• Exploration of Medicine

    eISSN: 2692-3106
    EiC: Lindsay A. Farrer, PhD, Boston University School of Medicine
    Frequency: Bimonthly
    APC: No Article Processing Charge
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: Scopus (Newly Accepted Mar. 2022), DOAJ, CAS, etc.
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    Articles
    Open Access
    Original Article
    High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney
    Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism  [...] Read more.
    Dewan S. A. Majid ... L. Gabriel Navar
    Published: April 26, 2022 Explor Med. 2022;3:205–218
    DOI: https://doi.org/10.37349/emed.2022.00086
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:188
    Download:34
    Times Cited: 0
    Open Access
    Review
    Reactive oxygen species in cardiovascular diseases: an update
    Cardiovascular diseases are among the leading causes of death worldwide, imposing major health threats. Reactive oxygen species (ROS) are one of the most important products from the process of redox [...] Read more.
    Juanjuan Fei ... Jun Ren
    Published: April 26, 2022 Explor Med. 2022;3:188–204
    DOI: https://doi.org/10.37349/emed.2022.00085
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:147
    Download:26
    Times Cited: 0
    Open Access
    Case Report
    Complex liver injury induced by combined Aloe Vera and vitamin A oral supplements, as assessed by histology and the updated RUCAM
    A case of combined acute and chronic liver injury related to consumption of multi-ingredient nutritional oral supplements containing Aloe Vera gel and vitamin A among other vitamins, minerals and di [...] Read more.
    Katerina Delladetsima ... Stratigoula Sakellariou
    Published: April 24, 2022 Explor Med. 2022;3:181–187
    DOI: https://doi.org/10.37349/emed.2022.00084
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:128
    Download:23
    Times Cited: 0
    Open Access
    Commentary
    Semaglutide: a game changer for metabolic diseases?
    Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1 RA) molecule approved for the treatment of both type 2 diabetes (T2D) and obesity. Semaglutide has a greater impact on glycated haemo [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: April 19, 2022 Explor Med. 2022;3:173–180
    DOI: https://doi.org/10.37349/emed.2022.00083
    View:222
    Download:28
    Times Cited: 0
    Open Access
    Original Article
    Development of systolic dysfunction unrelated to myocardial infarction in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: While it is commonly thought that left ventricular (LV) systolic function may insidiously deteriorate in hypertensive patients, few prospective data are available to support this notion.  [...] Read more.
    Marcello Chinali ... Richard B. Devereux
    Published: April 02, 2022 Explor Med. 2022;3:160–172
    DOI: https://doi.org/10.37349/emed.2022.00082
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:220
    Download:24
    Times Cited: 0
    Open Access
    Original Article
    Incident left bundle branch block predicts cardiovascular events and death in hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: Whether incident left bundle branch block (LBBB) is associated with increased cardiovascular (CV) morbidity and mortality in treated hypertensive patients with left ventricular hypertrophy ( [...] Read more.
    Casper N. Bang ... Peter M. Okin
    Published: March 29, 2022 Explor Med. 2022;3:149–159
    DOI: https://doi.org/10.37349/emed.2022.00081
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:185
    Download:19
    Times Cited: 0
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6197
    Download:143
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184–204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:3907
    Download:82
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a composite of arterial and ventri [...] Read more.
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. 2020;1:75–84
    DOI: https://doi.org/10.37349/emed.2020.00006
    View:3507
    Download:95
    Times Cited: 0
    Open Access
    Review
    Non-alcoholic fatty liver disease and transient elastography
    Nonalcoholic fatty liver disease (NAFLD) is a serious condition that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD is associated with metabolic syndrome (MetS) and all of its components. According to data, a [...] Read more.
    Ivana Mikolasevic ... Sandra Milic
    Published: August 31, 2020 Explor Med. 2020;1:205–217
    DOI: https://doi.org/10.37349/emed.2020.00014
    This article belongs to the special issue Exploring NAFLD/NASH
    View:3293
    Download:47
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusi [...] Read more.
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85–107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from port [...] Read more.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2951
    Download:62
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443–454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1096
    Download:149
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6197
    Download:143
    Open Access
    Review
    Angiotensin-(1-7) and Mas receptor in the brain
    The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher  [...] Read more.
    Natalia L. Rukavina Mikusic ... Mariela M. Gironacci
    Published: June 30, 2021 Explor Med. 2021;2:268–293
    DOI: https://doi.org/10.37349/emed.2021.00046
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1406
    Download:130
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a composite of arterial and ventri [...] Read more.
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. 2020;1:75–84
    DOI: https://doi.org/10.37349/emed.2020.00006
    View:3507
    Download:95
    Times Cited: 0
    Open Access
    Review
    Angiotensin peptides in the regulation of adrenal cortical function
    The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones. Evidence exists that angiotensin II r [...] Read more.
    Gian Paolo Rossi ... Teresa Maria Seccia
    Published: June 30, 2021 Explor Med. 2021;2:294–304
    DOI: https://doi.org/10.37349/emed.2021.00047
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1091
    Download:94
    Times Cited: 0
    Open Access
    Review
    The diagnostic conundrum in non-alcoholic fatty liver disease
    Non-alcoholic fatty liver disease (NAFLD) has become the most common liver alteration worldwide. It encompasses a spectrum of disorders that range from simple steatosis to a progressive form, defined non-alcoholic steatohepatitis  [...] Read more.
    Valerio Rosato ... Marcello Persico
    Published: October 30, 2020 Explor Med. 2020;1:259–286
    DOI: https://doi.org/10.37349/emed.2020.00018
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2645
    Download:93
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusi [...] Read more.
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85–107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause, values of glomerular filtration [...] Read more.
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42–50
    DOI: https://doi.org/10.37349/emed.2020.00004
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6197
    Download:143
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from port [...] Read more.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2951
    Download:62
    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP displays a range of severity, though even mild  [...] Read more.
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. 2020;1:4–26
    DOI: https://doi.org/10.37349/emed.2020.00002
    View:2210
    Download:77
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2754
    Download:92
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