• 102 results in Exploration of Medicine
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    Review
    Paradoxical role of reactive oxygen species in bone remodelling: implications in osteoporosis and possible nanotherapeutic interventions
    Osteoporosis is a metabolic bone disorder that affects both sexes and is the most common cause of fractures. Osteoporosis therapies primarily inhibit osteoclast activity, and are seldom designed to  [...] Read more.
    Largee Biswas ... Anita Kamra Verma
    Published: August 31, 2022 Explor Med. 2022;3:393–413
    DOI: https://doi.org/10.37349/emed.2022.00102
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
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    Open Access
    Case Report
    A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy
    C1q nephropathy is a rare glomerular disease. Clinical presentation is diverse and ranges from asymptomatic hematuria or proteinuria to symptoms and signs of nephrotic/nephritic syndrome. On light microscopy, it can be classified  [...] Read more.
    Randa Choueiri ... Vanessa Nseir
    Published: August 31, 2022 Explor Med. 2022;3:386–392
    DOI: https://doi.org/10.37349/emed.2022.00101
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    View:195
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    Open Access
    Original Article
    Mathematical model for transmission of Chlamydia due to sexual activity and unhygienic environment
    Aim: Sexually transmitted diseases (STDs) need to be studied systematically to better understand their global spread. Transmission of Chlamydia trachomatis is a severe public health issue, with r [...] Read more.
    Nita H. Shah ... Yash N. Shah
    Published: August 30, 2022 Explor Med. 2022;3:375–385
    DOI: https://doi.org/10.37349/emed.2022.00100
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    Open Access
    Original Article
    Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?
    Aim: Lactate dehydrogenase (LDH) is an enzyme that acts as a catalyst in the conversion of lactate to pyruvate which is abundantly found in liver, kidney, heart and muscles. Previous studies have all shown a strong positive correl [...] Read more.
    Charu Mishra ... Ranjan Kumar Dixit
    Published: August 29, 2022 Explor Med. 2022;3:368–374
    DOI: https://doi.org/10.37349/emed.2022.00099
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    Open Access
    Systematic Review
    Signaling pathways and targets of natural products in psoriasis treatment
    Aim: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with [...] Read more.
    Ly Thi Huong Nguyen
    Published: August 29, 2022 Explor Med. 2022;3:345–367
    DOI: https://doi.org/10.37349/emed.2022.00098
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    Open Access
    Review
    Feed your microbiome and improve sleep, stress resilience, and cognition
    The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagu [...] Read more.
    Maciej Chichlowski ... Neeraj Pandey
    Published: August 29, 2022 Explor Med. 2022;3:331–344
    DOI: https://doi.org/10.37349/emed.2022.00097
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
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    Open Access
    Systematic Review
    Downhill esophageal varices: a systematic review of the case reports
    Aim: The etiologies, presentation, and management of downhill varices in the era of modern medicine are relatively under-explored and mostly limited to case reports or case series. Methods: P [...] Read more.
    Hassam Ali ... Devika Kapuria
    Published: August 11, 2022 Explor Med. 2022;3:317–330
    DOI: https://doi.org/10.37349/emed.2022.00096
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    Open Access
    Letter to the Editor
    Adenine-rich diet: a potential mechanism for renal fibrosis progression
    Chronic kidney disease (CKD) is a major health problem but there are many modalities to prevent and manage CKD progression. Diet is one of these factors, which needs to be evaluated more. Adenine is a water-soluble nucleoprotein t [...] Read more.
    Majid Malaki
    Published: July 25, 2022 Explor Med. 2022;3:314–316
    DOI: https://doi.org/10.37349/emed.2022.00095
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    Open Access
    Original Article
    Construction and validation of gastric cancer diagnosis model based on machine learning
    Aim: To screen differentially expressed genes related to gastric cancer based on The Cancer Genome Atlas (TCGA) database and construct a gastric cancer diagnosis model by machine learning. Methods: [...] Read more.
    Fei Kong ... Wenzhen Yuan
    Published: June 29, 2022 Explor Med. 2022;3:300–313
    DOI: https://doi.org/10.37349/emed.2022.00094
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    Open Access
    Original Article
    Pyogenic liver abscess: contrast-enhanced ultrasound allows morpho-evolutive classification and guides personalized management
    Aim: The aim of this study is to propose a contrast-enhanced ultrasound (CEUS)-based morphologic classification of pyogenic liver abscess (PLA) reflecting different evolutive stages and to assess th [...] Read more.
    Giampiero Francica
    Published: June 28, 2022 Explor Med. 2022;3:289–299
    DOI: https://doi.org/10.37349/emed.2022.00093
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:249
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    Open Access
    Review
    Involvement of retroelements in the autoimmune response in humans
    Retroelements are mobile genomic components requiring reverse transcription into an RNA intermediate and then synthesis of complementary DNA for transposition. Human genome contains a vast amount of retroelements including retrotr [...] Read more.
    Sezer Okay
    Published: June 24, 2022 Explor Med. 2022;3:280–288
    DOI: https://doi.org/10.37349/emed.2022.00092
    This article belongs to the special issue The Role of Repetitive DNA Elements in the Development and Progression of Human Disease
    View:276
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    Open Access
    Editorial
    Does our microbiota eat with or without gluten?
    Giuseppe Merra ... Marco Marchetti
    Published: June 24, 2022 Explor Med. 2022;3:275–279
    DOI: https://doi.org/10.37349/emed.2022.00091
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:289
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    Open Access
    Review
    Recent advances of gut microbiota in chronic kidney disease patients
    Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of  [...] Read more.
    Ying-Yong Zhao
    Published: June 23, 2022 Explor Med. 2022;3:260–274
    DOI: https://doi.org/10.37349/emed.2022.00090
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    Open Access
    Meta-Analysis
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem [...] Read more.
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. 2022;3:249–259
    DOI: https://doi.org/10.37349/emed.2022.00089
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    Open Access
    Review
    Early taurine administration as a means for halting the cytokine storm progression in COVID-19 patients
    Around the world, more than 6.2 million individuals have died as a result of COVID-19. According to a recent survey conducted among immunologists, epidemiologists, and virologists, this disease is expected to become endemic. This  [...] Read more.
    Alberto Rubio-Casillas ... Raied Badierah
    Published: June 08, 2022 Explor Med. 2022;3:234–248
    DOI: https://doi.org/10.37349/emed.2022.00088
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:416
    Download:35
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    Open Access
    Review
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects  [...] Read more.
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. 2022;3:219–233
    DOI: https://doi.org/10.37349/emed.2022.00087
    View:424
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    Open Access
    Original Article
    High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney
    Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism  [...] Read more.
    Dewan S. A. Majid ... L. Gabriel Navar
    Published: April 26, 2022 Explor Med. 2022;3:205–218
    DOI: https://doi.org/10.37349/emed.2022.00086
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Review
    Reactive oxygen species in cardiovascular diseases: an update
    Cardiovascular diseases are among the leading causes of death worldwide, imposing major health threats. Reactive oxygen species (ROS) are one of the most important products from the process of redox [...] Read more.
    Juanjuan Fei ... Jun Ren
    Published: April 26, 2022 Explor Med. 2022;3:188–204
    DOI: https://doi.org/10.37349/emed.2022.00085
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:321
    Download:38
    Times Cited: 0
    Open Access
    Case Report
    Complex liver injury induced by combined Aloe Vera and vitamin A oral supplements, as assessed by histology and the updated RUCAM
    A case of combined acute and chronic liver injury related to consumption of multi-ingredient nutritional oral supplements containing Aloe Vera gel and vitamin A among other vitamins, minerals and di [...] Read more.
    Katerina Delladetsima ... Stratigoula Sakellariou
    Published: April 24, 2022 Explor Med. 2022;3:181–187
    DOI: https://doi.org/10.37349/emed.2022.00084
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:288
    Download:28
    Times Cited: 0
    Open Access
    Commentary
    Semaglutide: a game changer for metabolic diseases?
    Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1 RA) molecule approved for the treatment of both type 2 diabetes (T2D) and obesity. Semaglutide has a greater impact on glycated haemo [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: April 19, 2022 Explor Med. 2022;3:173–180
    DOI: https://doi.org/10.37349/emed.2022.00083
    View:458
    Download:39
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    Open Access
    Original Article
    Development of systolic dysfunction unrelated to myocardial infarction in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: While it is commonly thought that left ventricular (LV) systolic function may insidiously deteriorate in hypertensive patients, few prospective data are available to support this notion.  [...] Read more.
    Marcello Chinali ... Richard B. Devereux
    Published: April 02, 2022 Explor Med. 2022;3:160–172
    DOI: https://doi.org/10.37349/emed.2022.00082
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Original Article
    Incident left bundle branch block predicts cardiovascular events and death in hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: Whether incident left bundle branch block (LBBB) is associated with increased cardiovascular (CV) morbidity and mortality in treated hypertensive patients with left ventricular hypertrophy ( [...] Read more.
    Casper N. Bang ... Peter M. Okin
    Published: March 29, 2022 Explor Med. 2022;3:149–159
    DOI: https://doi.org/10.37349/emed.2022.00081
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Original Article
    Incident atrial fibrillation and heart failure in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: The present study investigated the appearance and severity of atrial fibrillation (AF) and heart failure (HF) in 8,702 hypertensive patients with left ventricular hypertrophy (LVH) receiving [...] Read more.
    Casper N. Bang ... Peter M. Okin
    Published: March 23, 2022 Explor Med. 2022;3:139–148
    DOI: https://doi.org/10.37349/emed.2022.00080
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Original Article
    Time-varying serum uric acid predicts new-onset atrial fibrillation in treated hypertensive patients. The LIFE Study
    Aim: The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study showed less new-onset atrial fibrillation (AF) in hypertensive patients receiving losartan- vs. atenolol-based t [...] Read more.
    Eran S. Zacks ... Richard B. Devereux
    Published: March 17, 2022 Explor Med. 2022;3:128–138
    DOI: https://doi.org/10.37349/emed.2022.00079
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Review
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging,  [...] Read more.
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. 2022;3:112–127
    DOI: https://doi.org/10.37349/emed.2022.00078
    View:2005
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    Open Access
    Original Article
    Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia
    Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously [...] Read more.
    Kristin E. Reeve ... Babbette LaMarca
    Published: February 25, 2022 Explor Med. 2022;3:99–111
    DOI: https://doi.org/10.37349/emed.2022.00077
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:464
    Download:39
    Times Cited: 0
    Open Access
    Review
    Multi-faced roles of reactive oxygen species in anti-tumor T cell immune responses and combination immunotherapy
    T cells play a central role in anti-tumor immunity, and reactive oxygen species (ROS) lie at the crossroad on the anti-tumor T cell responses. To activate efficient T cell immunity, a moderate level [...] Read more.
    Tao Wang, Haiyan Xu
    Published: February 25, 2022 Explor Med. 2022;3:77–98
    DOI: https://doi.org/10.37349/emed.2022.00076
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:757
    Download:32
    Times Cited: 0
    Open Access
    Editorial
    Elimination of hepatitis C virus infection in Europe: targeting the obstacles
    Dante Romagnoli
    Published: February 24, 2022 Explor Med. 2022;3:71–76
    DOI: https://doi.org/10.37349/emed.2022.00075
    This article belongs to the special issue Exploring Chronic Liver Disease
    Open Access
    Review
    Oxidative stress in obesity and insulin resistance
    Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published lite [...] Read more.
    Anastasija Panic ... Esma R. Isenovic
    Published: February 23, 2022 Explor Med. 2022;3:58–70
    DOI: https://doi.org/10.37349/emed.2022.00074
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole [...] Read more.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    Open Access
    Review
    Nano-immunotherapeutics: targeting approach as strategic regulation at tumor microenvironment for cancer treatment
    Cancer is the leading cause of mortality worldwide, which necessitates our consideration related to novel treatment approach. Tumor cells at the tumor microenvironment (TME), regulate a plethora of  [...] Read more.
    Priyanka Singh ... Anita Kamra Verma
    Published: February 16, 2022 Explor Med. 2022;3:22–42
    DOI: https://doi.org/10.37349/emed.2022.00072
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    Open Access
    Original Article
    Preclinical toxicity test results of a new antiviral–immune-modulator compound consisting of flavonoid molecules (COVID-19 clinical trial preliminary data)
    Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of bioavailability and molecular concentrations. The specific formula is then tested [...] Read more.
    Gürer G. Budak ... Orkun Tarkun
    Published: January 18, 2022 Explor Med. 2022;3:1–21
    DOI: https://doi.org/10.37349/emed.2022.00071
    View:516
    Download:41
    Times Cited: 0
    Open Access
    Review
    Antioxidant enzymes and vascular diseases
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in regulating endothelial function and vascular tone in the physiological conditions of a vascular system. However, oxidative stress has det [...] Read more.
    Jelena Radovanovic ... Esma R. Isenovic
    Published: December 31, 2021 Explor Med. 2021;2:544–555
    DOI: https://doi.org/10.37349/emed.2021.00070
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:720
    Download:53
    Times Cited: 0
    Open Access
    Review
    A global genetic epidemiological review of pseudoexfoliation syndrome
    Pseudoexfoliation (PXF) syndrome is an important public health concern requiring individual population level analysis. Disease prevalence differs by geographic location and ethnicity, and has environmental, demographic, genetic, a [...] Read more.
    Patrice M. Hicks ... Margaret M. DeAngelis
    Published: December 31, 2021 Explor Med. 2021;2:527–543
    DOI: https://doi.org/10.37349/emed.2021.00069
    View:581
    Download:46
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    Open Access
    Review
    Key roles of CCCTC-binding factor in cancer evolution and development
    The processes of cancer and embryonic development have a partially overlapping effect. Several transcription factor families, which are highly conserved in the evolutionary history of biology, play a key role in the development of [...] Read more.
    Zishuai Li ... Guangwen Cao
    Published: December 31, 2021 Explor Med. 2021;2:516–526
    DOI: https://doi.org/10.37349/emed.2021.00068
    View:476
    Download:30
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    Open Access
    Commentary
    Functions of two distinct Kupffer cells in the liver
    Tissue-resident macrophages play critically important roles in host homeostasis and pathogenesis of diseases, with the functions of phagocytosis, metabolism, and immune modulation. Recently, two research studies accomplished by a  [...] Read more.
    Chunye Zhang ... Ming Yang
    Published: December 31, 2021 Explor Med. 2021;2:511–515
    DOI: https://doi.org/10.37349/emed.2021.00067
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:794
    Download:68
    Times Cited: 0
    Open Access
    Review
    Molecular targets regulating endoplasmic reticulum-mitochondria crosstalk for NAFLD treatment
    Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease poses a significant impact on public healthcare and economic risk worldwide. As a multifactorial disease, NAFLD is usually associated with many com [...] Read more.
    Chunye Zhang, Ming Yang
    Published: December 31, 2021 Explor Med. 2021;2:494–510
    DOI: https://doi.org/10.37349/emed.2021.00066
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:536
    Download:48
    Times Cited: 0
    Open Access
    Original Article
    Cross-cultural adaptation of Delphi definitions of low back pain prevalence in French (Delphi DOLBaPP-F)
    Aim: The high heterogeneity in the definitions of low back pain encountered in the literature has led to the development of standardized definitions of this condition called “Delphi definitions of low back pain prevalence (D [...] Read more.
    Antarou Ly ... Clermont E. Dionne
    Published: December 31, 2021 Explor Med. 2021;2:483–493
    DOI: https://doi.org/10.37349/emed.2021.00065
    View:422
    Download:34
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    Open Access
    Review
    Obstetric implications of maternal chronic hepatitis B virus infection
    Antenatal screening for hepatitis B surface antigen seropositivity is widely adopted to identify pregnant women with chronic hepatitis B virus (HBV) infection in order to target their newborn infants for combined passive-active ne [...] Read more.
    Terence T. Lao
    Published: December 31, 2021 Explor Med. 2021;2:468–482
    DOI: https://doi.org/10.37349/emed.2021.00064
    View:412
    Download:24
    Times Cited: 0
    Open Access
    Review
    Future incidence and mortality of colorectal carcinoma in the United States: an updated overview of risk factors and preventative measures
    According to the Global Cancer Observatory (GLOBOCAN) 2020, colorectal carcinoma (CRC) was the second leading cause of cancer death globally. Current literature utilizes reported databases such as Surveillance, Epidemiology, and E [...] Read more.
    Hassam Ali
    Published: December 31, 2021 Explor Med. 2021;2:455–467
    DOI: https://doi.org/10.37349/emed.2021.00063
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443–454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1583
    Download:402
    Open Access
    Commentary
    Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
    Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone  [...] Read more.
    Amedeo Lonardo
    Published: October 31, 2021 Explor Med. 2021;2:435–442
    DOI: https://doi.org/10.37349/emed.2021.00061
    This article belongs to the special issue Exploring Chronic Liver Disease
    Open Access
    Review
    Aortic complications in pregnancy: the less remembered chapter—a narrative review
    Pregnancy increases the risk of common vascular events and also the rarer events like aortic dissection (AD)/aortic rupture and this is even more pronounced in patients with predisposing aortopathies. AD was found to occur in 0.00 [...] Read more.
    Preetha Rajasekaran ... Bashi V. Velayudhan
    Published: October 31, 2021 Explor Med. 2021;2:423–434
    DOI: https://doi.org/10.37349/emed.2021.00060
    This article belongs to the special issue Exploring Aortic Disease
    View:475
    Download:43
    Times Cited: 0
    Open Access
    Meta-Analysis
    A review of aortic thrombosis in COVID-19 infection
    Aim: As the novel coronavirus disease 2019 (COVID-19) pandemic impacts the global healthcare system, evolving data show increased frequency of arterial and venous thromboembolism among patients with COVID-19 infection. Aortic t [...] Read more.
    Korin Karabulut ... James Morgan
    Published: October 31, 2021 Explor Med. 2021;2:410–422
    DOI: https://doi.org/10.37349/emed.2021.00059
    This article belongs to the special issue Exploring Aortic Disease
    Open Access
    Review
    Exploring evidence-based innovative therapy for the treatment of chronic HBV infection: experimental and clinical
    With the advent of various vaccines and antimicrobial agents during the 20th century, the control and containment of infectious diseases appeared to be a matter of time. However, studies unveiled the diverse natures of microbes, t [...] Read more.
    Sheikh Mohammad Fazle Akbar ... Yoichi Hiasa
    Published: October 31, 2021 Explor Med. 2021;2:392–409
    DOI: https://doi.org/10.37349/emed.2021.00058
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:549
    Download:18
    Times Cited: 0
    Open Access
    Original Article
    Objective measurement of sleep by smartphone application: comparison with actigraphy and relation to self-reported sleep
    Aim: Smartphone technology is increasingly used by the public to assess sleep. Specific features of some sleep-tracking applications are comparable to actigraphy in objectively monitoring sleep. The clinical utility of smartpho [...] Read more.
    Taylor Maynard ... Sandy Neargarder
    Published: October 31, 2021 Explor Med. 2021;2:382–391
    DOI: https://doi.org/10.37349/emed.2021.00057
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    Open Access
    Commentary
    Breastfeeding duration and reduced risk of NAFLD in midlife of parous women
    Alessandro Mantovani ... Andrea Dalbeni
    Published: October 31, 2021 Explor Med. 2021;2:378–381
    DOI: https://doi.org/10.37349/emed.2021.00056
    This article belongs to the special issue Exploring Chronic Liver Disease
    Open Access
    Original Article
    High prevalence of false positive SARS-CoV2 serology in a cohort of patients with liver autoimmune diseases
    Aim: Monitoring the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) immunization in patients with autoimmune diseases is of particular concern to understand their response to the infection and to the v [...] Read more.
    Maria Giulia Cornacchia ... Gaetano Serviddio
    Published: August 31, 2021 Explor Med. 2021;2:372–377
    DOI: https://doi.org/10.37349/emed.2021.00055
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1156
    Download:36
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    Open Access
    Review
    Role of angiotensin II in the development of subcellular remodeling in heart failure
    The development of heart failure under various pathological conditions such as myocardial infarction (MI), hypertension and diabetes are accompanied by adverse cardiac remodeling and cardiac dysfunction. Since heart function is ma [...] Read more.
    Sukhwinder K. Bhullar ... Naranjan S. Dhalla
    Published: August 31, 2021 Explor Med. 2021;2:352–371
    DOI: https://doi.org/10.37349/emed.2021.00054
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Perspective
    Why the aortic dissection detection risk score is problematic in emergency departments
    Acute aortic syndromes, including aortic dissection (AD), are rare. The AD detection risk score (ADDRS) and associated investigation pathway were developed to reduce missed diagnosis of AD. The methodology for its development was  [...] Read more.
    Anne-Maree Kelly
    Published: August 31, 2021 Explor Med. 2021;2:348–351
    DOI: https://doi.org/10.37349/emed.2021.00053
    This article belongs to the special issue Exploring Aortic Disease
    Open Access
    Case Report
    Submucosal esophageal hematomas in a critically ill patient on anticoagulation
    Submucosal esophageal hematoma is an uncommon clinical complication of anticoagulation. Current literature is scarce regarding presentation and management in acute submucosal hematomas in critically ill patients. Patients often pr [...] Read more.
    Hassam Ali, Maliha Naseer
    Published: August 31, 2021 Explor Med. 2021;2:343–347
    DOI: https://doi.org/10.37349/emed.2021.00052
    View:519
    Download:19
    Times Cited: 0
    Open Access
    Review
    Pediatric vs. adult NAFLD to MAFLD transition: a welcome but tangled path
    The term non-alcoholic fatty liver disease (NAFLD) appears unfitting both in adults and in children. As obesity and metabolic syndrome play a relevant pathogenic role, an international group of adults’ liver disease experts has  [...] Read more.
    Angelo Colucci ... Claudia Mandato
    Published: August 31, 2021 Explor Med. 2021;2:333–342
    DOI: https://doi.org/10.37349/emed.2021.00051
    This article belongs to the special issue Exploring NAFLD/NASH
    Open Access
    Case Report
    Central pontine myelinolysis secondary to glycemic variability in type 1 diabetes: a case report and a systematic review of the literature
    Central pontine myelinolysis (CPM) is a rare manifestation of osmotic demyelination syndrome (ODS) which involves the pons and causes significant morbidity and mortality. CPM usually occurs in the setting of rapid correction of se [...] Read more.
    Stefania Di Agostino ... Mauro Maurantonio
    Published: August 31, 2021 Explor Med. 2021;2:324–332
    DOI: https://doi.org/10.37349/emed.2021.00050
    View:711
    Download:32
    Times Cited: 0
    Open Access
    Review
    Sex hormones abnormalities in non-alcoholic fatty liver disease: pathophysiological and clinical implications
    Obesity and metabolic syndrome are conditions at high risk for the development of complications such as type 2 diabetes mellitus, atherosclerotic cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). The growing p [...] Read more.
    Angelo Di Vincenzo ... Marco Rossato
    Published: August 31, 2021 Explor Med. 2021;2:311–323
    DOI: https://doi.org/10.37349/emed.2021.00049
    This article belongs to the special issue Exploring NAFLD/NASH
    View:789
    Download:53
    Times Cited: 0
    Open Access
    Commentary
    An engineered mayhem: YAP/TAZ mechanosignaling and hepatocarcinogenesis in NAFLD
    Gyorgy Baffy
    Published: August 31, 2021 Explor Med. 2021;2:305–310
    DOI: https://doi.org/10.37349/emed.2021.00048
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:902
    Download:37
    Times Cited: 0
    Open Access
    Review
    Angiotensin peptides in the regulation of adrenal cortical function
    The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones. Evidence exists that angiotensin II r [...] Read more.
    Gian Paolo Rossi ... Teresa Maria Seccia
    Published: June 30, 2021 Explor Med. 2021;2:294–304
    DOI: https://doi.org/10.37349/emed.2021.00047
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1291
    Download:99
    Times Cited: 0
    Open Access
    Review
    Angiotensin-(1-7) and Mas receptor in the brain
    The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher  [...] Read more.
    Natalia L. Rukavina Mikusic ... Mariela M. Gironacci
    Published: June 30, 2021 Explor Med. 2021;2:268–293
    DOI: https://doi.org/10.37349/emed.2021.00046
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1892
    Download:150
    Open Access
    Original Article
    Digital sleep measures and white matter health in the Framingham Heart Study
    Aim: Impaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort. Methods: The target population was [...] Read more.
    Robert Joseph Thomas ... Rhoda Au
    Published: June 30, 2021 Explor Med. 2021;2:253–267
    DOI: https://doi.org/10.37349/emed.2021.00045
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:966
    Download:32
    Times Cited: 0
    Open Access
    Original Article
    Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort
    Aim: Although clinicians primarily diagnose dementia based on a combination of metrics such as medical history and formal neuropsychological tests, recent work using linguistic analysis of narrative speech to identify dementia has [...] Read more.
    Larry Zhang ... Reza Hosseini Ghomi
    Published: June 30, 2021 Explor Med. 2021;2:232–252
    DOI: https://doi.org/10.37349/emed.2021.00044
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    Open Access
    Review
    Emerging nanomaterials for cancer immunotherapy
    Immunotherapy is a unique approach to treat cancer that targets tumours besides triggering the immune cells. It attempts to harness the supremacy and specificity of immune cells for the regression of malignancy. The key strategy o [...] Read more.
    Sureshbabu Ram Kumar Pandian ... Krishnan Sundar
    Published: June 30, 2021 Explor Med. 2021;2:208–231
    DOI: https://doi.org/10.37349/emed.2021.00043
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    Open Access
    Review
    Wave propagation and reflection in the aorta and implications of the aortic Windkessel
    Some have said that it is inappropriate and perhaps impossible to consider wave and Windkessel phenomena simultaneously. For 50 years, arterial hemodynamics has been dominated by the frequency-domain “impedance analysis” in wh [...] Read more.
    John V. Tyberg
    Published: June 30, 2021 Explor Med. 2021;2:198–207
    DOI: https://doi.org/10.37349/emed.2021.00042
    This article belongs to the special issue Exploring Aortic Disease
    View:642
    Download:35
    Times Cited: 0
    Open Access
    Perspective
    Vascular aging, the vascular cytoskeleton and aortic stiffness
    Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth m [...] Read more.
    Lova Prasadareddy Kajuluri ... Kathleen G Morgan
    Published: June 30, 2021 Explor Med. 2021;2:186–197
    DOI: https://doi.org/10.37349/emed.2021.00041
    This article belongs to the special issue Exploring Aortic Disease
    Open Access
    Review
    Nanomedicine in cancer therapy: promises and hurdles of polymeric nanoparticles
    The limitations of current cancer treatments have stimulated the application of nanotechnology to develop more effective and safer cancer therapies. Remarkable progress has been made in the development of nanomedicine to overcome  [...] Read more.
    Carmen Paus ... Alessandra Cambi
    Published: April 30, 2021 Explor Med. 2021;2:167–185
    DOI: https://doi.org/10.37349/emed.2021.00040
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:1136
    Download:40
    Open Access
    Review
    AS1411-functionalized delivery nanosystems for targeted cancer therapy
    Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and on [...] Read more.
    Pooria Safarzadeh Kozani ... Mohammad Tariq Malik
    Published: April 30, 2021 Explor Med. 2021;2:146–166
    DOI: https://doi.org/10.37349/emed.2021.00039
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:1241
    Download:53
    Open Access
    Original Article
    Angiotensin-(3-4) modulates the overweight- and undernutrition-induced ACE2 downregulation in renal proximal tubule cells: implications for COVID-19?
    Aim: The renal lesions–including severe acute kidney injury–are severe outcomes in severe acute respiratory syndrome coronavirus 2 infections. There are no reports regarding the influence of the nutritional status on the sever [...] Read more.
    Rafael Luzes ... Adalberto Vieyra
    Published: April 30, 2021 Explor Med. 2021;2:135–145
    DOI: https://doi.org/10.37349/emed.2021.00038
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1302
    Download:94
    Open Access
    Case Report
    Hepatic manifestations of drug reaction with eosinophilia and systemic symptoms syndrome
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening drug reaction, which can affect multiple organs. Patients with DRESS syndrome and hepatic manifestations may present alterati [...] Read more.
    Maria Gabriela Delgado ... Jean François Dufour
    Published: April 30, 2021 Explor Med. 2021;2:122–134
    DOI: https://doi.org/10.37349/emed.2021.00037
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1648
    Download:29
    Times Cited: 0
    Open Access
    Original Article
    Proof of concept: digital clock drawing behaviors prior to transcatheter aortic valve replacement may predict length of hospital stay and cost of care
    Aims: Reduced pre-operative cognitive functioning in older adults is a risk factor for postoperative complications, but it is unknown if preoperative digitally-acquired clock drawing test (CDT) cognitive screening variables, which [...] Read more.
    Margaret Ellenora Wiggins ... Catherine C. Price
    Published: April 30, 2021 Explor Med. 2021;2:110–121
    DOI: https://doi.org/10.37349/emed.2021.00036
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1703
    Download:28
    Open Access
    Original Article
    Risk factors in acute diabetic foot syndrome: analysis of 75 consecutive patients referred to a tertiary center in Modena, Italy
    Aim: Diabetic foot syndrome (DFS) is a complication of diabetes in which the presence of infections, ulceration and/or destruction of deep tissue associated with neuropathy, peripheral atherosclerosis and comorbidity affect the pr [...] Read more.
    Mauro Maurantonio ... Luca Roncucci
    Published: February 28, 2021 Explor Med. 2021;2:98–109
    DOI: https://doi.org/10.37349/emed.2021.00035
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1299
    Download:21
    Times Cited: 0
    Open Access
    Original Article
    Assessing the capacity for mental manipulation in patients with statically-determined mild cognitive impairment using digital technology
    Aims: Prior research employing a standard backward digit span test has been successful in operationally defining neurocognitive constructs associated with the Fuster’s model of executive attention. The current research sought to [...] Read more.
    Sheina Emrani ... David J. Libon
    Published: February 28, 2021 Explor Med. 2021;2:86–97
    DOI: https://doi.org/10.37349/emed.2021.00034
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1410
    Download:20
    Open Access
    Original Article
    A machine learning approach to identify correlates of current e-cigarette use in Canada
    Aim: Popularity of electronic cigarettes (i.e. e-cigarettes) is soaring in Canada. Understanding person-level correlates of current e-cigarette use (vaping) is crucial to guide tobacco policy, but prior studies have not fully iden [...] Read more.
    Rui Fu ... Michael Chaiton
    Published: February 28, 2021 Explor Med. 2021;2:74–85
    DOI: https://doi.org/10.37349/emed.2021.00033
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:1522
    Download:27
    Times Cited: 0
    Open Access
    Original Article
    Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes
    Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite their high heritability, few g [...] Read more.
    Richard Sherva ... Lindsay A. Farrer
    Published: February 28, 2021 Explor Med. 2021;2:60–73
    DOI: https://doi.org/10.37349/emed.2021.00032
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:1779
    Download:28
    Times Cited: 0
    Open Access
    Review
    Cell-derived vesicles for delivery of cancer immunotherapy
    In recent years, cancer immunotherapy has received unprecedented attention due to the clinical achievements. The applications of biomedical engineering and materials science to cancer immunotherapy have solved the challenges cause [...] Read more.
    Jialu Xu, Chao Wang
    Published: February 28, 2021 Explor Med. 2021;2:39–59
    DOI: https://doi.org/10.37349/emed.2021.00031
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:1406
    Download:55
    Open Access
    Review
    Cardiovascular involvement after liver transplantation: role of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    Patients submitted to liver transplantation (LT) are exposed to high risk of cardiovascular (CV) complications which are the main determinants of both short-term and long-term morbidity and mortality in LT. Non-alcoholic fatty liv [...] Read more.
    Rosa Lombardi ... Anna Ludovica Fracanzani
    Published: February 28, 2021 Explor Med 2021;2:20–38
    DOI: https://doi.org/10.37349/emed.2021.00030
    This article belongs to the special issue Exploring NAFLD/NASH
    View:1070
    Download:26
    Times Cited: 0
    Open Access
    Review
    Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies
    Silent coronary artery disease (CAD) is one of the manifestations of heart disease that particularly affects subjects with type 2 diabetes mellitus (T2DM). From a clinical point of view, silent CAD represents a constant challenge  [...] Read more.
    Saula Vigili de Kreutzenberg
    Published: February 28, 2021 Explor Med. 2021;2:1–19
    DOI: https://doi.org/10.37349/emed.2021.00029
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1381
    Download:31
    Times Cited: 0
    Open Access
    Original Article
    Identification of digital voice biomarkers for cognitive health
    Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identify voice biomarkers that are pr [...] Read more.
    Honghuang Lin ... Rhoda Au
    Published: December 31, 2020 Explor Med. 2020;1:406–417
    DOI: https://doi.org/10.37349/emed.2020.00028
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1632
    Download:52
    Open Access
    Original Article
    Detection of mild traumatic brain injury in pediatric populations using BrainCheck, a tablet-based cognitive testing software: a preliminary study
    Aim: Despite its high frequency of occurrence, mild traumatic brain injury (mTBI), or concussion, is difficult to recognize and diagnose, particularly in pediatric populations. Conventional methods to diagnose mTBI primarily re [...] Read more.
    Siao Ye ... Reza Hosseini Ghomi
    Published: December 31, 2020 Explor Med. 2020;1:396–405
    DOI: https://doi.org/10.37349/emed.2020.00027
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1495
    Download:56
    Times Cited: 0
    Open Access
    Original Article
    Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity
    Aim: Research suggests that Alzheimer’s disease (AD) is heterogeneous with numerous subtypes. Through a proprietary interactive ML system, several underlying biological mechanisms associated with AD pathology were uncovered.  [...] Read more.
    Bessi Qorri ... Joseph Geraci
    Published: December 31, 2020 Explor Med. 2020;1:377–395
    DOI: https://doi.org/10.37349/emed.2020.00026
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1916
    Download:48
    Open Access
    Review
    The entero-insular axis: a journey in the physiopathology of diabetes
    Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role. The discovery of the hormone insulin and the description of its [...] Read more.
    Roberta Malaguarnera ... Salvatore Piro
    Published: December 31, 2020 Explor Med. 2020;1:364–376
    DOI: https://doi.org/10.37349/emed.2020.00025
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1476
    Download:39
    Open Access
    Commentary
    The need for a harmonized speech dataset for Alzheimer’s disease biomarker development
    This commentary is the product of a concerted effort to understand the needs, barriers, and gaps in the field of speech and language biomarkers for Alzheimer’s disease (AD). It distills interviews, surveys, and extensive corresp [...] Read more.
    Nicole L. Bjorklund ... Lampros Kourtis
    Published: December 31, 2020 Explor Med. 2020;1:359–363
    DOI: https://doi.org/10.37349/emed.2020.00024
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:2036
    Download:81
    Times Cited: 0
    Open Access
    Perspective
    High-performance computing will assist experiments in recovery from COVID-19
    Bhushan Dharmadhikari ... Prabir Patra
    Published: October 30, 2020 Explor Med. 2020;1:355–358
    DOI: https://doi.org/10.37349/emed.2020.00023
    View:1320
    Download:17
    Times Cited: 0
    Open Access
    Original Article
    Going against the norm: validation of a novel alternative to brain SPECT normative datasets
    Aim: Quantitative analysis of brain single photon emission computed tomography (SPECT) perfusion imaging is dependent on normative datasets that are challenging to produce. This study investigated the combination of SPECT neuro [...] Read more.
    Lindsay M. Quandt, Cyrus A. Raji
    Published: October 30, 2020 Explor Med. 2020;1:331–354
    DOI: https://doi.org/10.37349/emed.2020.00022
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:2001
    Download:39
    Times Cited: 0
    Open Access
    Review
    Insulin pump therapy and continuous glucose monitoring in adults with type 2 diabetes: where are we now?
    Technology in diabetes is rapidly evolving, with the aim of helping affected people to safely optimize their blood glucose control. New technologies are now considered as an essential tool for managing glycemia predominantly in pe [...] Read more.
    Erika Pedone ... Amelia Caretto
    Published: October 30, 2020 Explor Med. 2020;1:314–330
    DOI: https://doi.org/10.37349/emed.2020.00021
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:2201
    Download:39
    Open Access
    Commentary
    Country rankings on the scientific production in endocrinology and diabetology
    Alessandro Mantovani ... Chiara Zusi
    Published: October 30, 2020 Explor Med. 2020;1:307–313
    DOI: https://doi.org/10.37349/emed.2020.00020
    View:1236
    Download:14
    Open Access
    Review
    The diagnostic conundrum in non-alcoholic fatty liver disease
    Non-alcoholic fatty liver disease (NAFLD) has become the most common liver alteration worldwide. It encompasses a spectrum of disorders that range from simple steatosis to a progressive form, defined non-alcoholic steatohepatitis  [...] Read more.
    Valerio Rosato ... Marcello Persico
    Published: October 30, 2020 Explor Med. 2020;1:259–286
    DOI: https://doi.org/10.37349/emed.2020.00018
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2999
    Download:105
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was [...] Read more.
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287–306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:3140
    Download:122
    Open Access
    Review
    Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
    Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways. Posttranslational modification [...] Read more.
    Fatiha Nassir
    Published: August 31, 2020 Explor Med. 2020;1:248–258
    DOI: https://doi.org/10.37349/emed.2020.00017
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2691
    Download:70
    Open Access
    Review
    Non-alcoholic fatty liver disease and transient elastography
    Nonalcoholic fatty liver disease (NAFLD) is a serious condition that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD is associated with metabolic syndrome (MetS) and all of its components. According to data, a [...] Read more.
    Ivana Mikolasevic ... Sandra Milic
    Published: August 31, 2020 Explor Med. 2020;1:205–217
    DOI: https://doi.org/10.37349/emed.2020.00014
    This article belongs to the special issue Exploring NAFLD/NASH
    View:3567
    Download:49
    Open Access
    Review
    Genetic and metabolic factors: the perfect combination to treat metabolic associated fatty liver disease
    The prevalence of nonalcoholic or more recently re-defined metabolic associated fatty liver disease (MAFLD) is rapidly growing worldwide. It is characterized by hepatic fat accumulation exceeding 5% of liver weight not attributabl [...] Read more.
    Marica Meroni ... Paola Dongiovanni
    Published: August 31, 2020 Explor Med. 2020;1:218–243
    DOI: https://doi.org/10.37349/emed.2020.00015
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2935
    Download:77
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184–204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:4318
    Download:98
    Open Access
    Perspective
    Visual communication and learning from COVID-19 to advance preparedness for pandemics
    The currently ongoing coronavirus disease 19 (COVID-19) pandemic has affected globally human health and economy. Research in progress has shown facts associated with this disease and raised questions relevant for disease control a [...] Read more.
    José de la Fuente ... Christian Gortázar
    Published: August 31, 2020 Explor Med. 2020;1:244–247
    DOI: https://doi.org/10.37349/emed.2020.00016
    View:2963
    Download:53
    Open Access
    Review
    The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis
    Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity and mortality, without having to-date any l [...] Read more.
    Michael Doulberis ... Stergios A. Polyzos
    Published: August 31, 2020 Explor Med. 2020;1:170–183
    DOI: https://doi.org/10.37349/emed.2020.00012
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2680
    Download:42
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from port [...] Read more.
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149–169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    Open Access
    Original Article
    Reduction of endoglin receptor impairs mononuclear cell-migration
    Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell surface and oxidative stress. M [...] Read more.
    Zhenying Han ... Hua Su
    Published: June 29, 2020 Explor Med. 2020;1:136–148
    DOI: https://doi.org/10.37349/emed.2020.00010
    View:1595
    Download:23
    Open Access
    Original Article
    Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study
    Aim: Epigenetic variation of DNA methylation of the mu-opioid receptor gene (OPRM1) has been identified in the blood and saliva of individuals with opioid use disorder (OUD) and infants with neonatal opioid withdrawal syndrome  [...] Read more.
    Elisha M. Wachman ... Huiping Zhang
    Published: June 29, 2020 Explor Med. 2020;1:124–135
    DOI: https://doi.org/10.37349/emed.2020.00009
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:2241
    Download:32
    Open Access
    Meta-Analysis
    GLP-1 receptor agonists for NAFLD treatment in patients with and without type 2 diabetes: an updated meta-analysis
    Aim: Recent randomized controlled trials (RCTs) have tested the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RA) to specifically treat non-alcoholic fatty liver disease (NAFLD). We performed a meta-analysis of R [...] Read more.
    Alessandro Mantovani ... Giovanni Targher
    Published: June 29, 2020 Explor Med. 2020;1:108–123
    DOI: https://doi.org/10.37349/emed.2020.00008
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1745
    Download:65
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusi [...] Read more.
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85–107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a composite of arterial and ventri [...] Read more.
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. 2020;1:75–84
    DOI: https://doi.org/10.37349/emed.2020.00006
    View:4057
    Download:107
    Times Cited: 0
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals towa [...] Read more.
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51–74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:6801
    Download:155
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause, values of glomerular filtration [...] Read more.
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42–50
    DOI: https://doi.org/10.37349/emed.2020.00004
    Open Access
    Original Article
    Identifying factors associated with opioid cessation in a biracial sample using machine learning
    Aim: Racial disparities in opioid use disorder (OUD) management exist, however, and there is limited research on factors that influence opioid cessation in different population groups. Methods: We employed multiple machine  [...] Read more.
    Jiayi W. Cox ... Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:27–41
    DOI: https://doi.org/10.37349/emed.2020.00003
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
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    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP displays a range of severity, though even mild  [...] Read more.
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. 2020;1:4–26
    DOI: https://doi.org/10.37349/emed.2020.00002
    View:2478
    Download:89
    Open Access
    Editorial
    Welcome message from the Editor-in-Chief
    Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:1–3
    DOI: https://doi.org/10.37349/emed.2020.00001
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    Times Cited: 0