About the Special Issue

The lung is a critical organ for the gas exchange and health. Chronic environmental exposures may cause injury of the respiratory barrier leading to inflammation, emphysema and progressive interstitial fibrosis leading respiratory failure. We will start with an overview of human fibrotic diseases and then address the following issues:

● Aerosol and systemic exposure to particles, smoke, allergens, chemicals, ozone, radiation viral, bacterial, parasite and helminth infection

● The clinical perspectives of COPD, rodent and in vitro models, predictive for COPD?

● Idiopathic pulmonary fibrosis IPF and preclinical models

● Molecular mechanisms of fibrosis progression and cell death pathways

● Role of TLR, Inflammasome, DNA sensing and cross-talk of pathways

● InflammAging, senescence and autophagy

● Inflammatory cytokine such TNF and IL-1 family member, growth factors…

● Contribution of intestinal microbiota and metabolism such as SCFA, tryptophan serotonin…

● Prevention and therapy, new therapeutic targets and drug candidates

Keywords: TNF, IL-1, growth factors, NLRP, TLR, autophagy, senescence, pollution, microbiome, metabolites, disease models

Call for Papers