• Exploration of Medicine

    eISSN: 2692-3106
    EiC: Lindsay A. Farrer, PhD, Boston University School of Medicine
    Frequency: Bimonthly
    APC: No Article Processing Charge
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: CAS, DOAJ, Portico, ResearchGate, CNKI Scholar, J-Gate, etc
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    Articles
    Open Access
    Review
    Sex hormones abnormalities in non-alcoholic fatty liver disease: pathophysiological and clinical implications
    Obesity and metabolic syndrome are conditions at high risk for the development of complications such as type 2 diabetes mellitus, atherosclerotic cardiovascular disease, and non-alcoholic fatty live...
    Angelo Di Vincenzo ... Marco Rossato
    Online First: July 19, 2021 Explor Med. 2021;2:Online First
    DOI: https://doi.org/10.37349/emed.2021.00049
    This article belongs to the special issue Exploring NAFLD/NASH
    View:75
    Download:14
    Times Cited: 0
    Open Access
    Commentary
    An engineered mayhem: YAP/TAZ mechanosignaling and hepatocarcinogenesis in NAFLD
    Gyorgy Baffy
    Online First: July 19, 2021 Explor Med. 2021;2:Online First
    DOI: https://doi.org/10.37349/emed.2021.00048
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:53
    Download:12
    Times Cited: 0
    Open Access
    Review
    Wave propagation and reflection in the aorta and implications of the aortic Windkessel
    Some have said that it is inappropriate and perhaps impossible to consider wave and Windkessel phenomena simultaneously. For 50 years, arterial hemodynamics has been dominated by the frequency-domai...
    John V. Tyberg
    Published: June 30, 2021 Explor Med. 2021;2:198-207
    DOI: https://doi.org/10.37349/emed.2021.00042
    This article belongs to the special issue Exploring Aortic Disease
    View:118
    Download:25
    Times Cited: 0
    Open Access
    Review
    Emerging nanomaterials for cancer immunotherapy
    Immunotherapy is a unique approach to treat cancer that targets tumours besides triggering the immune cells. It attempts to harness the supremacy and specificity of immune cells for the regression o...
    Sureshbabu Ram Kumar Pandian ... Krishnan Sundar
    Published: June 30, 2021 Explor Med. 2021;2:208-231
    DOI: https://doi.org/10.37349/emed.2021.00043
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:157
    Download:21
    Times Cited: 0
    Open Access
    Original Article
    Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort
    Aim: Although clinicians primarily diagnose dementia based on a combination of metrics such as medical history and formal neuropsychological tests, recent work using linguistic analysis of narrative...
    Larry Zhang ... Reza Hosseini Ghomi
    Published: June 30, 2021 Explor Med. 2021;2:232-252
    DOI: https://doi.org/10.37349/emed.2021.00044
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:139
    Download:17
    Times Cited: 0
    Open Access
    Original Article
    Digital sleep measures and white matter health in the Framingham Heart Study
    Aim: Impaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort. Me...
    Robert Joseph Thomas ... Rhoda Au
    Published: June 30, 2021 Explor Med. 2021;2:253-267
    DOI: https://doi.org/10.37349/emed.2021.00045
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:124
    Download:9
    Times Cited: 0
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mech...
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51-74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:4263
    Download:88
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge no...
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184-204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:2562
    Download:41
    Open Access
    Original Article
    Identifying factors associated with opioid cessation in a biracial sample using machine learning
    Aim: Racial disparities in opioid use disorder (OUD) management exist, however, and there is limited research on factors that influence opioid cessation in different population groups. Methods: ...
    Jiayi W. Cox ... Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:27-41
    DOI: https://doi.org/10.37349/emed.2020.00003
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:2424
    Download:50
    Times Cited: 0
    Open Access
    Review
    Non-alcoholic fatty liver disease and transient elastography
    Nonalcoholic fatty liver disease (NAFLD) is a serious condition that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD is associated with metabolic syndrome (MetS) and all of its ...
    Ivana Mikolasevic ... Sandra Milic
    Published: August 31, 2020 Explor Med. 2020;1:205-217
    DOI: https://doi.org/10.37349/emed.2020.00014
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2279
    Download:23
    Open Access
    Perspective
    Visual communication and learning from COVID-19 to advance preparedness for pandemics
    The currently ongoing coronavirus disease 19 (COVID-19) pandemic has affected globally human health and economy. Research in progress has shown facts associated with this disease and raised question...
    José de la Fuente ... Christian Gortázar
    Published: August 31, 2020 Explor Med. 2020;1:244-247
    DOI: https://doi.org/10.37349/emed.2020.00016
    View:2138
    Download:34
    Times Cited: 0
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of f...
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85-107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2077
    Download:52
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mech...
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51-74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:4263
    Download:88
    Open Access
    Review
    Angiotensin-(1-7) and Mas receptor in the brain
    The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associa...
    Natalia L. Rukavina Mikusic ... Mariela M. Gironacci
    Published: June 30, 2021 Explor Med. 2021;2:268-293
    DOI: https://doi.org/10.37349/emed.2021.00046
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:322
    Download:80
    Times Cited: 0
    Open Access
    Original Article
    Angiotensin-(3-4) modulates the overweight- and undernutrition-induced ACE2 downregulation in renal proximal tubule cells: implications for COVID-19?
    Aim: The renal lesions–including severe acute kidney injury–are severe outcomes in severe acute respiratory syndrome coronavirus 2 infections. There are no reports regarding ...
    Rafael Luzes ... Adalberto Vieyra
    Published: April 30, 2021 Explor Med. 2021;2:135-145
    DOI: https://doi.org/10.37349/emed.2021.00038
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:443
    Download:79
    Times Cited: 0
    Open Access
    Review
    Angiotensin peptides in the regulation of adrenal cortical function
    The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones. Evide...
    Gian Paolo Rossi ... Teresa Maria Seccia
    Published: June 30, 2021 Explor Med. 2021;2:294-304
    DOI: https://doi.org/10.37349/emed.2021.00047
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:320
    Download:79
    Times Cited: 0
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a ...
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. 2020;1:75-84
    DOI: https://doi.org/10.37349/emed.2020.00006
    View:1958
    Download:60
    Times Cited: 0
    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP dis...
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. 2020;1:4-26
    DOI: https://doi.org/10.37349/emed.2020.00002
    View:1605
    Download:55
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of f...
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85-107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2077
    Download:52
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mech...
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51-74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:4263
    Download:88
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and...
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149-169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:1808
    Download:34
    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP dis...
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. 2020;1:4-26
    DOI: https://doi.org/10.37349/emed.2020.00002
    View:1605
    Download:55
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause,...
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42-50
    DOI: https://doi.org/10.37349/emed.2020.00004
    View:1148
    Download:18
    Open Access
    Original Article
    Reduction of endoglin receptor impairs mononuclear cell-migration
    Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell su...
    Zhenying Han ... Hua Su
    Published: June 29, 2020 Explor Med. 2020;1:136-148
    DOI: https://doi.org/10.37349/emed.2020.00010
    View:1101
    Download:19
    Special Issues