• Special Issue Topic

    Gut Microbiota Derived Metabolites and Chronic Inflammatory Diseases

    Submission Deadline: September 30, 2024

    Guest Editor

    Dr. Zeneng Wang E-Mail

    Staff Scientist, Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, USA

    Research Keywords: gut microbiome; cardiovascular disease; atherosclerosis; metabolomics; mass spectrometry


    About the Special Issue

    Microbes inhabit human gut with a number reaching trillions, higher than the cell number composing human body and total genome size 150 times as long as human genome. Gut microbiota plays important roles in human health, which include maintaining gut barrier, helping digesting food, producing vitamins, preventing pathogen overgrowth and modulating human immunity as well. Gut microbiota is involved in synthesis of some bioactive metabolites, which circulate in human blood and are delivered to different target tissues, mediating the effects of gut microbiota. So gut microbiota is regarded as the largest endocrine organ. There are hundreds of gut microbiota derived metabolites reported. Some of them, such as short chain fatty acids, which are the fermented metabolites of dietary fiber, can maintain gut barrier, induce release of gut hormones, peptide YY (PYY) and glucagon like peptide 1 (GLP-1), to modulate satiety, energy harvest and fat storage and inhibit inflammation. Some of them, such as trimethylamine N-oxide, p-cresyl sulfate and indoxyl sulfate, show pro-inflammatory effects, leading to enhanced chronic inflammatory diseases. Recently gut microbiota metabolites of tryptophan, indole acetic acid and indole-3-propionic acid, have been reported to enhance sensitivity of chemotherapy against cancer. Targeting gut microbiota derived metabolites will become a strategy to treat chronic diseases. In this special issue, we will discuss the roles of gut microbiota derived metabolites in inflammatory chronic diseases, which will provide important clues to prevent and treat the diseases.

    Call for Papers

    Published Articles

    Open Access
    Review
    Natural polysaccharides-based postbiotics and their potential applications
    Postbiotics, representing the newest member of the family of biotics, are metabolites produced as a result of fermentation of lactic acid bacteria (LAB) in the De Man, Rogosa, and Sharpe (MRS) mediu [...] Read more.
    Weinan Du ... Juxiu Li
    Published: June 28, 2024 Explor Med. 2024;5:444–458
    DOI: https://doi.org/10.37349/emed.2024.00230
    View:743
    Download:19
    Times Cited: 0
    Open Access
    Original Article
    Analysis of microbiocenosis of a gingival sulcus and periodontal pockets of patients with periodontal diseases associated with systemic pathology
    Aim: The aim is to analyze the microbiome of gingival sulcus and periodontal pockets of patients with periodontal disease associated with systemic diseases. Methods: A microbiological study [...] Read more.
    Olha Denefil ... Khrystyna Loza
    Published: December 11, 2023 Explor Med. 2023;4:942–955
    DOI: https://doi.org/10.37349/emed.2023.00186
    View:1233
    Download:26