• Special Issue Topic

    Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer

    Submission Deadline: October 31, 2023

    Guest Editor

    Prof. Hailin Tang E-Mail

    Professor, Department of Experiment and Research, Sun Yat-Sen University Cancer Center, Guangzhou, China

    Research Keywords: Molecular mechanisms of malignant tumor pathogenesis and metastasis

    About the Special Issue

    As reported by the World Health Organization, cancer continues to rank as a leading cause of death around the world. Recent studies have shown that immune checkpoint therapy is effective in a variety of advanced solid tumors and is becoming a hotspot for research into antitumor drugs. The development of immune checkpoint therapies targeting PD-L1 and PD-1 has resulted in significant improvements for various cancers. However, some kinds of cancer were regarded as immune-quiescent tumor, which means only a small proportion of patients would benefit from immunotherapy in addition to a high rate of severe adverse events. Therefore, developing new strategy to target the tumor microenvironment factors is important for cancer immunotherapy.

    This topic is centered around all aspects of the immunotherapies targeting the tumor microenvironment of different cancers, including but not limited to immune checkpoint therapy, cancer related stroma cells, exhausted immune T cells, and immunotherapeutic drug delivery systems.

    Potential topics to be covered:

    • Novel immune cells or molecules in the cancer microenvironment

    • Mechanism of immune escape in cancer

    • Tumor microenvironment and cancer stem cells

    • Strategies to overcome immunotherapy resistance in cancer

    • New strategies to enhance immunotherapy effects

    • Personalized immunotherapy for cancer

    • Biomarkers for immunotherapy prediction

    • Lipid metabolism in immunotherapy

    • Exosomes in the cancer microenvironment

    • Immunotherapeutic drug delivery systems

    Keywords: Tumor microenvironment, cancer immunotherapy, PD-L1, immune escape, biomarker, multi-omics analysis

    Call for Papers

    Published Articles

    Open Access
    Emerging roles of type 1 innate lymphoid cells in tumour pathogenesis and cancer immunotherapy
    Innate lymphoid cells (ILCs) are the most recently discovered class of innate immune cells found to have prominent roles in various human immune-related pathologies such as infection and autoimmune  [...] Read more.
    James Michael Verner ... Eric Jou
    Published: April 23, 2024 Explor Target Antitumor Ther. 2024;5:296–315
    DOI: https://doi.org/10.37349/etat.2023.00219
    Times Cited: 0
    Open Access
    Melatonin, BAG-1 and cortisol circadian interactions in tumor pathogenesis and patterned immune responses
    A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in many studies [...] Read more.
    George Anderson
    Published: October 25, 2023 Explor Target Antitumor Ther. 2023;4:962–993
    DOI: https://doi.org/10.37349/etat.2023.00176