• Exploration of Neuroprotective Therapy

    eISSN: 2769-6510
    EiC: Rafael Franco, PhD
    Frequency: Bimonthly
    APC: No Article Processing Charge before July 31, 2026
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
    Indexing & Archiving: CAS, DOAJ, J-Gate, Dimensions, ResearchGate, etc.
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    Articles
    Open Access
    Review
    Rehabilitation for non-motor symptoms for patients with Parkinson’s disease from an α-synuclein perspective: a narrative review
    Parkinson’s disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbr [...] Read more.
    Zhaoyang Liu ... Wen Liu
    Published: August 27, 2023 Explor Neuroprot Ther. 2023;3:235–257
    DOI: https://doi.org/10.37349/ent.2023.00049
    This article belongs to the special issue Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
    View:244
    Download:15
    Times Cited: 0
    Open Access
    Review
    Targeting α-synuclein aggregation with immunotherapy: a promising therapeutic approach for Parkinson’s disease
    Parkinson’s disease (PD) is a prevalent neurodegenerative disease (NDD) affecting millions of individuals. The pathogenesis of PD centers around α-synuclein (α-Syn), a pivotal protein whose aggr [...] Read more.
    Gabriela Henriquez, Mahesh Narayan
    Published: August 25, 2023 Explor Neuroprot Ther. 2023;3:207–234
    DOI: https://doi.org/10.37349/ent.2023.00048
    This article belongs to the special issue Parkinsons Disease: Principal Targets and Interventional Mechanisms
    View:285
    Download:16
    Times Cited: 0
    Open Access
    Review
    Diffusion magnetic resonance imaging-based surrogate marker in amyotrophic lateral sclerosis
    Amyotrophic lateral sclerosis (ALS) is the most prevalent type of motor neuron disease (MND) and is diagnosed with a delay from the first appearance of symptoms. Surrogate markers that may be used t [...] Read more.
    Yuya Saito
    Published: August 25, 2023 Explor Neuroprot Ther. 2023;3:186–206
    DOI: https://doi.org/10.37349/ent.2023.00047
    This article belongs to the special issue Biomarkers in Amyotrophic Lateral Sclerosis
    Open Access
    Case Report
    Tension pneumocephalus as a complication of surgical evacuation of chronic subdural hematoma: case report and literature review
    The management of symptomatic chronic subdural hematoma (CSDH) is surgical evacuation and prognosis in most cases is good. Tension pneumocephalus is the presence of air under pressure in the intracr [...] Read more.
    Mohammed A. Azab ... Brandon Lucke-Wold
    Published: August 23, 2023 Explor Neuroprot Ther. 2023;3:177–185
    DOI: https://doi.org/10.37349/ent.2023.00046
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:230
    Download:17
    Times Cited: 0
    Open Access
    Review
    Muscle fatigue and exercise-related biomarkers in amyotrophic lateral sclerosis
    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder affecting motor neurons. The complex etiopathogenetic mechanism of ALS can lead to extensive alterations, including co [...] Read more.
    Francesca Bianchi ... Gabriele Siciliano
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:164–176
    DOI: https://doi.org/10.37349/ent.2023.00045
    This article belongs to the special issue Biomarkers in Amyotrophic Lateral Sclerosis
    View:303
    Download:19
    Times Cited: 0
    Open Access
    Review
    Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy
    Currently, the predominant targets for the treatment of Alzheimer’s disease (AD) are the main components of the two pathological structures: senile plaques (composed of amyloid beta peptide aggreg [...] Read more.
    Jesús Avila ... Félix Hernández
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:151–163
    DOI: https://doi.org/10.37349/ent.2023.00044
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
    View:307
    Download:24
    Times Cited: 0
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:4230
    Download:1299
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3890
    Download:235
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3823
    Download:239
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:3327
    Download:207
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:3150
    Download:195
    Open Access
    Review
    Cholesterol in autism spectrum disorders
    The autism spectrum disorder (ASD) comprises a series of neurological diseases that share serious alterations of the development of the central nervous system. The degree of disability may vary so t [...] Read more.
    Rafael Franco ... Irene Reyes-Resina
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:10–18
    DOI: https://doi.org/10.37349/ent.2021.00003
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2698
    Download:93
    Times Cited: 0
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:4230
    Download:1299
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3823
    Download:239
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3890
    Download:235
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:3327
    Download:207
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:3150
    Download:195
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:2305
    Download:115
    Open Access
    Review
    Blocking cholesterol storage to treat Alzheimer’s disease
    Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltr [...] Read more.
    Ta Yuan Chang ... James G. Gow
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
    DOI: https://doi.org/10.37349/ent.2021.00014
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1703
    Download:73
    Open Access
    Review
    Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
    Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the het [...] Read more.
    Xuntian Jiang, Daniel S. Ory
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
    DOI: https://doi.org/10.37349/ent.2021.00012
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1390
    Download:78
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3890
    Download:235
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3823
    Download:239
    Open Access
    Review
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:1892
    Download:53
    Open Access
    Review
    The glymphatic system and subarachnoid hemorrhage: disruption and recovery
    The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the b [...] Read more.
    Stephan Quintin ... Brandon Lucke-Wold
    Published: June 21, 2022 Explor Neuroprot Ther. 2022;2:118–130
    DOI: https://doi.org/10.37349/ent.2022.00023
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:1294
    Download:62
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