• Special Issue Topic

    Lung Fibrosis—Models and Mechanisms

    Submission Deadline: July 31, 2023

    Guest Editor

    Prof. Bernhard Ryffel E-Mail

    Professor, INEM, UMR7355, CNRS, University of Orleans, Orleans, France

    Research Keywords: mechanisms of inflammation, innate immune danger sensing, inflammasome activation, IL-33 and Th17/Th22 differentiation

    About the Special Issue

    The lung is a critical organ for the gas exchange and health. Chronic environmental exposures may cause injury of the respiratory barrier leading to inflammation, emphysema and progressive interstitial fibrosis leading respiratory failure. We will start with an overview of human fibrotic diseases and then address the following issues:

    ● Aerosol and systemic exposure to particles, smoke, allergens, chemicals, ozone, radiation viral, bacterial, parasite and helminth infection

    ● The clinical perspectives of COPD, rodent and in vitro models, predictive for COPD?

    ● Idiopathic pulmonary fibrosis IPF and preclinical models

    ● Molecular mechanisms of fibrosis progression and cell death pathways

    ● Role of TLR, Inflammasome, DNA sensing and cross-talk of pathways

    ● InflammAging, senescence and autophagy

    ● Inflammatory cytokine such TNF and IL-1 family member, growth factors…

    ● Contribution of intestinal microbiota and metabolism such as SCFA, tryptophan serotonin…

    ● Prevention and therapy, new therapeutic targets and drug candidates

    Keywords: TNF, IL-1, growth factors, NLRP, TLR, autophagy, senescence, pollution, microbiome, metabolites, disease models

    Call for Papers

    Published Articles

    Open Access
    The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD?
    Chronic obstructive pulmonary disease (COPD) is an inflammatory lung pathology characterized by persistent airflow limitation and is the third leading cause of death globally. COPD pathophysiology i [...] Read more.
    Silvia Siragusa ... Silvia Pontis
    Published: December 29, 2023 Explor Med. 2023;4:1116–1134
    DOI: https://doi.org/10.37349/emed.2023.00199
    Times Cited: 0
    Open Access
    Mechanism of lungs fibrosis in mycobacterial infection
    Lung tuberculosis (TB) remains a heavy burden on public health worldwide. This review discusses mainly the mechanisms of the development of pulmonary fibrosis in an experimental TB model in mice. Th [...] Read more.
    Lena B. Kim, Anna N. Putyatina
    Published: December 12, 2023 Explor Med. 2023;4:956–976
    DOI: https://doi.org/10.37349/emed.2023.00187
    Times Cited: 0
    Open Access
    Utility of fibroblasts derived from broncho-alveolar lavage of patients with idiopathic pulmonary fibrosis or related disorders to develop in vitro models
    Broncho-alveolar lavage (BAL) represents a safe tool for the differential diagnosis of various pulmonary fibrotic diseases. Idiopathic pulmonary fibrosis (IPF) belongs to a heterogeneous group of di [...] Read more.
    Paolo Giannoni ... Daniela de Totero
    Published: August 31, 2023 Explor Med. 2023;4:461–470
    DOI: https://doi.org/10.37349/emed.2023.00156
    Times Cited: 0
    Open Access
    Original Article
    Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D
    Aim: To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but t [...] Read more.
    Mauro G. Silva ... Walter Manucha
    Published: April 26, 2023 Explor Med. 2023;4:246–253
    DOI: https://doi.org/10.37349/emed.2023.00137
    Times Cited: 0