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Open Exploration

As an open access journal publisher, we provide an open platform where professionals can share their explorations of specific subjects, and everyone can enjoy unrestricted access to the knowledge. We persist in disseminating high quality content rapidly, widely and freely.

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Rigorous Review
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  • Featured Articles
    Open Access
    Original Article
    Untargeted and quantitative analyses of amine and phenol compounds in Baijiu via chemical isotope labeling
    Aim: The aim of this study is to comprehensively investigate the distribution of amine and phenol compounds in different flavors of Baijiu. Methods: 12C-/13C-dansyl chloride labeling was  [...] Read more.
    Xiaoyu Xie ... Guowang Xu
    Published: June 30, 2023 Explor Foods Foodomics. 2023;1:72–82
    DOI: https://doi.org/10.37349/eff.2023.00007
    Times Cited: 0
    Open Access
    Original Article
    Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
    Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA)  [...] Read more.
    Yi Ouyang ... Hui Liu
    Published: February 27, 2023 Explor Drug Sci. 2023;1:18–30
    DOI: https://doi.org/10.37349/eds.2023.00003
    This article belongs to the special issue Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics
    Times Cited: 0
    Open Access
    Quality of care, referral, and early diagnosis of axial spondyloarthritis
    Jürgen Braun ... Xenofon Baraliakos
    Published: April 12, 2023 Explor Musculoskeletal Dis. 2023;1:37–42
    DOI: https://doi.org/10.37349/emd.2023.00007
    Times Cited: 0
    Open Access
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    Times Cited: 0
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    Open Access
    Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
    The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a [...] Read more.
    Hanghang Wu ... Francisco Javier Cubero
    Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
    DOI: https://doi.org/10.37349/edd.2023.00020
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    Times Cited: 0
    Open Access
    High avidity of vaccine-induced immunoglobulin G against SARS-CoV-2: potential relevance for protective humoral immunity
    Avidity of immunoglobulin G (IgG) is defined as its binding strength to its target antigen. As a consequence of affinity maturation of the IgG response, avidity is maturing as well. Therefore, acute [...] Read more.
    Georg Bauer
    Published: March 16, 2022 Explor Immunol. 2022;2:133–156
    DOI: https://doi.org/10.37349/ei.2022.00040
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    Open Access
    Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease
    The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the human host can lead to various clinical manifestations, from symptomless carriers to mild to moderate to severe/critical illness. Therefore, the cli [...] Read more.
    Nitin Saksena ... Thyago H. Cardoso
    Published: December 29, 2022 Explor Immunol. 2022;2:794–811
    DOI: https://doi.org/10.37349/ei.2022.00084
    This article belongs to the special issue Immunology, Immunopathology and Genomics of SARS-COV-2
    Open Access
    Chemokine-targeted nanoparticles: stimulation of the immune system in cancer immunotherapy
    Surgery, chemotherapy, radiation therapy, and immunotherapy are potential therapeutic choices for many malignant and metastatic cancers. Despite adverse side effects and pain, surgery and chemothera [...] Read more.
    Ranjeet Singh ... Partha Pratim Manna
    Published: April 27, 2023 Explor Immunol. 2023;3:123–147
    DOI: https://doi.org/10.37349/ei.2023.00093
    This article belongs to the special issue Nanomaterials interaction with chemokines: perspectives for applied immunology
    Times Cited: 0
    Open Access
    Original Article
    STIM/Orai-mediated calcium entry elicits spontaneous TSLP overproduction in epidermal cells of atopic dermatitis mice
    Aim: Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease. Thymic stromal lymphopoietin (TSLP) is highly expressed in the epidermis of patients with AD and induces T helper 2 ( [...] Read more.
    Masanori Fujii ... Susumu Ohya
    Published: June 11, 2023 Explor Immunol. 2023;3:174–185
    DOI: https://doi.org/10.37349/ei.2023.00096
    This article belongs to the special issue Cytokines and Skin Diseases
    Times Cited: 0
    Open Access
    Antibody-drug conjugate therapies in multiple myeloma—what’s next on the horizon?
    Targeted immunotherapy has arisen over the past decade to the forefront of cancer care. Notably, targeted therapies such as antibody-drug conjugates (ADCs) are becoming more recognized for a novel a [...] Read more.
    Monique Hartley-Brown, Paul Richardson
    Published: January 14, 2022 Explor Target Antitumor Ther. 2022;3:1–10
    DOI: https://doi.org/10.37349/etat.2022.00067
    This article belongs to the special issue Antibody-Drug Conjugates
    Open Access
    Antibody-drug conjugates: beyond current approvals and potential future strategies
    The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in recent years have fuelled the ongoing development of this class of drugs. These novel agents combine the benefits [...] Read more.
    Siddharth Menon ... Hui K. Gan
    Published: April 28, 2022 Explor Target Antitumor Ther. 2022;3:252–277
    DOI: https://doi.org/10.37349/etat.2022.00082
    This article belongs to the special issue Antibody-Drug Conjugates
    Open Access
    Antibody-drug conjugates for lymphoma patients: preclinical and clinical evidences
    Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting of tumor cells, compared to systemic cyt [...] Read more.
    Marilia Barreca ... Francesco Bertoni
    Published: December 26, 2022 Explor Target Antitumor Ther. 2022;3:763–794
    DOI: https://doi.org/10.37349/etat.2022.00112
    This article belongs to the special issue Antibody-Drug Conjugates
    Open Access
    Encouraging probiotics for the prevention and treatment of immune-related adverse events in novel immunotherapies against malignant glioma
    Among the malignant tumors in the central nervous system (CNS), glioma is the most challenging tumor to the public society, which accounts for the majority of intracranial malignant tumors with impa [...] Read more.
    Sayuri Yoshikawa ... Satoru Matsuda
    Published: December 27, 2022 Explor Target Antitumor Ther. 2022;3:817–827
    DOI: https://doi.org/10.37349/etat.2022.00114
    This article belongs to the special issue Theranostic Frontiers in Neuro-Oncology
    Open Access
    Macrophages as potential targets in gene therapy for cancer treatment
    Macrophages, as ubiquitous and functionally diverse immune cells, play a central role in innate immunity and initiate adaptive immunity. Especially, tumor-associated macrophages (TAMs) are crucial c [...] Read more.
    Yuanzheng Huang ... Xiaoxuan Liu
    Published: February 28, 2023 Explor Target Antitumor Ther. 2023;4:89–101
    DOI: https://doi.org/10.37349/etat.2023.00124
    This article belongs to the special issue Gene Delivery Approach to Fight Cancer
    Times Cited: 0
    Open Access
    Medicinal chemistry advances in targeting class I histone deacetylases
    Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gen [...] Read more.
    Diaaeldin I. Abdallah ... Patrick T. Gunning
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:757–779
    DOI: https://doi.org/10.37349/etat.2023.00166
    This article belongs to the special issue Posttranslational Modifications in Health and Disease
    Times Cited: 0
    Open Access
    A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exer [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 27, 2022 Explor Med. 2022;3:468–478
    DOI: https://doi.org/10.37349/emed.2022.00108
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    Open Access
    Original Article
    Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
    Aim: Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to e [...] Read more.
    Gregory Giordano ... Angela D. Bryan
    Published: April 26, 2023 Explor Med. 2023;4:254–271
    DOI: https://doi.org/10.37349/emed.2023.00138
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    Times Cited: 0