• Special Issue Topic

    Medicinal Plants and Bioactive Phytochemicals in Neuroprotection

    Submission Deadline: June 30, 2025

    Guest Editor

    Prof. Marcello Iriti E-Mail

    Professor of Plant Biology and Pathology at the Department of Biomedical, Surgical and Dental Sciences, Milan State University, Milan, Italy

    Research Keywords: Phytotherapeutics, neuroprotection, natural products, neurodegenerative diseases, disease prevention, nutraceuticals

    About the Special Issue

    Medicinal and food plants represent an unlimited source of bioactive phytochemicals available for improving human health and preventing chronic, degenerative diseases. Indeed, a single plant contains hundreds or thousands of active metabolites able to target different mechanisms involved in brain aging and neurodegeneration including oxidative stress, neuroinflammation and immunosenescence associated with the often-irreversible deterioration of intellectual and cognitive faculties, Alzheimer's disease, and Parkinson's disease. From this perspective, phytotherapy and nutritional therapy can represent an effective preventive strategy to counteract the global burden of neurodegenerative disorders in association with physical activity and other lifestyles responsible for healthy ageing. However, for a suitable neuroprotective agent, a very important property is its ability to cross the blood-brain barrier (BBB), to reach target sites of the central nervous system (CNS). A limited number of studies, both in vitro and in animal models, have focused on the ability of phtyochemicals to cross the endothelial cell layer of the BBB, depending on the compound lipophilicity and the activity of specific plasma membrane transporters or receptors. Therefore, a better understanding of the bioavailability of dietary phytochemicals is crucial to correctly evaluate their bioactivity, interpret experimental results and design new approaches, particularly in the CNS. In fact, the biokinetic data supporting their absorption, distribution, metabolism, and excretion in the human body are still fragmentary, despite the huge number of indications on their bioactivity. Finally, although the presence of phytochemical receptors or transporters in brain tissues remains to be ascertained, compounds with multiple targets appear as a potential and promising class of therapeutics for the treatment of diseases of multifactorial etiology.

    Keywords: Neurodegenerative diseases, amyloidosis, oxidative stress, neuroinflammation, neuroaging, immunosenescence, phytotherapeutics, herbal remedies, nutritional therapy, bioactive phytochemicals, nutraceuticals, functional foods, ethnopharmacology

    Call for Papers

    Published Articles

    Open Access
    Neuroprotective prospectives of triterpenoids
    Neurological disorders including neurodegenerative disorders continue to pose significant therapeutic challenges. Triterpenoids, a diverse group of natural compounds found abundantly in plants, poss [...] Read more.
    Apoorva A. Bankar ... Nazma N. Inamdar
    Published: June 26, 2024 Explor Neurosci. 2024;3:231–254
    DOI: https://doi.org/10.37349/en.2024.00047
    Times Cited: 0
    Open Access
    Mini Review
    Neuroprotective compounds from three common medicinal plants of West Bengal, India: a mini review
    Neural disorders refer to conditions of the nervous system due to infection or degeneration of the neurons leading to either neurodegenerative disorder or neuropsychiatric disorder. Some such disord [...] Read more.
    Suvendu Ghosh ... Debosree Ghosh
    Published: December 26, 2023 Explor Neurosci. 2023;2:307–317
    DOI: https://doi.org/10.37349/en.2023.00030
    Times Cited: 0