• Special Issue Topic

    Cross Talk Among Skin Cells and Immune Cells

    Submission Deadline: June 30, 2021

    Guest Editor

    Dr. Masutaka Furue E-Mail

    Professor and Chair, Department of Dermatology; Director, Research and Clinical Center for Yusho and Dioxin, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Research Keywords: Atopic dermatitis, aryl hydrocarbon receptor, antioxidant, melanoma, skin disease, dioxin

    About the Special Issue

    As the skin is an interface organ between the body and external harsh atmosphere, it is equipped with barrier-forming skin cells and highly sophisticated immune cells providing innate and acquired immunity. Recent therapeutic advances such as biologics underpin a notion that selective cross talk among skin cells and specific immune cells develops a variety of skin diseases. For instance, psoriasis is driven by IL-23/IL-17A axis in concert with TNF-α axis. The IL-13/IL-4-induced JAK/STAT6&STAT3 activation is the major pathogenic pathway for the development atopic dermatitis. Th1-driven melanocyte damage is suspected in vitiligo. Stem cell transplantation is highlighted in the treatment of patients with severe systemic sclerosis. Immune checkpoint imhibitors are now indispensable treatment option for melanoma and other malignant neoplsams. These therapeutic evidence points that the characterization and evaluation of the cross talks among skin and immune cells may provide a clue to develop new targeted drugs for the immuner-related cutaneous diseases.

    In this Special Issue, we will publish cutting-edge information including keratinocytes, fibroblasts, dendritic cells, Th1/Th2/Th17/Treg cells, innate lymphoid cells, NK cells, and cyto-chemokines. We warmly welcome your submissions including original papers and reviews.

    Keywords: Keratinocytes, fibroblasts, dendritic cells, Th1/Th2/Th17/Treg cells, innate lymphoid cells, NK cells, and cyto-chemokines

    Published Articles

    Open Access
    Crosstalk between keratinocytes and immune cells in inflammatory skin diseases
    Cutaneous homeostasis is maintained by dynamic cellular communications between different cell types in the skin through interactions with various mediators, including cytokines, chemokines and antim [...] Read more.
    Xinhui Ni, Yuping Lai
    Published: December 31, 2021 Explor Immunol. 2021;1:418–431
    DOI: https://doi.org/10.37349/ei.2021.00028
    Open Access
    Skin and immune cells crosstalk via circadian regulations
    Both innate and adaptive immune cells exist in the skin, predominantly in the dermis layer. Recent studies have focused on how and which circadian rhythms contribute to maintain good health. Over re [...] Read more.
    Kanami Orihara
    Published: October 31, 2021 Explor Immunol. 2021;1:285–294
    DOI: https://doi.org/10.37349/ei.2021.00019
    Open Access
    Original Article
    The two faces of mast cells in vitiligo pathogenesis
    Aim: Previously, we reported increased number of T helper 17 (Th17) cells in vitiligo. However, in our recent study, tryptase and interleukin (IL)17 double positive cells which identified by polycl [...] Read more.
    Ichiro Katayama ... Mari Wataya-Kaneda
    Published: October 31, 2021 Explor Immunol. 2021;1:269–284
    DOI: https://doi.org/10.37349/ei.2021.00018
    Times Cited: 0
    Open Access
    Original Article
    Serum profiles of tryptophan-kynurenine pathway metabolites in psoriasis
    Aim: Chronic inflammation is closely associated with tryptophan (TRP)-kynurenine (KYN) metabolic pathway. However, TRP-KYN pathway has not been fully elucidated in psoriasis, a systemic inflammator [...] Read more.
    Mariko Seishima ... Kuniaki Saito
    Published: October 31, 2021 Explor Immunol. 2021;1:258–268
    DOI: https://doi.org/10.37349/ei.2021.00017
    Open Access
    Macrophages and fibroblasts underpin skin immune responses
    There are various types of skin immune responses including inflammatory skin diseases and skin malignancy. Macrophages and fibroblasts are skin resident cells that had been overlooked in terms of im [...] Read more.
    Makoto Sugaya
    Published: August 31, 2021 Explor Immunol. 2021;1:226–242
    DOI: https://doi.org/10.37349/ei.2021.00015
    Times Cited: 0
    Open Access
    Vitamin D and immunomodulation in the skin: a useful affirmative nexus
    Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune r [...] Read more.
    Saptadip Samanta
    Published: June 30, 2021 Explor Immunol. 2021;1:90–111
    DOI: https://doi.org/10.37349/ei.2021.00009
    Times Cited: 0
    Open Access
    Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
    Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 rece [...] Read more.
    Masutaka Furue, Mihoko Furue
    Published: April 30, 2021 Explor Immunol. 2021;1:37–47
    DOI: https://doi.org/10.37349/ei.2021.00005
    Open Access
    The role of interleukin-24 in atopic dermatitis
    Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl  [...] Read more.
    Yen Hai Vu ... Gaku Tsuji
    Published: April 30, 2021 Explor Immunol. 2021;1:4–15
    DOI: https://doi.org/10.37349/ei.2021.00002
    Times Cited: 0