• Exploration of Digestive Diseases

    eISSN: 2833-6321
    EiC: Jose C. Fernandez-Checa, PhD, Spanish National Research Council at the Institute of Biomedical Research of Barcelona (IIBB-CSIC); Institute of Biomedical Research August Pi i Sunyer (IDIBAPS); CIBEREHD
    Frequency: Bimonthly
    APC: No Article Processing Charge before July 31, 2027
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
    Indexing & Archiving: Google Scholar, DOAJ
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    Articles
    Open Access
    Review
    The central role of mitochondrial metabolism in hepatic steatosis
    Mitochondria are present in all mammalian cells except matured red blood cells. Mitochondria consist of several metabolic pathways for glucose, fatty acids, amino acids, and bioenergetic pathways fo [...] Read more.
    Sanda Win ... Filbert Win Min Aung
    Published: February 29, 2024 Explor Dig Dis. 2024;3:42–68
    DOI: https://doi.org/10.37349/edd.2024.00039
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
    View:261
    Download:13
    Times Cited: 0
    Open Access
    Review
    SERPINB3 in fibrogenic chronic liver diseases and primary liver cancers
    Chronic liver diseases (CLDs), which are typically characterized by fibrogenic progression towards liver cirrhosis and related complications eventually leading to organ failure and can also lead to  [...] Read more.
    Patrizia Pontisso, Maurizio Parola
    Published: February 28, 2024 Explor Dig Dis. 2024;3:22–41
    DOI: https://doi.org/10.37349/edd.2024.00038
    This article belongs to the special issue Fibrosis and Hepatobiliary Cancer
    View:113
    Download:7
    Times Cited: 0
    Open Access
    Review
    Bile as a liquid biopsy matrix: potential applications and limitations
    Hunting for tumoral material in body fluids, traditionally in blood, the so-called liquid biopsy is set to revolutionize the diagnosis and management of oncological patients. However, other biofluid [...] Read more.
    Maria Arechederra ... Carmen Berasain
    Published: February 04, 2024 Explor Dig Dis. 2024;3:5–21
    DOI: https://doi.org/10.37349/edd.2024.00037
    View:208
    Download:11
    Times Cited: 0
    Open Access
    Editorial
    Precision medicine in chemotherapy: Is there room for advancement in colorectal cancer?
    Michele Ghidini
    Published: January 18, 2024 Explor Dig Dis. 2024;3:2–4
    DOI: https://doi.org/10.37349/edd.2024.00036
    This article belongs to the special issue Latest Updates in the Endoscopic, Surgical and Medical Treatment of Resectable and Advanced Gastrointestinal Cancers
    View:180
    Download:5
    Times Cited: 0
    Open Access
    Correction
    Correction: Familial achalasia isolated or syndromic: about 18 families
    Editorial Office
    Published: January 11, 2024 Explor Dig Dis 2024;3:1
    DOI: https://doi.org/10.37349/edd.2024.00035
    View:153
    Download:7
    Times Cited: 0
    Open Access
    Review
    Deciphering the liver enigma: distinguishing drug-induced liver injury and metabolic dysfunction-associated steatotic liver disease—a comprehensive narrative review
    Drug-induced liver injury (DILI) poses a complex and heterogeneous clinical challenge, which often resembles non-drug related acute or chronic liver diseases, such as metabolic dysfunction-associate [...] Read more.
    Miren García-Cortés ... Alberto García-García
    Published: December 27, 2023 Explor Dig Dis 2023;2:318–336
    DOI: https://doi.org/10.37349/edd.2023.00034
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:338
    Download:18
    Times Cited: 0
    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:2555
    Download:81
    Times Cited: 0
    Open Access
    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:2462
    Download:73
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:1949
    Download:58
    Open Access
    Original Article
    The hepatocyte growth factor induces an anti-inflammatory and repairing response in the cholestasis-induced colon damage
    Aim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such [...] Read more.
    Jocelyn López-Ramirez ... Leticia Bucio-Ortiz
    Published: August 11, 2022 Explor Dig Dis. 2022;1:40–50
    DOI: https://doi.org/10.37349/edd.2022.00004
    View:1866
    Download:54
    Times Cited: 0
    Open Access
    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
    View:1772
    Download:91
    Times Cited: 0
    Open Access
    Editorial
    Exploration of Digestive Diseases, where discovery and communication meet
    Jose C. Fernandez-Checa
    Published: July 01, 2022 Explor Dig Dis. 2022;1:1–3
    DOI: https://doi.org/10.37349/edd.2022.00001
    View:1367
    Download:41
    Times Cited: 0
    Open Access
    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
    View:1772
    Download:91
    Times Cited: 0
    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:2555
    Download:81
    Times Cited: 0
    Open Access
    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:2462
    Download:73
    Open Access
    Review
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:1191
    Download:64
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:1949
    Download:58
    Open Access
    Review
    Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions
    The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) a [...] Read more.
    Alejandro Cueto-Sánchez ... Marina Villanueva-Paz
    Published: April 26, 2023 Explor Dig Dis. 2023;2:56–76
    DOI: https://doi.org/10.37349/edd.2023.00018
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:1013
    Download:57
    Times Cited: 0
    Open Access
    Editorial
    Extra-hepatic cancers in metabolic fatty liver syndromes
    Amedeo Lonardo
    Published: February 24, 2023 Explor Dig Dis. 2023;2:11–17
    DOI: https://doi.org/10.37349/edd.2023.00014
    Open Access
    Perspective
    The intermicrovillar adhesion complex in gut barrier function and inflammation
    The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to b [...] Read more.
    Bernadette Mödl ... Robert Eferl
    Published: October 11, 2022 Explor Dig Dis. 2022;1:72–79
    DOI: https://doi.org/10.37349/edd.2022.00006
    View:1066
    Download:41
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:1949
    Download:58
    Open Access
    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:2462
    Download:73
    Open Access
    Case Report
    Diagnostic workup of suspected hereditary cholestasis in adults: a case report
    Hereditary cholestasis comprises a broad spectrum of clinical phenotypes of varying severity. Severe forms such as progressive familial intrahepatic cholestasis (PFIC) mostly affect children with di [...] Read more.
    Carola Dröge ... Verena Keitel
    Published: April 21, 2023 Explor Dig Dis. 2023;2:34–43
    DOI: https://doi.org/10.37349/edd.2023.00016
    This article belongs to the special issue CHOLESTASIS
    Open Access
    Review
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:1191
    Download:64
    Special Issues
    From the Editor-in-Chief
    "It is a great pleasure to serve as the newly appointed Editor-in-Chief of Exploration of Digestive Diseases (EDD). The journal will be a powerful platform for the publication and dissemination of cutting edge science and will devote to increase the knowledge of digestive diseases." said Prof. Fernandez-Checa. "Translational research and clinical perspectives on liver, biliary, digestive tract and pancreatic diseases will pave the way for improving diagnosis and treatment. With the guidelines of Open Exploration Publishing services, the new EDD journal seeks to become a reference in discovery and education in digestive diseases."
    Jose C. Fernandez-Checa
    Editor-in-Chief of Exploration of Digestive Diseases