• Special Issue Topic

    Targeting Transcription Factors for Cancer Therapy

    Submission Deadline: July 31, 2020

    Guest Editor

    Dr. Gautam Sethi E-Mail

    Associate Professor, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

    Research Keywords: signal transduction; apoptosis; transcription factors; metastasis; mouse models of cancer

    About the Special Issue

    Transcription factors play an important role in regulating gene expression by binding to specific DNA sequences. However, once deregulated several transcription factors can mediate ontogenesis and mediate tumor initiation, promotion and progression. They can regulate a number of genes involved in abnormal proliferation, survival, angiogenesis, and metastasis of tumor cells. A number of pharmacological strategies have been employed to target the aberrant activation of transcription factors to control tumorigenesis. These include approaches to affect their expression, by mitigating protein/protein interactions, and by preventing their DNA binding at specific DNA-interacting sites. This special issue will highlight these strategies and the potential utility of these transcription factors as “druggable targets”.

    Keywords: transcription factors; cancer; gene expression; apoptosis; small molecules

    Published Articles

    Open Access
    Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
    Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer facto [...] Read more.
    Honey Pavithran, Ranjith Kumavath
    Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:26–35
    DOI: https://doi.org/10.37349/etat.2021.00031
    Open Access
    An overview of the potential anticancer properties of cardamonin
    Cancer is one of the leading causes of mortality, contributing to 9.6 million deaths globally in 2018 alone. Although several cancer treatments exist, they are often associated with severe side effe [...] Read more.
    Shanaya Ramchandani ... Manoj Garg
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:413–426
    DOI: https://doi.org/10.37349/etat.2020.00026
    Open Access
    Targeting transcription factors in cancer drug discovery
    Cancer drug discovery is currently dominated by clinical trials or clinical research. Several potential drug candidates have been brought into the pipeline of drug discovery after showing very promi [...] Read more.
    Partha Mitra
    Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:401–412
    DOI: https://doi.org/10.37349/etat.2020.00025
    Open Access
    Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
    Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains [...] Read more.
    Sosmitha Girisa ... Ajaikumar B. Kunnumakkara
    Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:313–342
    DOI: https://doi.org/10.37349/etat.2020.00019
    Open Access
    Possible applications of salvianolic acid B against different cancers
    Cancer is the second death causing disease worldwide after cardiovascular abnormalities. The difficulty in treating tumor cells with more precise targeted interventions and recurrence of cancer afte [...] Read more.
    Iram Shahzadi ... Reza Mohammadinejad
    Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:218–238
    DOI: https://doi.org/10.37349/etat.2020.00014
    Open Access
    A brief overview of antitumoral actions of bruceine D
    Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually a [...] Read more.
    Zi Wayne Sin ... Manoj Garg
    Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:200–217
    DOI: https://doi.org/10.37349/etat.2020.00013
    Open Access
    An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
    Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone [...] Read more.
    Irum Naz ... Kwang Seok Ahn
    Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:153–170
    DOI: https://doi.org/10.37349/etat.2020.00010