• Special Issue Topic

    Novel Therapeutic Approaches for the Treatment of Depression

    Submission Deadline: June 20, 2024

    Guest Editors

    Prof. Dirk M. Hermann E-Mail

    Professor of Vascular Neurology, Dementia and Ageing Research, Department of Neurology and Center for Translational and Behavioral Neurosciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

    Research Keywords: Ischemic stroke, neuroprotection, neurorestoration, depressive disorders, brain remodeling, angiogenesis, stem cells, extracellular vesicles


    Dr. Ayan Mohamud Yusuf E-Mail

    Department of Neurology and Center for Translational and Behavioral Neurosciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

    Research Keywords: Ischemic stroke, neuroprotection, neurorestoration, depressive disorders, brain remodeling, angiogenesis, stem cells, extracellular vesicles


    About the Special Issue

    Depression is one of the most common psychiatric disorders. The underlying molecular pathogenesis of depressive disorders and the mode of action of antidepressants still remain inadequately understood. The effects of antidepressants have mainly been attributed to modulation of monoaminergic neurotransmitter systems. A large number of patients however do not respond to antidepressant treatment. Electroconvulsive treatment, transcranial magnetic stimulation and the anesthetic ketamine have emerged as alternative treatment strategies for patients with treatment refractory depression. An in-depth understanding of signaling pathways that are modulated by these interventions may help identify specific targets and thereby aid the development of more efficacious treatments.

    We welcome studies which evaluate the disease mechanisms of depressive disorders or studies which investigate the molecular targets of antidepressants, electroconvulsive treatment, transcranial magnetic stimulation or ketamine.

    Keywords: Depression, treatment refractory depression, antidepressants, electroconvulsive treatment, transcranial magnetic stimulation, ketamine

    Call for Papers

    Published Articles

    Open Access
    Review
    Psychology of bipolar depression: revisiting past and present researches, prospects ahead, and moving toward future directions
    Bipolar disorder (BD) is a debilitating psychiatric disorder characterized by recurrent depression, mania, and hypomania episodes. The interaction of psychological, neuropsychological, and neurobiol [...] Read more.
    Behrooz Afshari
    Published: December 29, 2023 Explor Neurosci. 2023;2:331–349
    DOI: https://doi.org/10.37349/en.2023.00032
    View:403
    Download:18
    Times Cited: 0
    Open Access
    Review
    Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature
    Over the past decade, knowledge of the pathophysiology and immunology of multiple sclerosis (MS) and depression, and the complex links to vitamin D (VitD) balance, has increased rapidly. Both diseas [...] Read more.
    Hans-Klaus Goischke
    Published: August 31, 2023 Explor Neurosci. 2023;2:160–192
    DOI: https://doi.org/10.37349/en.2023.00020
    View:587
    Download:21
    Times Cited: 0