• Special Issue Topic

    Gene Delivery Approach to Fight Cancer

    Submission Deadline: February 28, 2022

    Guest Editor

    Prof. Xiangyang Shi E-Mail

    Professor of Biomedical Engineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China

    Research Keywords: dendrimers; drug delivery; nanomedicine; theranostics; nanofibers

    About the Special Issue

    Gene therapy represents a promising approach for cancer treatment, which has shown good selectivity and efficacy in experimental system. Gene therapy refers to the introduction of genetic material into a cell to achieve a therapeutic response. Today, the gene delivery methods can be physical (e.g., microinjection, electroporation or biolistics), chemical (e.g., cationic lipid or nanoparticle carriers) or biological (e.g., viral or bacterial vectors). To achieve the high efficiency, low cytotoxicity and minimal side-effect on normal physiology, more and more novel approaches are emerging for cancer treatment. This themed issue on Gene delivery approach to fight cancer brings together some of the world's reputed experts to discuss current research and future prospects in the use of gene delivery for cancer therapy.

    The potential topics for this special issue include, but are not limited to, the following:

     ★ Viral Transfection

     ★ Cationic Lipid Transfection

     ★ Polymer-based vector system

     ★ Nanovectors

     ★ Plasmid DNA

     ★ Antisense oligonucleotide

     ★ RNAi

     ★ Combinational therapy

     ★ Theranostics

    Published Articles

    Open Access
    Macrophages as potential targets in gene therapy for cancer treatment
    Macrophages, as ubiquitous and functionally diverse immune cells, play a central role in innate immunity and initiate adaptive immunity. Especially, tumor-associated macrophages (TAMs) are crucial c [...] Read more.
    Yuanzheng Huang ... Xiaoxuan Liu
    Published: February 28, 2023 Explor Target Antitumor Ther. 2023;4:89–101
    DOI: https://doi.org/10.37349/etat.2023.00124
    Open Access
    Applications and challenges of biomaterial mediated mRNA delivery
    With the rapid development of gene therapy technology and the outbreak of coronavirus disease 2019 (COVID-19), messenger RNA (mRNA) therapeutics have attracted more and more attention, and the COVID [...] Read more.
    Huapan Fang, Qian Chen
    Published: August 31, 2022 Explor Target Antitumor Ther. 2022;3:428–444
    DOI: https://doi.org/10.37349/etat.2022.00093
    Open Access
    Original Article
    Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response
    Aim: Gene-based immunotherapy against cancer is limited by low gene transfer efficiency. In the literature, interleukin-12 (IL-12) encoding plasmid associated with sonoporation has been shown to en [...] Read more.
    Hai Doan Do ... Nathalie Mignet
    Published: June 29, 2022 Explor Target Antitumor Ther. 2022;3:398–413
    DOI: https://doi.org/10.37349/etat.2022.00090
    Times Cited: 0
    Open Access
    Polyester materials for mRNA delivery
    Messenger RNA (mRNA) has recently made important progress in clinical implementation, offering a promising therapeutic option for infectious disease and cancer. However, the nature of mRNA molecules [...] Read more.
    Wang Chen ... Dandan Zhu
    Published: March 11, 2022 Explor Target Antitumor Ther. 2022;3:117–127
    DOI: https://doi.org/10.37349/etat.2022.00075
    Open Access
    Engineered phosphorus dendrimers as powerful non-viral nanoplatforms for gene delivery: a great hope for the future of cancer therapeutics
    During the past two decades, tremendous progress has been made in the dendrimer-based delivery of therapeutic molecules including, for instance, small molecules, macromolecules, and genes. This revi [...] Read more.
    Serge Mignani ... Jean-Pierre Majoral
    Published: February 25, 2022 Explor Target Antitumor Ther. 2022;3:50–61
    DOI: https://doi.org/10.37349/etat.2022.00071