• Exploration of Medicine

    eISSN: 2692-3106
    EiC: Lindsay A. Farrer, PhD
    Frequency: Bimonthly
    APC: No Article Processing Charge before January 31, 2025
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: Scopus, Google Scholar, DOAJ, CAS, etc.
    Follow the journal:
    Follow the journal:
    Articles
    Open Access
    Original Article
    Relationship between gingival and peri-implant sulcular fluid active matrix metalloproteinase-8 concentration and clinical indices in healthy and diseased conditions
    Aim: The study was to evaluate the active matrix metalloproteinase-8 (aMMP-8) concentration in gingival crevicular fluid (GCF) and in peri-implant sulcular fluid (PISF) in healthy and diseased co [...] Read more.
    Renzo Guarnieri ... Luca Testarelli
    Published: April 22, 2024 Explor Med. 2024;5:243–256
    DOI: https://doi.org/10.37349/emed.2024.00219
    This article belongs to the special issue Biomaterials and Biomarkers in Dentistry: Up to Date
    View:31
    Download:4
    Times Cited: 0
    Open Access
    Original Article
    Cellular adenylate energy charge and adenine nucleotides in brain tissue during hypoglycemia in newly born BALB/c mice pups
    Aim: Hypoglycemia occurs in the neonatal period but the exact pathophysiology of the resulting brain injury at the cellular level is not well known. Therefore, a neonatal murine model was develop [...] Read more.
    Hassib Narchi ... Radhakrishnan Subramanian
    Published: April 22, 2024 Explor Med. 2024;5:232–242
    DOI: https://doi.org/10.37349/emed.2024.00218
    View:35
    Download:5
    Times Cited: 0
    Open Access
    Review
    Medicinal and immunological aspects of bacteriophage therapy to combat antibiotic resistance
    Bacteriophages are viruses that infect bacterial cells and use their machinery to reproduce. This unique characteristic holds immense promise for combating antibiotic-resistant bacterial infections, [...] Read more.
    Isra Noor ... Ahmad Syibli Othman
    Published: April 22, 2024 Explor Med. 2024;5:215–231
    DOI: https://doi.org/10.37349/emed.2024.00217
    View:69
    Download:9
    Times Cited: 0
    Open Access
    Original Article
    The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer’s disease in the Framingham Heart Study
    Aim: Endothelial dysfunction has been associated with both cerebrovascular pathology and Alzheimer’s disease (AD). However, the connection between circulating endothelial cells and the risk of  [...] Read more.
    Yixuan Wang ... Wei Qiao Qiu
    Published: April 12, 2024 Explor Med. 2024;5:193–214
    DOI: https://doi.org/10.37349/emed.2024.00216
    This article belongs to the special issue Neurophysiological Mechanisms of Aging and Dementia
    View:199
    Download:10
    Times Cited: 0
    Open Access
    Original Article
    The influence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) family history on patients with ME/CFS
    Aim: It is unclear if individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with family histories of ME/CFS differ from those with ME/CFS without this family history. To ex [...] Read more.
    Leonard A. Jason, Sarah Ngonmedje
    Published: April 11, 2024 Explor Med. 2024;5:185–192
    DOI: https://doi.org/10.37349/emed.2024.00215
    View:2399
    Download:29
    Times Cited: 0
    Open Access
    Review
    The coevolution of Covid-19 and host immunity
    The dynamic of the virus-host interaction is subject to constant evolution, which makes it difficult to predict when the SARS-CoV-2 pandemic will become endemic. Vaccines in conjunction with efforts [...] Read more.
    Azizul Haque, Anudeep B. Pant
    Published: April 08, 2024 Explor Med. 2024;5:167–184
    DOI: https://doi.org/10.37349/emed.2024.00214
    This article belongs to the special issue RNA World in Health and Disease
    View:436
    Download:6
    Times Cited: 0
    Open Access
    Review
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging,  [...] Read more.
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. 2022;3:112–127
    DOI: https://doi.org/10.37349/emed.2022.00078
    View:10112
    Download:183
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:9520
    Download:212
    Open Access
    Original Article
    Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
    Aim: Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to e [...] Read more.
    Gregory Giordano ... Angela D. Bryan
    Published: April 26, 2023 Explor Med. 2023;4:254–271
    DOI: https://doi.org/10.37349/emed.2023.00138
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:7681
    Download:236
    Open Access
    Original Article
    A large-scale survey of cannabis use for sleep: preferred products and perceived effects in comparison to over-the-counter and prescription sleep aids
    Aim: Cannabis use for sleep-related problems is on the rise; however, little is known about the cannabis products people are using for sleep or the perceived effects of cannabis in comparison to  [...] Read more.
    Amanda Stueber, Carrie Cuttler
    Published: October 25, 2023 Explor Med. 2023;4:709–719
    DOI: https://doi.org/10.37349/emed.2023.00171
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:7388
    Download:122
    Times Cited: 0
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184–204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:6460
    Download:137
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6013
    Download:246
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443–454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:4593
    Download:1824
    Open Access
    Perspective
    A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exer [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 27, 2022 Explor Med. 2022;3:468–478
    DOI: https://doi.org/10.37349/emed.2022.00108
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:2896
    Download:1416
    Open Access
    Review
    Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing
    Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford [...] Read more.
    Naoko Suga ... Satoru Matsuda
    Published: October 31, 2023 Explor Med. 2023;4:822–838
    DOI: https://doi.org/10.37349/emed.2023.00180
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:1282
    Download:477
    Times Cited: 0
    Open Access
    Perspective
    A U.S. Food and Drug Administration perspective on cannabis research and drug development
    Since the early 1970s, the U.S. Food and Drug Administration (FDA) has received over 800 investigational new drug applications (INDs) for, and pre-INDs pertaining to, research of cannabis or cannabi [...] Read more.
    Cassandra L. Taylor, Schuyler A. Pruyn
    Published: October 31, 2023 Explor Med. 2023;4:813–821
    DOI: https://doi.org/10.37349/emed.2023.00179
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:4329
    Download:262
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6013
    Download:246
    Open Access
    Original Article
    Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
    Aim: Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to e [...] Read more.
    Gregory Giordano ... Angela D. Bryan
    Published: April 26, 2023 Explor Med. 2023;4:254–271
    DOI: https://doi.org/10.37349/emed.2023.00138
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:7681
    Download:236
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6013
    Download:246
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause, values of glomerular filtration [...] Read more.
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42–50
    DOI: https://doi.org/10.37349/emed.2020.00004
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from port [...] Read more.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:5719
    Download:105
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusi [...] Read more.
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85–107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    View:5734
    Download:125
    Open Access
    Meta-Analysis
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem [...] Read more.
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. 2022;3:249–259
    DOI: https://doi.org/10.37349/emed.2022.00089
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:9520
    Download:212
    Special Issues