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Exploration of Targeted Anti-tumor Therapy
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  • Special Issue Topic

    Integrated Approaches for Non-Small-Cell Lung Cancer

    Submission Deadline: April 30, 2023

    Guest Editors

    Dr. Alessandro Morabito E-Mail

    Director of Thoracic Medical Oncology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy

    Research Keywords: Lung cancer; target based agents; angiogenesis inhibitors; immunotherapy; clinical trials


    Dr. Edoardo Mercadante E-Mail

    Director of Thoracic Surgery Unit, National Cancer Institute IRCCS ”Pascale Foundation”, Naples, Italy


    About the Special Issue

    The treatment landscape of patients with non-­small-­cell lung cancer (NSCLC) has dramatically changed in recent years, thanks to the improvement in the knowledge of the biology of NSCLC, the discovery of targetable oncogenic drivers, the positive results obtained with immunotherapy in different settings (advanced, locally advanced, adjuvant, neoadjuvant) and the optimal integration of surgery, radiotherapy and systemic treatments. Furthermore, thanks to the advent of technology, surgical minimally invasive treatments (Robotic and Thoracoscopic) are always less traumatic, thus, increasing the number of surgical candidates, even in fragile and with co-morbidities patients.

    For NSCLC patients with early and locally advanced disease a through therapeutic revolution is currently ongoing and a multidisciplinary approach is mandatory. This Special Issue will highlight the current state of treatment of early and locally advanced NSCLC patients, focusing on the approved indications of surgery, radiotherapy and systemic treatments, including chemotherapy, immunotherapy and targeted based agents. Moreover, the strategies to improve the results obtained to date and the challenge to face resistance disease will be discussed. Finally, the role of liquid biopsy in this setting and its potential implementation will be evaluated.

    The possible topics could be (but not limited to) :

    • The role of radioterapy in early stage NSCLC

    • Advancement in radiotherapy for locally advanced NSCLC

    • New surgical approaches for early stage NSCLC

    • Role of surgery for locally advanced NSCLC

    • Immunotherapy for locally advanced NSCLC

    • Target based agents for oncogene addicted locally advanced NSCLC

    • The role of liquid biopsy in early stage NSCLC

    • Advancement in the treatment of locally advanced NSCLC

    • Minimally invasive surgery and its efficacy on lymphadenectomy

    • Activity of a Lung Cancer MDT: benefits and barriers

    Keywords: Early stage NSCLC; locally advanced NSCLC; thoracic radiotherapy; thoracic surgery; adjuvant treatment; liquid biopsy; immunotherapy

    Call for Papers

    Published Articles

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    • Aims and Scope
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    • Ongoing Special Issues
      Off-Label Drugs and -Omics Data in Cancer Treatment
      COVID-19 and Cancer
      Antibody-Drug Conjugates
      The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy
      Gene Delivery Approach to Fight Cancer
      The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
      Cancer Immunotherapy and Tumor Microenvironment
      Theranostic Frontiers in Neuro-Oncology
      Plant Extracts as an Infinite Resource for New Anticancer Agents
      Cancer Stem Cell Targeting Therapy
      Emerging Screening Technologies in Drug Discovery
      Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
      Artificial Intelligence for Precision Oncology
      Integrated Approaches for Non-Small-Cell Lung Cancer
      Innovative Strategies to Target Triple-negative Breast Cancer
      DNA Damage as Target for Therapeutic Intervention
      Therapeutic Targeting of the Tumor Microenvironment
      Molecular Targeted Therapy for Cancer
      Novel Strategies and Targets for Immunotherapy of Cancer
      Molecular Diagnosis and Personalized Therapy of Cancer
      Recent Approaches in Tumor Metabolism
      Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
      Posttranslational Modifications in Health and Disease
    • Completed Special Issues
      Liquid Biopsy in Thoracic Cancer
      Targeting Transcription Factors for Cancer Therapy
      Immunotherapy in Cancer Patients
      Calcium Signaling Apparatus in Cancers
      Proteolysis Targeting Chimera (PROTAC)
      Precision Medicine for Cholangiocarcinoma
      Endocrine Resistant Breast Cancer
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    • Exploration of Targeted Anti-tumor Therapy
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