• Exploration of Neuroscience

    eISSN: 2834-5347
    EiC: Dirk M. Hermann, MD, University of Duisburg-Essen
    Frequency: Bimonthly
    APC: No Article Processing Charge before September 30, 2027
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
    Indexing & Archiving: DOAJ
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    Articles
    Open Access
    Mini Review
    Nutritional treatment with the ketogenic diet in children with refractory epilepsy: a narrative review
    The two mainstays of therapy for refractory epilepsy are medication and surgery. Child behavioral and cognitive aspects of epilepsy can be improved by using a specialized dietary regimen such as the [...] Read more.
    Srilaxmi Vityala ... Swathi Nenavath
    Published: October 30, 2023 Explor Neurosci. 2023;2:245–250
    DOI: https://doi.org/10.37349/en.2023.00025
    This article belongs to the special issue Epilepsy
    View:1584
    Download:579
    Times Cited: 0
    Open Access
    Original Article
    Estimation of the allelic status of apolipoprotein E4 isoforms with fully automated LUMIPULSE® assays
    Aim: Apolipoprotein E (ApoE) isoforms, especially the ApoE4 isoform, are genetic risk factors for Alzheimer’s disease (AD). Moreover, the APOE ε4 haplotype has a dose-dependent association wit [...] Read more.
    Tatsushi Yuri ... Hisashi Nojima
    Published: October 16, 2023 Explor Neurosci. 2023;2:238–244
    DOI: https://doi.org/10.37349/en.2023.00024
    This article belongs to the special issue Alzheimer’s Disease
    View:295
    Download:20
    Times Cited: 0
    Open Access
    Review
    Investigation into the vascular contributors to dementia and the associated treatments
    As the average lifespan has increased, memory disorders have become a more pressing public health concern. However, dementia in the elderly population is often neglected in light of other health pri [...] Read more.
    Caroline Grace Davidson ... Brandon Lucke-Wold
    Published: October 15, 2023 Explor Neurosci. 2023;2:224–237
    DOI: https://doi.org/10.37349/en.2023.00023
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:303
    Download:19
    Times Cited: 0
    Open Access
    Review
    Sleep disorders contribute to the development of dementia and Alzheimer’s disease
    Life is the highest form of adaptation to the environment which is based on energy metabolism. To maintain life, the neuromuscular system must constantly interact with the environment. The striatal  [...] Read more.
    Janusz Wiesław Błaszczyk
    Published: October 08, 2023 Explor Neurosci. 2023;2:212–223
    DOI: https://doi.org/10.37349/en.2023.00022
    This article belongs to the special issue Alzheimer’s Disease
    View:307
    Download:11
    Times Cited: 0
    Open Access
    Review
    Negative environmental influences on the developing brain mediated by epigenetic modifications
    Brain development, a complex process, consisting of several phases, starting as early as two weeks after conception, and continuing through childhood till early adolescence, is crucial for the devel [...] Read more.
    Maya Komar-Fletcher ... Joanna Michalina Jurek
    Published: September 28, 2023 Explor Neurosci. 2023;2:193–211
    DOI: https://doi.org/10.37349/en.2023.00021
    View:343
    Download:18
    Times Cited: 0
    Open Access
    Review
    Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature
    Over the past decade, knowledge of the pathophysiology and immunology of multiple sclerosis (MS) and depression, and the complex links to vitamin D (VitD) balance, has increased rapidly. Both diseas [...] Read more.
    Hans-Klaus Goischke
    Published: August 31, 2023 Explor Neurosci. 2023;2:160–192
    DOI: https://doi.org/10.37349/en.2023.00020
    This article belongs to the special issue Novel Therapeutic Approaches for the Treatment of Depression
    View:336
    Download:19
    Times Cited: 0
    Open Access
    Mini Review
    Nutritional treatment with the ketogenic diet in children with refractory epilepsy: a narrative review
    The two mainstays of therapy for refractory epilepsy are medication and surgery. Child behavioral and cognitive aspects of epilepsy can be improved by using a specialized dietary regimen such as the [...] Read more.
    Srilaxmi Vityala ... Swathi Nenavath
    Published: October 30, 2023 Explor Neurosci. 2023;2:245–250
    DOI: https://doi.org/10.37349/en.2023.00025
    This article belongs to the special issue Epilepsy
    View:1584
    Download:579
    Times Cited: 0
    Open Access
    Review
    Impact of circadian clock dysfunction on human health
    All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic act [...] Read more.
    Saptadip Samanta, Sk Asif Ali
    Published: September 29, 2022 Explor Neurosci. 2022;1:4–30
    DOI: https://doi.org/10.37349/en.2022.00002
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:1311
    Download:52
    Times Cited: 0
    Open Access
    Review
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:1084
    Download:42
    Times Cited: 0
    Open Access
    Review
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    Open Access
    Editorial
    Cutting edges in neuroscience to exceed borders
    Dirk M. Hermann
    Published: September 01, 2022 Explor Neurosci. 2022;1:1–3
    DOI: https://doi.org/10.37349/en.2022.00001
    Open Access
    Perspective
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    Open Access
    Mini Review
    Nutritional treatment with the ketogenic diet in children with refractory epilepsy: a narrative review
    The two mainstays of therapy for refractory epilepsy are medication and surgery. Child behavioral and cognitive aspects of epilepsy can be improved by using a specialized dietary regimen such as the [...] Read more.
    Srilaxmi Vityala ... Swathi Nenavath
    Published: October 30, 2023 Explor Neurosci. 2023;2:245–250
    DOI: https://doi.org/10.37349/en.2023.00025
    This article belongs to the special issue Epilepsy
    View:1584
    Download:579
    Times Cited: 0
    Open Access
    Review
    Impact of circadian clock dysfunction on human health
    All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic act [...] Read more.
    Saptadip Samanta, Sk Asif Ali
    Published: September 29, 2022 Explor Neurosci. 2022;1:4–30
    DOI: https://doi.org/10.37349/en.2022.00002
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:1311
    Download:52
    Times Cited: 0
    Open Access
    Review
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    Open Access
    Editorial
    Cutting edges in neuroscience to exceed borders
    Dirk M. Hermann
    Published: September 01, 2022 Explor Neurosci. 2022;1:1–3
    DOI: https://doi.org/10.37349/en.2022.00001
    Open Access
    Perspective
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    Open Access
    Review
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:1084
    Download:42
    Times Cited: 0
    Open Access
    Editorial
    Cutting edges in neuroscience to exceed borders
    Dirk M. Hermann
    Published: September 01, 2022 Explor Neurosci. 2022;1:1–3
    DOI: https://doi.org/10.37349/en.2022.00001
    Open Access
    Review
    Neuregulins: subcellular localization, signaling pathways and their relationship with neuroplasticity and neurological diseases
    Neuregulins (NRGs) and their cognate ErbB receptors (ErbB2–ErbB4) constitute a vast group of proteins encoded by six different genes (NRG16) and many isoforms with critical  [...] Read more.
    Marines Longart ... Juan Carlos Martínez
    Published: September 29, 2022 Explor Neurosci. 2022;1:31–53
    DOI: https://doi.org/10.37349/en.2022.00003
    Open Access
    Perspective
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    Open Access
    Review
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    Open Access
    Review
    Impact of circadian clock dysfunction on human health
    All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic act [...] Read more.
    Saptadip Samanta, Sk Asif Ali
    Published: September 29, 2022 Explor Neurosci. 2022;1:4–30
    DOI: https://doi.org/10.37349/en.2022.00002
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:1311
    Download:52
    Times Cited: 0
    Open Access
    Review
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:1084
    Download:42
    Times Cited: 0
    Special Issues
    From the Editor-in-Chief
    It is a great pleasure to serve as the newly appointed Editor-in-Chief of Exploration of Neuroscience (EN). EN will be a strong platform for the publication of groundshaking, cutting edge science that will expand our knowledge of neurological diseases and disease treatment. Advances in molecular, cellular and system neurosciences have greatly expanded our understanding of the healthy and the injured brain in recent years, which has set up fascinating perspectives for the development of new treatment options. With the infrastructures and support of Open Exploration Publishing services, the new EN journal seeks to become a reference in discovery and education in neurological diseases.
    Dirk M. Hermann
    Editor-in-Chief of Exploration of Neuroscience