifier: NCT04411446).

    Mauro G. Silva ... Walter Manucha
    Published: April 26, 2023 Explor Med. 2023;4:246–253
    DOI: https://doi.org/10.37349/emed.2023.00137
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    Aim:

    To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but treated with high doses of vitamin D (vitD).

    Methods:

    From the 218 patients recruited (ClinicalTrials.gov NCT04411446), 16 participated in this sub-study and were randomized to a single oral dose of 500,000 IU vitD (n = 10) or placebo (n = 6). Plasmatic Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and tumor necrosis factor alpha (TNF-α) by enzyme-linked immunosorbent assay before and after treatment. Parallel, serum 25-hydroxyvitamin D3 (25-OH vitD) concentrations as vitD status was measured by a chemiluminescence immunoassay.

    Results:

    A trend towards an increase in Ang-(1-7) and a decrease in Ang II levels were observed in placebo- and vitD-treated COVID-19 patients compared to baseline values. There was no difference in Ang II and Ang-(1-7) levels between placebo- and vitD-treated COVID-19 patients. Similar results were obtained with ILs profile. COVID-19 patients showed an increase in the protective component of the RAS which was not improved by vitD treatment.

    Conclusions:

    VitD did not improve RAS disbalance in COVID-19. Notwithstanding, the authors visualize that acute treatment with high doses of vitD may show a trend to a decline in inflammatory ILs and an increase in protective markers. Finally, the authors would like to highlight the limitations of this preliminary study, namely the small number of patients and the use of a large single bolus dose of vitD rather than lower daily doses for extended periods with prolonged follow-up times. All these factors need special consideration in the designs of new vitD supplementation trials. All these factors need special consideration in the designs of new vitD supplementation trials (ClinicalTrials.gov identifier: NCT04411446).

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