• Special Issue Topic


    Submission Deadline: November 10, 2022

    Guest Editor

    Prof. Jose J. G. Marin E-Mail

    Head of Dept. Physiology & Pharmacology, University of Salamanca; Experimental Hepatology and Drug Targeting (HEVEPHARM); Carlos III National Institute of Health, Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd); Salamanca Institute for Biomedical Research (IBSAL); Salamanca, Spain.

    Research Keywords: bile acids; cholestasis; liver and gastrointestinal cancer; chemoresistance and chemosensitization; drug targeting; gene therapy

    About the Special Issue

    Many liver diseases are accompanied by cholestasis, which is defined nowadays as the partial or total reduction of bile flow to the duodenum due to the lack of secretion by the liver, associated with hepatocellular and ductular functional failure, or the retention in the biliary system by obstruction at some point of the biliary tree, resulting in any event in the regurgitation into the blood of cholephilic substances, i.e., compounds typically secreted in the bile, such as bile acids and bilirubin. 

    This special issue will review updated information regarding several critical aspects involving the etiology and pathophysiology of cholestasis, with a particular focus on the role of inborn errors in proteins accounting for bile acid transport and metabolism. The usefulness of bile acids and other compounds in the diagnosis and treatment of cholestasis, as well as clinical aspects of this condition, will also be reviewed. This special issue will also benefit from contributions on any additional question affecting this complex problem, from alteration in the endocrine and paracrine regulation of the biliary function to the relationship of cholestasis with cholesterol metabolism by hepatocytes and the physiological and pathological involvement of cholangiocytes and the biliary tree in the overall secretory function of the liver. Liver diseases in which cholestasis is an essential accompanying feature, such as some types of drug-induced liver injury (DILI), among others, will also have room in this special issue. Finally, another broad field of interest in cholestasis research and clinics concerns the crosstalk between the liver and gut in both directions, regarding the FXR/FGF19 pathway of communication between intestinal epithelial cells and hepatocytes and the other way around the impact of bile acids on intestinal digestive function and microbiota biology.

    Keywords: cholestasis; bile acid; bile flow; bilirubin; FXR; FGF19 Transport; metabolism

    Call for Papers

    Published Articles

    Open Access
    Interplay of autophagy, apoptosis, and senescence in primary biliary cholangitis
    The pathogenesis of primary biliary cholangitis (PBC) is particularly complicated as both intrinsic and extrinsic factors are implicated. Several forms of cellular death, both programmable and non-p [...] Read more.
    Elias Kouroumalis ... Argyro Voumvouraki
    Published: October 16, 2023 Explor Dig Dis. 2023;2:223–245
    DOI: https://doi.org/10.37349/edd.2023.00028
    Times Cited: 0
    Open Access
    Drug-induced cholestasis: causative agents and challenges in diagnosis and management
    Drug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominan [...] Read more.
    Jose M. Pinazo-Bandera ... Miren García-Cortés
    Published: September 18, 2023 Explor Dig Dis. 2023;2:202–222
    DOI: https://doi.org/10.37349/edd.2023.00027
    Times Cited: 0
    Open Access
    Pathophysiology of biochemical signs of primary biliary cholangitis
    Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a rare chronic autoimmune cholestatic liver disease, affecting mostly females. With PBС develops chronic cholang [...] Read more.
    Vasiliy Ivanovich Reshetnyak, Igor Veniaminovich Maev
    Published: August 27, 2023 Explor Dig Dis. 2023;2:149–171
    DOI: https://doi.org/10.37349/edd.2023.00024
    Times Cited: 0
    Open Access
    Case Report
    Diagnostic workup of suspected hereditary cholestasis in adults: a case report
    Hereditary cholestasis comprises a broad spectrum of clinical phenotypes of varying severity. Severe forms such as progressive familial intrahepatic cholestasis (PFIC) mostly affect children with di [...] Read more.
    Carola Dröge ... Verena Keitel
    Published: April 21, 2023 Explor Dig Dis. 2023;2:34–43
    DOI: https://doi.org/10.37349/edd.2023.00016
    Open Access
    Monitoring the hepatobiliary function using image techniques and labeled cholephilic compounds
    Evaluation of the hepatobiliary function is critical for the clinicians, not only for the diagnosis of a large variety of liver diseases but also in the follow-up and management of some patients, for instance, those with different [...] Read more.
    Beatriz Sanchez de Blas ... Marta R. Romero
    Published: February 28, 2023 Explor Dig Dis. 2023;2:18–33
    DOI: https://doi.org/10.37349/edd.2023.00015
    Open Access
    The bile acid receptor TGR5 and cholestasis
    Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.
    Grégory Merlen ... Thierry Tordjmann
    Published: December 30, 2022 Explor Dig Dis. 2022;1:154–169
    DOI: https://doi.org/10.37349/edd.2022.00011
    Times Cited: 0
    Open Access
    Cholestasis associated to inborn errors in bile acid synthesis
    Several metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or tauri [...] Read more.
    Ricardo Espinosa-Escudero ... Maria J. Monte
    Published: December 7, 2022 Explor Dig Dis. 2022;1:137–153
    DOI: https://doi.org/10.37349/edd.2022.00010
    Times Cited: 0
    Open Access
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008