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Exploration of Targeted Anti-tumor Therapy
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  • Special Issue Topic

    Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer

    Submission Deadline: October 31, 2023

    Guest Editor

    Prof. Hailin Tang E-Mail

    Professor, Department of Experiment and Research, Sun Yat-Sen University Cancer Center, Guangzhou, China

    Research Keywords: Molecular mechanisms of malignant tumor pathogenesis and metastasis


    About the Special Issue

    As reported by the World Health Organization, cancer continues to rank as a leading cause of death around the world. Recent studies have shown that immune checkpoint therapy is effective in a variety of advanced solid tumors and is becoming a hotspot for research into antitumor drugs. The development of immune checkpoint therapies targeting PD-L1 and PD-1 has resulted in significant improvements for various cancers. However, some kinds of cancer were regarded as immune-quiescent tumor, which means only a small proportion of patients would benefit from immunotherapy in addition to a high rate of severe adverse events. Therefore, developing new strategy to target the tumor microenvironment factors is important for cancer immunotherapy.

    This topic is centered around all aspects of the immunotherapies targeting the tumor microenvironment of different cancers, including but not limited to immune checkpoint therapy, cancer related stroma cells, exhausted immune T cells, and immunotherapeutic drug delivery systems.

    Potential topics to be covered:

    • Novel immune cells or molecules in the cancer microenvironment

    • Mechanism of immune escape in cancer

    • Tumor microenvironment and cancer stem cells

    • Strategies to overcome immunotherapy resistance in cancer

    • New strategies to enhance immunotherapy effects

    • Personalized immunotherapy for cancer

    • Biomarkers for immunotherapy prediction

    • Lipid metabolism in immunotherapy

    • Exosomes in the cancer microenvironment

    • Immunotherapeutic drug delivery systems

    Keywords: Tumor microenvironment, cancer immunotherapy, PD-L1, immune escape, biomarker, multi-omics analysis

    Call for Papers

    Published Articles

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    • Aims and Scope
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    • Ongoing Special Issues
      Off-Label Drugs and -Omics Data in Cancer Treatment
      COVID-19 and Cancer
      Antibody-Drug Conjugates
      The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy
      Gene Delivery Approach to Fight Cancer
      The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
      Cancer Immunotherapy and Tumor Microenvironment
      Theranostic Frontiers in Neuro-Oncology
      Plant Extracts as an Infinite Resource for New Anticancer Agents
      Cancer Stem Cell Targeting Therapy
      Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
      Artificial Intelligence for Precision Oncology
      Innovative Strategies to Target Triple-negative Breast Cancer
      DNA Damage as Target for Therapeutic Intervention
      Therapeutic Targeting of the Tumor Microenvironment
      Molecular Targeted Therapy for Cancer
      Novel Strategies and Targets for Immunotherapy of Cancer
      Molecular Diagnosis and Personalized Therapy of Cancer
      Recent Approaches in Tumor Metabolism
      Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
      Emerging Screening Technologies in Drug Discovery
      Integrated Approaches for Non-Small-Cell Lung Cancer
      Posttranslational Modifications in Health and Disease
      Therapeutic Targeting of Tumor Metabolism
      Cancer Epigenetics: Implications for Novel Therapeutic Strategies
      Current Innovative Cancer Treatment
    • Completed Special Issues
      Liquid Biopsy in Thoracic Cancer
      Targeting Transcription Factors for Cancer Therapy
      Immunotherapy in Cancer Patients
      Calcium Signaling Apparatus in Cancers
      Proteolysis Targeting Chimera (PROTAC)
      Precision Medicine for Cholangiocarcinoma
      Endocrine Resistant Breast Cancer
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