• Special Issue Topic
    Targeting Transcription Factors for Cancer Therapy
    Submission Deadline: July 31, 2020

    Guest Editor

    Dr. Gautam Sethi E-Mail

    Associate Professor, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

    Research Keywords: signal transduction; apoptosis; transcription factors; metastasis; mouse models of cancer


    About the Special Issue

    Transcription factors play an important role in regulating gene expression by binding to specific DNA sequences. However, once deregulated several transcription factors can mediate ontogenesis and mediate tumor initiation, promotion and progression. They can regulate a number of genes involved in abnormal proliferation, survival, angiogenesis, and metastasis of tumor cells. A number of pharmacological strategies have been employed to target the aberrant activation of transcription factors to control tumorigenesis. These include approaches to affect their expression, by mitigating protein/protein interactions, and by preventing their DNA binding at specific DNA-interacting sites. This special issue will highlight these strategies and the potential utility of these transcription factors as “druggable targets”.

    Keywords: transcription factors; cancer; gene expression; apoptosis; small molecules

    Call for Papers

    Published Articles

    Open Access
    Review
    A brief overview of antitumoral actions of bruceine D
    Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually a...
    Zi Wayne Sin ... Manoj Garg
    Online First: July 21, 2020 Explor Target Antitumor Ther. 2020;1:Online First
    DOI: https://doi.org/10.37349/etat.2020.00013
    Viewed:98
    Downloaded:5
    Cited:0
    Open Access
    Review
    An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
    Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone ...
    Irum Naz ... Kwang Seok Ahn
    Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:153-170
    DOI: https://doi.org/10.37349/etat.2020.00010
    Viewed:234
    Downloaded:18
    Cited:0