• Exploration of Digestive Diseases

    eISSN: 2833-6321
    EiC: Jose C. Fernandez-Checa, PhD, Spanish National Research Council at the Institute of Biomedical Research of Barcelona (IIBB-CSIC); Institute of Biomedical Research August Pi i Sunyer (IDIBAPS); CIBEREHD
    Frequency: Bimonthly
    APC: No Article Processing Charge before July 31, 2027
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
    Indexing & Archiving: Google Scholar, DOAJ
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    Articles
    Open Access
    Review
    Hepatocellular carcinoma surveillance after HBsAg seroclearance
    Hepatitis B surface antigen (HBsAg) seroclearance is considered the functional cure and the optimal treatment endpoint for chronic hepatitis B (CHB). Patients with CHB who cleared HBsAg generally ha [...] Read more.
    Jimmy Che-To Lai ... Terry Cheuk-Fung Yip
    Published: May 11, 2024 Explor Dig Dis. 2024;3:175–189
    DOI: https://doi.org/10.37349/edd.2024.00046
    This article belongs to the special issue Chronic Hepatitis B and C
    View:173
    Download:15
    Times Cited: 0
    Open Access
    Review
    Deciphering the cross-talk between miRNA and tight junctions in hepatocellular carcinoma
    The most common type of liver cancer is hepatocellular carcinoma (HCC) causes a lower survival rate even after systemic treatment. Previous studies have shown evidence that various molecular and epi [...] Read more.
    Siva Bala Subramaniyan, Balasubramaniyan Vairappan
    Published: May 11, 2024 Explor Dig Dis. 2024;3:163–174
    DOI: https://doi.org/10.37349/edd.2024.00045
    This article belongs to the special issue Fibrosis and Hepatobiliary Cancer
    View:110
    Download:6
    Times Cited: 0
    Open Access
    Original Article
    Optimization of protocols for blood-derived extracellular vesicles for studies in liver diseases
    Aim: Extracellular vesicles (EVs) have gained significant attention for their diagnostic and therapeutic potential in various diseases, including liver disorders. This study focuses on optimizing [...] Read more.
    Magnolia Martínez-Aguilar ... Han Moshage
    View:339
    Download:19
    Times Cited: 0
    Open Access
    Review
    Helicobacter pylori and gastric cancer: a critical approach to who really needs eradication
    It is generally accepted that eradication of Helicobacter pylori (H. pylori) infection may reduce the risk of the development of gastric cancer. Recommendations for global generalized tests and trea [...] Read more.
    Elias Kouroumalis ... Argyro Voumvouraki
    View:300
    Download:16
    Times Cited: 0
    Open Access
    Review
    Second- and third-line treatment agents in autoimmune hepatitis (AIH): Where do we stand?
    Autoimmune hepatitis (AIH) is a chronic liver disease of unknown aetiology that can lead to end stage liver disease if left without treatment. Corticosteroids with or without azathioprine (AZA) are  [...] Read more.
    Pinelopi Arvaniti ... Maria-Carlota Londoño
    Published: April 10, 2024 Explor Dig Dis. 2024;3:92–106
    DOI: https://doi.org/10.37349/edd.2024.00042
    View:180
    Download:9
    Times Cited: 0
    Open Access
    Case Report
    Remarkable alpha-fetoprotein elevation and pseudo-infarction of cirrhotic liver: case report
    This is a case of remarkable alpha-fetoprotein in a female patient with known cryptogenic liver cirrhosis. Both ultrasound and triphasic computed tomography (CT) abdomen cannot diagnose or exclude h [...] Read more.
    Maged Tharwat Elghannam ... Mohammed Darwish ELTalkawy
    Published: March 29, 2024 Explor Dig Dis. 2024;3:86–91
    DOI: https://doi.org/10.37349/edd.2024.00041
    View:210
    Download:10
    Times Cited: 0
    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:2885
    Download:94
    Open Access
    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:2679
    Download:77
    Open Access
    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
    View:2392
    Download:115
    Times Cited: 0
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:2176
    Download:62
    Open Access
    Original Article
    The hepatocyte growth factor induces an anti-inflammatory and repairing response in the cholestasis-induced colon damage
    Aim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such [...] Read more.
    Jocelyn López-Ramirez ... Leticia Bucio-Ortiz
    Published: August 11, 2022 Explor Dig Dis. 2022;1:40–50
    DOI: https://doi.org/10.37349/edd.2022.00004
    View:2062
    Download:57
    Times Cited: 0
    Open Access
    Review
    Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
    The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a [...] Read more.
    Hanghang Wu ... Francisco Javier Cubero
    Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
    DOI: https://doi.org/10.37349/edd.2023.00020
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:1939
    Download:49
    Times Cited: 0
    Open Access
    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
    View:2392
    Download:115
    Times Cited: 0
    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:2885
    Download:94
    Open Access
    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:2679
    Download:77
    Open Access
    Review
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:1497
    Download:71
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:2176
    Download:62
    Open Access
    Review
    Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions
    The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) a [...] Read more.
    Alejandro Cueto-Sánchez ... Marina Villanueva-Paz
    Published: April 26, 2023 Explor Dig Dis. 2023;2:56–76
    DOI: https://doi.org/10.37349/edd.2023.00018
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:1239
    Download:62
    Times Cited: 0
    Open Access
    Editorial
    Extra-hepatic cancers in metabolic fatty liver syndromes
    Amedeo Lonardo
    Published: February 24, 2023 Explor Dig Dis. 2023;2:11–17
    DOI: https://doi.org/10.37349/edd.2023.00014
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:2176
    Download:62
    Open Access
    Perspective
    The intermicrovillar adhesion complex in gut barrier function and inflammation
    The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to b [...] Read more.
    Bernadette Mödl ... Robert Eferl
    Published: October 11, 2022 Explor Dig Dis. 2022;1:72–79
    DOI: https://doi.org/10.37349/edd.2022.00006
    View:1340
    Download:43
    Open Access
    Review
    Alcohol-related liver disease: also a question of what you drink?
    Excessive alcohol intake is still among the leading causes of chronic liver diseases. Epidemiological studies suggest that per capita consumption of alcohol from various alcohol beverages e.g., beer [...] Read more.
    Finn Jung ... Ina Bergheim
    Published: June 30, 2023 Explor Dig Dis. 2023;2:118–132
    DOI: https://doi.org/10.37349/edd.2023.00022
    This article belongs to the special issue Nutrition, Intestinal Barrier and Metabolic Liver Disease
    Open Access
    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:2679
    Download:77
    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:2885
    Download:94
    Special Issues
    From the Editor-in-Chief
    "It is a great pleasure to serve as the newly appointed Editor-in-Chief of Exploration of Digestive Diseases (EDD). The journal will be a powerful platform for the publication and dissemination of cutting edge science and will devote to increase the knowledge of digestive diseases." said Prof. Fernandez-Checa. "Translational research and clinical perspectives on liver, biliary, digestive tract and pancreatic diseases will pave the way for improving diagnosis and treatment. With the guidelines of Open Exploration Publishing services, the new EDD journal seeks to become a reference in discovery and education in digestive diseases."
    Jose C. Fernandez-Checa
    Editor-in-Chief of Exploration of Digestive Diseases