• Special Issue Topic

    Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis

    Submission Deadline: June 30, 2022

    Guest Editor

    Prof. Yingyong Zhao E-Mail

    Professor, Faculty of Life Science & Medicine, Northwest University, China

    About the Special Issue

    Kidney disease and its complications are a major public health problem with increased morbidity and mortality worldwide. Patients with chronic kidney disease (CKD) are at increased risk for the development of cardiovascular disease (CVD) beyond traditional risk factors. The progression of CKD shows that patients reach end-stage renal disease and require renal replacement therapies such as hemodialysis, peritoneal dialysis and transplantation. Traditional clinical biomarkers of renal function (blood urea nitrogen and serum creatinine) are not sensitive or specific enough and only increase significantly after the presence of substantial CKD. Therefore, more sensitive biomarkers of CKD are needed. CKD-specific biomarkers at an early disease stage and early diagnosis of specific renal diseases would enable improved therapeutic treatment and reduced the personal and financial burdens.

    Mounting studies have demonstrated the pathophysiological mechanism of CKD and its complications. Kidney damage is mediated by hypertension, diabetes mellitus, hypercholesterolemia, obesity, tobacco use and CKD-specific risk factors, including systemic disease, such as vascular calcification, atherosclerosis and immunological disorders. Recent findings indicate the impact of long non-coding RNA, gut microbiota, ageing and uremic toxins. A number of studies by both animal model and patients have demonstrated their effect on renal disease. The further studies should be performed in renal diseases. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are identified as the first-line therapies that proved efficient to retard the progression of hypertension, CVD and CKD. Nevertheless, although this approach is undoubtedly effective, many CKD patients who are treated with these drugs progress to end-stage renal disease and require renal replacement therapies such as dialysis and transplantation.

    This special issue is focusing on the discovery of novel biomarkers used in disease diagnosis and understanding the pathophysiology of CKD and its related systemic disease for developing new therapeutic strategies in renal disease. Both basic and clinical studies are welcomed in renal disease and its complications.

    We invite investigators to contribute original research articles and reviews concerning the biomarker identification, disease diagnosis, pathological mechanism and therapeutic strategies in renal disease and its complications. The spectrum of coverage is broad, encompassing basic and clinical studies by using the methods of cellular and molecular biology, systems biology and meta-analysis. Potential topics include, but are not limited to: 

    ● Novel biomarker identification and discovery used disease diagnosis in renal disease and its complications by cellular and molecular biology and systems biology

    ● The mechanism of cellular and molecular biology by basic research and clinical studies

    ● Systems biology-based on the illumination of the pathogenesis of kidney disease

    ● The long non-coding RNA, gut microbiota, ageing-associated physiological and pathological mechanism in renal disease

    ● Basic and clinical research for assessing the efficacy and safety of drugs in renal disease

    ● Methodological research such as meta-analysis, protocol of clinical trials in kidney disease

    Keywords: chronic kidney disease, acute kidney injury, cardiovascular disease, hypertension, diabetes, long non-coding RNA, gut microbiota, ageing, uremic toxins, biological activity, medical use, pharmacological interactions

    Published Articles

    Open Access
    Original Article
    Prognostic importance of neutrophil-lymphocyte ratio in non-dialysis chronic kidney disease patients—a hospital-based prospective cohort
    Aim: In patients with cancer, ischemic heart disease, and peripheral vascular disease, the neutrophil-lymphocyte ratio (NLR), a measure of systemic inflammation, has been demonstrated to predict  [...] Read more.
    Ishfaq Rashid ... Shivani Jaswal
    Published: May 17, 2023 Explor Med. 2023;4:299–313
    DOI: https://doi.org/10.37349/emed.2023.00141
    Open Access
    Original Article
    Predictive value of SII and sd-LDL for contrast-induced acute kidney injury in STEMI patients undergoing percutaneous coronary intervention
    Aim: To investigate the relationship between the incidence of contrast-induced acute kidney injury (CI-AKI) and the level of small dense low-density lipoprotein (sd-LDL) and systemic immune-infla [...] Read more.
    Guoqi Shen ... Wenhua Li
    Published: December 28, 2022 Explor Med. 2022;3:571–582
    DOI: https://doi.org/10.37349/emed.2022.00114
    Times Cited: 0
    Open Access
    Case Report
    A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy
    C1q nephropathy is a rare glomerular disease. Clinical presentation is diverse and ranges from asymptomatic hematuria or proteinuria to symptoms and signs of nephrotic/nephritic syndrome. On light microscopy, it can be classified  [...] Read more.
    Randa Choueiri ... Vanessa Nseir
    Published: August 31, 2022 Explor Med. 2022;3:386–392
    DOI: https://doi.org/10.37349/emed.2022.00101
    Open Access
    Letter to the Editor
    Adenine-rich diet: a potential mechanism for renal fibrosis progression
    Chronic kidney disease (CKD) is a major health problem but there are many modalities to prevent and manage CKD progression. Diet is one of these factors, which needs to be evaluated more. Adenine is a water-soluble nucleoprotein t [...] Read more.
    Majid Malaki
    Published: July 25, 2022 Explor Med. 2022;3:314–316
    DOI: https://doi.org/10.37349/emed.2022.00095
    Open Access
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem [...] Read more.
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. 2022;3:249–259
    DOI: https://doi.org/10.37349/emed.2022.00089
    Open Access
    Recent advances of gut microbiota in chronic kidney disease patients
    Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of  [...] Read more.
    Ying-Yong Zhao
    Published: June 23, 2022 Explor Med. 2022;3:260–274
    DOI: https://doi.org/10.37349/emed.2022.00090