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Special Issue TopicNuclear Receptors and the Digestive Tract: from Molecular Physiology to Clinics via Pharmacology
Submission Deadline: November 30, 2025Guest Editors
Prof. Amedeo Lonardo E-Mail
Professor, Department of Internal Medicine, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
Research Keywords: NAFLD, NASH, MAFLD, metabolic syndrome, cirrhosis, liver cancer, sex differences
Prof. Ralf Weiskirchen E-Mail
Professor, Institut für Molekulare Pathobiochemie, Experimentelle Gentherapie und Klinische Chemie, RWTH Universitätsklinikum Aachen, Aachen, Germany
Research Keywords: Fibrosis, cytokines, chemokines, liver disease, gastrointestinal disease, biomarkers, pathogenesis
About the Special Issue
Nuclear receptors (NRs) are ligand-activated transcription factors that, by binding to specific DNA sequences, affect gene expression at the transcriptional level in response to hormones, diets, and other stimuli.
NRs play a crucial role in metabolic disorders, chronic inflammatory diseases, and immune system-related disorders. Their application extends to the enterohepatic axis, MASLD, MASH, metabolic syndrome, cholestasis, inflammatory bowel disease, and cancer of the digestive system.
This special issue is dedicated to exploring all basic and clinical aspects, from physiology to pathology, from disease diagnosis to treatment, involving NRs in relation to the organs of the digestive tract, the liver and the pancreas.
We welcome various types of manuscripts, including well-detailed case studies, original articles, mini-reviews, reviews, etc.
Keywords: Nuclear receptors, digestive tract, enterohepatic axis, MASLD, MASH, metabolic syndrome, cholestasis, inflammatory bowel disease, cancer
Call for Papers
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