| 1 |
2024 |
Yossra Gharbi, Rocío Mercado. A comprehensive review of emerging approaches in machine learning forde novoPROTAC design, Digital Discovery. 2024; 3: 2158.
https://doi.org/10.1039/D4DD00177J |
| 2 |
2024 |
Ritesh P. Bhole, Sapana Patil, Harshad S. Kapare, Rupesh V. Chikhale, Shailendra S. Gurav. PROTAC Beyond Cancer- Exploring the New Therapeutic Potential of Proteolysis Targeting Chimeras, Current Topics in Medicinal Chemistry. 2024; 24: 2050.
https://doi.org/10.2174/0115680266309968240621072550 |
| 3 |
2025 |
M. A. A. Mamun, Anush G. Bakunts, Alexander L. Chernorudskiy. Targeted degradation of extracellular proteins: state of the art and diversity of degrader designs, Journal of Hematology & Oncology. 2025; 18: 52.
https://doi.org/10.1186/s13045-025-01703-4 |
| 4 |
2025 |
Natalia Kubryń, Łukasz Fijałkowski, Jacek Nowaczyk, Amer Jamil, Alicja Nowaczyk. PROTAC Technology as a New Tool for Modern Pharmacotherapy, Molecules. 2025; 30: 2123.
https://doi.org/10.3390/molecules30102123 |
| 5 |
2025 |
Christopher Veeck, Lennart Laube, Anke Werner, Wibke Diederich, Stephan Becker. 2025;
https://doi.org/10.1101/2025.05.03.652023 |
| 6 |
2021 |
Santanu Hati, Marisa Zallocchi, Robert Hazlitt, Yuju Li, Sarath Vijayakumar, Jaeki Min, Zoran Rankovic, Sándor Lovas, Jian Zuo. AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss, European Journal of Medicinal Chemistry. 2021; 226: 113849113849.
https://doi.org/10.1016/j.ejmech.2021.113849 |
| 7 |
2024 |
Nisha Setia, Haider Thaer Abdulhameed Almuqdadi, Mohammad Abid. Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders, European Journal of Medicinal Chemistry. 2024; 265: 116041116041.
https://doi.org/10.1016/j.ejmech.2023.116041 |
| 8 |
2025 |
Ranit Dutta, Anirudh Devarajan, Amelia Talluri, Ritam Das, S. Thayumanavan. Dual-Action-Only PROTACs, Journal of the American Chemical Society. 2025; 147: 9074.
https://doi.org/10.1021/jacs.5c00131 |
| 9 |
2024 |
Advait Dubey, Kavita Pal, Vikram Gota. 2024; 169.
https://doi.org/10.1007/978-981-97-5077-1_9 |
| 10 |
2024 |
Eslam M. H. Ali, Cody A. Loy, Darci J. Trader. 2024;
https://doi.org/10.1101/2024.01.20.576376 |
| 11 |
2023 |
Yilin Gu, Yizhe Li, Jiaxing Wang, Lele Zhang, Jifa Zhang, Yuxi Wang. Targeting ferroptosis: Paving new roads for drug design and discovery, European Journal of Medicinal Chemistry. 2023; 247: 115015115015.
https://doi.org/10.1016/j.ejmech.2022.115015 |
| 12 |
2024 |
Abhishek Wahi, Hemant R. Jadhav, Shikha Thakur, Sushma Dev, Priyanka Mohanty, Priti Jain. 2024; 39.
https://doi.org/10.1007/978-981-97-5077-1_3 |
| 13 |
2023 |
Maokai Jiang, Yuankun Wang, Yumeng Zhuang, Xianzhang Wang, Lei Yao. 2023;
https://doi.org/10.2139/ssrn.4585000 |
| 14 |
2023 |
Chelsi M. Almodóvar‐Rivera, Zhen Zhang, Jingyao Li, Haibo Xie, Yu Zhao, Le Guo, Marissa G. Mannhardt, Weiping Tang. A Modular Chemistry Platform for the Development of a Cereblon E3 Ligase‐Based Partial PROTAC Library, ChemBioChem. 2023; 24: e202300482.
https://doi.org/10.1002/cbic.202300482 |
| 15 |
2023 |
Giulia Apprato, Giulia D’Agostini, Paolo Rossetti, Giuseppe Ermondi, Giulia Caron. In Silico Tools to Extract the Drug Design Information Content of Degradation Data: The Case of PROTACs Targeting the Androgen Receptor, Molecules. 2023; 28: 1206.
https://doi.org/10.3390/molecules28031206 |
| 16 |
2022 |
Federica Pedrucci, Claudia Pappalardo, Giovanni Marzaro, Nicola Ferri, Alberto Ferlin, Luca De Toni. Proteolysis Targeting Chimeric Molecules: Tuning Molecular Strategies for a Clinically Sound Listening, International Journal of Molecular Sciences. 2022; 23: 6630.
https://doi.org/10.3390/ijms23126630 |
| 17 |
2024 |
Ming Yang, Hua Xiang, Guoshun Luo. Targeting focal adhesion kinase (FAK) for cancer therapy: FAK inhibitors, FAK-based dual-target inhibitors and PROTAC degraders, Biochemical Pharmacology. 2024; 224: 116246116246.
https://doi.org/10.1016/j.bcp.2024.116246 |
| 18 |
2024 |
Keerti Jain, Sukuru Chinna Reddy, Sreevardhan Moode, Piyush Mehra, Sofiya Tarannum, Manisha Patel, Vineet Kumar Jain, Harvinder Popli. 2024; 89.
https://doi.org/10.1007/978-981-97-5077-1_5 |
| 19 |
2024 |
Shuihong Cheng, Yong Feng, Wei Li, Tong Liu, Xun Lv, Xiaomei Tong, Gan Xi, Xin Ye, Xuebing Li. Development of novel antivrial agents that induce the degradation of the main protease of human-infecting coronaviruses, European Journal of Medicinal Chemistry. 2024; 275: 116629116629.
https://doi.org/10.1016/j.ejmech.2024.116629 |
| 20 |
2024 |
Yuxuan Wang, Yanyi He, Qidong You, Lei Wang. Design of bifunctional molecules to accelerate post-translational modifications: achievements and challenges, Drug Discovery Today. 2024; 29: 104194104194.
https://doi.org/10.1016/j.drudis.2024.104194 |
| 21 |
2023 |
Qiong Li, Li Zhou, Siyuan Qin, Zhao Huang, Bowen Li, Ruolan Liu, Mei Yang, Edouard C. Nice, Huili Zhu, Canhua Huang. Proteolysis-targeting chimeras in biotherapeutics: Current trends and future applications, European Journal of Medicinal Chemistry. 2023; 257: 115447115447.
https://doi.org/10.1016/j.ejmech.2023.115447 |
| 22 |
2023 |
Qian-Qian Zhou, Hai-Tao Xiao, Fan Yang, Yong-Dan Wang, Ping Li, Zu-Guo Zheng. Advancing targeted protein degradation for metabolic diseases therapy, Pharmacological Research. 2023; 188: 106627106627.
https://doi.org/10.1016/j.phrs.2022.106627 |
| 23 |
2025 |
Shiou‐Ting Lin, Chien‐Hua Wang, Ai‐Lin Chen, Tsung‐Shing Andrew Wang. Utilizing Alkyne‐Nitrone Cycloaddition for the Convenient Multi‐Component Assembly of Protein Degraders and Biological Probes, Chemistry – A European Journal. 2025; 31: e202403184.
https://doi.org/10.1002/chem.202403184 |
| 24 |
2025 |
Jacopo Zattoni, Paola Vottero, Gea Carena, Chiara Uliveto, Giulia Pozzati, Benedetta Morabito, Ebenezea Gitari, Jack Tuszynski, Maral Aminpour. A comprehensive primer and review of PROTACs and their In Silico design, Computer Methods and Programs in Biomedicine. 2025; 264: 108687108687.
https://doi.org/10.1016/j.cmpb.2025.108687 |
| 25 |
2024 |
Shareef Shaik, Prasanna Kumar Reddy Gayam, Manish Chaudhary, Gurvinder Singh, Aravinda Pai. Advances in designing ternary complexes: Integrating in-silico and biochemical methods for PROTAC optimisation in target protein degradation, Bioorganic Chemistry. 2024; 153: 107868107868.
https://doi.org/10.1016/j.bioorg.2024.107868 |
| 26 |
2024 |
Yang Li, Junfeng Qu, Lizhi Jiang, Xiaoyu Peng, Kaiyue Wu, Miaojia Chen, Yuanyuan Peng, Xuan Cao. Application and challenges of nitrogen heterocycles in PROTAC linker, European Journal of Medicinal Chemistry. 2024; 273: 116520116520.
https://doi.org/10.1016/j.ejmech.2024.116520 |
| 27 |
2024 |
Špela Janež, Samo Guzelj, Žiga Jakopin. Linker Chemistry and Connectivity Fine-Tune the Immune Response and Kinetic Solubility of Conjugated NOD2/TLR7 Agonists, Bioconjugate Chemistry. 2024; 35: 1723.
https://doi.org/10.1021/acs.bioconjchem.4c00321 |
| 28 |
2025 |
Hailong Yang, Lu Gan, Huabei Zhang. Design, Synthesis, Anticancer Evaluation and Molecular Docking of Pyrimidine, Pyrido[4,3-d]pyrimidine and 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine Derivatives as Novel KRAS-G12D Inhibitors and PROTACs, Pharmaceuticals. 2025; 18: 696.
https://doi.org/10.3390/ph18050696 |
| 29 |
2024 |
Si Yan, Guangshuai Zhang, Wei Luo, Mengwei Xu, Rui Peng, Ziwei Du, Yan Liu, Zhaofang Bai, Xiaohe Xiao, Shuanglin Qin. PROTAC technology: From drug development to probe technology for target deconvolution, European Journal of Medicinal Chemistry. 2024; 276: 116725116725.
https://doi.org/10.1016/j.ejmech.2024.116725 |
| 30 |
2025 |
Cody A. Loy, Eslam M. H. Ali, Laurence J. Seabrook, Timothy J. Harris, Kate A. Kragness, Lauren Albrecht, Darci J. Trader. ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation, Journal of Medicinal Chemistry. 2025; 68: 9694.
https://doi.org/10.1021/acs.jmedchem.5c00485 |
| 31 |
2022 |
Liena Qin, Han Dai, Junfeng Wang. Key Considerations in Targeted Protein Degradation Drug Discovery and Development, Frontiers in Chemistry. 2022; 10: 934337.
https://doi.org/10.3389/fchem.2022.934337 |
| 32 |
2023 |
José A. Villegas, Tasneem M. Vaid, Michael E. Johnson, Terry W. Moore. Mapping the energy landscape of PROTAC-mediated protein-protein interactions, Computational and Structural Biotechnology Journal. 2023; 21: 1885.
https://doi.org/10.1016/j.csbj.2023.02.049 |
| 33 |
2024 |
Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wang. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer’s disease and related tauopathies, Science Bulletin. 2024; 69: 1137.
https://doi.org/10.1016/j.scib.2024.01.019 |
| 34 |
2023 |
Namy George, Md. Jawaid Akhtar, Khalid Al Balushi, Sher Zaman Safi, Syed Najmul Hejaz Azmi, Shah Alam Khan. The emerging role of proteolysis targeting chimeras (PROTACs) in the treatment of Alzheimer’s disease, Medicinal Chemistry Research. 2023;
https://doi.org/10.1007/s00044-023-03026-w |
| 35 |
2021 |
José A. Villegas, Tasneem M. Vaid, Michael E. Johnson, Terry W. Moore. 2021;
https://doi.org/10.1101/2021.08.31.458424 |
| 36 |
2024 |
Jun Xia, James K.S. Norris, May-Li MacKinnon, Sam Butterworth. Proteolysis Targeting Chimeras (PROTACs): An Innovative Strategy for Targeted Protein Degradation and Disease Treatment, International Journal of Drug Discovery and Pharmacology. 2024; 100015.
https://doi.org/10.53941/ijddp.2024.100015 |
| 37 |
2021 |
Haixia Liu, Xinyu Ding, Linyi Liu, Qianglong Mi, Quanju Zhao, YuBao Shao, Chaowei Ren, Jinju Chen, Ying Kong, Xing Qiu, Nicola Elvassore, Xiaobao Yang, Qianqian Yin, Biao Jiang. Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation, European Journal of Medicinal Chemistry. 2021; 223: 113645113645.
https://doi.org/10.1016/j.ejmech.2021.113645 |
| 38 |
2023 |
Anna Pasieka, Eleonora Diamanti, Elisa Uliassi, Maria Laura Bolognesi. Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists?, ChemMedChem. 2023; 18: e202300422.
https://doi.org/10.1002/cmdc.202300422 |
| 39 |
2024 |
Diana Castagna, Benoit Gourdet, Roland Hjerpe, Philip MacFaul, Andrew Novak, Guillaume Revol, Etienne Rochette, Allan Jordan. 2024; 63: 61.
https://doi.org/10.1016/bs.pmch.2024.07.002 |
