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Open Exploration

As an open access journal publisher, we provide an open platform where professionals can share their explorations of specific subjects, and everyone can enjoy unrestricted access to the knowledge. We persist in disseminating high quality content rapidly, widely and freely.

Open to Broad Readership
Authors Retain Copyright
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  • Featured Articles
    Open Access
    Turbulence at Twitter with leadership change: implications for health research and science communication
    Twitter has been an invaluable social media platform for scientists to share research and host discourse among academics and the public. The change of ownership at Twitter has changed how scientists [...] Read more.
    Ronan Lordan, Hari Prasad Devkota
    Published: November 01, 2023 Explor Digit Health Technol. 2023;1:4–10
    DOI: https://doi.org/10.37349/edht.2023.00002
    This article belongs to the special issue Social Media Applications in Biomedical Research
    Open Access
    Atlantic algae as food and their extracts
    Among the species of the rich algological flora of the North Atlantic, some can be used for direct consumption in human food, although few are currently cultivated on a large scale and/or marketed f [...] Read more.
    Leonel Pereira
    Published: April 27, 2023 Explor Foods Foodomics. 2023;1:15–31
    DOI: https://doi.org/10.37349/eff.2023.00003
    This article belongs to the special issue The food (r)evolution towards food quality/security and human nutrition
    Open Access
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    Times Cited: 0
    Open Access
    Original Article
    Utility of dimethylsulfoxide to preserve synovial fluid samples for microcrystal detection and identification
    Aims: To study whether the addition of dimethylsulfoxide (DMSO) to synovial fluid (SF) samples could be helpful to store frozen samples to improve the rates of detection and identification of cry [...] Read more.
    Fernando Pérez-Ruiz ... Juan J. Mateos-Mazón
    Published: February 21, 2023 Explor Musculoskeletal Dis. 2023;1:4–10
    DOI: https://doi.org/10.37349/emd.2023.00002
    Times Cited: 0
    Open Access
    Case Report
    Similarities and differences between gouty arthritis and rheumatoid arthritis—an interesting case with a short look into the literature
    Gout often presents as acute arthritis but may also present with chronic joint inflammation. For the diagnosis of an acute gout attack with its typical symptoms, the differentiation towards a bacter [...] Read more.
    David Kiefer ... Juergen Braun
    Published: February 24, 2023 Explor Musculoskeletal Dis. 2023;1:11–19
    DOI: https://doi.org/10.37349/emd.2023.00003
    Open Access
    Is there a place for magnetic resonance imaging in diffuse idiopathic skeletal hyperostosis?
    Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by the new bone formation and enthesopathies of the axial and peripheral skeleton. The diagnosis of DISH current [...] Read more.
    Iris Eshed
    Published: April 27, 2023 Explor Musculoskeletal Dis. 2023;1:43–53
    DOI: https://doi.org/10.37349/emd.2023.00008
    This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease
    Times Cited: 0
    Open Access
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    Open Access
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    Open Access
    Metabolic correction of neurodegenerative pathologies: the role of macronutrients and timing
    Despite decades of intensive research, effective treatment and prevention strategies for neurodegenerative diseases (NDDs) remain elusive. This review focuses on Alzheimer’s and Parkinson’s dise [...] Read more.
    Yuri Zilberter, Tanya Zilberter
    Published: April 21, 2023 Explor Neurosci. 2023;2:67–81
    DOI: https://doi.org/10.37349/en.2023.00013
    Times Cited: 0
    Open Access
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    Open Access
    Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
    The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a [...] Read more.
    Hanghang Wu ... Francisco Javier Cubero
    Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
    DOI: https://doi.org/10.37349/edd.2023.00020
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    Times Cited: 0
    Open Access
    γδ T cell costimulatory ligands in antitumor immunity
    Antitumor immunity relies on the ability of T cells to recognize and kill tumor targets. γδ T cells are a specialized subset of T cells that predominantly localizes to non-ly [...] Read more.
    Joseph M. McGraw, Deborah A. Witherden
    Published: February 24, 2022 Explor Immunol. 2022;2:79–97
    DOI: https://doi.org/10.37349/ei.2022.00038
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
    Open Access
    Novel insights based on the plasticity of γδ T cells in the tumor microenvironment
    γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can reco [...] Read more.
    Yue Wang ... Wei He
    Published: February 24, 2022 Explor Immunol. 2022;2:98–132
    DOI: https://doi.org/10.37349/ei.2022.00039
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
    Open Access
    Mechanism of NLRP3 inflammasome activation and its role in Alzheimer’s disease
    Alzheimer’s disease (AD) is a common neurological disease in the elderly, and the major manifestations are cognitive dysfunction, neuronal loss, and neuropathic lesions in the brain. In  [...] Read more.
    Xiaohan Gao ... Xueling Dai
    Published: May 07, 2022 Explor Immunol. 2022;2:229–244
    DOI: https://doi.org/10.37349/ei.2022.00048
    Open Access
    Uterine natural killer cells and successful pregnancy: from mouse experiments to human physiology
    Uterine natural killer (uNK) cells, a specific type of natural killer (NK) cells, are important cells at the foeto-maternal interface in humans as well as in mice. uNK cells are part of the innate l [...] Read more.
    Marijke M. Faas
    Published: August 25, 2022 Explor Immunol. 2022;2:518–539
    DOI: https://doi.org/10.37349/ei.2022.00065
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    Open Access
    A non-redundant role of complement protein C1q in normal and adverse pregnancy
    Complement component 1q (C1q) is the recognition molecule of the classical pathway of the complement system that can bind to an array of closely spaced antigen-bound immunoglobulin G (IgG) and IgM a [...] Read more.
    Chiara Agostinis ... Roberta Bulla
    Published: August 31, 2022 Explor Immunol. 2022;2:622–636
    DOI: https://doi.org/10.37349/ei.2022.00072
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    Open Access
    Chemokines and nanomaterials: interaction for useful immune-applications
    Chemokines are homeostatic or inflammatory small proteins regulating immune cell migration and are structurally characterized by cysteine disulfide bridges. Around 50 human chemokines binding almost [...] Read more.
    Giuseppe Bardi
    Published: August 31, 2022 Explor Immunol. 2022;2:637–647
    DOI: https://doi.org/10.37349/ei.2022.00073
    This article belongs to the special issue Nanomaterials interaction with chemokines: perspectives for applied immunology
    Open Access
    New antibody-drug conjugates (ADCs) in breast cancer—an overview of ADCs recently approved and in later stages of development
    Antibody-drug conjugates (ADCs) have changed the treatment of breast cancer (BC) in more recent years. BC is a heterogenous group of malignancies with a broad range of histopathological characterist [...] Read more.
    Kira-Lee Koster ... Markus Joerger
    Published: February 24, 2022 Explor Target Antitumor Ther. 2022;3:27–36
    DOI: https://doi.org/10.37349/etat.2022.00069
    This article belongs to the special issue Antibody-Drug Conjugates
    Open Access
    Advancing antibody-drug conjugates in gynecological malignancies: myth or reality?
    Antibody-drug conjugates (ADCs) represent a new class of therapeutic agents designed to target specific antigens on tumor cells, combining the specificity of monoclonal antibodies to the cytotoxicit [...] Read more.
    Marta Nerone ... Ilaria Colombo
    Published: April 19, 2022 Explor Target Antitumor Ther. 2022;3:149–171
    DOI: https://doi.org/10.37349/etat.2022.00077
    This article belongs to the special issue Antibody-Drug Conjugates
    Open Access
    Genomic alterations in cholangiocarcinoma: clinical significance and relevance to therapy
    Improving the survival of patients with cholangiocarcinoma (CCA) has long proved challenging, although the treatment of this disease nowadays is on advancement. The historical invariability of survi [...] Read more.
    Marianeve Carotenuto ... Nicola Normanno
    Published: April 26, 2022 Explor Target Antitumor Ther. 2022;3:200–223
    DOI: https://doi.org/10.37349/etat.2022.00079
    This article belongs to the special issue Precision Medicine for Cholangiocarcinoma
    Open Access
    Original Article
    Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response
    Aim: Gene-based immunotherapy against cancer is limited by low gene transfer efficiency. In the literature, interleukin-12 (IL-12) encoding plasmid associated with sonoporation has been shown to en [...] Read more.
    Hai Doan Do ... Nathalie Mignet
    Published: June 29, 2022 Explor Target Antitumor Ther. 2022;3:398–413
    DOI: https://doi.org/10.37349/etat.2022.00090
    This article belongs to the special issue Gene Delivery Approach to Fight Cancer
    Times Cited: 0
    Open Access
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole [...] Read more.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    Open Access
    Oxidative stress in obesity and insulin resistance
    Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published lite [...] Read more.
    Anastasija Panic ... Esma R. Isenovic
    Published: February 23, 2022 Explor Med. 2022;3:58–70
    DOI: https://doi.org/10.37349/emed.2022.00074
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    Open Access
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging,  [...] Read more.
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. 2022;3:112–127
    DOI: https://doi.org/10.37349/emed.2022.00078
    Open Access
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects  [...] Read more.
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. 2022;3:219–233
    DOI: https://doi.org/10.37349/emed.2022.00087
    Open Access
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem [...] Read more.
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. 2022;3:249–259
    DOI: https://doi.org/10.37349/emed.2022.00089
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis