• Special Issue Topic

    Intervention of Neuroimmune Responses

    Submission Deadline: April 30, 2023

    Guest Editor

    Dr. Raymond Chuen-Chung Chang E-Mail

    Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, and State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China

    Research Keywords: neuroinflammation; neurodegeneration; microglia; exercise; herbal medicine

    About the Special Issue

    It has been considered that the brain is an immune privilege site. However, with the new findings of lymphatic vessels in the dural sinus and infiltration of activated macrophages as well as lymphocytes, the concept of immune privilege site should be totally revised. In fact, immune responses occurs when we get infection in the childhood and adulthood, chronic pain, surgery, high fat, polluted environment, aging. Neuroimmune responses often affect progressive neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, Huntington’s disease, Dementia with Lewy Body), acute neurological disorders (stroke, brain trauma, spinal cord injury, pain, epilepsy), and mental disorders (depression, post-traumatic injury, stress, psychosis, schizophrenia). Our brain usually does not welcome neuroimmune responses. Therefore, we have to understand more the basic mechanisms of neuroimmune responses and any potential interventions. Therapeutic strategies can be pharmacological (anti-inflammatory, potential herbal medicine and healthy food/natural products, gut microbiota, immunotherapy, miRNA), non-pharmacological (different exercise, environmental enrichment, acupuncture), and even cell therapy (stem cells, stimulation of endogenous stem cells, modification of immune stem cells).

    This special issues aims to collect studies from different types of therapeutic interventions or prevention by all the above methods/strategies. We welcome review articles, original laboratory work, clinical study, drug trial, case study and systematic review. This special issue provides a platform for the science community to discuss and share strategies of intervention and prevention of neuroimmune responses.

    Keywords: neuroimmune; therapeutic intervention; preventive medicine; herbal medicine; exercise; acupuncture; miRNA

    Call for Papers

    Published Articles

    Open Access
    Cerebral stroke-induced neurogenesis: insights and therapeutic implications
    Stroke, one of the leading causes of global morbidity and mortality, results from disrupted cerebral blood circulation, leads to cellular damage or death. Ischemic stroke, the predominant subtype, r [...] Read more.
    Mydhili Radhakrishnan ... Sumana Chakravarty
    Published: April 26, 2024 Explor Neuroprot Ther. 2024;4:172–197
    DOI: https://doi.org/10.37349/ent.2024.00078
    Times Cited: 0
    Open Access
    Exploration of transcutaneous vagus nerve stimulation as a treatment option for adjuvant cancer and heart failure therapy
    Vagus nerve stimulation (VNS) has gained prominence in the treatment of various clinical disorders such as migraine, depression, and tinnitus. Based on increased scientific knowledge of the VNS and  [...] Read more.
    Niklas Frank ... Carola Y. Förster
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:363–397
    DOI: https://doi.org/10.37349/ent.2023.00056
    Times Cited: 0
    Open Access
    Toll-like receptor 4 in the interface between neuroimmune response and behavioral alterations caused by stress
    Different stressors can elicit neuroinflammatory responses modulated by innate immunity receptors, such as the family of Toll-like receptors (TLRs). The TLR4, a pattern recognition receptor (PRR), i [...] Read more.
    Fábio José Coelho Souza-Junior ... Sabrina Francesca Lisboa
    Published: October 31, 2022 Explor Neuroprot Ther. 2022;2:182–209
    DOI: https://doi.org/10.37349/ent.2022.00028
    Open Access
    Autism: genetics, environmental stressors, maternal immune activation, and the male bias in autism
    Autism spectrum disorder (ASD) is a class of neurodevelopmental disorders (NDD) characterized by deficits in three domains: impairments in social interactions, language, and communication, and increased stereotyped restrictive/rep [...] Read more.
    Sarah Otaru, David A. Lawrence
    Published: August 11, 2022 Explor Neuroprot Ther. 2022;2:141–161
    DOI: https://doi.org/10.37349/ent.2022.00025
    Times Cited: 0
    Open Access
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019