• Exploration of Immunology

    EiC: Dominique J. Charron, MD, PhD, Hospital Saint Louis
    Adjunct-EiC: Reem Al-Daccak, PhD, Hospital Saint Louis
    Frequency: Bimonthly
    APC: No Article Processing Charge
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Permanent Archive: Portico
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    Open Access
    Original Article
    Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition
    Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect antibody drug characteristics and quality control. In order to provide a global feature of N-glycan interactions in response to antigen and Fc receptor bindings, the interactions among Fc N-glycans and N-glycans’ interaction with Fc CH2 and CH3 domains have been studied....
    Buyong Ma
    Online First: April 19, 2021 Explor Immunol. 2021;1:Online First
    DOI: https://doi.org/10.37349/ei.2021.00004
    Times Cited: 0
    Open Access
    Original Study
    In silico investigation of binding affinities between human leukocyte antigen class I molecules and SARS-CoV-2 virus spike and ORF1ab proteins
    Aim: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019, a global pandemic. There is hence an urgent need for effective approaches to...
    Spyros A. Charonis ... Apostolos P. Georgopoulos
    Online First: March 30, 2021 Explor Immunol. 2021;1:Online First
    DOI: https://doi.org/10.37349/ei.2021.00003
    Times Cited: 0
    Open Access
    The role of interleukin-24 in atopic dermatitis
    Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl hydrocarbon receptor modulator, has been demonstrated to attenuate the development of AD in clinical studies. Recently, we found that tapinarof upregulated the expression of filaggrin and loricrin, which are essential proteins in skin barrier functions. Paradoxically, tapinarof induced interleukin (IL)-24 secretion by normal human keratinocytes. IL-24 is produced by T hel...
    Yen Hai Vu ... Gaku Tsuji
    Online First: March 01, 2021 Explor Immunol. 2021;1:Online First
    DOI: https://doi.org/10.37349/ei.2021.00002
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    Times Cited: 0
    Open Access
    Exploration of Immunology: challenging knowledge, developing curiosity and transforming passion into discovery
    Dominique J Charron, Reem Al-Daccak
    Online First: December 01, 2020 Explor Immunol. 2020;1:Online First
    DOI: https://doi.org/10.37349/ei.2021.00001
    Times Cited: 0
    Special Issues