• Special Issue Topic

    The HPA Axis in Health and Disease

    Submission Deadline: December 02, 2024

    Guest Editor

    Charlotte Steenblock E-Mail

    Research group leader at the Dept. of Internal Medicine III, University Clinic Carl Gustav Carus, TU Dresden, Germany.

    Research Keywords: diabetes mellitus type 1; metabolism; adrenal; endocrine stem cells


    About the Special Issue

    The endocrine stress system comprises the hypothalamus, pituitary gland, and adrenal gland, which collectively form the HPA axis. The hypothalamus acts as a central relay to control the endocrine response of the pituitary and adrenal glands. While a proper stress response is necessary for survival, stress is also linked to various disorders, such as depression, anxiety, and post-traumatic stress disorder. Research suggests that early life stress or maltreatment may increase the risk of developing major psychiatric disorders, substance and alcohol abuse, and medical conditions like diabetes in adulthood. Dysregulation of the endocrine stress axis has been observed in studies on depressed adult men and women with early life stress. Stress-induced changes in the stress axis activity are influenced by genetic predisposition and epigenetic factors. Despite extensive research into proper regulation and possible dysregulation of the endocrine stress axis in health and disease, the biological mechanisms underlying increased vulnerability to disease after stress are still not fully understood. We are collecting original research and review articles from experts in the field to further our understanding of how the HPA axis is regulated in both health and disease.

    Keywords: HPA axis; hypothalamus; pituitary; adrenal; stress; epigenetics; signalling

    Call for Papers

    Published Articles

    Open Access
    Original Article
    Epigenetics in etiopathology of hyperprolactinemia
    Aim: Epigenetic alterations have been reported in patients with pituitary tumors and those on antipsychotic drugs, which are also responsible for hyperprolactinemia. This suggests a possible role [...] Read more.
    Amanpreet Kaur Kalsi ... Jai Bhagwan Sharma
    Published: May 22, 2024 Explor Endocr Metab Dis. 2024;1:39–55
    DOI: https://doi.org/10.37349/eemd.2024.00006
    View:327
    Download:9
    Times Cited: 0
    Open Access
    Commentary
    Unique original endocrine findings: the endoplasmic reticulum-mitochondrial unit in steroid producing cells
    Stefan R. Bornstein ... Waldemar Kanczkowski
    Published: April 01, 2024 Explor Endocr Metab Dis. 2024;1:12–15
    DOI: https://doi.org/10.37349/eemd.2023.00003