• Exploration of Drug Science

    eISSN: 2836-7677
    EiC: Fernando Albericio, PhD, Universidad de Barcelona and University of KwaZulu-Natal
    Frequency: Bimonthly
    APC: No Article Processing Charge before January 31, 2028
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: Google Scholar, Portico
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    Articles
    Open Access
    Mini Review
    Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses
    The search for novel therapeutic agents to combat the crisis of antimicrobial resistance has spanned from terrestrial to unique, marine environments. Currently, most of the drugs available for usage [...] Read more.
    Galana Siro, Atanas Pipite
    Published: February 29, 2024 Explor Drug Sci. 2024;2:117–125
    DOI: https://doi.org/10.37349/eds.2024.00038
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:189
    Download:11
    Times Cited: 0
    Open Access
    Review
    Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery
    The influenza virus glycoprotein hemagglutinin (HA) participates in critical steps of the attachment of viral particles to the host cell membrane receptor and membrane fusion. Due to its crucial inv [...] Read more.
    Francisco Javier Hermoso-Pinilla ... Francisco Javier Luque
    Published: February 29, 2024 Explor Drug Sci. 2024;2:85–116
    DOI: https://doi.org/10.37349/eds.2024.00037
    View:221
    Download:13
    Times Cited: 0
    Open Access
    Review
    Seaweed: a sustainable solution for greening drug manufacturing in the pursuit of sustainable healthcare
    The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to drug production is crucial. This review focuse [...] Read more.
    Leonel Pereira, João Cotas
    Published: February 27, 2024 Explor Drug Sci. 2024;2:50–84
    DOI: https://doi.org/10.37349/eds.2024.00036
    This article belongs to the special issue Greening Drug Manufacturing for a Sustainable Healthcare
    View:845
    Download:24
    Times Cited: 0
    Open Access
    Review
    Effect of the size of nucleic acid delivery systems on their fate in cancer treatment
    Nucleic acid therapeutics are emerging as a promising class of medicines, offering unique therapeutic options for cancer at the gene level. However, the druggability of nucleic acid therapeutics is  [...] Read more.
    Mengyun Ye ... Dandan Zhu
    Published: February 01, 2024 Explor Drug Sci. 2024;2:38–49
    DOI: https://doi.org/10.37349/eds.2024.00035
    This article belongs to the special issue Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics
    View:231
    Download:12
    Times Cited: 0
    Open Access
    Review
    Revisiting 310-helices: biological relevance, mimetics and applications
    310-Helices represent the third most abundant secondary structure proteins. Although understandably overshadowed by α-helices for decades, the 310-helix structure is slowly regaining certain releva [...] Read more.
    Diego Núñez-Villanueva
    Published: February 01, 2024 Explor Drug Sci. 2024;2:6–37
    DOI: https://doi.org/10.37349/eds.2024.00034
    This article belongs to the special issue Mimicking Nature: Biomimetics as Tools for Diagnosis and Therapeutics
    View:428
    Download:24
    Times Cited: 0
    Open Access
    Case Report
    Histological diagnosis of primary biliary cholangitis in one patient without cholestasis alterations: a case report that escaped guidelines
    Primary biliary cholangitis (PBC) is an autoimmune cholangiopathy that affects mainly women and, if untreated, can evolve into biliary cirrhosis. Its prevalence varies worldwide, depending on race,  [...] Read more.
    Matteo Biagi ... Pietro Andreone
    Published: January 22, 2024 Explor Drug Sci. 2024;2:1–5
    DOI: https://doi.org/10.37349/eds.2024.00033
    This article belongs to the special issue Innovative Therapeutics in Hepato-Gastroenterology
    View:220
    Download:12
    Times Cited: 0
    Open Access
    Editorial
    Drug discovery: a multifactorial ecosystem
    Fernando Albericio
    Published: January 01, 2023 Explor Drug Sci. 2023;1:1–5
    DOI: https://doi.org/10.37349/eds.2022.00001
    View:5271
    Download:83
    Times Cited: 0
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:1925
    Download:138
    Open Access
    Original Article
    Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
    Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA)  [...] Read more.
    Yi Ouyang ... Hui Liu
    Published: February 27, 2023 Explor Drug Sci. 2023;1:18–30
    DOI: https://doi.org/10.37349/eds.2023.00003
    This article belongs to the special issue Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics
    View:1545
    Download:107
    Times Cited: 0
    Open Access
    Review
    Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins
    It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell  [...] Read more.
    Qiushi Chen ... Xuechen Li
    Published: February 28, 2023 Explor Drug Sci. 2023;1:31–54
    DOI: https://doi.org/10.37349/eds.2023.00004
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:1381
    Download:63
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:1273
    Download:48
    Times Cited: 0
    Open Access
    Review
    Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery
    Seaweeds, also known as marine algae, have gained attention as a promising source of bioactive compounds with potential applications in drug discovery. This review explores the emerging field of sea [...] Read more.
    Leonel Pereira, Ana Valado
    Published: December 28, 2023 Explor Drug Sci. 2023;1:475–496
    DOI: https://doi.org/10.37349/eds.2023.00032
    View:1200
    Download:39
    Times Cited: 0
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:1925
    Download:138
    Open Access
    Original Article
    Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
    Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA)  [...] Read more.
    Yi Ouyang ... Hui Liu
    Published: February 27, 2023 Explor Drug Sci. 2023;1:18–30
    DOI: https://doi.org/10.37349/eds.2023.00003
    This article belongs to the special issue Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics
    View:1545
    Download:107
    Times Cited: 0
    Open Access
    Editorial
    Drug discovery: a multifactorial ecosystem
    Fernando Albericio
    Published: January 01, 2023 Explor Drug Sci. 2023;1:1–5
    DOI: https://doi.org/10.37349/eds.2022.00001
    View:5271
    Download:83
    Times Cited: 0
    Open Access
    Review
    Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins
    It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell  [...] Read more.
    Qiushi Chen ... Xuechen Li
    Published: February 28, 2023 Explor Drug Sci. 2023;1:31–54
    DOI: https://doi.org/10.37349/eds.2023.00004
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:1381
    Download:63
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:1273
    Download:48
    Times Cited: 0
    Open Access
    Review
    Approved antibacterial drugs in the last 10 years: from the bench to the clinic
    Bacterial infections constitute one of the major cases of primary medical incidences worldwide. Historically, the fight against bacterial infections in humans has been an ongoing battle, due to the  [...] Read more.
    Miguel García-Castro ... Juan Manuel López-Romero
    Published: June 30, 2023 Explor Drug Sci. 2023;1:180–209
    DOI: https://doi.org/10.37349/eds.2023.00013
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:803
    Download:44
    Times Cited: 0
    Open Access
    Review
    Focused ultrasound for treatment of peripheral brain tumors
    Malignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) t [...] Read more.
    Phillip Mitchell Johansen ... Brandon Lucke-Wold
    Published: April 28, 2023 Explor Drug Sci. 2023;1:107–125
    DOI: https://doi.org/10.37349/eds.2023.00009
    Open Access
    Systematic Review
    Utilizing the Ethereum blockchain for retrieving and archiving augmented reality surgical navigation data
    Aim: Conventional techniques to share and archive spinal imaging data raise issues with trust and security, with novel approaches being more greatly considered. Ethereum smart contracts present o [...] Read more.
    Sai Batchu ... Brandon Lucke-Wold
    Published: February 28, 2023 Explor Drug Sci. 2023;1:55–63
    DOI: https://doi.org/10.37349/eds.2023.00005
    Open Access
    Review
    Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in December 2019 quickly escalated to pandemic levels and had a severe impact on public health. There are 761 m [...] Read more.
    Atri Das ... Shantanabha Das
    Published: October 24, 2023 Explor Drug Sci. 2023;1:336–376
    DOI: https://doi.org/10.37349/eds.2023.00024
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    Open Access
    Review
    Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins
    It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell  [...] Read more.
    Qiushi Chen ... Xuechen Li
    Published: February 28, 2023 Explor Drug Sci. 2023;1:31–54
    DOI: https://doi.org/10.37349/eds.2023.00004
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:1381
    Download:63
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:1925
    Download:138
    Open Access
    Editorial
    Drug discovery: a multifactorial ecosystem
    Fernando Albericio
    Published: January 01, 2023 Explor Drug Sci. 2023;1:1–5
    DOI: https://doi.org/10.37349/eds.2022.00001
    View:5271
    Download:83
    Times Cited: 0
    Special Issues
    From the Editor-in-Chief
    The journey from the idea in the laboratory to the drug on the market is possibly the most exciting scientific process and, at the same time, the one with the most significant impact from both social and economic point of view. On the one hand, a new drug helps restore health and improves well-being, even saving lives, but it requires many years of work (an average of 15 years) and a large investment. Exploration of Drug Science (EDS) was born with the idea of covering all the steps of this often magical process, from the discovery itself, the preclinical phase, to the clinical phase. As the new Editor-in-Chief of EDS, I would like to invite colleagues to use our platform to share their latest findings with the scientific committee.
    Fernando Albericio
    Editor-in-Chief of Exploration of Drug Science