• Special Issue Topic
    Cholesterol Dyshomeostasis in Neurological Diseases
    Submission Deadline: September 30, 2021

    Guest Editors

    Dr. Ta-Yuan Chang E-Mail

    Professor, Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

    Research Keywords: cholesterol metabolism; membrane proteins; Alzheimer's disease; NPC disease; Vascular dementia

    Dr. Catherine Chang E-Mail

    Principal Research Scientist, Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

    Research Keywords: cholesterol metabolism; structure and function analysis of ACAT/SOAT; membrane proteins; Alzheimer's disease; NPC disease

    About the Special Issue

    Cholesterol is a lipid molecule that is essential to the structure and function of biological membranes, as well as the growth and maintenance of all mammalian cells. The metabolites of cholesterol, including oxysterols, neurosteroids, and bile acids, play important regulatory roles in mammalian physiology. Increasing evidence implicates the involvement of cholesterol dyshomeostasis in diverse neurological diseases, including Alzheimer disease, autism, Huntington disease, multiple sclerosis, Niemann-Pick type C disease, Smith-Lemli-Opitz syndrome, and vascular dementia. The mechanistic connections between cholesterol and the pathophysiology of these diseases, are as yet inadequately understood.

    To stimulate research in this burgeoning area, we are organizing a special issue of the Journal, entitled “Cholesterol Dyshomeostasis in Neurological Diseases,” that will contain 6 to 10 invited reviews written by leading scientists in the relevant research fields. We are also soliciting additional relevant manuscripts that describe original research, meta-analysis, commentary, or editorial. Manuscripts that address the following areas will be particularly welcome: roles of cholesterol or its metabolites in the brain; brain-penetrating agents to facilitate CNS cholesterol homeostasis; and neurological alterations caused by cholesterol imbalance in the CNS or by hypercholesterolemia and atherosclerosis.

    The deadline for manuscript submission is September 30th, 2021. Each qualified manuscript will undergo prompt and thorough peer-review. The published issue will receive wide promotion by the Journal to the international scientific community. The goal of this special issue is ultimately to stimulate the discovery and development of novel, cholesterol-related neuroprotective therapies by scientists working in the basic, translational, and clinical neuroscience arenas. This issue can also be used as a timely resource for graduate students and postdoctoral fellows entering the field of neurodegeneration research.

    Keywords: cholesterol; membranes; neuroscience; neuroprotective therapies; neurological disease

    Call for Papers

    Published Articles

    Open Access
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo...
    Kamran Tariq, Bryan W. Luikart
    Online First: October 09, 2021 Explor Neuroprot Ther. 2021;1:Online First
    DOI: https://doi.org/10.37349/ent.2021.00008
    Times Cited: 0
    Open Access
    Cholesterol in autism spectrum disorders
    The autism spectrum disorder (ASD) comprises a series of neurological diseases that share serious alterations of the development of the central nervous system. The degree of disability may vary so t...
    Rafael Franco ... Irene Reyes-Resina
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:10-18
    DOI: https://doi.org/10.37349/ent.2021.00003
    Times Cited: 0