• About the Journal
    Exploration of Targeted Anti-tumor Therapy, a peer-reviewed, open access online journal, publishes articles on all aspects of cancer research, including clinical diagnosis and analysis, case report, prevention, intervention treatment, pre-clinical and clinical trials of all types of cancers. Submissions with good originality, well-designed experiments and rigorous data are particularly welcomed.
    From the Editors-in-Chief
    It is a particularly exciting time to be involved in cancer research and I am delighted to take on the role of co-Editor-in-Chief of the new journal Exploration of Targeted Anti-tumor Therapy. The journal will provide a platform for publication of studies on all aspects of the development of targeted anti-cancer drugs and will appeal to a broad range of readers. I look forward to receiving submissions of your manuscripts describing cutting-edge research in this fast moving and important field.
    Graham Packham
    Co-Editor-in-Chief of Exploration of Targeted Anti-tumor Therapy
    I am really honored to take on the role of co-Editor-in-Chief of this new journal—Exploration of Targeted Anti-tumor Therapy. Like many colleagues, I spent a large part of my professional life researching new cancer therapies. The efforts of the scientific community have allowed the development of targeted therapies to affect significantly the course of the main tumors. In this scenario, ETAT wants to represent a platform for discussion and evaluation on all aspects related to the development of targeted therapies, from the identification of the target to its validation and clinical exploration, including the evaluation of biomarkers of activity and toxicity. We therefore await your contributions to build together a place of confrontation that favors scientific progress in the field of target therapies.
    Nicola Normanno
    Co-Editor-in-Chief of Exploration of Targeted Anti-tumor Therapy
    Latest Articles
    Open Access
    The impact of tumour pH on cancer progression: strategies for clinical intervention
    Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasi...
    Carol Ward ... Simon P Langdon
    Online First: April 09, 2020 Explor Target Antitumor Ther. 2020;1:Online First
    DOI: https://doi.org/10.37349/etat.2020.00005
    Open Access
    Original Article
    Implementation of an NGS panel for clinical practice in paraffin-embedded tissue samples from locally advanced and metastatic melanoma patients
    Aim: Single biomarker diagnostic test of BRAFV600 locus in metastatic melanoma is mandatory for treatment decision; however, multiple-gene based techniques, such as targeted next-generation sequenc...
    Paola Castillo ... Cristina Teixido
    Online First: April 1, 2020 Explor Target Antitumor Ther. 2020;1:Online First
    DOI: https://doi.org/10.37349/etat.2020.00006
    Open Access
    Colorectal cancer genomic biomarkers in the clinical management of patients with metastatic colorectal carcinoma
    Colorectal carcinoma (CRC) is an heterogeneous disease in which different genetic alterations play a role in its pathogenesis and progression and offer potential for therapeutic intervention. The re...
    Anna Maria Rachiglio ... Nicola Normanno
    Published: February 29, 2020 Explor Target Antitumor Ther. 2020;1:53-70
    DOI: https://doi.org/10.37349/etat.2020.00004
    Open Access
    Inhibitors of the Fanconi anaemia pathway as potential antitumour agents for ovarian cancer
    The Fanconi anaemia (FA) pathway is an important mechanism for cellular DNA damage repair, which functions to remove toxic DNA interstrand crosslinks. This is particularly relevant in the context of...
    Sarah J Taylor ... Simon P Langdon
    Published: February 29, 2020 Explor Target Antitumor Ther. 2020;1:26-52
    DOI: https://doi.org/10.37349/etat.2020.00003