• Special Issue Topic

    Biomaterials and Biomarkers in Dentistry: Up to Date

    Submission Deadline: December 31, 2023

    Guest Editor

    Prof. Gaetano Isola E-Mail

    Professor, Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Catania, Italy

    Research Keywords: periodontal disease, periodontal regeneration, biomaterials, salivary diagnostics, oral medicine, biomarkers, oral health, general health, quality of life

    About the Special Issue

    In the current era of tissue engineering and regenerative medicine tactics, biomaterials in dentistry are key research areas, and these new advances define the new Frontier in many medical disciplines. Biomaterials play a crucial part in the growth of maxillofacial regenerative therapies, allowing for more complex oral rehabilitation for patients with missing teeth.

    Moreover, as evidenced by current scientific literature, the development of new molecular biomarkers constitutes a highly creative and successful diagnostic and therapeutic strategy. The classification of patients based on changes in local/systemic levels of biomolecules may result in the customization of the whole therapy pathway. Oral health professionals—both clinicians and researchers—have accepted the challenge in order to close the gap with other medical disciplines where customized therapy is a well-established reality. For breast cancer and melanoma, genetic typing of the tumor/patient has led to a remarkable improvement in early diagnosis and the identification of treatment targets, altering prognosis and survival significantly.

    Despite good observations in animal models and excellent outcomes reported for several existing regenerative procedures and materials in people, there is a lack of rigorous evidence on the extent to which reported clinical benefits represent real bone and periodontal regeneration.

    Consequently, the purpose of this Special Issue is to update and consolidate the existing information on the influence of biomaterials in reconstructive bone and defects and atrophies utilizing various types of biomaterials to improve periodontal wound healing or regeneration.

    We invite interventional research that aim to further our understanding of the efficacy of biomaterials and biomarkers in dentistry. Review studies, particularly those employing conceptual frameworks, on any of the aforementioned themes are also encouraged.

    Keywords: biomaterials, periodontal regeneration, bone regeneration, adjuvants, periodontal disease, peri-implant disease, growth factors, oral surgery, periodontal surgery

    Call for Papers

    Published Articles

    Open Access
    Original Article
    Relationship between gingival and peri-implant sulcular fluid active matrix metalloproteinase-8 concentration and clinical indices in healthy and diseased conditions
    Aim: The study was to evaluate the active matrix metalloproteinase-8 (aMMP-8) concentration in gingival crevicular fluid (GCF) and in peri-implant sulcular fluid (PISF) in healthy and diseased co [...] Read more.
    Renzo Guarnieri ... Luca Testarelli
    Published: April 22, 2024 Explor Med. 2024;5:243–256
    DOI: https://doi.org/10.37349/emed.2024.00219
    Times Cited: 0
    Open Access
    Original Article
    The most suitable system to grind the whole tooth to use it as graft material
    Aim: In regenerative dentistry, the success is influenced by the graft material, which should act as an osteoconductive scaffold. It provides a mineral substrate during resorption and induces the [...] Read more.
    Elio Minetti ... Francesco Inchingolo
    Published: February 06, 2024 Explor Med. 2024;5:1–16
    DOI: https://doi.org/10.37349/emed.2024.00202
    Times Cited: 0
    Open Access
    Case Report
    A successful case of maturogenesis by stepwise excavation using calcium-enriched mixture cement
    This case report demonstrates the successful induction of apexogenesis in an extensively carious lower right first molar with immature roots through the use of stepwise excavation and calcium-enrich [...] Read more.
    Saeed Asgary, Laleh Alim Marvasti
    Published: October 27, 2023 Explor Med. 2023;4:733–738
    DOI: https://doi.org/10.37349/emed.2023.00173
    Times Cited: 0
    Open Access
    Impact exerted by scaffolds and biomaterials in periodontal bone and tissue regeneration engineering: new challenges and perspectives for disease treatment
    The periodontium is an appropriate target for regeneration, as it cannot restore its function following disease. Significantly, the periodontium’s limited regenerative capacity could be enhanced through the development of novel  [...] Read more.
    Simona Santonocito ... Gaetano Isola
    Published: April 26, 2023 Explor Med. 2023;4:215–234
    DOI: https://doi.org/10.37349/emed.2023.00135
    Times Cited: 0