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    Molecular Diagnosis and Personalized Therapy of Cancer

    Submission Deadline: October 30, 2023

    Guest Editors

    Prof. Monica Fedele E-Mail

    Research Director, Institute for Experimental Endocrinology and Oncology Gaetano Salvatore (IEOS), Department of Biomedical Sciences, National Research Council (CNR), Naples, Italy


    Prof. Andrea Vecchione E-Mail

    Full Professor of Pathologic Anatomy, University of Rome La Sapienza, c/o Azienda Ospedaliero-Universitaria Sant'Andrea, Rome, Italy


    About the Special Issue

    Cancer is a highly heterogeneous and dynamic disease that evolves from the accumulation of genetic and epigenetic mutations affecting key driver molecules responsible for the malignant and chemo-resistant phenotype.

    In recent years, there has been a groundbreaking expansion in technological advances and therapeutic innovations in cancer medicine. Cancer diagnostics have begun moving away from sole reliance on direct biopsy of tumor tissue for cancer detection, diagnosis, and treatment monitoring. Consequently, pathologists have flanked molecular diagnosis to the morphological approach to discriminate within each tumor type, specific subtypes with different clinical outcomes. As a result, the classification of tumors has changed to include both morphological and molecular criteria. For most cancer types, specific biomarkers have been characterized, which can predict the success of specific therapy and are themselves targets of the treatment. However, each of these factors is influenced by the unique genetic signature, which may affect the expressivity of the malignant phenotype and its response to pharmacological approaches. Therefore, it becomes increasingly imperative to personalize cancer treatment by tailoring the best treatment approach to the patient.

    With this special issue, we would like to summarize current knowledge on the latest molecular approaches to personalized cancer diagnosis and therapy and welcome any contribution, including original research articles, reviews, opinions, and hypotheses, which may open a discussion on new perspectives about this topic.

    Keywords: biomarker, targeted therapy, personalized cancer medicine, molecular signature

    Call for Papers

    Published Articles

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    • Aims and Scope
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    • Ongoing Special Issues
      Off-Label Drugs and -Omics Data in Cancer Treatment
      COVID-19 and Cancer
      Antibody-Drug Conjugates
      The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy
      Gene Delivery Approach to Fight Cancer
      The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
      Cancer Immunotherapy and Tumor Microenvironment
      Theranostic Frontiers in Neuro-Oncology
      Plant Extracts as an Infinite Resource for New Anticancer Agents
      Cancer Stem Cell Targeting Therapy
      Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
      Artificial Intelligence for Precision Oncology
      Innovative Strategies to Target Triple-negative Breast Cancer
      DNA Damage as Target for Therapeutic Intervention
      Therapeutic Targeting of the Tumor Microenvironment
      Molecular Targeted Therapy for Cancer
      Novel Strategies and Targets for Immunotherapy of Cancer
      Molecular Diagnosis and Personalized Therapy of Cancer
      Recent Approaches in Tumor Metabolism
      Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
      Emerging Screening Technologies in Drug Discovery
      Integrated Approaches for Non-Small-Cell Lung Cancer
      Posttranslational Modifications in Health and Disease
      Therapeutic Targeting of Tumor Metabolism
      Cancer Epigenetics: Implications for Novel Therapeutic Strategies
      Current Innovative Cancer Treatment
    • Completed Special Issues
      Liquid Biopsy in Thoracic Cancer
      Targeting Transcription Factors for Cancer Therapy
      Immunotherapy in Cancer Patients
      Calcium Signaling Apparatus in Cancers
      Proteolysis Targeting Chimera (PROTAC)
      Precision Medicine for Cholangiocarcinoma
      Endocrine Resistant Breast Cancer
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