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Open Access

Review

Cholesterol in autism spectrum disorders
The autism spectrum disorder (ASD) comprises a series of neurological diseases that share serious alterations of the development of the central nervous system. The degree of disability may vary so t...

Rafael Franco ... Irene Reyes-Resina

Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:10-18
DOI: https://doi.org/10.37349/ent.2021.00003
This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases

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Review

Neurological complications during HIV infection
Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef...

Jose M. Martinez-Navio

Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19-32
DOI: https://doi.org/10.37349/ent.2021.00004

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Review

Gut microbial imbalance and neurodegenerative proteinopathies: from molecular mechanisms to prospects of clinical applications
The pathogenic basis behind some of the most prevalent neurodegenerative diseases in advanced societies, known as proteinopathies, deals with alterations in protein homeostasis. Despite the broad di...

Paula Alonso-García ... Eva Martínez-Pinilla

Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:33-54
DOI: https://doi.org/10.37349/ent.2021.00005

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Review

Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered ...

María S. García-Gutiérrez ... Jorge Manzanares

Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55-71
DOI: https://doi.org/10.37349/ent.2021.00006

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Review

The role of interleukin-24 in atopic dermatitis
Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl ...

Yen Hai Vu ... Gaku Tsuji

Published: April 30, 2021 Explor Immunol. 2021;1:4-15
DOI: https://doi.org/10.37349/ei.2021.00002
This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells

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Review

Immunology of biodegradable nanoparticles: a brief overview on a wide growing field
Immunity is continuously evolving by evolutionary mechanisms shaped by pathogenic stimuli of different kinds. Man-made nanomaterials (NMs) have been developed in the last decades and represent a nov...

Anissa Pisani, Giuseppe Bardi

Published: April 30, 2021 Explor Immunol. 2021;1:48-60
DOI: https://doi.org/10.37349/ei.2021.00006

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Review

Immunopathogenesis of severe acute respiratory syndrome coronavirus-2: evolving knowledge and its current status
As the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is a new virus, the current knowledge on the immunopathogenesis of this newly emerged SARS-CoV-2 is beginning to unravel with intens...

Nitin Saksena ... Monica Miranda-Saksena

Published: June 30, 2021 Explor Immunol. 2021;1:61-79
DOI: https://doi.org/10.37349/ei.2021.00007

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Review

L-arginine as a novel target for clinical intervention in inflammatory bowel disease
Arginase-1 (Arg1) and the inducible nitric oxide synthase 2 (NOS2) compete for the common substrate L-arginine, semi-essential amino acid, and central intestinal metabolite. Both enzymes exhibit var...

Björn Nüse, Jochen Mattner

Published: June 30, 2021 Explor Immunol. 2021;1:80-89
DOI: https://doi.org/10.37349/ei.2021.00008

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Review

Vitamin D and immunomodulation in the skin: a useful affirmative nexus
Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune r...

Saptadip Samanta

Published: June 30, 2021 Explor Immunol. 2021;1:90-111
DOI: https://doi.org/10.37349/ei.2021.00009
This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells

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Review

Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regene...

Panagiotis Mallis ... Catherine Stavropoulos Giokas

Published: June 30, 2021 Explor Immunol. 2021;1:112-139
DOI: https://doi.org/10.37349/ei.2021.00010

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Review

The impact of tumour pH on cancer progression: strategies for clinical intervention
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasi...

Carol Ward ... Simon P Langdon

Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:71-100
DOI: https://doi.org/10.37349/etat.2020.00005

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Review

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors
Chronic lymphocytic leukemia is a common form of leukemia and is dependent on growth-promoting signaling via the B-cell receptor. The Bruton tyrosine kinase (BTK) is an important mediator of B-cell ...

Rachael Arthur ... Graham Packham

Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:131-152
DOI: https://doi.org/10.37349/etat.2020.00009
This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)

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Open Access

Review

Current strategies for the design of PROTAC linkers: a critical review
PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead” ...

Robert I. Troup ... Matthias G. J. Baud

Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:273-312
DOI: https://doi.org/10.37349/etat.2020.00018
This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)

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Times Cited: 7

Open Access

Review

Targeting HER2 in breast cancer: new drugs and paradigms on the horizon
About 15–20% of all breast cancers (BCs) are defined human epidermal growth factor receptor 2 (HER2)-positive, based on the overexpression of HER2 protein and/or amplification...

Paolo Tarantino ... Giuseppe Curigliano

Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:139-155
DOI: https://doi.org/10.37349/etat.2021.00037

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Review

Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mech...

Noel C. Salvoza ... Natalia Rosso

Published: April 30, 2020 Explor Med. 2020;1:51-74
DOI: https://doi.org/10.37349/emed.2020.00005
This article belongs to the special issue Exploring NAFLD/NASH

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Review

Perspectives of nonalcoholic fatty liver disease research: a personal point of view
Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of f...

Amedeo Lonardo, Stefano Ballestri

Published: June 29, 2020 Explor Med. 2020;1:85-107
DOI: https://doi.org/10.37349/emed.2020.00007
This article belongs to the special issue Exploring NAFLD/NASH

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Times Cited: 7

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Review

Nonalcoholic fatty liver disease and portal hypertension
Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and...

Marvin Ryou ... Gyorgy Baffy

Published: June 29, 2020 Explor Med. 2020;1:149-169
DOI: https://doi.org/10.37349/emed.2020.00011
This article belongs to the special issue Exploring NAFLD/NASH

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Review

Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially know...

Carlo Acierno ... Ferdinando Carlo Sasso

Published: October 30, 2020 Explor Med. 2020;1:287-306
DOI: https://doi.org/10.37349/emed.2020.00019
This article belongs to the special issue Exploring NAFLD/NASH

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Open Access

Original Article

Going against the norm: validation of a novel alternative to brain SPECT normative datasets
Aim: Quantitative analysis of brain single photon emission computed tomography (SPECT) perfusion imaging is dependent on normative datasets that are challenging to produce. This study investigated ...

Lindsay M. Quandt, Cyrus A. Raji

Published: October 30, 2020 Explor Med. 2020;1:331-354
DOI: https://doi.org/10.37349/emed.2020.00022
This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research

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Original Article

Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity
Aim: Research suggests that Alzheimer’s disease (AD) is heterogeneous with numerous subtypes. Through a proprietary interactive ML system, several underlying biological mechanisms associa...

Bessi Qorri ... Joseph Geraci

Published: December 31, 2020 Explor Med. 2020;1:377-395
DOI: https://doi.org/10.37349/emed.2020.00026
This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research

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Featured Special lssues

The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy

Dr. Donatella Del Bufalo Dr. Germain Gillet

Submission Deadline: November 30, 2021

Published Articles: 0

Gene Delivery Approach to Fight Cancer

Prof. Xiangyang Shi

Submission Deadline: February 28, 2022

Published Articles: 0

Endocrine Resistant Breast Cancer

Dr. Simon Langdon Dr. Valerie Speirs

Submission Deadline: October 31, 2021

Published Articles: 0

Antibody-Drug Conjugates

Dr. Francesco Bertoni Dr. Anastasios Stathis

Submission Deadline: October 31, 2021

Published Articles: 0

COVID-19 and Cancer

Prof. Rossana Berardi

Submission Deadline: June 30, 2021

Published Articles: 0

Exploring Chronic Liver Disease

Dr. Amedeo Lonardo

Submission Deadline: September 30, 2021

Published Articles: 2

Exploring Aortic Disease

Dr. Kathleen G. Morgan

Submission Deadline: May 31, 2021

Published Articles: 2

Precision Medicine for Cholangiocarcinoma

Prof. Lorenza Rimassa

Submission Deadline: September 30, 2021

Published Articles: 0

Nanomedicine and Cancer Immunotherapy

Dr. Haijun Yu Dr. Yang Shi

Submission Deadline: July 31, 2021

Published Articles: 4

Angiotensins—A Century of Progress

Dr. Carlos M. Ferrario Dr. Leanne Groban

Submission Deadline: December 31, 2020

Published Articles: 3

The‌ ‌Sepsis‌ ‌induced‌ ‌Immune‌ ‌Conundrum

Didier‌ ‌Payen

Submission Deadline: December 31, 2021

Published Articles: 0

Exploring Type 2 Diabetes Mellitus

Dr. Alessandro Mantovani Dr. Giovanni Targher

Submission Deadline: July 31, 2020

Published Articles: 6

Interplay of γδ T cells and Tumor Cells

Dieter Kabelitz Zhinan Yin

Submission Deadline: December 31, 2021

Published Articles: 0

Digital Biomarkers: The New Frontier for Medicine and Research

Dr. Rhoda Au

Submission Deadline: June 20, 2020

Published Articles: 9

Vaccine-induced Immune Responses Against SARS-CoV-2 Infections

Wangxue Chen

Submission Deadline: August 31, 2021

Published Articles: 0

Exploring NAFLD/NASH

Dr. Amedeo Lonardo Dr. Giovanni Targher

Submission Deadline: June 01, 2020

Published Articles: 11

Human Reproduction: Involvement of the Immune System

Gérard Chaouat Satish Kumar Gupta Nathalie Lédée

Submission Deadline: October 31, 2021

Published Articles: 0

Neuroprotective Nitric Oxide and Its Metabolites (Nitrite and Nitrate)

Prof. Hyun-Ock Pae

Submission Deadline: December 31, 2021

Published Articles: 0

Immunotherapy in Cancer Patients

Prof. Rossana Berardi

Submission Deadline: September 30, 2020

Published Articles: 8

Calcium Signaling Apparatus in Cancers

Dr. Zui Pan

Submission Deadline: May 31, 2021

Published Articles: 3

The Biological Basis of Substance Use Disorders

Dr. Richard M. Sherva

Submission Deadline: June 30, 2021

Published Articles: 4

Off-Label Drugs and -Omics Data in Cancer Treatment

Dr. Luca Agnelli Dr. Giancarlo Pruneri

Submission Deadline: June 30, 2021

Published Articles: 1

Cross Talk Among Skin Cells and Immune Cells

Masutaka Furue

Submission Deadline: June 30, 2021

Published Articles: 3

Intervention of Neuroimmune Responses

Dr. Raymond Chuen-Chung Chang

Submission Deadline: January 31, 2022

Published Articles: 0

Liquid Biopsy in Thoracic Cancer

Dr. Floriana Morgillo Dr. Carminia Maria Della Corte

Submission Deadline: May 20, 2020

Published Articles: 9

Targeting Transcription Factors for Cancer Therapy

Dr. Gautam Sethi

Submission Deadline: July 31, 2020

Published Articles: 7

Proteolysis Targeting Chimera (PROTAC)

Dr. Matthias Baud

Submission Deadline: July 31, 2021

Published Articles: 4

Cholesterol Dyshomeostasis in Neurological Diseases

Dr. Ta-Yuan Chang Dr. Catherine Chang

Submission Deadline: September 30, 2021

Published Articles: 1

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