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Open Exploration

As an open access journal publisher, we provide an open platform where professionals can share their explorations of specific subjects, and everyone can enjoy unrestricted access to the knowledge. We persist in disseminating high quality content rapidly, widely and freely.

Open to Broad Readership
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  • Featured Articles
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:1618
    Download:95
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    Open Access
    Review
    Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases
    The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by cytochrome P450 46A1 (CYP46A1).  [...] Read more.
    Irina A. Pikuleva
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:159–172
    DOI: https://doi.org/10.37349/ent.2021.00013
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:737
    Download:64
    Times Cited: 0
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1014
    Download:85
    Open Access
    Review
    The role of interleukin-24 in atopic dermatitis
    Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl  [...] Read more.
    Yen Hai Vu ... Gaku Tsuji
    Published: April 30, 2021 Explor Immunol. 2021;1:4–15
    DOI: https://doi.org/10.37349/ei.2021.00002
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:2782
    Download:125
    Times Cited: 0
    Open Access
    Review
    Immunology of biodegradable nanoparticles: a brief overview on a wide growing field
    Immunity is continuously evolving by evolutionary mechanisms shaped by pathogenic stimuli of different kinds. Man-made nanomaterials (NMs) have been developed in the last decades and represent a nov [...] Read more.
    Anissa Pisani, Giuseppe Bardi
    Published: April 30, 2021 Explor Immunol. 2021;1:48–60
    DOI: https://doi.org/10.37349/ei.2021.00006
    View:1795
    Download:73
    Open Access
    Review
    Immunopathogenesis of severe acute respiratory syndrome coronavirus-2: evolving knowledge and its current status
    As the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is a new virus, the current knowledge on the immunopathogenesis of this newly emerged SARS-CoV-2 is beginning to unravel with intens [...] Read more.
    Nitin Saksena ... Monica Miranda-Saksena
    Published: June 30, 2021 Explor Immunol. 2021;1:61–79
    DOI: https://doi.org/10.37349/ei.2021.00007
    View:1293
    Download:63
    Times Cited: 0
    Open Access
    Review
    Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
    Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regene [...] Read more.
    Panagiotis Mallis ... Catherine Stavropoulos Giokas
    Published: June 30, 2021 Explor Immunol. 2021;1:112–139
    DOI: https://doi.org/10.37349/ei.2021.00010
    View:1232
    Download:37
    Open Access
    Review
    The impact of tumour pH on cancer progression: strategies for clinical intervention
    Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasi [...] Read more.
    Carol Ward ... Simon P Langdon
    Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:71–100
    DOI: https://doi.org/10.37349/etat.2020.00005
    View:8491
    Download:461
    Open Access
    Review
    Current strategies for the design of PROTAC linkers: a critical review
    PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead”  [...] Read more.
    Robert I. Troup ... Matthias G. J. Baud
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:273–312
    DOI: https://doi.org/10.37349/etat.2020.00018
    This article belongs to the special issue Proteolysis Targeting Chimera (PROTAC)
    View:11837
    Download:1653
    Open Access
    Review
    Role of estrogen receptor coregulators in endocrine resistant breast cancer
    Breast cancer (BC) is the most ubiquitous cancer in women. Approximately 70–80% of BC diagnoses are positive for estrogen receptor (ER) alpha (ERα). The steroid ho [...] Read more.
    Kristin A. Altwegg, Ratna K. Vadlamudi
    Published: August 30, 2021 Explor Target Antitumor Ther. 2021;2:385–400
    DOI: https://doi.org/10.37349/etat.2021.00052
    This article belongs to the special issue Endocrine Resistant Breast Cancer
    View:1313
    Download:74
    Open Access
    Review
    Current options and future directions of systemic therapy for advanced biliary tract cancer
    Biliary tract cancers (BTCs) are aggressive tumors arising from different portions of the biliary tree and classified according to the anatomical location in intrahepatic (i) cholangiocarcinoma (CCA [...] Read more.
    Maria Giuseppina Prete ... Lorenza Rimassa
    Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:416–433
    DOI: https://doi.org/10.37349/etat.2021.00054
    This article belongs to the special issue Precision Medicine for Cholangiocarcinoma
    View:895
    Download:59
    Times Cited: 0
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6197
    Download:143
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusi [...] Read more.
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85–107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from port [...] Read more.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2950
    Download:62
    Open Access
    Review
    Angiotensin-(1-7) and Mas receptor in the brain
    The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher  [...] Read more.
    Natalia L. Rukavina Mikusic ... Mariela M. Gironacci
    Published: June 30, 2021 Explor Med. 2021;2:268–293
    DOI: https://doi.org/10.37349/emed.2021.00046
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1406
    Download:130