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  • Exploration of Medicine

    eISSN: 2692-3106
    EiC: Lindsay A. Farrer, USA
    Frequency: Continuous Publication
    APC: $2,000 per article (See APC Waivers and Discounts)
    Publishing Model: Open Access
    Peer Review Model: Single Blind
    Indexing & Archiving: Scopus, Google Scholar, DOAJ, CAS, Dimensions, Portico, etc. The journal is also the member of COPE.
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    Articles
    Open Access
    Original Article
    Assessment of CD4+ T cell recovery after direct-acting antiviral hepatitis C treatment in HIV/HCV coinfected immunological nonresponders to ART
    Aim: This study investigated the effects of successful hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) on CD4+ T cell recovery in HIV/HCV coinfected immunological non-respo [...] Read more.
    Violetta Vlasova ... Konstantin Shmagel
    View:4
    Download:2
    Times Cited: 0
    Open Access
    Original Article
    Analysis of SDC2 and SEPT9 promoters methylation in plasma cfDNA to detect colorectal and precancerous lesions
    Aim: Analysis of circulating free DNA (cfDNA) is now broadly used to diagnose, assess treatment response, and recurrence of various tumor types. Detection of aberrant cfDNA methylation in plasma  [...] Read more.
    Viktoria Borobova ... Sergey Kovalenko
    Published: May 21, 2025 Explor Med. 2025;6:1001322
    DOI: https://doi.org/10.37349/emed.2025.1001322
    This article belongs to the special issue Molecular Diagnostics in Oncology
    View:20
    Download:3
    Times Cited: 0
    Open Access
    Original Article
    Adherence to dietary supplementation with menaquinone-7, a vitamin K2 analogue
    Aim: The VitaK-CAC (vitamin K-coronary artery calcification) trial is a double-blind, randomized, placebo-controlled trial in patients with pre-existent CAC who were treated for two years with ei [...] Read more.
    Liv M Vossen ... Peter W de Leeuw
    Published: May 21, 2025 Explor Med. 2025;6:1001321
    DOI: https://doi.org/10.37349/emed.2025.1001321
    View:35
    Download:3
    Times Cited: 0
    Open Access
    Original Article
    Comparative analysis of differentially expressed genes in breast cancer across Asian and European populations: insights into molecular pathways and biomarkers
    Aim: Breast cancer (BC) is the most common malignancy among women and a leading cause of cancer-related mortality. Early detection and prediction are crucial for prognosis and targeted therapy se [...] Read more.
    Prabhu Meganathan ... Shreshta Reddy
    Published: May 21, 2025 Explor Med. 2025;6:1001320
    DOI: https://doi.org/10.37349/emed.2025.1001320
    View:69
    Download:9
    Times Cited: 0
    Open Access
    Original Article
    The effect of acupressure on anxiety, fatigue, and blood pressure in hemodialysis patients: a randomized controlled trial study
    Aim: The present study determined the effect of acupressure on anxiety, fatigue, and blood pressure in hemodialysis patients. Methods: This randomized controlled clinical trial study was co [...] Read more.
    Manizhe Nasirizade ... Hamidreza Bahrami-Taghanaki
    Published: May 21, 2025 Explor Med. 2025;6:1001319
    DOI: https://doi.org/10.37349/emed.2025.1001319
    View:33
    Download:6
    Times Cited: 0
    Open Access
    Review
    Artificial intelligence and complex natural products for cardiovascular infection prevention and oxidative damage mitigation
    The cardiovascular system remains vulnerable to a multitude of threats, including infections, inflammation, and oxidative stress. These factors contribute significantly to the development and progre [...] Read more.
    Jose M. Prieto-Garcia
    Published: May 09, 2025 Explor Med. 2025;6:1001318
    DOI: https://doi.org/10.37349/emed.2025.1001318
    This article belongs to the special issue Artificial Intelligence and Machine Learning in Cardiovascular Medicine
    View:222
    Download:3
    Times Cited: 0
    Open Access
    Original Article
    A large-scale survey of cannabis use for sleep: preferred products and perceived effects in comparison to over-the-counter and prescription sleep aids
    Aim: Cannabis use for sleep-related problems is on the rise; however, little is known about the cannabis products people are using for sleep or the perceived effects of cannabis in comparison to  [...] Read more.
    Amanda Stueber, Carrie Cuttler
    Published: October 25, 2023 Explor Med. 2023;4:709–719
    DOI: https://doi.org/10.37349/emed.2023.00171
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:33295
    Download:185
    Open Access
    Review
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging,  [...] Read more.
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. 2022;3:112–127
    DOI: https://doi.org/10.37349/emed.2022.00078
    View:21438
    Download:279
    Open Access
    Review
    3D printing in biomedicine: advancing personalized care through additive manufacturing
    The integration of three-dimensional (3D) printing techniques into the domains of biomedical research and personalized medicine highlights the evolving paradigm shifts within contemporary healthcare [...] Read more.
    Kalyani Pathak ... Barbie Borthakur
    Published: December 29, 2023 Explor Med. 2023;4:1135–1167
    DOI: https://doi.org/10.37349/emed.2023.00200
    This article belongs to the special issue Exploration of 3D and 4D Printing in the Biomedical and Personalized Medicine Fields: Merits and Challenges
    View:20507
    Download:315
    Open Access
    Review
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects  [...] Read more.
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. 2022;3:219–233
    DOI: https://doi.org/10.37349/emed.2022.00087
    View:19545
    Download:496
    Open Access
    Original Article
    Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
    Aim: Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to e [...] Read more.
    Gregory Giordano ... Angela D. Bryan
    Published: April 26, 2023 Explor Med. 2023;4:254–271
    DOI: https://doi.org/10.37349/emed.2023.00138
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:15440
    Download:286
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole [...] Read more.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:13648
    Download:393
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443–454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:7188
    Download:2252
    Open Access
    Perspective
    A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exer [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 27, 2022 Explor Med. 2022;3:468–478
    DOI: https://doi.org/10.37349/emed.2022.00108
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:4566
    Download:1845
    Open Access
    Review
    Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing
    Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford [...] Read more.
    Naoko Suga ... Satoru Matsuda
    Published: October 31, 2023 Explor Med. 2023;4:822–838
    DOI: https://doi.org/10.37349/emed.2023.00180
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:3066
    Download:906
    Open Access
    Review
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects  [...] Read more.
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. 2022;3:219–233
    DOI: https://doi.org/10.37349/emed.2022.00087
    View:19545
    Download:496
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole [...] Read more.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:13648
    Download:393
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:9911
    Download:345
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:9911
    Download:345
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole [...] Read more.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:13648
    Download:393
    Open Access
    Review
    3D printing in biomedicine: advancing personalized care through additive manufacturing
    The integration of three-dimensional (3D) printing techniques into the domains of biomedical research and personalized medicine highlights the evolving paradigm shifts within contemporary healthcare [...] Read more.
    Kalyani Pathak ... Barbie Borthakur
    Published: December 29, 2023 Explor Med. 2023;4:1135–1167
    DOI: https://doi.org/10.37349/emed.2023.00200
    This article belongs to the special issue Exploration of 3D and 4D Printing in the Biomedical and Personalized Medicine Fields: Merits and Challenges
    View:20507
    Download:315
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause, values of glomerular filtration [...] Read more.
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42–50
    DOI: https://doi.org/10.37349/emed.2020.00004
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from port [...] Read more.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:9690
    Download:140
    Open Access
    Original Article
    Identification of digital voice biomarkers for cognitive health
    Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identify voice biomarkers that are pr [...] Read more.
    Honghuang Lin ... Rhoda Au
    Published: December 31, 2020 Explor Med. 2020;1:406–417
    DOI: https://doi.org/10.37349/emed.2020.00028
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:5074
    Download:106
    Special Issues