Exploration of Asthma & Allergy

Special Issue Topic

Precision Medicine in Allergy and Rhinology

Submission Deadline: April 10, 2023

Guest Editors

Prof. Pongsakorn Tantilipikorn; E-Mail

Associate Professor, and Chairperson, Center of Research Excellent in Allergy & Immunology, Assistant President in Research & Academic Affairs, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Research Keywords: Allergic Rhinitis, Allergen Immunotherapy, Rhinosinusitis, Airway Inflammation, Molecular Allergy

Dr. Dichapong Kanjanawasee E-Mail

Center of excellent research of Allergy and Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Research Keywords: Precision Medicine, Molecular Diagnosis, Allergen-specific Immunotherapy, Chronic Rhinosinusitis, Allergic Rhinitis

About the Special Issue

Precision medicine has become popular over the recent years. Precision medicine is defined as a personalized approach that incorporates an individual's genetics, environment, and lifestyle to help determine the management and prevention of diseases. It can enhance the efficacy of the treatment regime and thus, lower the cost. Currently, precision medicine is hugely involved in the field of allergy and rhinology and there are challenges to be implemented.The goal of this special issue is to bring together the updates on precision medicine in rhinology and allergy.

Keywords: Precision Medicine, Personalized Medicine, Biologics, Molecular Diagnosis, Component Resolved Diagnosis, Allergen-specific Immunotherapy

Call for Papers

Published Articles

Open Access

Review

Precision medicine: how to approach the adolescent asthmatic
It is well known that adolescent patients often have less than optimal outcomes. Adolescence is a time of much transition, physically, emotionally, and socially all of which have effects on asthma m [...] Read more.

It is well known that adolescent patients often have less than optimal outcomes. Adolescence is a time of much transition, physically, emotionally, and socially all of which have effects on asthma management and outcomes. Pubertal changes affect asthma, but mostly it is the move towards independence from the parents, peer pressures, stigma of illness, and adherence issues that cause the issue. It is thus important to learn to treat the patient directly, wherein currently often children are treated through the parent, to ensure success.

Alan Kaplan

Published: October 31, 2023 Explor Asthma Allergy. 2023;1:153–162
DOI: https://doi.org/10.37349/eaa.2023.00016

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It is well known that adolescent patients often have less than optimal outcomes. Adolescence is a time of much transition, physically, emotionally, and socially all of which have effects on asthma management and outcomes. Pubertal changes affect asthma, but mostly it is the move towards independence from the parents, peer pressures, stigma of illness, and adherence issues that cause the issue. It is thus important to learn to treat the patient directly, wherein currently often children are treated through the parent, to ensure success.

Open Access

Original Article

Assessing chronic rhinosinusitis with nasal polyps severity by “Japanese epidemiological survey of refractory eosinophilic chronic rhinosinusitis” algorithm
Aim: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease with different subtypes that affect patients’ quality of life. This study aim to evaluate the severity of CRSwNP and [...] Read more.

Aim:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease with different subtypes that affect patients’ quality of life. This study aim to evaluate the severity of CRSwNP and the risk of treatment resistance using the “Japanese epidemiological survey of refractory eosinophilic chronic rhinosinusitis” (JESREC) algorithm in outpatients at a university hospital.

Methods:

A retrospective study was conducted reviewing the medical records of CRSwNP outpatients. Clinical data including age, sex, blood eosinophilia, computered tomography (CT) scans, presence of asthma, and nonsteroidal anti-inflammatory drug (NSAID) use were assessed.

Results:

Medical records of 83 patients diagnosed with CRSwNP were analyzed, with 44 (53%) females and 39 (47%) males. The mean age was 61.8 years ± 14.1 years (range: 19–90 years). According to the JESREC algorithm, 9 (10.8%) patients were categorized as non-eosinophilic chronic rhinosinusitis (neCRS), and 74 (89%) were classified as eosinophilic chronic rhinosinusitis (eCRS). Among the eCRS patients, 13 (17.6%) were mild, 32 (43.2%) were moderate, and 29 (39.2%) were severe. Asthma was identified as a comorbidity in 57 patients (68.6%).

Conclusions:

A predominance of eCRS with moderate to severe risk of treatment resistance was confirmed. Considering the heterogeneity of chronic rhinosinusitis (CRS), the JESREC algorithm comes up as an instrument that uses objective criteria to assess higher risks of recurrency and refractoriness among patients before surgical treatment, helping to predict type2-driven biologics need.

Sérgio Duarte Dortas ... Solange Oliveira Rodrigues Valle

Published: June 16, 2023 Explor Asthma Allergy. 2023;1:49–54
DOI: https://doi.org/10.37349/eaa.2023.00007

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Aim:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease with different subtypes that affect patients’ quality of life. This study aim to evaluate the severity of CRSwNP and the risk of treatment resistance using the “Japanese epidemiological survey of refractory eosinophilic chronic rhinosinusitis” (JESREC) algorithm in outpatients at a university hospital.

Methods:

A retrospective study was conducted reviewing the medical records of CRSwNP outpatients. Clinical data including age, sex, blood eosinophilia, computered tomography (CT) scans, presence of asthma, and nonsteroidal anti-inflammatory drug (NSAID) use were assessed.

Results:

Medical records of 83 patients diagnosed with CRSwNP were analyzed, with 44 (53%) females and 39 (47%) males. The mean age was 61.8 years ± 14.1 years (range: 19–90 years). According to the JESREC algorithm, 9 (10.8%) patients were categorized as non-eosinophilic chronic rhinosinusitis (neCRS), and 74 (89%) were classified as eosinophilic chronic rhinosinusitis (eCRS). Among the eCRS patients, 13 (17.6%) were mild, 32 (43.2%) were moderate, and 29 (39.2%) were severe. Asthma was identified as a comorbidity in 57 patients (68.6%).

Conclusions:

A predominance of eCRS with moderate to severe risk of treatment resistance was confirmed. Considering the heterogeneity of chronic rhinosinusitis (CRS), the JESREC algorithm comes up as an instrument that uses objective criteria to assess higher risks of recurrency and refractoriness among patients before surgical treatment, helping to predict type2-driven biologics need.

Guest Editors

About the Special Issue

Call for Papers

Published Articles

Aim:

Methods:

Results:

Conclusions:

Aim:

Methods:

Results:

Conclusions: