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  • Exploration of Drug Science

    eISSN: 2836-7677
    EiC: Fernando Albericio, South Africa
    Frequency: Continuous Publication
    APC: No Article Processing Charge before January 31, 2028
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: DOAJ, Google Scholar, CAS, Dimensions, Portico, etc.
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    Articles
    Open Access
    Original Article
    Interaction of brequinar and analogs with PD-L1: a molecular docking analysis
    Aim: The immunosuppressive drug brequinar (BQR) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) active against autoimmune diseases and viral infections. This oral drug is currently  [...] Read more.
    Gérard Vergoten, Christian Bailly
    Published: June 09, 2025 Explor Drug Sci. 2025;3:1008113
    DOI: https://doi.org/10.37349/eds.2025.1008113
    View:47
    Download:5
    Times Cited: 0
    Open Access
    Review
    Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application
    Pentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molec [...] Read more.
    Dmitrii Platov ... Mikhail Drenichev
    Published: May 29, 2025 Explor Drug Sci. 2025;3:1008112
    DOI: https://doi.org/10.37349/eds.2025.1008112
    This article belongs to the special issue Bioactive Molecules from Natural Sources
    View:154
    Download:12
    Times Cited: 0
    Open Access
    Original Article
    Cytochrome P450 2C9-mediated interactions: molecular docking studies of natural anti-arthritic compounds
    Aim: This study aimed to elucidate the structural basis for the interaction of five natural anti-arthritic compounds, diacerein, rhein, glucosamines (glucosamine 3-sulfate, G3S, and glucosamine 6 [...] Read more.
    Boon Hooi Tan ... Chin Eng Ong
    Published: May 27, 2025 Explor Drug Sci. 2025;3:1008111
    DOI: https://doi.org/10.37349/eds.2025.1008111
    View:125
    Download:7
    Times Cited: 0
    Open Access
    Review
    Antimicrobial peptides: structure, function, mechanism of action and therapeutic applications in human diseases
    Microbial pathogens with antibiotic resistance have become challenging to manage in the last few decades. The situation is alarming and a threat to humankind. Despite emerging new drug candidates, t [...] Read more.
    Rahul Dilawari ... Neha Parmar
    Published: May 09, 2025 Explor Drug Sci. 2025;3:1008110
    DOI: https://doi.org/10.37349/eds.2025.1008110
    View:990
    Download:32
    Times Cited: 0
    Open Access
    Original Article
    High-risk neuroblastoma stage 4 (NBS4): multi-target inhibitors for c-Src kinases (Csk) and retinoic acid (RA) signalling pathways
    Aim: This paper investigates two possible treatment targets for neuroblastoma (NB) stage 4 (NBS4), c-Src kinase (Csk) and retinoic acid (RA) signalling pathways as potential candidates for a mult [...] Read more.
    Amgad Gerges, Una Canning
    Published: May 09, 2025 Explor Drug Sci. 2025;3:1008109
    DOI: https://doi.org/10.37349/eds.2025.1008109
    View:328
    Download:13
    Times Cited: 0
    Open Access
    Original Article
    Combinatorial and fragment-based in silico design of PI3K-alpha natural hybrid antagonists for breast cancer therapeutics
    Aim: The PI3K (phosphoinositide 3-kinase)-alpha isoform is found upregulated in 30–40% of breast cancer. Currently, there are limited selective and specific drugs that target PI3K-alpha, and no [...] Read more.
    Navya Aggarwal ... Banashree Bondhopadhyay
    Published: April 29, 2025 Explor Drug Sci. 2025;3:1008108
    DOI: https://doi.org/10.37349/eds.2025.1008108
    View:322
    Download:10
    Times Cited: 0
    Open Access
    Editorial
    Drug discovery: a multifactorial ecosystem
    Fernando Albericio
    Published: January 01, 2023 Explor Drug Sci. 2023;1:1–5
    DOI: https://doi.org/10.37349/eds.2022.00001
    View:15257
    Download:120
    Times Cited: 0
    Open Access
    Review
    A review of the effects of pharmaceutical pollutants on humans and aquatic ecosystem
    The presence of high-quality water is essential not only for human survival but also for the well-being of plants and animals. This research aimed to examine studies investigating the occurrence of  [...] Read more.
    Jaya Vinny Eapen ... Jayesh Antony
    Published: August 28, 2024 Explor Drug Sci. 2024;2:484–507
    DOI: https://doi.org/10.37349/eds.2024.00058
    View:12692
    Download:273
    Open Access
    Review
    Approved antibacterial drugs in the last 10 years: from the bench to the clinic
    Bacterial infections constitute one of the major cases of primary medical incidences worldwide. Historically, the fight against bacterial infections in humans has been an ongoing battle, due to the  [...] Read more.
    Miguel García-Castro ... Juan Manuel López-Romero
    Published: June 30, 2023 Explor Drug Sci. 2023;1:180–209
    DOI: https://doi.org/10.37349/eds.2023.00013
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:11205
    Download:312
    Open Access
    Review
    Seaweed: a sustainable solution for greening drug manufacturing in the pursuit of sustainable healthcare
    The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to drug production is crucial. This review focuse [...] Read more.
    Leonel Pereira, João Cotas
    Published: February 27, 2024 Explor Drug Sci. 2024;2:50–84
    DOI: https://doi.org/10.37349/eds.2024.00036
    This article belongs to the special issue Greening Drug Manufacturing for a Sustainable Healthcare
    View:8995
    Download:171
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:8815
    Download:280
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:8132
    Download:193
    Open Access
    Review
    Approved antibacterial drugs in the last 10 years: from the bench to the clinic
    Bacterial infections constitute one of the major cases of primary medical incidences worldwide. Historically, the fight against bacterial infections in humans has been an ongoing battle, due to the  [...] Read more.
    Miguel García-Castro ... Juan Manuel López-Romero
    Published: June 30, 2023 Explor Drug Sci. 2023;1:180–209
    DOI: https://doi.org/10.37349/eds.2023.00013
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:11205
    Download:312
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:8815
    Download:280
    Open Access
    Review
    A review of the effects of pharmaceutical pollutants on humans and aquatic ecosystem
    The presence of high-quality water is essential not only for human survival but also for the well-being of plants and animals. This research aimed to examine studies investigating the occurrence of  [...] Read more.
    Jaya Vinny Eapen ... Jayesh Antony
    Published: August 28, 2024 Explor Drug Sci. 2024;2:484–507
    DOI: https://doi.org/10.37349/eds.2024.00058
    View:12692
    Download:273
    Open Access
    Review
    Antioxidants from microalgae and their potential impact on human well-being
    In recent times, there has been a revolutionary surge in antioxidant research, with a focus on harnessing microalgae to enhance wellness and extend human longevity. Microalgae, a diverse group of un [...] Read more.
    Leonel Pereira ... Ana Valado
    Published: May 31, 2024 Explor Drug Sci. 2024;2:292–321
    DOI: https://doi.org/10.37349/eds.2024.00048
    This article belongs to the special issue Greening Drug Manufacturing for a Sustainable Healthcare
    View:6993
    Download:214
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:8132
    Download:193
    Open Access
    Review
    Seaweed: a sustainable solution for greening drug manufacturing in the pursuit of sustainable healthcare
    The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to drug production is crucial. This review focuse [...] Read more.
    Leonel Pereira, João Cotas
    Published: February 27, 2024 Explor Drug Sci. 2024;2:50–84
    DOI: https://doi.org/10.37349/eds.2024.00036
    This article belongs to the special issue Greening Drug Manufacturing for a Sustainable Healthcare
    View:8995
    Download:171
    Open Access
    Review
    A review of the effects of pharmaceutical pollutants on humans and aquatic ecosystem
    The presence of high-quality water is essential not only for human survival but also for the well-being of plants and animals. This research aimed to examine studies investigating the occurrence of  [...] Read more.
    Jaya Vinny Eapen ... Jayesh Antony
    Published: August 28, 2024 Explor Drug Sci. 2024;2:484–507
    DOI: https://doi.org/10.37349/eds.2024.00058
    View:12692
    Download:273
    Open Access
    Review
    Seaweed: a sustainable solution for greening drug manufacturing in the pursuit of sustainable healthcare
    The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to drug production is crucial. This review focuse [...] Read more.
    Leonel Pereira, João Cotas
    Published: February 27, 2024 Explor Drug Sci. 2024;2:50–84
    DOI: https://doi.org/10.37349/eds.2024.00036
    This article belongs to the special issue Greening Drug Manufacturing for a Sustainable Healthcare
    View:8995
    Download:171
    Open Access
    Review
    Antioxidants from microalgae and their potential impact on human well-being
    In recent times, there has been a revolutionary surge in antioxidant research, with a focus on harnessing microalgae to enhance wellness and extend human longevity. Microalgae, a diverse group of un [...] Read more.
    Leonel Pereira ... Ana Valado
    Published: May 31, 2024 Explor Drug Sci. 2024;2:292–321
    DOI: https://doi.org/10.37349/eds.2024.00048
    This article belongs to the special issue Greening Drug Manufacturing for a Sustainable Healthcare
    View:6993
    Download:214
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:8815
    Download:280
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:8132
    Download:193
    Open Access
    Review
    Therapeutic proteins immunogenicity: a peptide point of view
    Protein therapeutics are extensively used in the treatment of autoimmune diseases, but a subset of patients appears to be refractory to these treatments, mainly due to the development of an immune r [...] Read more.
    Feliciana Real-Fernandez ... Paolo Rovero
    Published: October 26, 2023 Explor Drug Sci. 2023;1:377–387
    DOI: https://doi.org/10.37349/eds.2023.00025
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:4356
    Download:132
    Special Issues
    From the Editor-in-Chief
    The journey from the idea in the laboratory to the drug on the market is possibly the most exciting scientific process and, at the same time, the one with the most significant impact from both social and economic point of view. On the one hand, a new drug helps restore health and improves well-being, even saving lives, but it requires many years of work (an average of 15 years) and a large investment. Exploration of Drug Science (EDS) was born with the idea of covering all the steps of this often magical process, from the discovery itself, the preclinical phase, to the clinical phase. As the new Editor-in-Chief of EDS, I would like to invite colleagues to use our platform to share their latest findings with the scientific committee.
    Fernando Albericio
    Editor-in-Chief of Exploration of Drug Science