• Special Issue Topic

    Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs

    Submission Deadline: October 31, 2022

    Guest Editor

    Dr. Md Noushad Javed E-Mail

    Assistant Professor, School of Medical and Allied Sciences (SMAS), K.R. Mangalam University, India

    About the Special Issue

    Although in this current era, several promises are already translated challenges into a therapeutic solution, owing to the innovative approach of integrating existing knowledge of medical sciences with contemporary technological advancements.

    Despite this, in parallel to the above, due to the emergence of new diseases, increasing complexity of existing disorders, as well as higher incidences of drug resistance; the medical fraternity and scientists are facing immense challenges with escalating of newly discovered conceptualized bench products into shelves of the clinics because of several regulatory, ethical, and financial restrictions. In order to avoid such hurdles for listing new drugs on the shelves, of late there is increasing interest in the repositioning of existing drugs, from one shelf to another with the addition of a new profile with the existing purposing.

    As such practices become an important part of the drug development process and clinicians, we are here aimed to discuss the latest experimental and computation methods as well as scientific techniques as an operational approach for targeted delivery of the drugs as well as their repurposing in new inflammatory clinical indications, including cancer.

    In brief, implementing a judicious and comprehensive strategy to repositioning of existing drugs would ultimately provide unique clinical, operational, as well as business opportunities.

    Published Articles

    Open Access
    N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain
    Neuropathic pain (NP) remains maltreated for a wide number of patients by the currently available treatments and little research has been done in finding new drugs for treating NP. Ziconotide (Prial [...] Read more.
    Shikha Choudhary ... Md Sabir Alam
    Published: February 28, 2023 Explor Med. 2023;4:85–106
    DOI: https://doi.org/10.37349/emed.2023.00126
    Open Access
    An overview of current strategies and future prospects in drug repurposing in tuberculosis
    A large number of the population faces mortality as an effect of tuberculosis (TB). The line of treatment in the management of TB faces a jolt with ever-increasing multi-drug resistance (DR) cases.  [...] Read more.
    Dilpreet Singh ... Pooja A. Chawla
    Published: February 28, 2023 Explor Med. 2023;4:71–84
    DOI: https://doi.org/10.37349/emed.2023.00125
    Open Access
    Original Article
    Molecular docking analysis of peptide-based antiviral agents against SARS-CoV-2 main protease: an approach towards drug repurposing
    Aim: Utilizing the therapeutic potentials of previously approved medications against a new target or pharmacological response is known as drug repurposing. The health and scientific communities a [...] Read more.
    Abhishek Chaurasiya ... Pooja A. Chawla
    Published: February 27, 2023 Explor Med. 2023;4:33–44
    DOI: https://doi.org/10.37349/emed.2023.00123
    Times Cited: 0
    Open Access
    Quality by design based development of nanostructured lipid carrier: a risk based approach
    The aim of this review is to discuss the development of nanostructured lipid carrier (NLC) by the application of quality by design (QbD). QbD started with the evolution of the quality concept and sl [...] Read more.
    Tausif Alam
    Published: December 31, 2022 Explor Med. 2022;3:617–638
    DOI: https://doi.org/10.37349/emed.2022.00118
    Times Cited: 0
    Open Access
    The journey of dostarlimab: a successful weapon for cancer treatment
    In a number of malignancies, new immuno-oncology therapies that focus on the programmed cell death 1 (PD-1) have improvised the patient condition along with a positive aftereffect. Monoclonal antibo [...] Read more.
    Rouchan Ali ... Pooja A. Chawla
    Published: December 29, 2022 Explor Med. 2022;3:592–606
    DOI: https://doi.org/10.37349/emed.2022.00116
    Times Cited: 0
    Open Access
    Antioxidant and photoprotective potential of Polypodium leucotomos
    In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and [...] Read more.
    Rosy Yesela Mancilla Santa Cruz ... María Segunda Aurora Prado
    Published: December 29, 2022 Explor Med. 2022;3:607–616
    DOI: https://doi.org/10.37349/emed.2022.00117
    Times Cited: 0
    Open Access
    Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system
    Fernandoa adenophylla (FA, Heterophragma adenophyllum) is a plant, cultivated throughout Africa and Southeast Asia. It contains potent phytochemicals such as novel naphthoquinones, their derivatives [...] Read more.
    Sangeet Kumar Mall ... Md Sabir Alam
    Published: November 14, 2022 Explor Med. 2022;3:516–539
    DOI: https://doi.org/10.37349/emed.2022.00111
    Times Cited: 0
    Open Access
    Role of mitochondria in brain functions and related disorders
    Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplast [...] Read more.
    Monu Yadav ... Anil Kumar
    Published: October 31, 2022 Explor Med. 2022;3:494–515
    DOI: https://doi.org/10.37349/emed.2022.00110
    Times Cited: 0
    Open Access
    Nutritional prospects of wheatgrass (Triticum aestivum) and its effects in treatment and chemoprevention
    Nutraceuticals are organic and traditional foods consumed nowadays to maintain a healthy lifestyle and get rid of lifestyle diseases like obesity, cancer, diabetes, hypertension, etc. Globally, herb [...] Read more.
    Neha Minocha ... Parijat Pandey
    Published: October 12, 2022 Explor Med. 2022;3:432–442
    DOI: https://doi.org/10.37349/emed.2022.00104