• Special Issue Topic

    The Role of Adaptor Proteins in Lymphoid Cell Signaling

    Submission Deadline: December 10, 2022

    Guest Editor

    Dr. Noah Isakov E-Mail

    Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P.O.Box 653, Beer Sheva 84105, Israel

    Research Keywords: Signal transduction, tyrosine kinases, adaptor proteins, T cell activation, immune regulation

    About the Special Issue

    Adaptor proteins are devoid of intrinsic catalytic activity but possess multiple protein-binding modules which can interact independently or simultaneously with distinct effector molecules and orchestrate the spatial and temporal formation of signal transducing multiprotein complexes. By linking activated cell-surface receptors to their downstream effector molecules, adaptor proteins promote signal propagation, thereby regulating physiological responses, such as cell division, differentiation, death and metabolism.

    Individual adaptor proteins can deliver several different signals by utilizing distinct combinations of binding partners. In addition, the activity of adaptor proteins is subject to regulation by enzymes, such as kinases and isomerases, which modulate their structure and have impact on their ability to interact with distinct effector molecules.

    Efforts by many investigators have led to the identification and characterization of a large number of adaptor proteins and demonstrated the positive and negative roles of these molecules in signal transduction.

    Many of the adaptor proteins were initially identified in lymphoid cells, in which they couple T- and B- lymphocyte antigen receptors to downstream signaling pathways which regulate lymphocyte development and immune responses. Adaptor proteins are found in all type of lymphocyte subpopulations and are involved in the regulation of their distinct effector functions.  

    In general, adaptor proteins in lymphoid cells are critical components of mechanisms leading to inflammation and activation of the distinct immune functions. They also take part in processes that promote immune tolerance and contribute to aberrant immune functions that result in anergy and autoimmunity.

    The present Special Issue will focus on a number of adaptor proteins that play essential roles in the regulation of lymphoid cell functions under normal and pathological conditions. Special emphasis will be given to adaptors that regulate signal transduction downstream of the B cell and T cell antigen receptors, as well as receptors for agonists and antagonists that contribute to the fine tuning of the immune response. This Special Issue will also include detailed description of selected adaptor protein domains and epitopes involved in the protein-protein interaction processes, their mode of regulation and their binding partners. Both original research and focused review manuscripts are welcomed.

    Keywords: Adaptor proteins, signal transduction, T cell and B cell activation, immune regulation

    Published Articles

    Open Access
    Conformational and functional regulation of the chicken tumor virus number 10 (CT10) regulator of kinase II (CrkII) adaptor protein by cyclophilin A
    The Src homology 2 (SH2) and SH3 domain-containing chicken tumor virus number 10 (CT10) regulator of kinase (Crk) adaptor proteins include three cellular members that serve as integral constituents  [...] Read more.
    Noah Isakov
    Published: June 30, 2023 Explor Immunol. 2023;3:217–232
    DOI: https://doi.org/10.37349/ei.2023.00099
    Times Cited: 0
    Open Access
    Role of an adaptor protein human germinal center-associated lymphoma (HGAL) in cell signaling and lymphomagenesis
    Human germinal center (GC)-associated lymphoma (HGAL) is a multi-domain adaptor protein expressed in GC B lymphocytes, T follicular helper (Tfh) cells and lymphomas derived from these cells. HGAL ex [...] Read more.
    Xiaoyu Jiang, Izidore S. Lossos
    Published: June 28, 2023 Explor Immunol. 2023;3:186–206
    DOI: https://doi.org/10.37349/ei.2023.00097
    Times Cited: 0
    Open Access
    Localization in vesicles, clusters and supramolecular complexes as key elements of LAT function
    Linker for activation of T cells (LAT) is a central adaptor protein in proximal T cell activation. A key element of its adaptor function is the efficiency with which LAT interacts with its binding p [...] Read more.
    Laura E. McMillan, Christoph Wülfing
    Published: April 27, 2023 Explor Immunol. 2023;3:148–157
    DOI: https://doi.org/10.37349/ei.2023.00094
    Times Cited: 0
    Open Access
    Role of Vav1, a hematopoietic signal transduction molecule, as an adaptor protein in health and disease
    The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety of external signals. Small protein modules called Src homology  [...] Read more.
    Shulamit Katzav
    Published: April 28, 2023 Explor Immunol. 2023;3:158–173
    DOI: https://doi.org/10.37349/ei.2023.00095
    Times Cited: 0
    Open Access
    Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes
    Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of intracellular signaling adaptors that associate with the cytoplasmic tails of a diverse range of lymphocyte receptors [...] Read more.
    Mari Hikosaka Kuniishi ... Takanori So
    Published: February 27, 2023 Explor Immunol. 2023;3:40–55
    DOI: https://doi.org/10.37349/ei.2023.00088
    Open Access
    Signal-transducing adaptor protein-2 modulates T-cell functions
    Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical  [...] Read more.
    Tadashi Matsuda ... Kenji Oritani
    Published: December 27, 2022 Explor Immunol. 2022;2:771–782
    DOI: https://doi.org/10.37349/ei.2022.00082
    Times Cited: 0