• Special Issue Topic

    Emerging Concepts in Subarachnoid Hemorrhage

    Submission Deadline: September 30, 2022

    Guest Editor

    Dr. Brandon Lucke-Wold E-Mail

    Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.

    Research Keywords: subarachnoid hemorrhage; neurosurgery; neurotrauma; simulation


    About the Special Issue

    Subarachnoid hemorrhage (SAH) continues to present serious challenges for clinicians and researchers. High morbidity and mortality exist with 1/3 of patients never making it to the hospital. As endovascular techniques have emerged, safe and more efficient aneurysm securement options are now available. The shift has become a focus on secondary mechanisms that occur after the initial hemorrhage. It is well known that vasospasm and delayed cerebral ischemia develop days to weeks after injury. What is still poorly understood are the contributory mechanisms leading to these downstream cascades. This has limited the development of effective therapeutics. This special issue will focus on those emerging topics. We are interested in both clinical and pre-clinical studies as well as focused reviews. Topics of particular importance include the role of microglia, the neuroinflammatory surge, and how the glymphatic system may contribute. Authors are encouraged to provide novel and innovative research to address such topics and help propel the field forward. This forum offers a unique advantage for sharing ideas and encouraging collaborative efforts.

    Keywords: subarachnoid hemorrhage; neuroinflammation; vasospasm; delayed cerebral ischemia; glymphatics

    Call for Papers

    Published Articles

    Open Access
    Case Report
    Paraclinoid unruptured giant aneurysm with therapeutic success
    The global prevalence of intracranial aneurysms (IA) ranges from 5–10%, with a demographic variation. Large and giant aneurysms typically involve cavernous and paraclinoid se [...] Read more.
    Gonçalo Januário
    Published: August 30, 2022 Explor Neuroprot Ther. 2022;2:174–181
    DOI: https://doi.org/10.37349/ent.2022.00027
    View:172
    Download:20
    Times Cited: 0
    Open Access
    Review
    Delayed cerebral ischemia and therapeutic approaches after subarachnoid hemorrhage
    Delayed cerebral ischemia after subarachnoid hemorrhage is one of the most important causes of mortality and poor functional outcome in patients. Initially, the etiology and treatment of delayed cer [...] Read more.
    Fettah Eren ... Sueda Ecem Yilmaz
    Published: August 22, 2022 Explor Neuroprot Ther. 2022;2:162–173
    DOI: https://doi.org/10.37349/ent.2022.00026
    View:171
    Download:23
    Times Cited: 0
    Open Access
    Review
    The glymphatic system and subarachnoid hemorrhage: disruption and recovery
    The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the b [...] Read more.
    Stephan Quintin ... Brandon Lucke-Wold
    Published: June 21, 2022 Explor Neuroprot Ther. 2022;2:118–130
    DOI: https://doi.org/10.37349/ent.2022.00023
    View:510
    Download:40
    Times Cited: 0
    Open Access
    Review
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    View:1161
    Download:36