• Subscribe
    • Sign up for updates about the journal.
  • Sign in
  • Register
Exploration of Medicine
  • About
    • About the Journal
    • Editorial Board
    • Editorial Policies
    • Newsletter
    • Contact Us
  • Articles
    • Current Issue
    • Archives
  • Special Issue
    • All Special Issues
    • Guest Editor Guidelines
  • For Authors
    • Author Instructions
    • Editorial Process
    • Article Processing Charge
    • Submit a Manuscript
  • For Reviewers
    • Peer Review Guidelines
    • Reviewer Acknowledgment
    • To Be a Reviewer
  • Focus
  • Home
  • Exploration of Medicine
  • Special Issues
  • Special Issue Topic

    Gut Microbiota Derived Metabolites and Chronic Inflammatory Diseases

    Submission Deadline: December 31, 2023

    Guest Editor

    Dr. Zeneng Wang E-Mail

    Staff Scientist, Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, USA

    Research Keywords: gut microbiome; cardiovascular disease; atherosclerosis; metabolomics; mass spectrometry


    About the Special Issue

    Microbes inhabit human gut with a number reaching trillions, higher than the cell number composing human body and total genome size 150 times as long as human genome. Gut microbiota plays important roles in human health, which include maintaining gut barrier, helping digesting food, producing vitamins, preventing pathogen overgrowth and modulating human immunity as well. Gut microbiota is involved in synthesis of some bioactive metabolites, which circulate in human blood and are delivered to different target tissues, mediating the effects of gut microbiota. So gut microbiota is regarded as the largest endocrine organ. There are hundreds of gut microbiota derived metabolites reported. Some of them, such as short chain fatty acids, which are the fermented metabolites of dietary fiber, can maintain gut barrier, induce release of gut hormones, peptide YY (PYY) and glucagon like peptide 1 (GLP-1), to modulate satiety, energy harvest and fat storage and inhibit inflammation. Some of them, such as trimethylamine N-oxide, p-cresyl sulfate and indoxyl sulfate, show pro-inflammatory effects, leading to enhanced chronic inflammatory diseases. Recently gut microbiota metabolites of tryptophan, indole acetic acid and indole-3-propionic acid, have been reported to enhance sensitivity of chemotherapy against cancer. Targeting gut microbiota derived metabolites will become a strategy to treat chronic diseases. In this special issue, we will discuss the roles of gut microbiota derived metabolites in inflammatory chronic diseases, which will provide important clues to prevent and treat the diseases.

    Call for Papers

    Published Articles

    • Submit a Manuscript
    • Aims and Scope
    • Editorial Board
    • Author Instructions
    • Ongoing Special Issues
      The Role of Repetitive DNA Elements in the Development and Progression of Human Disease
      Colon Controlled Microbiome Function: Role, Impact, Structure, Pathogenetic Significance, Therapeutic and Diagnostic Management
      The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
      Recent Advances in Hypertension
      Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
      Perspectives on Causal Mechanisms, Prevention and Management of Pediatric Obesity and Related Comorbidities
      Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
      The Biological Basis of Substance Use Disorders
      Nanomedicine and Cancer Immunotherapy
      Exploring Aortic Disease
      Cellular Models for In Vitro Modeling of Parkinson’s Disease
      Role of Microbiome in Ocular Diseases
      Advances in Wound Healing
      Determinants of Exceptional Longevity
      Genetic and Epigenetic Control of Autophagy in Human Diseases
      RNA World in Health and Disease
      Lung Fibrosis—Models and Mechanisms
      Exploration of 3D and 4D Printing in the Biomedical and Personalized Medicine Fields: Merits and Challenges
      Biomaterials and Biomarkers in Dentistry: Up to Date
      Gut Microbiota Derived Metabolites and Chronic Inflammatory Diseases
      Vitamin D—Current and the Future
      Emerging Infectious Diseases
      Applications of Radiomics in Precision Medicine
      Functional Biomaterials and Tumor Immunotherapy
      Breast Cancer: Basic and Clinical Advances
      Advances in the Identification and Mechanisms of Action of Luminal Compounds Involved in Inflammatory Bowel Diseases
      Drug Adherence in Hypertension
    • Completed Special Issues
      Exploring NAFLD/NASH
      Digital Biomarkers: The New Frontier for Medicine and Research
      Exploring Type 2 Diabetes Mellitus
      Angiotensins—A Century of Progress
      Exploring Chronic Liver Disease
      Reactive Oxygen Species (ROS) in Pathophysiological Conditions
      Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    • Guest Editor
    • About the Special Issue
    • Call for Papers
    • Published Articles
    • Exploration of Medicine
    • eISSN 2692-3106
    • emjournal@explorationpub.com
    • About the Journal
    • Author Instructions
    • Editorial Board
    • Editorial Policies
    • Editorial Process
    • Follow the Journal
    • JOURNALS
    • Exploration of Medicine
    • Exploration of Targeted Anti-tumor Therapy
    • Exploration of Immunology
    • Exploration of Neuroprotective Therapy
    • Exploration of Digestive Diseases
    • Exploration of Neuroscience
    • Exploration of Musculoskeletal Diseases
    • Exploration of Asthma & Allergy
    • Exploration of Drug Science
    • Exploration of Foods and Foodomics
    • Exploration of BioMat-X
    • Exploration of Digital Health Technologies
    • Exploration of Cardiology
    • Exploration of Endocrine and Metabolic Disease
    • ABOUT
    • Company Information
    • Open Access
    • Editorial Policies
    • Peer Review Policy
    • Contact Us
    • FOLLOW
    • Terms of Service Privacy Cookies
Copyright © 2023 Open Exploration Publishing Inc.