• Exploration of Medicine

    eISSN: 2692-3106
    EiC: Lindsay A. Farrer, PhD, Boston University School of Medicine
    Frequency: Bimonthly
    APC: No Article Processing Charge
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
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    Articles
    Open Access
    Original Article
    Proof of concept: digital clock drawing behaviors prior to transcatheter aortic valve replacement may predict length of hospital stay and cost of care
    Aims: Reduced pre-operative cognitive functioning in older adults is a risk factor for postoperative complications, but it is unknown if preoperative digitally-acquired clock drawing test (CDT) cognitive screening variables, which allow for more nuanced examination of patient performance, may predict lengthier hospital stay and greater cost of hospital care. This issue is particularly relevant for older adults undergoing transcatheter aortic valve replacement (TAVR), as this surgical procedure is chosen for intermediate-risk older adults needing aortic replacement. This proof of concept research explored if specific latency and graphomotor variables indicative of planning from digitally-acquired command and copy clock drawing would predict post-TAVR duration and cost of hospitalization, over and above age, education, American Society of Anesthesiologists (ASA) physical status classification score, and frailty....
    Margaret Ellenora Wiggins ... Catherine C. Price
    Online First: March 05, 2021 Exploration of Medicine 2021;2:Online First
    DOI: https://doi.org/10.37349/emed.2021.00036
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
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    Times Cited: 0
    Open Access
    Review
    Cell-derived vesicles for delivery of cancer immunotherapy
    In recent years, cancer immunotherapy has received unprecedented attention due to the clinical achievements. The applications of biomedical engineering and materials science to cancer immunotherapy ...
    Jialu Xu, Chao Wang
    Published: February 28, 2021 Explor Med. 2021;2:39-59
    DOI: https://doi.org/10.37349/emed.2021.00031
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:463
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    Times Cited: 0
    Open Access
    Original Article
    Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes
    Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite ...
    Richard Sherva ... Lindsay A. Farrer
    Published: February 28, 2021 Explor Med. 2021;2:60-73
    DOI: https://doi.org/10.37349/emed.2021.00032
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:632
    Download:11
    Times Cited: 0
    Open Access
    Original Article
    A machine learning approach to identify correlates of current e-cigarette use in Canada
    Aim: Popularity of electronic cigarettes (i.e. e-cigarettes) is soaring in Canada. Understanding person-level correlates of current e-cigarette use (vaping) is crucial to guide tobacco policy, but ...
    Rui Fu ... Michael Chaiton
    Published: February 28, 2021 Explor Med. 2021;2:74-85
    DOI: https://doi.org/10.37349/emed.2021.00033
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:627
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    Times Cited: 0
    Open Access
    Original Article
    Assessing the capacity for mental manipulation in patients with statically-determined mild cognitive impairment using digital technology
    Aims: Prior research employing a standard backward digit span test has been successful in operationally defining neurocognitive constructs associated with the Fuster's model of executiv...
    Sheina Emrani ... David J. Libon
    Published: February 28, 2021 Exploration of Medicine 2021;2:86-97
    DOI: https://doi.org/10.37349/emed.2021.00034
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:368
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    Times Cited: 0
    Open Access
    Original Article
    Risk factors in acute diabetic foot syndrome: analysis of 75 consecutive patients referred to a tertiary center in Modena, Italy
    Aim: Diabetic foot syndrome (DFS) is a complication of diabetes in which the presence of infections, ulceration and/or destruction of deep tissue associated with neuropathy, peripheral atherosclero...
    Mauro Maurantonio ... Luca Roncucci
    Published: February 28, 2021 Explor Med. 2021;2:98-109
    DOI: https://doi.org/10.37349/emed.2021.00035
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
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    Times Cited: 0
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