• Special Issue Topic

    Enteric Neuro-Gliopathies: Ready for Prime Time?

    Submission Deadline: March 31, 2025

    Guest Editor

    Prof. Gabrio Bassotti E-Mail

    Associate Professor of Gastroenterology, Perugia University School of Medicine, Perugia, Italy

    Research Keywords: Constipation, gastrointestinal motility, enteric glial cells, entero-neurogliopathies

    About the Special Issue

    There is presently wide consensus on the fact that the enteric nervous system (ENS) represents a “second brain” for organisms. The ENS controls almost all activities of the gut, and it is mainly composed of enteric neurons, enteric glial cells (EGC), and interstitial cells of Cajal (ICC), arranged in a complex neural networks throughout the intestinal wall. Among the many complex functions regulated by the ENS, one of the most important is related to the control of intestinal motility. Indeed, there is mounting evidence that several of the so-called “functional” disorders are actually due to ENS dysfunction, and should be probably reclassified as “enteric neuro-gliopathies”.

    In this special issue will be considered studies (basic science and clinical) on the possible dysfunction of the cell types forming the ENS in the pathophysiology of enteric dysmotilities and enteric motor/perceptive disorders affecting the gut-brain axis.

    Call for Papers

    Published Articles

    Open Access
    Do enteric glial cells play a role in the pathophysiology of major depression?
    Major depressive disorder (MDD) is a common mental disorder associated with significant suffering and disability. Recent evidence has highlighted the role of the gut-brain axis in the pathogenesis o [...] Read more.
    Ravi Philip Rajkumar
    Published: April 28, 2024 Explor Neurosci. 2024;3:156–174
    DOI: https://doi.org/10.37349/en.2024.00042
    Times Cited: 0
    Open Access
    Systematic Review
    Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective
    Background: The main objective of the study was to carry out a systematic literature review to investigate the beneficial role of antioxidants in obesity and diabetes and the association of antio [...] Read more.
    Luxita Sharma, Dhananjay Sharma
    Published: April 07, 2024 Explor Neurosci. 2024;3:103–129
    DOI: https://doi.org/10.37349/en.2024.00039
    Times Cited: 0