• Exploration of Neuroprotective Therapy

    eISSN: 2769-6510
    EiC: Rafael Franco, Spain
    Frequency: Bimonthly
    APC: No Article Processing Charge before July 31, 2026
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
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    Articles
    Open Access
    Review
    Exploring therapeutical targets and innovative treatments for ischemic stroke: a comprehensive review
    This review focuses on the current advances in the field of therapeutic targets and treatments for stroke. Stroke is a major health problem worldwide, with significant impacts on morbidity and morta [...] Read more.
    Lidija Radenovic
    Published: November 20, 2024 Explor Neuroprot Ther. 2024;4:459–484
    DOI: https://doi.org/10.37349/ent.2024.00094
    This article belongs to the special issue Therapeutic Targets for Neuroprotection in Ischemic Stroke
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    Times Cited: 0
    Open Access
    Review
    Potentialities of IGF-1 for regulating oxidative stress in neuroinflammation and neurodegeneration: theoretical review
    Insulin-like growth factor-1 (IGF-1) elicits a variety of effects on the regulation of oxidative stress, a topic that remains shrouded in controversy. This intricate regulation plays a pivotal role  [...] Read more.
    Macarena Lorena Herrera ... Claudia Beatriz Hereñú
    Published: October 31, 2024 Explor Neuroprot Ther. 2024;4:442–458
    DOI: https://doi.org/10.37349/ent.2024.00093
    View:371
    Download:18
    Times Cited: 0
    Open Access
    Review
    Protein kinases as therapeutic targets for Alzheimer’s disease: a brief review
    Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disorder, with an unknown etiology and a multifactorial pathophysiology characterized by protein misfolding, neuroinflamma [...] Read more.
    Isabela Marie Fernandes Silva ... Claudio Viegas Jr.
    Published: October 28, 2024 Explor Neuroprot Ther. 2024;4:411–441
    DOI: https://doi.org/10.37349/ent.2024.00092
    View:363
    Download:32
    Times Cited: 0
    Open Access
    Mini Review
    Impaired glymphatic clearance is an important cause of Alzheimer’s disease
    Alzheimer’s disease (AD) is the leading cause of dementia worldwide. The disease is characterized by the abnormal accumulation of amyloid β (Aβ) protein creating neuritic plaques, hyperphosphory [...] Read more.
    Iyawnna Hazzard ... Forshing Lui
    Published: October 24, 2024 Explor Neuroprot Ther. 2024;4:401–410
    DOI: https://doi.org/10.37349/ent.2024.00091
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
    View:489
    Download:24
    Times Cited: 0
    Open Access
    Perspective
    Reversion or compensation of mild cognitive impairment to normal cognition: strategies to prevent the development of Alzheimer’s disease continuum
    Alzheimer’s disease continuum has been described as the progressive stages of the disease over a long period. This progression can be categorized into three main stages: preclinical, mild cognitiv [...] Read more.
    Marina Avila-Villanueva, Jesús Avila
    Published: September 27, 2024 Explor Neuroprot Ther. 2024;4:392–400
    DOI: https://doi.org/10.37349/ent.2024.00090
    View:619
    Download:23
    Times Cited: 0
    Open Access
    Review
    Possible roles of heteroreceptor complexes in excitotoxic processes
    Excitotoxicity represents a neuropathological process, describing the toxic actions of excitatory neurotransmitters, where the excessive or prolonged activation of glutamate receptors triggers a cas [...] Read more.
    Diego Guidolin ... Luigi F. Agnati
    Published: September 24, 2024 Explor Neuroprot Ther. 2024;4:366–391
    DOI: https://doi.org/10.37349/ent.2024.00089
    This article belongs to the special issue GPCR Heteroreceptor Complexes as Key Players in Neuroprotection
    View:546
    Download:24
    Times Cited: 0
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:9161
    Download:391
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:8414
    Download:313
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:7302
    Download:2090
    Open Access
    Review
    Biomarkers in small fiber neuropathy
    Small fiber neuropathy (SFN) is a relatively common, but largely understudied neurological syndrome which has affected the lives of many globally. The common symptoms of SFN include pain, dysesthesi [...] Read more.
    Amanda C. Y. Chan ... Joy Vijayan
    Published: December 30, 2022 Explor Neuroprot Ther. 2022;2:264–283
    DOI: https://doi.org/10.37349/ent.2022.00033
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:6930
    Download:109
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:6277
    Download:184
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:5372
    Download:256
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:7302
    Download:2090
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:9161
    Download:391
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:8414
    Download:313
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:5372
    Download:256
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:5151
    Download:219
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:6277
    Download:184
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:8414
    Download:313
    Open Access
    Review
    Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
    Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the het [...] Read more.
    Xuntian Jiang, Daniel S. Ory
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
    DOI: https://doi.org/10.37349/ent.2021.00012
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    Open Access
    Review
    Blocking cholesterol storage to treat Alzheimer’s disease
    Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltr [...] Read more.
    Ta Yuan Chang ... James G. Gow
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
    DOI: https://doi.org/10.37349/ent.2021.00014
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:3860
    Download:100
    Open Access
    Review
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    Open Access
    Review
    The glymphatic system and subarachnoid hemorrhage: disruption and recovery
    The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the b [...] Read more.
    Stephan Quintin ... Brandon Lucke-Wold
    Published: June 21, 2022 Explor Neuroprot Ther. 2022;2:118–130
    DOI: https://doi.org/10.37349/ent.2022.00023
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:3006
    Download:97
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:9161
    Download:391
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