• Exploration of Medicine

    eISSN: 2692-3106
    EiC: Lindsay A. Farrer, PhD
    Frequency: Bimonthly
    APC: No Article Processing Charge before January 31, 2025
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: Scopus, Google Scholar, DOAJ, CAS, etc.
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    Articles
    Open Access
    Systematic Review
    Exploring the cardiovascular effects of hypertonic lactate: a systematic review of animal studies
    Background: The naturally occurring metabolite lactate has traditionally been considered as a waste product of anaerobic metabolism whose production was confined to hypoxic states. However, more  [...] Read more.
    Oskar Kjærgaard Hørsdal
    Published: July 10, 2024 Explor Med. 2024;5:493–512
    DOI: https://doi.org/10.37349/emed.2024.00235
    View:59
    Download:4
    Times Cited: 0
    Open Access
    Correction
    Correction: Influence of dental implant site preparation method on three aspects of the site: magnetodynamic mallet versus conventional drill
    Domenico Baldi ... Jacopo Colombo
    Published: July 10, 2024 Explor Med. 2024;5:492
    DOI: https://doi.org/10.37349/emed.2024.00234
    View:55
    Download:4
    Times Cited: 0
    Open Access
    Systematic Review
    Debonding issues in orthodontics: an RCTs systematic review
    Background: This systematic review aims to critically assess the literature on the debonding process of orthodontic brackets from enamel surfaces. The review evaluates Randomized Controlled Trial [...] Read more.
    Francesca Gorassini ... Gabriele Cervino
    Published: July 05, 2024 Explor Med. 2024;5:477–491
    DOI: https://doi.org/10.37349/emed.2024.00233
    This article belongs to the special issue Oral Health Interconnections and Multidisciplinary Approaches
    View:128
    Download:5
    Times Cited: 0
    Open Access
    Original Article
    Influence of dental implant site preparation method on three aspects of the site: magnetodynamic mallet versus conventional drill
    Aim: Magnetodynamic surgery has assumed increasing importance in recent years. The purpose of the present study was to compare in vitro, using dry porcine ribs, two methods of dental implant site [...] Read more.
    Domenico Baldi ... Jacopo Colombo
    Published: July 05, 2024 Explor Med. 2024;5:467–476
    DOI: https://doi.org/10.37349/emed.2024.00232
    This article belongs to the special issue Biomaterials and Biomarkers in Dentistry: Up to Date
    View:124
    Download:6
    Times Cited: 0
    Open Access
    Case Report
    Creating smiles: a case study on the transformational power of dental CAD/CAM technology
    The integration of digital technologies like CAD/CAM systems and intraoral scanners is transforming the field of dentistry, providing numerous benefits for both patients and dental professionals. Th [...] Read more.
    Zeina Darwich ... Chadi Azmeh
    Published: June 28, 2024 Explor Med. 2024;5:459–466
    DOI: https://doi.org/10.37349/emed.2024.00231
    This article belongs to the special issue Oral Health Interconnections and Multidisciplinary Approaches
    View:165
    Download:9
    Times Cited: 0
    Open Access
    Review
    Natural polysaccharides-based postbiotics and their potential applications
    Postbiotics, representing the newest member of the family of biotics, are metabolites produced as a result of fermentation of lactic acid bacteria (LAB) in the De Man, Rogosa, and Sharpe (MRS) mediu [...] Read more.
    Weinan Du ... Juxiu Li
    Published: June 28, 2024 Explor Med. 2024;5:444–458
    DOI: https://doi.org/10.37349/emed.2024.00230
    This article belongs to the special issue Gut Microbiota Derived Metabolites and Chronic Inflammatory Diseases
    View:120
    Download:7
    Times Cited: 0
    Open Access
    Review
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging,  [...] Read more.
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. 2022;3:112–127
    DOI: https://doi.org/10.37349/emed.2022.00078
    View:11638
    Download:196
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:10059
    Download:225
    Open Access
    Original Article
    A large-scale survey of cannabis use for sleep: preferred products and perceived effects in comparison to over-the-counter and prescription sleep aids
    Aim: Cannabis use for sleep-related problems is on the rise; however, little is known about the cannabis products people are using for sleep or the perceived effects of cannabis in comparison to  [...] Read more.
    Amanda Stueber, Carrie Cuttler
    Published: October 25, 2023 Explor Med. 2023;4:709–719
    DOI: https://doi.org/10.37349/emed.2023.00171
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:9491
    Download:138
    Times Cited: 0
    Open Access
    Original Article
    Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
    Aim: Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to e [...] Read more.
    Gregory Giordano ... Angela D. Bryan
    Published: April 26, 2023 Explor Med. 2023;4:254–271
    DOI: https://doi.org/10.37349/emed.2023.00138
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:9172
    Download:246
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184–204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:6926
    Download:143
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6539
    Download:263
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443–454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:5182
    Download:1959
    Open Access
    Perspective
    A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exer [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 27, 2022 Explor Med. 2022;3:468–478
    DOI: https://doi.org/10.37349/emed.2022.00108
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:3250
    Download:1550
    Open Access
    Review
    Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing
    Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford [...] Read more.
    Naoko Suga ... Satoru Matsuda
    Published: October 31, 2023 Explor Med. 2023;4:822–838
    DOI: https://doi.org/10.37349/emed.2023.00180
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:1726
    Download:611
    Open Access
    Perspective
    A U.S. Food and Drug Administration perspective on cannabis research and drug development
    Since the early 1970s, the U.S. Food and Drug Administration (FDA) has received over 800 investigational new drug applications (INDs) for, and pre-INDs pertaining to, research of cannabis or cannabi [...] Read more.
    Cassandra L. Taylor, Schuyler A. Pruyn
    Published: October 31, 2023 Explor Med. 2023;4:813–821
    DOI: https://doi.org/10.37349/emed.2023.00179
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:5262
    Download:281
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6539
    Download:263
    Open Access
    Review
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects  [...] Read more.
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. 2022;3:219–233
    DOI: https://doi.org/10.37349/emed.2022.00087
    View:6215
    Download:253
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6539
    Download:263
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause, values of glomerular filtration [...] Read more.
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42–50
    DOI: https://doi.org/10.37349/emed.2020.00004
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusi [...] Read more.
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85–107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6425
    Download:125
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from port [...] Read more.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6183
    Download:110
    Open Access
    Meta-Analysis
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem [...] Read more.
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. 2022;3:249–259
    DOI: https://doi.org/10.37349/emed.2022.00089
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    Open Access
    Original Article
    Identification of digital voice biomarkers for cognitive health
    Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identify voice biomarkers that are pr [...] Read more.
    Honghuang Lin ... Rhoda Au
    Published: December 31, 2020 Explor Med. 2020;1:406–417
    DOI: https://doi.org/10.37349/emed.2020.00028
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    Special Issues