• Special Issue Topic

    Diffuse Idiopathic Skeletal Hyperostosis-A common but neglected disease

    Submission Deadline: March 30, 2023

    Guest Editor

    Dr. Reuven Mader E-Mail

    Ha'Emek Medical Center, Afula, Israel

    Research Keywords: Hypertrophic bone disease, spondyloarthritis, inflammatory arthritis

    About the Special Issue

    Diffuse Idiopathic Skeletal Hyperostosis (DISH), is a disease characterized by ossification and calcification of entheses and ligaments. Its predilection site of involvement is the spine, and in particular the thoracic segment. Nevertheless, involvement of peripheral skeletal sites such as peripheral entheses, joints' capsules, and hypertrophic involvement of peripheral joints is common. It has also been associated with features of the metabolic syndrome such as diabetes mellitus, hyperlipidemia, obesity, hypertension and a higher cardiovascular risk. The prevalence of DISH increases with age and can reach on average 10-15% of patients >50 years of age. At present the accepted diagnostic criteria, allow for diagnosis only in a late well established disease. Although the condition is known for many years, we lack good scientific evidence for its clinical manifestations, pathogenesis, genetics, early diagnosis, and treatment modalities. Stiffening of the spine due to new bone formation may cause several complications, and in particular complex fractures with possible dreadful complications. 

    This special edition of Explorations on Diffuse Idiopathic Skeletal Hyperostosis, aims at providing a comprehensive review of our current knowledge and future challenges on important topics of DISH. These will discuss issues about the similarities and differences between DISH, inflammatory spondylitis, and ossification of the posterior longitudinal ligaments, mechanical complications of the condition and the current surgical approach, the clinical manifestations beyond the musculoskeletal system, our knowledge about its genetics and other topics. A better recognition of DISH will draw attention to this often neglected entity, and hopefully will stimulate researcher to further explore this condition.

    (After the information of this special issue was launched online, Dr. Reuven Mader passed away. Subsequently, all manuscripts submitted to the special issue were processed by the Editor-in-Chief or other editorial board members acting as the Academic Editors, and the Editor-in-Chief made the final decisions on all manuscripts for this special issue.)

    Keywords: DISH, new bone formation, enthesopathies, metabolic syndrome, hypertrophic bone disease

    Published Articles

    Open Access
    Multifaceted aspects of chronic disease: do diffuse idiopathic skeletal hyperostosis affect the quality of life?
    Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition that affects the spine and peripheral joints, characterized by the progressive ossification of ligaments and tendons. It is a no [...] Read more.
    Greta Pellegrino ... Piercarlo Sarzi-Puttini
    Published: January 23, 2024 Explor Musculoskeletal Dis. 2024;2:31–39
    DOI: https://doi.org/10.37349/emd.2024.00031
    Times Cited: 0
    Open Access
    Diffuse idiopathic skeletal hyperostosis, beyond the musculoskeletal system
    It has been suggested that diffuse idiopathic skeletal hyperostosis (DISH), a skeletal disease characterized by the ligamentous ossification of the anterolateral spine, is a radiological entity with [...] Read more.
    Fabiola Atzeni ... Reuven Mader
    Published: December 04, 2023 Explor Musculoskeletal Dis. 2023;1:216–227
    DOI: https://doi.org/10.37349/emd.2023.00024
    Times Cited: 0
    Open Access
    Diffuse idiopathic skeletal hyperostosis and axial spondyloarthritis—similarities and differences
    Diffuse idiopathic skeletal hyperostosis (DISH) and axial spondyloarthritis (axSpA) are diseases with inflammatory involvement of the axial skeleton that can result in new bone formation that may le [...] Read more.
    David Kiefer ... Xenofon Baraliakos
    Published: November 20, 2023 Explor Musculoskeletal Dis. 2023;1:194–206
    DOI: https://doi.org/10.37349/emd.2023.00022
    Times Cited: 0
    Open Access
    Genetic basis for skeletal new bone formation
    Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, includi [...] Read more.
    Bruna Parreira ... Jácome Bruges-Armas
    Published: October 23, 2023 Explor Musculoskeletal Dis. 2023;1:143–170
    DOI: https://doi.org/10.37349/emd.2023.00018
    Times Cited: 0
    Open Access
    Original Article
    Prevalence and factors associated to diffuse idiopathic skeletal hyperostosis in gout
    Aim: To evaluate the prevalence, associated factors, and the impact of diffuse idiopathic skeletal hyperostosis (DISH) in patients with gout. Methods: Patients with gout entering into an in [...] Read more.
    Fernando Pérez-Ruiz ... Ana María Herrero-Beites
    Published: September 27, 2023 Explor Musculoskeletal Dis. 2023;1:121–127
    DOI: https://doi.org/10.37349/emd.2023.00016
    Times Cited: 0
    Open Access
    Perioperative management, operative techniques, and pitfalls in the surgical treatment of patients with diffuse idiopathic skeletal hyperostosis: a narrative review
    Diffuse idiopathic skeletal hyperostosis (DISH) can lead to dysphagia, airway obstruction, and unstable vertebral fractures. Surgery can be performed to relieve cervical compression or stabilize fra [...] Read more.
    Netanja I. Harlianto ... Jorrit-Jan Verlaan
    Published: August 29, 2023 Explor Musculoskeletal Dis. 2023;1:84–96
    DOI: https://doi.org/10.37349/emd.2023.00013
    Open Access
    Is there a place for magnetic resonance imaging in diffuse idiopathic skeletal hyperostosis?
    Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by the new bone formation and enthesopathies of the axial and peripheral skeleton. The diagnosis of DISH current [...] Read more.
    Iris Eshed
    Published: April 27, 2023 Explor Musculoskeletal Dis. 2023;1:43–53
    DOI: https://doi.org/10.37349/emd.2023.00008
    Times Cited: 0