• Special Issue Topic

    Drug-induced Liver Injury: From Bench to Clinical Application

    Submission Deadline: December 15, 2022

    Guest Editors

    Prof. Jose C Fernandez-Checa E-Mail

    Spanish National Research Council at the Institute of Biomedical Research of Barcelona (IIBB-CSIC); Institute of Biomedical Research August Pi i Sunyer (IDIBAPS); CIBEREHD

    Research Keywords: mitochondria, ASH, NASH, liver cancer, cholesterol

    Prof. Wen-Xing Ding E-Mail

    University of Kansas Medical Center, Kansas City, KS, USA

    Research Keywords: autophagy, mitochondria, alcohol associated liver disease, alcohol-associated pancreatitis, drug-induced liver injury (DILI), lipid metabolism

    About the Special Issue

    Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and a leading reason for drug withdrawal from the market. Unlike intrinsic DILI, which is predictable, reproducible, and dose-dependent, idiosyncratic DILI is unpredictable, not strictly dose-dependent, and although rare it accounts for 10% to 15% of ALF cases in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a major health issue for which there is a pressing need to find novel and effective therapies. Although significant progress has been made in understanding the molecular mechanisms underlying DILI, our incomplete knowledge of its pathogenesis and inability to predict DILI is largely due to both discordance between human and animal DILI in preclinical drug development and a lack of models that faithfully recapitulate complex pathophysiological features of human DILI. This is exemplified by the hepatotoxicity of acetaminophen (APAP) overdose, a major cause of ALF because of its extensive worldwide use as an analgesic. Despite recent progress with current animal and in vitro models, the mechanisms involved in the hepatotoxicity of APAP are still not fully understood. 

    In this Special Issue, we invite experts in the field to cover a wide range of topics of interest in enhancing our current understanding of DILI, from novel technological and in vitro approaches to metabolomics profile and computational modelling as well as clinical implications and registry. Our hope is to collect a state-of-the-art collection of articles that may stimulate mutidisciplinary research in this critical field of basic and clinical liver research.

    Keywords: Acetaminophen hepatotoxicity; iPSC; metabolomics; computational modelling; microbiota; idiosyncratic DILI.

    Published Articles

    Open Access
    Deciphering the liver enigma: distinguishing drug-induced liver injury and metabolic dysfunction-associated steatotic liver disease—a comprehensive narrative review
    Drug-induced liver injury (DILI) poses a complex and heterogeneous clinical challenge, which often resembles non-drug related acute or chronic liver diseases, such as metabolic dysfunction-associate [...] Read more.
    Miren García-Cortés ... Alberto García-García
    Published: December 27, 2023 Explor Dig Dis 2023;2:318–336
    DOI: https://doi.org/10.37349/edd.2023.00034
    Times Cited: 0
    Open Access
    Original Article
    An analysis on the clinical features and risk factors associated with the prognosis of patients with drug-induced liver injury
    Aim: This is a Chinese population-based study aimed to determine the causes and clinical features of drug-induced liver injury (DILI) from traditional Chinese medicines (TCMs) and current Western m [...] Read more.
    Qian Wei ... Jinsheng Guo
    Published: June 30, 2023 Explor Dig Dis. 2023;2:100–117
    DOI: https://doi.org/10.37349/edd.2023.00021
    Times Cited: 0
    Open Access
    Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
    The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a [...] Read more.
    Hanghang Wu ... Francisco Javier Cubero
    Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
    DOI: https://doi.org/10.37349/edd.2023.00020
    Times Cited: 0
    Open Access
    Liver injury related to Japanese herbal medicines: clinical features and diagnosis
    The word “Kampo medicine” means the traditional Japanese herbal medicine. Even “natural herb” can cause drug-induced liver injury (DILI). In this review, the characteristics of Kampo medicin [...] Read more.
    Naoki Mantani
    Published: June 27, 2023 Explor Dig Dis. 2023;2:77–82
    DOI: https://doi.org/10.37349/edd.2023.00019
    Times Cited: 0
    Open Access
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    Open Access
    Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions
    The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) a [...] Read more.
    Alejandro Cueto-Sánchez ... Marina Villanueva-Paz
    Published: April 26, 2023 Explor Dig Dis. 2023;2:56–76
    DOI: https://doi.org/10.37349/edd.2023.00018
    Times Cited: 0