• Exploration of Drug Science

    eISSN: 2836-7677
    EiC: Fernando Albericio, PhD, Universidad de Barcelona and University of KwaZulu-Natal
    Frequency: Bimonthly
    APC: No Article Processing Charge before January 31, 2028
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: Google Scholar, Portico
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    Articles
    Open Access
    Perspective
    Daropeptide natural products
    Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post- [...] Read more.
    Suze Ma ... Qi Zhang
    Published: April 19, 2024 Explor Drug Sci. 2024;2:190–202
    DOI: https://doi.org/10.37349/eds.2024.00042
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:101
    Download:6
    Times Cited: 0
    Open Access
    Review
    Stapled peptides: targeting protein-protein interactions in drug development
    Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promis [...] Read more.
    Qian Zhang ... Chunqiu Zhang
    Published: April 18, 2024 Explor Drug Sci. 2024;2:154–189
    DOI: https://doi.org/10.37349/eds.2024.00041
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:91
    Download:10
    Times Cited: 0
    Open Access
    Perspective
    Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives
    Five families of investigational products are in clinical investigation to slow or reverse normal aging processes [longevity candidates, mesenchymal stem cells, senolytics drugs, sirtuin activators, [...] Read more.
    Ricardo P. Garay
    Published: April 10, 2024 Explor Drug Sci. 2024;2:144–153
    DOI: https://doi.org/10.37349/eds.2024.00040
    This article belongs to the special issue Recent Advances with Investigational Compounds and Strategies to Delay or Reverse Normal Aging Processes
    View:95
    Download:5
    Times Cited: 0
    Open Access
    Review
    Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonists for the treatment of obesity and diabetes mellitus
    Pharmaceutical interventions play a vital role in managing various conditions, including weight-related issues such as obesity. In this context, lifestyle changes are often challenging to maintain,  [...] Read more.
    Alexander C. Martins ... Fernando Albericio
    Published: April 03, 2024 Explor Drug Sci. 2024;2:126–143
    DOI: https://doi.org/10.37349/eds.2024.00039
    View:231
    Download:14
    Times Cited: 0
    Open Access
    Mini Review
    Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses
    The search for novel therapeutic agents to combat the crisis of antimicrobial resistance has spanned from terrestrial to unique, marine environments. Currently, most of the drugs available for usage [...] Read more.
    Galana Siro, Atanas Pipite
    Published: February 29, 2024 Explor Drug Sci. 2024;2:117–125
    DOI: https://doi.org/10.37349/eds.2024.00038
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:345
    Download:19
    Times Cited: 0
    Open Access
    Review
    Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery
    The influenza virus glycoprotein hemagglutinin (HA) participates in critical steps of the attachment of viral particles to the host cell membrane receptor and membrane fusion. Due to its crucial inv [...] Read more.
    Francisco Javier Hermoso-Pinilla ... Francisco Javier Luque
    Published: February 29, 2024 Explor Drug Sci. 2024;2:85–116
    DOI: https://doi.org/10.37349/eds.2024.00037
    View:376
    Download:22
    Times Cited: 0
    Open Access
    Editorial
    Drug discovery: a multifactorial ecosystem
    Fernando Albericio
    Published: January 01, 2023 Explor Drug Sci. 2023;1:1–5
    DOI: https://doi.org/10.37349/eds.2022.00001
    View:7098
    Download:91
    Times Cited: 0
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:2140
    Download:151
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:1750
    Download:63
    Times Cited: 0
    Open Access
    Original Article
    Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
    Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA)  [...] Read more.
    Yi Ouyang ... Hui Liu
    Published: February 27, 2023 Explor Drug Sci. 2023;1:18–30
    DOI: https://doi.org/10.37349/eds.2023.00003
    This article belongs to the special issue Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics
    View:1659
    Download:108
    Times Cited: 0
    Open Access
    Review
    Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins
    It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell  [...] Read more.
    Qiushi Chen ... Xuechen Li
    Published: February 28, 2023 Explor Drug Sci. 2023;1:31–54
    DOI: https://doi.org/10.37349/eds.2023.00004
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:1553
    Download:64
    Open Access
    Review
    Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery
    Seaweeds, also known as marine algae, have gained attention as a promising source of bioactive compounds with potential applications in drug discovery. This review explores the emerging field of sea [...] Read more.
    Leonel Pereira, Ana Valado
    Published: December 28, 2023 Explor Drug Sci. 2023;1:475–496
    DOI: https://doi.org/10.37349/eds.2023.00032
    View:1403
    Download:44
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:2140
    Download:151
    Open Access
    Original Article
    Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
    Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA)  [...] Read more.
    Yi Ouyang ... Hui Liu
    Published: February 27, 2023 Explor Drug Sci. 2023;1:18–30
    DOI: https://doi.org/10.37349/eds.2023.00003
    This article belongs to the special issue Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics
    View:1659
    Download:108
    Times Cited: 0
    Open Access
    Editorial
    Drug discovery: a multifactorial ecosystem
    Fernando Albericio
    Published: January 01, 2023 Explor Drug Sci. 2023;1:1–5
    DOI: https://doi.org/10.37349/eds.2022.00001
    View:7098
    Download:91
    Times Cited: 0
    Open Access
    Review
    Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins
    It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell  [...] Read more.
    Qiushi Chen ... Xuechen Li
    Published: February 28, 2023 Explor Drug Sci. 2023;1:31–54
    DOI: https://doi.org/10.37349/eds.2023.00004
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:1553
    Download:64
    Open Access
    Review
    The protective role of GLP-1 in neuro-ophthalmology
    Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging po [...] Read more.
    Sohum Sheth ... Brandon Lucke-Wold
    Published: August 28, 2023 Explor Drug Sci. 2023;1:221–238
    DOI: https://doi.org/10.37349/eds.2023.00015
    View:1750
    Download:63
    Times Cited: 0
    Open Access
    Review
    Approved antibacterial drugs in the last 10 years: from the bench to the clinic
    Bacterial infections constitute one of the major cases of primary medical incidences worldwide. Historically, the fight against bacterial infections in humans has been an ongoing battle, due to the  [...] Read more.
    Miguel García-Castro ... Juan Manuel López-Romero
    Published: June 30, 2023 Explor Drug Sci. 2023;1:180–209
    DOI: https://doi.org/10.37349/eds.2023.00013
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:1162
    Download:61
    Times Cited: 0
    Open Access
    Systematic Review
    Utilizing the Ethereum blockchain for retrieving and archiving augmented reality surgical navigation data
    Aim: Conventional techniques to share and archive spinal imaging data raise issues with trust and security, with novel approaches being more greatly considered. Ethereum smart contracts present o [...] Read more.
    Sai Batchu ... Brandon Lucke-Wold
    Published: February 28, 2023 Explor Drug Sci. 2023;1:55–63
    DOI: https://doi.org/10.37349/eds.2023.00005
    Open Access
    Review
    Focused ultrasound for treatment of peripheral brain tumors
    Malignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) t [...] Read more.
    Phillip Mitchell Johansen ... Brandon Lucke-Wold
    Published: April 28, 2023 Explor Drug Sci. 2023;1:107–125
    DOI: https://doi.org/10.37349/eds.2023.00009
    View:1106
    Download:34
    Open Access
    Review
    Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in December 2019 quickly escalated to pandemic levels and had a severe impact on public health. There are 761 m [...] Read more.
    Atri Das ... Shantanabha Das
    Published: October 24, 2023 Explor Drug Sci. 2023;1:336–376
    DOI: https://doi.org/10.37349/eds.2023.00024
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    Open Access
    Review
    Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins
    It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell  [...] Read more.
    Qiushi Chen ... Xuechen Li
    Published: February 28, 2023 Explor Drug Sci. 2023;1:31–54
    DOI: https://doi.org/10.37349/eds.2023.00004
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:1553
    Download:64
    Open Access
    Review
    Nature-inspired and medicinally relevant short peptides
    Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th [...] Read more.
    Maria G. Ciulla ... Kamal Kumar
    Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
    DOI: https://doi.org/10.37349/eds.2023.00011
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:2140
    Download:151
    Open Access
    Original Article
    Insights into the binding selectivity of harzianoic acids A and B to tetraspanin CD81
    Aim: Harzianoic acids A and B (Hz-A/B) are two rare cyclobutene-containing sesquiterpenes isolated from a marine strain of the sponge-associated fungus Trichoderma harzianum. They display anticancer and antiviral effects, r [...] Read more.
    Gérard Vergoten, Christian Bailly
    Published: November 01, 2023 Explor Drug Sci. 2023;1:405–419
    DOI: https://doi.org/10.37349/eds.2023.00027
    Special Issues
    From the Editor-in-Chief
    The journey from the idea in the laboratory to the drug on the market is possibly the most exciting scientific process and, at the same time, the one with the most significant impact from both social and economic point of view. On the one hand, a new drug helps restore health and improves well-being, even saving lives, but it requires many years of work (an average of 15 years) and a large investment. Exploration of Drug Science (EDS) was born with the idea of covering all the steps of this often magical process, from the discovery itself, the preclinical phase, to the clinical phase. As the new Editor-in-Chief of EDS, I would like to invite colleagues to use our platform to share their latest findings with the scientific committee.
    Fernando Albericio
    Editor-in-Chief of Exploration of Drug Science