• Exploration of Neuroscience

    eISSN: 2834-5347
    EiC: Dirk M. Hermann, MD, University of Duisburg-Essen
    Frequency: Bimonthly
    APC: No Article Processing Charge before September 30, 2027
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
    Indexing & Archiving: Google Scholar, DOAJ, etc.
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    Articles
    Open Access
    Original Article
    First outcomes of a therapeutic platform for drug resistant epilepsy based on transcutaneous electrical vagus nerve stimulation
    Aim: The aim of this paper is to discuss the main features and first outcomes of a therapeutic platform proposed to implement a public health therapeutic service for patients suffering refractory [...] Read more.
    Rene Ivan Gonzalez-Fernandez ... Jose Luis Hernandez-Caceres
    Published: April 12, 2024 Explor Neurosci. 2024;3:144–155
    DOI: https://doi.org/10.37349/en.2024.00041
    This article belongs to the special issue Epilepsy
    View:147
    Download:3
    Times Cited: 0
    Open Access
    Review
    Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs
    Brain metastasis is the most prevalent neurologic problem of systemic cancer and it can increase the mortality rate in patients with cancer. It occurs more in patients with lung cancer, breast cance [...] Read more.
    Zohreh Khosravi Dehaghi
    Published: April 10, 2024 Explor Neurosci. 2024;3:130–143
    DOI: https://doi.org/10.37349/en.2024.00040
    This article belongs to the special issue Current Approaches to Malignant Tumors of the Nervous System
    View:174
    Download:8
    Times Cited: 0
    Open Access
    Systematic Review
    Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective
    Background: The main objective of the study was to carry out a systematic literature review to investigate the beneficial role of antioxidants in obesity and diabetes and the association of antio [...] Read more.
    Luxita Sharma, Dhananjay Sharma
    Published: April 07, 2024 Explor Neurosci. 2024;3:103–129
    DOI: https://doi.org/10.37349/en.2024.00039
    This article belongs to the special issue Enteric Neuro-Gliopathies: Ready for Prime Time?
    View:177
    Download:11
    Times Cited: 0
    Open Access
    Review
    Crop and pesticide effects on gut microbiota and neurological functions: a review
    Pesticides are used to ensure the mass production and quality of foods, depending on the environment where they are grown. Trace amounts of pesticides are ingested through diet and high ratios of it [...] Read more.
    Tomomi Komura ... Yoshikazu Nishikawa
    Published: April 07, 2024 Explor Neurosci. 2024;3:80–102
    DOI: https://doi.org/10.37349/en.2024.00038
    View:140
    Download:11
    Times Cited: 0
    Open Access
    Review
    Cuban policosanol: a natural compound for ischemic stroke treatment
    Stroke is among the leading causes of mortality and disability; therefore, it constitutes a relevant health problem. Cuban policosanol presents lipid-lowering, antiplatelet, antioxidant and vascular [...] Read more.
    Vivian Molina Cuevas, Ambar Oyarzábal Yera
    Published: February 26, 2024 Explor Neurosci. 2024;3:65–79
    DOI: https://doi.org/10.37349/en.2024.00037
    This article belongs to the special issue Cerebral Ischemia, Genetics, Comorbidities, Risk Factors and New Therapeutic Options for Neurorestoration
    View:374
    Download:13
    Times Cited: 0
    Open Access
    Review
    Current state of knowledge on the centrifugal visual system (including the pinealo-to-retinal connection) in mammals and its hypothesized role in circadian rhythms
    The ubiquity of circadian rhythms in living organisms has generally been accepted by researchers over the last century. Indeed, morphology and molecular biology of the circadian clock were described [...] Read more.
    Viktória Vereczki ... Ágnes Csáki
    Published: February 22, 2024 Explor Neurosci. 2024;3:51–64
    DOI: https://doi.org/10.37349/en.2024.00036
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:408
    Download:11
    Times Cited: 0
    Open Access
    Mini Review
    Nutritional treatment with the ketogenic diet in children with refractory epilepsy: a narrative review
    The two mainstays of therapy for refractory epilepsy are medication and surgery. Child behavioral and cognitive aspects of epilepsy can be improved by using a specialized dietary regimen such as the [...] Read more.
    Srilaxmi Vityala ... Swathi Nenavath
    Published: October 30, 2023 Explor Neurosci. 2023;2:245–250
    DOI: https://doi.org/10.37349/en.2023.00025
    This article belongs to the special issue Epilepsy
    View:2378
    Download:614
    Times Cited: 0
    Open Access
    Review
    Impact of circadian clock dysfunction on human health
    All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic act [...] Read more.
    Saptadip Samanta, Sk Asif Ali
    Published: September 29, 2022 Explor Neurosci. 2022;1:4–30
    DOI: https://doi.org/10.37349/en.2022.00002
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:2028
    Download:73
    Open Access
    Review
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:1969
    Download:53
    Open Access
    Perspective
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    View:1783
    Download:49
    Open Access
    Review
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:1648
    Download:48
    Times Cited: 0
    Open Access
    Review
    Metabolic correction of neurodegenerative pathologies: the role of macronutrients and timing
    Despite decades of intensive research, effective treatment and prevention strategies for neurodegenerative diseases (NDDs) remain elusive. This review focuses on Alzheimer’s and Parkinson’s dise [...] Read more.
    Yuri Zilberter, Tanya Zilberter
    Published: April 21, 2023 Explor Neurosci. 2023;2:67–81
    DOI: https://doi.org/10.37349/en.2023.00013
    View:1571
    Download:43
    Times Cited: 0
    Open Access
    Mini Review
    Nutritional treatment with the ketogenic diet in children with refractory epilepsy: a narrative review
    The two mainstays of therapy for refractory epilepsy are medication and surgery. Child behavioral and cognitive aspects of epilepsy can be improved by using a specialized dietary regimen such as the [...] Read more.
    Srilaxmi Vityala ... Swathi Nenavath
    Published: October 30, 2023 Explor Neurosci. 2023;2:245–250
    DOI: https://doi.org/10.37349/en.2023.00025
    This article belongs to the special issue Epilepsy
    View:2378
    Download:614
    Times Cited: 0
    Open Access
    Review
    Impact of circadian clock dysfunction on human health
    All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic act [...] Read more.
    Saptadip Samanta, Sk Asif Ali
    Published: September 29, 2022 Explor Neurosci. 2022;1:4–30
    DOI: https://doi.org/10.37349/en.2022.00002
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:2028
    Download:73
    Open Access
    Review
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:1969
    Download:53
    Open Access
    Review
    Inflammatory responses involved in post-cardiac arrest brain injury: mechanisms, regulation, and therapeutic potential
    Neuroinflammation plays a key role in the pathogenesis of post-cardiac arrest (CA) brain injury. Innate immune cells sense a variety of danger signals through pattern-recognition receptors and evoke [...] Read more.
    Yuzhen Zhang ... Kaibin Huang
    Published: April 26, 2023 Explor Neurosci. 2023;2:82–97
    DOI: https://doi.org/10.37349/en.2023.00014
    View:1020
    Download:50
    Times Cited: 0
    Open Access
    Perspective
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    View:1783
    Download:49
    Open Access
    Review
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:1648
    Download:48
    Times Cited: 0
    Open Access
    Review
    Update for astrocytomas: medical and surgical management considerations
    Astrocytomas include a wide range of tumors with unique mutations and varying grades of malignancy. These tumors all originate from the astrocyte, a star-shaped glial cell that plays a major role in [...] Read more.
    Matthew Willman ... Brandon Lucke-Wold
    Published: February 23, 2023 Explor Neurosci. 2023;2:1–26
    DOI: https://doi.org/10.37349/en.2023.00009
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:1208
    Download:34
    Open Access
    Review
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:1969
    Download:53
    Open Access
    Editorial
    Cutting edges in neuroscience to exceed borders
    Dirk M. Hermann
    Published: September 01, 2022 Explor Neurosci. 2022;1:1–3
    DOI: https://doi.org/10.37349/en.2022.00001
    View:1124
    Download:44
    Open Access
    Review
    Impact of circadian clock dysfunction on human health
    All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic act [...] Read more.
    Saptadip Samanta, Sk Asif Ali
    Published: September 29, 2022 Explor Neurosci. 2022;1:4–30
    DOI: https://doi.org/10.37349/en.2022.00002
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:2028
    Download:73
    Open Access
    Review
    Neuregulins: subcellular localization, signaling pathways and their relationship with neuroplasticity and neurological diseases
    Neuregulins (NRGs) and their cognate ErbB receptors (ErbB2–ErbB4) constitute a vast group of proteins encoded by six different genes (NRG16) and many isoforms with critical  [...] Read more.
    Marines Longart ... Juan Carlos Martínez
    Published: September 29, 2022 Explor Neurosci. 2022;1:31–53
    DOI: https://doi.org/10.37349/en.2022.00003
    View:1196
    Download:41
    Open Access
    Perspective
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    View:1783
    Download:49
    Special Issues
    From the Editor-in-Chief
    It is a great pleasure to serve as the newly appointed Editor-in-Chief of Exploration of Neuroscience (EN). EN will be a strong platform for the publication of groundshaking, cutting edge science that will expand our knowledge of neurological diseases and disease treatment. Advances in molecular, cellular and system neurosciences have greatly expanded our understanding of the healthy and the injured brain in recent years, which has set up fascinating perspectives for the development of new treatment options. With the infrastructures and support of Open Exploration Publishing services, the new EN journal seeks to become a reference in discovery and education in neurological diseases.
    Dirk M. Hermann
    Editor-in-Chief of Exploration of Neuroscience