• Exploration of Neuroprotective Therapy

    eISSN: 2769-6510
    EiC: Rafael Franco, PhD
    Frequency: Bimonthly
    APC: No Article Processing Charge
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
    Indexing & Archiving: CAS, DOAJ, J-Gate, Dimensions, ResearchGate, etc.
    Follow the journal:
    Follow the journal:
    Articles
    Open Access
    Original Article
    Efficacy of memantine compared with sodium valproate as prophylactic treatment for migraine: a controlled randomized pilot study
    Aim: To compare the efficacy of memantine with that of valproate as a prophylactic treatment for episodic migraine within three months. The efficacy, safety, and response rate were evaluated.  [...] Read more.
    Damaris Vazquez-Guevara ... Ildefonso Rodriguez-Leyva
    Published: April 28, 2023 Explor Neuroprot Ther. 2023;3:131–138
    DOI: https://doi.org/10.37349/ent.2023.00042
    View:138
    Download:5
    Times Cited: 0
    Open Access
    Review
    Reversible cerebral vasoconstriction syndrome: a clinical and therapeutic challenge
    Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by thunderclap headache and intracranial segmental vasoconstriction with or without signs of neurological deficit with a variabl [...] Read more.
    Andrés Ricaurte-Fajardo ... Nathalia Melo Gonzalez
    Published: April 28, 2023 Explor Neuroprot Ther. 2023;3:120–130
    DOI: https://doi.org/10.37349/ent.2023.00041
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:184
    Download:20
    Times Cited: 0
    Open Access
    Review
    Epigenetic and non-epigenetic mechanisms in the accelerated cellular aging in late-onset Alzheimer’s disease
    Late-onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's disease (AD) and its risk increases exponentially with aging. The incidence of LOAD is reported to  [...] Read more.
    Kajal Rawat, Prathiba Garlapally
    Published: April 28, 2023 Explor Neuroprot Ther. 2023;3:105–119
    DOI: https://doi.org/10.37349/ent.2023.00040
    This article belongs to the special issue Recent Advances in Neurochemistry and Genetics of Late-onset Alzheimer's Disease
    View:140
    Download:15
    Times Cited: 0
    Open Access
    Review
    Innate and adaptive glial cell responses in Alzheimer’s disease
    Alzheimer’s disease (AD), which affects around twenty-seven million people globally, is an aging-related neurodegenerative condition characterized by the extracellular deposition of misfolded amyl [...] Read more.
    Ankita Singh, Tiratha Raj Singh
    Published: April 03, 2023 Explor Neuroprot Ther. 2023;3:90–104
    DOI: https://doi.org/10.37349/ent.2023.00039
    This article belongs to the special issue Glia and Neuroprotection
    View:247
    Download:19
    Times Cited: 0
    Open Access
    Review
    The role of microbiota-gut-brain axis in neurodegenerative diseases: biochemical and therapeutic aspects
    The enteric nervous system (ENS) is considered by some authors as the second human brain, given its fundamental role in the regulation process of the central nervous system (CNS). Recent data from s [...] Read more.
    Januário T. Ernesto ... Cláudio Viegas Jr.
    Published: March 29, 2023 Explor Neuroprot Ther. 2023;3:71–89
    DOI: https://doi.org/10.37349/ent.2023.00038
    View:354
    Download:24
    Times Cited: 0
    Open Access
    Review
    Neuroprotective agents in acute ischemic stroke
    Acute ischemic stroke (AIS) is the leading cause of disability and one of the top causes of mortality worldwide. The current standard of care is reperfusion therapy including intravenous thrombolysi [...] Read more.
    Grace YY Chia ... Benjamin YQ Tan
    Published: February 28, 2023 Explor Neuroprot Ther. 2023;3:47–70
    DOI: https://doi.org/10.37349/ent.2023.00037
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:392
    Download:20
    Times Cited: 0
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:3403
    Download:975
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3047
    Download:197
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2979
    Download:192
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:2770
    Download:188
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:2607
    Download:177
    Open Access
    Review
    Cholesterol in autism spectrum disorders
    The autism spectrum disorder (ASD) comprises a series of neurological diseases that share serious alterations of the development of the central nervous system. The degree of disability may vary so t [...] Read more.
    Rafael Franco ... Irene Reyes-Resina
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:10–18
    DOI: https://doi.org/10.37349/ent.2021.00003
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2382
    Download:91
    Times Cited: 0
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:3403
    Download:975
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3047
    Download:197
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2979
    Download:192
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:2770
    Download:188
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:2607
    Download:177
    Open Access
    Review
    Peroxisomes in intracellular cholesterol transport: from basic physiology to brain pathology
    Peroxisomes are actively involved in the metabolism of various lipids including fatty acids, ether phospholipids, bile acids as well as the processing of reactive oxygen and nitrogen species. Recent [...] Read more.
    Jian Xiao ... Jie Luo
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:127–145
    DOI: https://doi.org/10.37349/ent.2021.00011
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1787
    Download:105
    Open Access
    Review
    Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
    Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the het [...] Read more.
    Xuntian Jiang, Daniel S. Ory
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
    DOI: https://doi.org/10.37349/ent.2021.00012
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1183
    Download:75
    Open Access
    Review
    Blocking cholesterol storage to treat Alzheimer’s disease
    Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltr [...] Read more.
    Ta Yuan Chang ... James G. Gow
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
    DOI: https://doi.org/10.37349/ent.2021.00014
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1441
    Download:68
    Open Access
    Review
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:1618
    Download:46
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2979
    Download:192
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3047
    Download:197
    Open Access
    Review
    The glymphatic system and subarachnoid hemorrhage: disruption and recovery
    The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the b [...] Read more.
    Stephan Quintin ... Brandon Lucke-Wold
    Published: June 21, 2022 Explor Neuroprot Ther. 2022;2:118–130
    DOI: https://doi.org/10.37349/ent.2022.00023
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:1004
    Download:55
    Special Issues