Dr. Masutaka Furue E-Mail
Professor and Chair, Department of Dermatology; Director, Research and Clinical Center for Yusho and Dioxin, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Research Keywords: atopic dermatitis, aryl hydrocarbon receptor, antioxidant, melanoma, skin disease, dioxin
As the skin is an interface organ between the body and external harsh atmosphere, it is equipped with barrier-forming skin cells and highly sophisticated immune cells providing innate and acquired immunity. Recent therapeutic advances such as biologics underpin a notion that selective cross talk among skin cells and specific immune cells develops a variety of skin diseases. For instance, psoriasis is driven by IL-23/IL-17A axis in concert with TNF-α axis. The IL-13/IL-4-induced JAK/STAT6&STAT3 activation is the major pathogenic pathway for the development atopic dermatitis. Th1-driven melanocyte damage is suspected in vitiligo. Stem cell transplantation is highlighted in the treatment of patients with severe systemic sclerosis. Immune checkpoint imhibitors are now indispensable treatment option for melanoma and other malignant neoplsams. These therapeutic evidence points that the characterization and evaluation of the cross talks among skin and immune cells may provide a clue to develop new targeted drugs for the immuner-related cutaneous diseases.
In this Special Issue, we will publish cutting-edge information including keratinocytes, fibroblasts, dendritic cells, Th1/Th2/Th17/Treg cells, innate lymphoid cells, NK cells, and cyto-chemokines. We warmly welcome your submissions including original papers and reviews.
Keywords: keratinocytes, fibroblasts, dendritic cells, Th1/Th2/Th17/Treg cells, innate lymphoid cells, NK cells, and cyto-chemokines