• Exploration of Neuroprotective Therapy

    eISSN: 2769-6510
    EiC: Rafael Franco, PhD
    Frequency: Bimonthly
    APC: No Article Processing Charge before July 31, 2026
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
    Indexing & Archiving: CAS, DOAJ, Google Scholar, J-Gate, Dimensions, etc.
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    Articles
    Open Access
    Original Article
    Cognitive-motor interference in multiple sclerosis and healthy controls: results from single, dual, and triple task posturography
    Aim: This article is based on our previous research, which was presented as a poster at the ECTRIMS Congress 2018 and published as a conference abstract (https://www.professionalabstracts.com/ect [...] Read more.
    Patrik Althoff ... Tanja Schmitz-Hübsch
    Published: June 12, 2024 Explor Neuroprot Ther. 2024;4:273–287
    DOI: https://doi.org/10.37349/ent.2024.00082
    View:149
    Download:7
    Times Cited: 0
    Open Access
    Systematic Review
    Effect of gardening physical activity on neuroplasticity and cognitive function
    Background: The beneficial effects of gardening as a form of physical activity have garnered growing interest in recent years. This research aimed to evaluate the effect of gardening as a physica [...] Read more.
    Antonio G. Lentoor
    Published: June 05, 2024 Explor Neuroprot Ther. 2024;4:251–272
    DOI: https://doi.org/10.37349/ent.2024.00081
    This article belongs to the special issue Empower Yourself - Physical Activity as Prevention and Rehabilitation of Neurological and Psychiatric Diseases
    View:248
    Download:11
    Times Cited: 0
    Open Access
    Review
    Advances in pharmacogenomics: optimizing antiepileptic drug therapy for drug-resistant epilepsy
    Epilepsy, a complex neurological disorder, is influenced by intricate interactions within cortical, hippocampal, or thalamocortical neuronal networks, presenting a genetically complex condition with [...] Read more.
    Amna Shahid ... Sameen Abbas
    Published: May 28, 2024 Explor Neuroprot Ther. 2024;4:240–250
    DOI: https://doi.org/10.37349/ent.2024.00080
    View:226
    Download:7
    Times Cited: 0
    Open Access
    Review
    Diverse avenues of research support the transmethylation theory of psychosis: implications for neuroprotection
    Transmethylation in the context of psychiatry has historically referred to the enzymatic transfer of a methyl group from one biochemical to another, whose resulting function can change so dramatical [...] Read more.
    Christine L. Miller
    Published: May 15, 2024 Explor Neuroprot Ther. 2024;4:198–239
    DOI: https://doi.org/10.37349/ent.2024.00079
    This article belongs to the special issue Defending the Brain and the Mind: Exploring Neuroprotective Therapies for Mental Health Disorders
    View:347
    Download:14
    Times Cited: 0
    Open Access
    Review
    Cerebral stroke-induced neurogenesis: insights and therapeutic implications
    Stroke, one of the leading causes of global morbidity and mortality, results from disrupted cerebral blood circulation, leads to cellular damage or death. Ischemic stroke, the predominant subtype, r [...] Read more.
    Mydhili Radhakrishnan ... Sumana Chakravarty
    Published: April 26, 2024 Explor Neuroprot Ther. 2024;4:172–197
    DOI: https://doi.org/10.37349/ent.2024.00078
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:500
    Download:33
    Times Cited: 0
    Open Access
    Original Article
    Lifetime stressors relate to invisible symptoms of multiple sclerosis
    Aim: Childhood stressors can increase adult stress perception and may accumulate over the lifespan to impact symptoms of multiple sclerosis (MS). Growing evidence links childhood stressors (e.g., [...] Read more.
    Carri S. Polick ... Sarah A. Stoddard
    Published: April 22, 2024 Explor Neuroprot Ther. 2024;4:158–171
    DOI: https://doi.org/10.37349/ent.2024.00077
    View:521
    Download:24
    Times Cited: 0
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:6450
    Download:285
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:6349
    Download:322
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:6061
    Download:1847
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:4335
    Download:221
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:4321
    Download:154
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:4312
    Download:211
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:6061
    Download:1847
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:6349
    Download:322
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:6450
    Download:285
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:4335
    Download:221
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:4312
    Download:211
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:4321
    Download:154
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:6450
    Download:285
    Open Access
    Review
    Blocking cholesterol storage to treat Alzheimer’s disease
    Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltr [...] Read more.
    Ta Yuan Chang ... James G. Gow
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
    DOI: https://doi.org/10.37349/ent.2021.00014
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    Open Access
    Review
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    Open Access
    Review
    Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
    Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the het [...] Read more.
    Xuntian Jiang, Daniel S. Ory
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
    DOI: https://doi.org/10.37349/ent.2021.00012
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:6349
    Download:322
    Open Access
    Review
    The glymphatic system and subarachnoid hemorrhage: disruption and recovery
    The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the b [...] Read more.
    Stephan Quintin ... Brandon Lucke-Wold
    Published: June 21, 2022 Explor Neuroprot Ther. 2022;2:118–130
    DOI: https://doi.org/10.37349/ent.2022.00023
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:2146
    Download:76
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