• 181 results in Exploration of Medicine
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    Original Article
    Figuring the characteristics of the Delta variant SARS-CoV-2 gene mutations in an Indonesian hospital: a descriptive study
    Aim: Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 has undergone several mutations, and ult [...] Read more.
    Phey Liana ... Tungki Pratama Umar
    Published: October 31, 2023 Explor Med. 2023;4:839–846
    DOI: https://doi.org/10.37349/emed.2023.00181
    This article belongs to the special issue Emerging Infectious Diseases
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    Open Access
    Review
    Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing
    Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford [...] Read more.
    Naoko Suga ... Satoru Matsuda
    Published: October 31, 2023 Explor Med. 2023;4:822–838
    DOI: https://doi.org/10.37349/emed.2023.00180
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:351
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    Open Access
    Perspective
    A U.S. Food and Drug Administration perspective on cannabis research and drug development
    Since the early 1970s, the U.S. Food and Drug Administration (FDA) has received over 800 investigational new drug applications (INDs) for, and pre-INDs pertaining to, research of cannabis or cannabi [...] Read more.
    Cassandra L. Taylor, Schuyler A. Pruyn
    Published: October 31, 2023 Explor Med. 2023;4:813–821
    DOI: https://doi.org/10.37349/emed.2023.00179
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
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    Open Access
    Review
    Recent advancements in skin cancer treatment: a critical review
    The prevalence of skin cancer has increased hastily in the recent decade for both kinds of melanoma and non-melanoma skin cancer. Skin cancers mostly encompass keratinocyte cancers: cutaneous squamo [...] Read more.
    Rajat Goyal ... Rohit Sharma
    Published: October 31, 2023 Explor Med. 2023;4:782–812
    DOI: https://doi.org/10.37349/emed.2023.00178
    View:444
    Download:18
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    Review
    Contemporary review: recognition, management, and screening for radiation-induced heart disease
    Radiation is a primary therapy in the treatment of thoracic malignancies with clear survival benefits. Consequently, patients with cancer are living longer but may be subject to a wide array of card [...] Read more.
    Chirag Mehta ... Jess Brar
    Published: October 30, 2023 Explor Med. 2023;4:772–781
    DOI: https://doi.org/10.37349/emed.2023.00177
    View:349
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    Open Access
    Review
    Determinants of human longevity: input of environment, nutrition, physical activity, eustress, heredity, health care, motivation, and mental state
    The paper aims to review the possibilities of a complex transdisciplinary approach to forming health and longevity. Determinants of productive longevity (DPL) and health culture are reviewed; defini [...] Read more.
    Renad I. Zhdanov ... Alexey S. Sozinov
    Published: October 30, 2023 Explor Med. 2023;4:755–771
    DOI: https://doi.org/10.37349/emed.2023.00176
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:330
    Download:19
    Times Cited: 0
    Open Access
    Perspective
    Antiseptic pyolytics and warming wet compresses improve the prospect of healing chronic wounds
    Infection and suppuration of chronic wounds reduce the effectiveness of their treatment with a course of antibiotics and antiseptics combined with frequently renewed dressings. Therefore, daily shor [...] Read more.
    Aleksandr Urakov ... Marina Zavarzina
    Published: October 27, 2023 Explor Med. 2023;4:747–754
    DOI: https://doi.org/10.37349/emed.2023.00175
    This article belongs to the special issue Advances in Wound Healing
    View:160
    Download:15
    Times Cited: 0
    Open Access
    Case Report
    Cheiro-oral-pedal syndrome of the pons and the role of imaging in diagnosis and management
    The patient is a 58-year-old male who presented with chief complaints of right-sided numbness, tingling, and loss of temperature sensation in the upper and lower extremities. The patient’s symptom [...] Read more.
    Zachary I. Merhavy ... Thomas C. Varkey
    Published: October 27, 2023 Explor Med. 2023;4:739–746
    DOI: https://doi.org/10.37349/emed.2023.00174
    This article belongs to the special issue Applications of Radiomics in Precision Medicine
    View:413
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    Open Access
    Case Report
    A successful case of maturogenesis by stepwise excavation using calcium-enriched mixture cement
    This case report demonstrates the successful induction of apexogenesis in an extensively carious lower right first molar with immature roots through the use of stepwise excavation and calcium-enrich [...] Read more.
    Saeed Asgary, Laleh Alim Marvasti
    Published: October 27, 2023 Explor Med. 2023;4:733–738
    DOI: https://doi.org/10.37349/emed.2023.00173
    This article belongs to the special issue Biomaterials and Biomarkers in Dentistry: Up to Date
    View:196
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    Open Access
    Review
    Association of oral bacteriome and oral squamous cell carcinoma
    Oral cancer is the most common carcinoma of head and neck cancers. The majority of oral cancers are oral squamous cell carcinoma (OSCC). Among the various etiological factors, oral microbes—bacter [...] Read more.
    Karthika Panneerselvam ... Mathan Mohan
    Published: October 27, 2023 Explor Med. 2023;4:720–732
    DOI: https://doi.org/10.37349/emed.2023.00172
    View:148
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    Open Access
    Original Article
    A large-scale survey of cannabis use for sleep: preferred products and perceived effects in comparison to over-the-counter and prescription sleep aids
    Aim: Cannabis use for sleep-related problems is on the rise; however, little is known about the cannabis products people are using for sleep or the perceived effects of cannabis in comparison to  [...] Read more.
    Amanda Stueber, Carrie Cuttler
    Published: October 25, 2023 Explor Med. 2023;4:709–719
    DOI: https://doi.org/10.37349/emed.2023.00171
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:1652
    Download:49
    Times Cited: 0
    Open Access
    Original Article
    Modelling α-synuclein processing in primary patient cells for pharmacological intervention
    Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the di [...] Read more.
    Jessica K. Smith ... Alex M. Sykes
    Published: October 25, 2023 Explor Med. 2023;4:695–708
    DOI: https://doi.org/10.37349/emed.2023.00170
    View:269
    Download:10
    Times Cited: 0
    Open Access
    Case Report
    Cranial nerve VII on gadolinium contrast-enhanced magnetic resonance imaging in the case of Bell’s palsy
    Bell’s palsy is a rapid unilateral peripheral paralysis of cranial nerve VII whose etiology is varied, most commonly associated with an acute infectious or inflammatory demyelinating process. Nerv [...] Read more.
    Alvaro Alvarez ... Avtar Singh
    Published: October 23, 2023 Explor Med. 2023;4:688–694
    DOI: https://doi.org/10.37349/emed.2023.00169
    This article belongs to the special issue Applications of Radiomics in Precision Medicine
    View:245
    Download:16
    Times Cited: 0
    Open Access
    Review
    Self-replicating RNA viruses in vaccine development
    Self-replicating RNA viruses such as alphaviruses, flaviviruses, paramyxoviruses, and rhabdoviruses have been engineered as expression vectors for vaccine development. The prominent feature of self- [...] Read more.
    Kenneth Lundstrom
    Published: October 10, 2023 Explor Med. 2023;4:670–687
    DOI: https://doi.org/10.37349/emed.2023.00168
    This article belongs to the special issue RNA World in Health and Disease
    View:241
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    Open Access
    Perspective
    Diabetes and substance use: a perspective within drug rehabilitation
    Diabetes mellitus has become increasingly more common and diagnosed within the global population. Coupled with the continued prevalence of substance use, there are some distinct considerations for u [...] Read more.
    Abuelgasim Elrasheed A. Alhassan ... Simon Elliott
    Published: October 08, 2023 Explor Med. 2023;4:664–669
    DOI: https://doi.org/10.37349/emed.2023.00167
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:207
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    Open Access
    Review
    Mechanistic insights on anticancer drugs with specific biological targets and signalling pathways
    Complex enzyme interactions play a role in the spread of cancer, a process fueled by unregulated cell proliferation. DNA topoisomerases, which are important for fixing DNA topological problems, have [...] Read more.
    Mohsina Patwekar ... Rohit Sharma
    Published: September 15, 2023 Explor Med. 2023;4:637–663
    DOI: https://doi.org/10.37349/emed.2023.00166
    View:448
    Download:20
    Times Cited: 0
    Open Access
    Original Article
    Body mass, blood pressure, and cognitive functioning among octogenarians and centenarians
    Aim: The purpose of this study was to examine the association among body mass, blood pressure (BP), and cognitive functioning for octogenarians and centenarians. Methods: A total of 300 par [...] Read more.
    Peter Martin ... Leonard W. Poon
    Published: September 15, 2023 Explor Med. 2023;4:625–636
    DOI: https://doi.org/10.37349/emed.2023.00165
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:360
    Download:22
    Times Cited: 0
    Open Access
    Original Article
    Comparison of eating habits and gut microbiota of preschool children with obesity
    Aim: Childhood obesity is a global health concern that affects the daily life of children. It has a complex pathogenesis that involves genetic and nutritional factors among others. Moreover, the  [...] Read more.
    Shymaa M. Al-Jabri ... Awatif A. Al-Judaibi
    Published: September 04, 2023 Explor Med. 2023;4:612–624
    DOI: https://doi.org/10.37349/emed.2023.00164
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:351
    Download:28
    Times Cited: 0
    Open Access
    Review
    Unveiling the role of artificial intelligence for wound assessment and wound healing prediction
    Wound healing is a very dynamic and complex process as it involves the patient, wound-level parameters, as well as biological, environmental, and socioeconomic factors. Its process includes hemostas [...] Read more.
    Dinh T. P. Le, Tuan D. Pham
    Published: August 31, 2023 Explor Med. 2023;4:589–611
    DOI: https://doi.org/10.37349/emed.2023.00163
    This article belongs to the special issue Advances in Wound Healing
    View:411
    Download:16
    Times Cited: 0
    Open Access
    Review
    Autophagy and diabetes
    The current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medici [...] Read more.
    Milan Obradovic ... Esma R. Isenovic
    Published: August 31, 2023 Explor Med. 2023;4:576–588
    DOI: https://doi.org/10.37349/emed.2023.00162
    This article belongs to the special issue Genetic and Epigenetic Control of Autophagy in Human Diseases
    View:330
    Download:12
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    Open Access
    Review
    An overview of current advances and pharmaceutical uses of 3D and 4D printing
    The development of patient-specific prosthetics, medication administration, the manufacture of tissues and organs, and surgical planning have all benefited significantly from the use of three-dimens [...] Read more.
    Pankaj Sharma, Vinay Jain
    Published: August 31, 2023 Explor Med. 2023;4:560–575
    DOI: https://doi.org/10.37349/emed.2023.00161
    This article belongs to the special issue Exploration of 3D and 4D Printing in the Biomedical and Personalized Medicine Fields: Merits and Challenges
    View:345
    Download:17
    Times Cited: 0
    Open Access
    Review
    Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target
    Abnormal energy metabolism is one of the ten hallmarks of tumors, and tumor cell metabolism provides energy and a suitable microenvironment for tumorigenesis and metastasis. Tumor cells can consume  [...] Read more.
    Weimei Xing ... Mingyue Zhu
    Published: August 31, 2023 Explor Med. 2023;4:541–559
    DOI: https://doi.org/10.37349/emed.2023.00160
    View:302
    Download:21
    Times Cited: 0
    Open Access
    Review
    RNA-RNA competitive interactions: a molecular civil war ruling cell physiology and diseases
    The idea that proteins are the main determining factors in the functioning of cells and organisms, and their dysfunctions are the first cause of pathologies, has been predominant in biology and biom [...] Read more.
    Cristina Barbagallo ... Marco Ragusa
    Published: August 31, 2023 Explor Med. 2023;4:504–540
    DOI: https://doi.org/10.37349/emed.2023.00159
    This article belongs to the special issue RNA World in Health and Disease
    View:283
    Download:16
    Times Cited: 0
    Open Access
    Review
    Cannabis-based medicinal products (CBMPs) for the treatment of Long COVID symptoms: current and potential applications
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can result in a range of persistent symptoms impacting everyday functioning for a considerable proportion of patients, a condit [...] Read more.
    Hannah Thurgur ... David J. Nutt
    Published: August 31, 2023 Explor Med. 2023;4:487–503
    DOI: https://doi.org/10.37349/emed.2023.00158
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:1427
    Download:31
    Times Cited: 0
    Open Access
    Review
    Autophagy in ischemic stroke: role of circular RNAs
    Stroke, a central nervous system (CNS) injury, is responsible for the second leading cause of death in the world, bringing a great burden on the world. Stroke is normally divided into ischemic and h [...] Read more.
    Yiting Hong ... Honghong Yao
    Published: August 31, 2023 Explor Med. 2023;4:471–486
    DOI: https://doi.org/10.37349/emed.2023.00157
    This article belongs to the special issue Genetic and Epigenetic Control of Autophagy in Human Diseases
    View:276
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    Open Access
    Perspective
    Utility of fibroblasts derived from broncho-alveolar lavage of patients with idiopathic pulmonary fibrosis or related disorders to develop in vitro models
    Broncho-alveolar lavage (BAL) represents a safe tool for the differential diagnosis of various pulmonary fibrotic diseases. Idiopathic pulmonary fibrosis (IPF) belongs to a heterogeneous group of di [...] Read more.
    Paolo Giannoni ... Daniela de Totero
    Published: August 31, 2023 Explor Med. 2023;4:461–470
    DOI: https://doi.org/10.37349/emed.2023.00156
    This article belongs to the special issue Lung Fibrosis—Models and Mechanisms
    View:245
    Download:10
    Times Cited: 0
    Open Access
    Original Article
    An easy and safe method of subconjunctival injection of antimetabolites in glaucoma surgery
    Aim: The use of 5-fluorouracil in glaucoma surgery is associated with a high risk of corneal complications, as even minimal doses of the drug at the ocular surface inhibit corneal epithelial cell [...] Read more.
    Sergey N. Svetozarskiy ... Anna N. Sporysheva
    Published: August 30, 2023 Explor Med. 2023;4:453–460
    DOI: https://doi.org/10.37349/emed.2023.00155
    View:261
    Download:10
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    Open Access
    Original Article
    The brain activities of individuals with or without motivation to change: a preliminary study among cigarette smokers
    Aim: Cigarette smoking is an addictive behavior that requires high motivation to change, a phenotype related to the functional activity of the brain. The study aims to examine motiv [...] Read more.
    Rasmon Kalayasiri ... Witaya Sungkarat
    Published: August 30, 2023 Explor Med. 2023;4:441–452
    DOI: https://doi.org/10.37349/emed.2023.00154
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:248
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    Open Access
    Original Article
    Small patient datasets reveal genetic drivers of non-small cell lung cancer subtypes using machine learning for hypothesis generation
    Aim: Many small datasets of significant value exist in the medical space that are being underutilized. Due to the heterogeneity of complex disorders found in oncology, systems capable of discover [...] Read more.
    Moses Cook ... Joseph Geraci
    Published: July 26, 2023 Explor Med. 2023;4:428–440
    DOI: https://doi.org/10.37349/emed.2023.00153
    View:838
    Download:49
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    Open Access
    Case Report
    Conservative approach in adult right-sided Bochdalek hernia with an intrathoracic ectopic kidney
    Bochdalek hernia (BH) is a congenital diaphragmatic defect primarily diagnosed in neonates and is usually left-sided. Adult diagnosis, especially of right-sided BH is exceedingly rare and usually pr [...] Read more.
    Husam El Sharu ... Ahmed Hebishy
    Published: July 12, 2023 Explor Med. 2023;4:421–427
    DOI: https://doi.org/10.37349/emed.2023.00152
    View:445
    Download:30
    Times Cited: 0
    Open Access
    Original Article
    Associations between methamphetamine and alcohol use disorder, suicidal ideation, and lowered quality of life in methamphetamine users
    Aim: There is a strong comorbidity between methamphetamine (MA) and alcohol use whereby MA use may contribute to increased alcohol consumption. This study aims to determine the associations betwe [...] Read more.
    Ketsupar Jirakran ... Rasmon Kalayasiri
    Published: June 30, 2023 Explor Med. 2023;4:409–420
    DOI: https://doi.org/10.37349/emed.2023.00151
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:379
    Download:30
    Times Cited: 0
    Open Access
    Original Article
    Exploring medical cannabis use in individuals with a traumatic brain injury
    Aim: Traumatic brain injury (TBI) is a common neurological condition, which can present with a wide range of neuropsychological symptoms. Treating this broad spectrum of symptoms represents a sig [...] Read more.
    Elizabeth N. R. Schjelderup ... Alasdair M. Barr
    Published: June 30, 2023 Explor Med. 2023;4:393–408
    DOI: https://doi.org/10.37349/emed.2023.00150
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:530
    Download:26
    Times Cited: 0
    Open Access
    Review
    Molecular mechanism of electroacupuncture for improving perioperative complications with the guidance of enhanced recovery after surgery
    Enhanced recovery after surgery (ERAS) is a recommended surgical strategy at present, the core content is to reduce perioperative stress response and postoperative complications through perioperativ [...] Read more.
    Yu Mao, Lifang Yang
    Published: June 30, 2023 Explor Med. 2023;4:380–392
    DOI: https://doi.org/10.37349/emed.2023.00149
    View:330
    Download:21
    Times Cited: 0
    Open Access
    Original Article
    Cannabinoid-based medicines in clinical care of chronic non-cancer pain: an analysis of pain mechanism and cannabinoid profile
    Aim: Among treatments for chronic non-cancer pain (CNCP), cannabinoid-based medicines (CBMs) have become extremely popular. Evidence remains modest and limited primarily to delta-9-tetrahydrocann [...] Read more.
    Lucile Rapin ... Michael Dworkind
    Published: June 30, 2023 Explor Med. 2023;4:363–379
    DOI: https://doi.org/10.37349/emed.2023.00148
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:535
    Download:20
    Times Cited: 0
    Open Access
    Review
    The impact of COVID-19 pandemic on diagnosis and management of gastrointestinal cancers
    Gastrointestinal (GI) cancer is one of the leading causes of death that affect many patients around the world. The coronavirus disease 2019 (COVID-19) pandemic significantly impacted our healthcare  [...] Read more.
    Byung Soo Yoo ... David A. Johnson
    Published: June 28, 2023 Explor Med. 2023;4:356–362
    DOI: https://doi.org/10.37349/emed.2023.00147
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:424
    Download:9
    Times Cited: 0
    Open Access
    Original Article
    Association between coronavirus 2019 disease and pseudoneurological complaints: analysis of case-control data
    Aim: Pseudoneurological complaints (PNCs) are highly prevalent among the general population. Coronavirus disease 2019 (COVID-19) adversely influences such complaints in individuals who recovered  [...] Read more.
    Mohammad Ali ... Tajnuva Mehjabin
    Published: June 28, 2023 Explor Med. 2023;4:343–355
    DOI: https://doi.org/10.37349/emed.2023.00146
    View:257
    Download:13
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    Open Access
    Original Article
    Type 2 diabetes mellitus and coronary artery stenosis: a risk pattern association study
    Aim: Cardiovascular diseases (CVD) are the leading cause of death globally. In the condition of type 2 diabetes mellitus (T2DM), the prevalence of CVD increase parallel with the rise of metabolic [...] Read more.
    Dharmsheel Shrivastav ... Vimal Mehta
    Published: June 28, 2023 Explor Med. 2023;4:336–342
    DOI: https://doi.org/10.37349/emed.2023.00145
    This article belongs to the special issue Exploring Aortic Disease
    View:320
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    Open Access
    Letter to the Editor
    Vascular accesses: Which choice? Less is more, more or less
    In the context of in-hospital care management, the need for infusion therapies involves the choice of appropriate devices. Historically, there is no consensus about the preference for vascular acces [...] Read more.
    Regina Frontera, Mirko Barone
    Published: May 31, 2023 Explor Med. 2023;4:333–335
    DOI: https://doi.org/10.37349/emed.2023.00144
    View:413
    Download:27
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    Open Access
    Original Article
    Effect of overweight and obesity on spirometric parameters in children and adolescent with asthma
    Aim: Being overweight and obesity are factors in the negative modification of bronchial asthma (BA). The mechanisms of the aggravating effect of obesity on the course of BA have not yet been fully determined, but include changes i [...] Read more.
    Regina N. Khramova ... Olga V. Khaletskaya
    Published: May 30, 2023 Explor Med. 2023;4:323–332
    DOI: https://doi.org/10.37349/emed.2023.00143
    This article belongs to the special issue Perspectives on Causal Mechanisms, Prevention and Management of Pediatric Obesity and Related Comorbidities
    View:469
    Download:35
    Times Cited: 0
    Open Access
    Original Article
    Effect of number of dissected lymph nodes on prognosis of patients with stage II and III colorectal cancer
    Aim: There is a correlation between the number of resected lymph nodes (LNs) and survival as well as staging in patients with colorectal cancer (CRC). This cohort discussed the effect of the numb [...] Read more.
    Reihane Mokarian Rajabi ... Sayyideh Forough Hosseini
    Published: May 30, 2023 Explor Med. 2023;4:314–322
    DOI: https://doi.org/10.37349/emed.2023.00142
    View:356
    Download:19
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    Original Article
    Prognostic importance of neutrophil-lymphocyte ratio in non-dialysis chronic kidney disease patients—a hospital-based prospective cohort
    Aim: In patients with cancer, ischemic heart disease, and peripheral vascular disease, the neutrophil-lymphocyte ratio (NLR), a measure of systemic inflammation, has been demonstrated to predict  [...] Read more.
    Ishfaq Rashid ... Shivani Jaswal
    Published: May 17, 2023 Explor Med. 2023;4:299–313
    DOI: https://doi.org/10.37349/emed.2023.00141
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    View:572
    Download:30
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    Open Access
    Original Article
    Serum levels of ceruloplasmin and magnesium in polycystic ovarian syndrome: a cross sectional study
    Aim: Polycystic ovarian syndrome (PCOS) is the most common endocrine condition, affecting 5–7% of reproductive-age women worldwide. It is associated with low-grade chronic inflammation, insulin [...] Read more.
    Pratibha Misra ... Yaongamphi Vashum
    Published: April 27, 2023 Explor Med. 2023;4:286–298
    DOI: https://doi.org/10.37349/emed.2023.00140
    View:487
    Download:24
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    Open Access
    Original Article
    Can we estimate the causal effects of diet and sedentary behavior on schoolchildren’s overweight/obesity from observational studies?
    Aim: To investigate the causal impact of diet and sedentary behavior on Brazilian schoolchildren’s overweight/obesity using the data from observational studies. Methods: Annual cros [...] Read more.
    Emil Kupek
    Published: April 27, 2023 Explor Med. 2023;4:272–285
    DOI: https://doi.org/10.37349/emed.2023.00139
    This article belongs to the special issue Perspectives on Causal Mechanisms, Prevention and Management of Pediatric Obesity and Related Comorbidities
    View:489
    Download:30
    Times Cited: 0
    Open Access
    Original Article
    Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
    Aim: Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to e [...] Read more.
    Gregory Giordano ... Angela D. Bryan
    Published: April 26, 2023 Explor Med. 2023;4:254–271
    DOI: https://doi.org/10.37349/emed.2023.00138
    This article belongs to the special issue Beyond Weed: Clinical Applications of Cannabis and Cannabinoids
    View:5021
    Download:209
    Times Cited: 0
    Open Access
    Original Article
    Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D
    Aim: To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but t [...] Read more.
    Mauro G. Silva ... Walter Manucha
    Published: April 26, 2023 Explor Med. 2023;4:246–253
    DOI: https://doi.org/10.37349/emed.2023.00137
    This article belongs to the special issue Lung Fibrosis—Models and Mechanisms
    View:464
    Download:20
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    Open Access
    Original Article
    Abnormal glucose tolerance in children: oral glucose tolerance test is fit-for-purpose
    Aim: Childhood obesity is accompanied by an increased prevalence of abnormal glucose tolerance (AGT) including the prediabetes states. This study aims to investigate and evaluate the use of oral gl [...] Read more.
    Vivian Yuet Ho Law ... Louis Tsz Wang Chan
    Published: April 26, 2023 Explor Med. 2023;4:235–245
    DOI: https://doi.org/10.37349/emed.2023.00136
    This article belongs to the special issue Perspectives on Causal Mechanisms, Prevention and Management of Pediatric Obesity and Related Comorbidities
    View:402
    Download:13
    Times Cited: 0
    Open Access
    Review
    Impact exerted by scaffolds and biomaterials in periodontal bone and tissue regeneration engineering: new challenges and perspectives for disease treatment
    The periodontium is an appropriate target for regeneration, as it cannot restore its function following disease. Significantly, the periodontium’s limited regenerative capacity could be enhanced through the development of novel  [...] Read more.
    Simona Santonocito ... Gaetano Isola
    Published: April 26, 2023 Explor Med. 2023;4:215–234
    DOI: https://doi.org/10.37349/emed.2023.00135
    This article belongs to the special issue Biomaterials and Biomarkers in Dentistry: Up to Date
    View:526
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    Original Article
    Forward head posture and neck disability: what is the effect on lung function?
    Aim: Forward head posture (FHP) is a very common pathological neck posture among people who frequently use multimedia devices, and it could be related to some musculoskeletal disorders. However, it [...] Read more.
    Giada Annarumma ... Felice Sirico
    Published: April 26, 2023 Explor Med. 2023;4:207–214
    DOI: https://doi.org/10.37349/emed.2023.00134
    View:488
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    Review
    Immunomodulation strategies against COVID-19 evidence: key nutrients and dietary approaches
    The novel coronavirus disease-2019 (COVID-19) has created a major public health crisis. Various dietary factors may enhance immunological activity against COVID-19 and serve as a method to combat se [...] Read more.
    Lindsey B. Cundra ... David A. Johnson
    Published: April 25, 2023 Explor Med. 2023;4:189–206
    DOI: https://doi.org/10.37349/emed.2023.00133
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:474
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    Original Article
    Development of solid lipid nanoparticle gel for transdermal delivery system of chaulmoogra oil
    Aim: The main objective of the study was to formulate, evaluate and perform an optimization study of chaulmoogra oil-loaded solid lipid nanoparticles (SLNs) based gel. Methods: The study involves isolation, identification, and qu [...] Read more.
    Rabea Parveen ... Sayeed Ahmad
    Published: April 25, 2023 Explor Med. 2023;4:176–188
    DOI: https://doi.org/10.37349/emed.2023.00132
    View:332
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    Review
    Low copy repeats in the genome: from neglected to respected
    DNA paralogs that have a length of at least 1 kilobase (kb) and are duplicated with a sequence identity of over 90% are classified as low copy repeats (LCRs) or segmental duplications (SDs). They co [...] Read more.
    Lisanne Vervoort, Joris R. Vermeesch
    Published: April 25, 2023 Explor Med. 2023;4:166–175
    DOI: https://doi.org/10.37349/emed.2023.00131
    This article belongs to the special issue The Role of Repetitive DNA Elements in the Development and Progression of Human Disease
    Open Access
    Review
    Gastrointestinal microbiome and coronavirus disease: evidence of a bidirectional association
    The gastrointestinal (GI) microbiome remains an emerging topic of study and the characterization and impact on human health and disease continue to be an area of great interest. Similarly, the coron [...] Read more.
    Kevin V. Houston ... David A. Johnson
    Published: April 25, 2023 Explor Med. 2023;4:157–165
    DOI: https://doi.org/10.37349/emed.2023.00130
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:562
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    Review
    Oxidative stress and inflammation: the root causes of aging
    Oxygen free radicals [reactive oxygen species (ROS)] and nitrogen free radicals [reactive nitrogen species (RNS)] are generated by mitochondria during adenosine triphosphate synthesis, and catalytic [...] Read more.
    Prasert Sobhon ... Sawaek Weerakiet
    Published: April 17, 2023 Explor Med. 2023;4:127–156
    DOI: https://doi.org/10.37349/emed.2023.00129
    This article belongs to the special issue Determinants of Exceptional Longevity
    View:614
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    Meta-Analysis
    Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain
    Aim: Hypertension (HTN) is a major cause of heart failure but the precise pathways by which HTN leads to heart failure are not resolved. Newer echocardiographic techniques permit assessment of my [...] Read more.
    Simon W. Rabkin
    Published: April 10, 2023 Explor Med. 2023;4:115–126
    DOI: https://doi.org/10.37349/emed.2023.00128
    This article belongs to the special issue Recent Advances in Hypertension
    View:570
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    Commentary
    m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection
    m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs. [...] Read more.
    Hiromichi Sato ... Hideshi Ishii
    Published: February 28, 2023 Explor Med. 2023;4:107–114
    DOI: https://doi.org/10.37349/emed.2023.00127
    This article belongs to the special issue RNA World in Health and Disease
    View:621
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    Review
    N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain
    Neuropathic pain (NP) remains maltreated for a wide number of patients by the currently available treatments and little research has been done in finding new drugs for treating NP. Ziconotide (Prial [...] Read more.
    Shikha Choudhary ... Md Sabir Alam
    Published: February 28, 2023 Explor Med. 2023;4:85–106
    DOI: https://doi.org/10.37349/emed.2023.00126
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:551
    Download:33
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    Review
    An overview of current strategies and future prospects in drug repurposing in tuberculosis
    A large number of the population faces mortality as an effect of tuberculosis (TB). The line of treatment in the management of TB faces a jolt with ever-increasing multi-drug resistance (DR) cases.  [...] Read more.
    Dilpreet Singh ... Pooja A. Chawla
    Published: February 28, 2023 Explor Med. 2023;4:71–84
    DOI: https://doi.org/10.37349/emed.2023.00125
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:554
    Download:24
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    Review
    Oxidative stress, inflammation, dysfunctional redox homeostasis and autophagy cause age-associated diseases
    Aging and age-associated diseases (AADs) are growing risk factors in societies worldwide. During aging, there is an accumulation of excessive oxygen free radicals [reactive oxygen species (ROS)] and nitrogen free radicals [reactiv [...] Read more.
    Prasert Sobhon ... Sawaek Weerakiet
    Published: February 28, 2023 Explor Med. 2023;4:45–70
    DOI: https://doi.org/10.37349/emed.2023.00124
    This article belongs to the special issue Genetic and Epigenetic Control of Autophagy in Human Diseases
    View:605
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    Original Article
    Molecular docking analysis of peptide-based antiviral agents against SARS-CoV-2 main protease: an approach towards drug repurposing
    Aim: Utilizing the therapeutic potentials of previously approved medications against a new target or pharmacological response is known as drug repurposing. The health and scientific communities a [...] Read more.
    Abhishek Chaurasiya ... Pooja A. Chawla
    Published: February 27, 2023 Explor Med. 2023;4:33–44
    DOI: https://doi.org/10.37349/emed.2023.00123
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:585
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    Original Article
    Disparities and trends in suicidal ideations for inflammatory bowel disease hospitalizations: a decade-long national database analysis
    Aim: Patients with inflammatory bowel disease (IBD) are more likely to develop anxiety or depression. The study aimed to describe the trends and disparities of suicidal ideation (SI) in hospitali [...] Read more.
    Hassam Ali ... Ramona Rajapakse
    Published: February 24, 2023 Explor Med. 2023;4:23–32
    DOI: https://doi.org/10.37349/emed.2023.00122
    View:487
    Download:24
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    Original Article
    An association study of the PNPLA3 I148M polymorphism (rs738409) with serum lipids in patients with dyslipidemia
    Aim: One single nucleotide polymorphism (SNP) rs738409 in the patatin-like phospholipase domain- containing protein 3 (PNPLA3) gene has been considered a major genetic risk factor of nonalcoholic [...] Read more.
    Despoina Ioannidou ... Antonis Goulas
    Published: February 22, 2023 Explor Med. 2023;4:16–22
    DOI: https://doi.org/10.37349/emed.2023.00121
    View:422
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    Original Article
    Alterations in metabolic status of healthy individuals with and without obesity during transition from adolescence to young adulthood
    Aim: Extensive research is carried out throughout the world in healthy persons with obesity phenotype in concern with prevalence, metabolic profiling, etc. To the best of the authors’ knowledge, not many studies have investigate [...] Read more.
    Smita S. Sonoli ... Reshma D. Channashetti
    Published: February 21, 2023 Explor Med. 2023;4:3–15
    DOI: https://doi.org/10.37349/emed.2023.00120
    View:415
    Download:24
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    Letter to the Editor
    Ultra-widefield imaging technologies in the peripheral retinal pathologies
    Lokman Balyen
    Published: February 16, 2023 Explor Med. 2023;4:1–2
    DOI: https://doi.org/10.37349/emed.2023.00119
    View:373
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    Review
    Quality by design based development of nanostructured lipid carrier: a risk based approach
    The aim of this review is to discuss the development of nanostructured lipid carrier (NLC) by the application of quality by design (QbD). QbD started with the evolution of the quality concept and sl [...] Read more.
    Tausif Alam
    Published: December 31, 2022 Explor Med. 2022;3:617–638
    DOI: https://doi.org/10.37349/emed.2022.00118
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:567
    Download:56
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    Review
    Antioxidant and photoprotective potential of Polypodium leucotomos
    In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and [...] Read more.
    Rosy Yesela Mancilla Santa Cruz ... María Segunda Aurora Prado
    Published: December 29, 2022 Explor Med. 2022;3:607–616
    DOI: https://doi.org/10.37349/emed.2022.00117
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:551
    Download:45
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    Review
    The journey of dostarlimab: a successful weapon for cancer treatment
    In a number of malignancies, new immuno-oncology therapies that focus on the programmed cell death 1 (PD-1) have improvised the patient condition along with a positive aftereffect. Monoclonal antibo [...] Read more.
    Rouchan Ali ... Pooja A. Chawla
    Published: December 29, 2022 Explor Med. 2022;3:592–606
    DOI: https://doi.org/10.37349/emed.2022.00116
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:644
    Download:23
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    Open Access
    Case Report
    Right atrial thrombus, junctional tachycardia, and critical lower limb ischemia: three rare complications of severe acute respiratory syndrome coronavirus 2 infection
    In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and [...] Read more.
    Said Makani ... Youssef Tijani
    Published: December 29, 2022 Explor Med. 2022;3:583–591
    DOI: https://doi.org/10.37349/emed.2022.00115
    This article belongs to the special issue Exploring Aortic Disease
    View:549
    Download:19
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    Original Article
    Predictive value of SII and sd-LDL for contrast-induced acute kidney injury in STEMI patients undergoing percutaneous coronary intervention
    Aim: To investigate the relationship between the incidence of contrast-induced acute kidney injury (CI-AKI) and the level of small dense low-density lipoprotein (sd-LDL) and systemic immune-infla [...] Read more.
    Guoqi Shen ... Wenhua Li
    Published: December 28, 2022 Explor Med. 2022;3:571–582
    DOI: https://doi.org/10.37349/emed.2022.00114
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    View:522
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    Case Report
    An unusual presentation of Whipple’s disease: adenopathies, polyarthralgia and dermatomyositis-like symptoms
    Whipple’s disease (WD) is a rare systemic disease caused by gram-positive bacillus bacteria that invades multiple organs mainly the intestinal epithelium. Its manifestation is not only l [...] Read more.
    Randa Choueiry ... Joseph Amara
    Published: December 27, 2022 Explor Med. 2022;3:561–570
    DOI: https://doi.org/10.37349/emed.2022.00113
    View:431
    Download:15
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    Review
    Let’s review the gut microbiota in systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a chronic, immune-mediated disease associated with significant morbidity and mortality. New evidence suggests that diet, gut microbiota, intestinal permeability [...] Read more.
    Inês Almada-Correia ... João Eurico Fonseca
    View:457
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    Open Access
    Review
    Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system
    Fernandoa adenophylla (FA, Heterophragma adenophyllum) is a plant, cultivated throughout Africa and Southeast Asia. It contains potent phytochemicals such as novel naphthoquinones, their derivatives [...] Read more.
    Sangeet Kumar Mall ... Md Sabir Alam
    Published: November 14, 2022 Explor Med. 2022;3:516–539
    DOI: https://doi.org/10.37349/emed.2022.00111
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:786
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    Review
    Role of mitochondria in brain functions and related disorders
    Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplast [...] Read more.
    Monu Yadav ... Anil Kumar
    Published: October 31, 2022 Explor Med. 2022;3:494–515
    DOI: https://doi.org/10.37349/emed.2022.00110
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    View:778
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    Review
    Development of nanobiosensors for human immunodeficiency virus detection—a mini review
    Acquired immunodeficiency syndrome (AIDS) is a global disease caused by human immunodeficiency virus (HIV). About 50 million people have died worldwide due to HIV-1 infection alone. HIV is a primary [...] Read more.
    Shurfa Mudenkattil ... Koyeli Girigoswami
    Published: October 31, 2022 Explor Med. 2022;3:479–493
    DOI: https://doi.org/10.37349/emed.2022.00109
    View:506
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    Perspective
    A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exer [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 27, 2022 Explor Med. 2022;3:468–478
    DOI: https://doi.org/10.37349/emed.2022.00108
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:1878
    Download:1020
    Open Access
    Commentary
    Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease
    Current evidence on benefits of night-time blood pressure (BP) lowering drug treatment on cardiovascular disease (CVD) prevention attributable to the Ambulatory Blood Pressure Monitoring in the Pred [...] Read more.
    Chau Le Bao Ho, Christopher M. Reid
    Published: October 27, 2022 Explor Med. 2022;3:461–467
    DOI: https://doi.org/10.37349/emed.2022.00107
    This article belongs to the special issue Recent Advances in Hypertension
    Open Access
    Meta-Analysis
    Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis
    Aim: Wound healing is a complex phenomenon with various biological changes in tissue integrity, low-level laser therapy (LLLT) has acquired several unique components to help into accelerating tis [...] Read more.
    Seyyed Amir Seyyedi ... Rohollah Valizadeh
    Published: October 27, 2022 Explor Med. 2022;3:451–460
    DOI: https://doi.org/10.37349/emed.2022.00106
    View:489
    Download:31
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    Original Article
    Seminal fructose and citric acid concentrations relative to sperm parameters among men for fertility evaluation in Yaoundé, Cameroon
    Aim: Given the male infertility’s pluri-etiological nature, thorough examinations are needed for its evaluation. Fructose and citric acid are simple biomolecules, easy to assay, which provide reliable information on the seminal [...] Read more.
    Bih Tanni ... Christopher Odianosen Aimakhu
    Published: October 27, 2022 Explor Med. 2022;3:443–450
    DOI: https://doi.org/10.37349/emed.2022.00105
    View:1103
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    Review
    Nutritional prospects of wheatgrass (Triticum aestivum) and its effects in treatment and chemoprevention
    Nutraceuticals are organic and traditional foods consumed nowadays to maintain a healthy lifestyle and get rid of lifestyle diseases like obesity, cancer, diabetes, hypertension, etc. Globally, herb [...] Read more.
    Neha Minocha ... Parijat Pandey
    Published: October 12, 2022 Explor Med. 2022;3:432–442
    DOI: https://doi.org/10.37349/emed.2022.00104
    This article belongs to the special issue Techniques in Repurposing and Targeted Delivery: Bringing a New Life to Shelved Drugs
    Open Access
    Review
    Vasopressin: a possible link between hypoxia and hypertension
    Cardiovascular and respiratory diseases are frequently associated with transient and prolonged hypoxia, whereas hypoxia exerts pro-hypertensive effects, through stimulation of the sympathetic system [...] Read more.
    Ewa Szczepańska-Sadowska, Tymoteusz Żera
    Published: October 11, 2022 Explor Med. 2022;3:414–431
    DOI: https://doi.org/10.37349/emed.2022.00103
    This article belongs to the special issue Recent Advances in Hypertension
    View:701
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    Review
    Paradoxical role of reactive oxygen species in bone remodelling: implications in osteoporosis and possible nanotherapeutic interventions
    Osteoporosis is a metabolic bone disorder that affects both sexes and is the most common cause of fractures. Osteoporosis therapies primarily inhibit osteoclast activity, and are seldom designed to  [...] Read more.
    Largee Biswas ... Anita Kamra Verma
    Published: August 31, 2022 Explor Med. 2022;3:393–413
    DOI: https://doi.org/10.37349/emed.2022.00102
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:888
    Download:58
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    Case Report
    A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy
    C1q nephropathy is a rare glomerular disease. Clinical presentation is diverse and ranges from asymptomatic hematuria or proteinuria to symptoms and signs of nephrotic/nephritic syndrome. On light microscopy, it can be classified  [...] Read more.
    Randa Choueiri ... Vanessa Nseir
    Published: August 31, 2022 Explor Med. 2022;3:386–392
    DOI: https://doi.org/10.37349/emed.2022.00101
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    Open Access
    Original Article
    Mathematical model for transmission of Chlamydia due to sexual activity and unhygienic environment
    Aim: Sexually transmitted diseases (STDs) need to be studied systematically to better understand their global spread. Transmission of Chlamydia trachomatis is a severe public health issue, with r [...] Read more.
    Nita H. Shah ... Yash N. Shah
    Published: August 30, 2022 Explor Med. 2022;3:375–385
    DOI: https://doi.org/10.37349/emed.2022.00100
    View:691
    Download:41
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    Original Article
    Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?
    Aim: Lactate dehydrogenase (LDH) is an enzyme that acts as a catalyst in the conversion of lactate to pyruvate which is abundantly found in liver, kidney, heart and muscles. Previous studies have all shown a strong positive correl [...] Read more.
    Charu Mishra ... Ranjan Kumar Dixit
    Published: August 29, 2022 Explor Med. 2022;3:368–374
    DOI: https://doi.org/10.37349/emed.2022.00099
    View:688
    Download:22
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    Systematic Review
    Signaling pathways and targets of natural products in psoriasis treatment
    Aim: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with [...] Read more.
    Ly Thi Huong Nguyen
    Published: August 29, 2022 Explor Med. 2022;3:345–367
    DOI: https://doi.org/10.37349/emed.2022.00098
    View:1029
    Download:50
    Open Access
    Review
    Feed your microbiome and improve sleep, stress resilience, and cognition
    The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagu [...] Read more.
    Maciej Chichlowski ... Neeraj Pandey
    Published: August 29, 2022 Explor Med. 2022;3:331–344
    DOI: https://doi.org/10.37349/emed.2022.00097
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:1304
    Download:77
    Open Access
    Systematic Review
    Downhill esophageal varices: a systematic review of the case reports
    Aim: The etiologies, presentation, and management of downhill varices in the era of modern medicine are relatively under-explored and mostly limited to case reports or case series. Methods: P [...] Read more.
    Hassam Ali ... Devika Kapuria
    Published: August 11, 2022 Explor Med. 2022;3:317–330
    DOI: https://doi.org/10.37349/emed.2022.00096
    View:1232
    Download:55
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    Open Access
    Letter to the Editor
    Adenine-rich diet: a potential mechanism for renal fibrosis progression
    Chronic kidney disease (CKD) is a major health problem but there are many modalities to prevent and manage CKD progression. Diet is one of these factors, which needs to be evaluated more. Adenine is a water-soluble nucleoprotein t [...] Read more.
    Majid Malaki
    Published: July 25, 2022 Explor Med. 2022;3:314–316
    DOI: https://doi.org/10.37349/emed.2022.00095
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    View:1188
    Download:89
    Open Access
    Original Article
    Construction and validation of gastric cancer diagnosis model based on machine learning
    Aim: To screen differentially expressed genes related to gastric cancer based on The Cancer Genome Atlas (TCGA) database and construct a gastric cancer diagnosis model by machine learning. Methods: [...] Read more.
    Fei Kong ... Wenzhen Yuan
    Published: June 29, 2022 Explor Med. 2022;3:300–313
    DOI: https://doi.org/10.37349/emed.2022.00094
    View:875
    Download:101
    Open Access
    Original Article
    Pyogenic liver abscess: contrast-enhanced ultrasound allows morpho-evolutive classification and guides personalized management
    Aim: The aim of this study is to propose a contrast-enhanced ultrasound (CEUS)-based morphologic classification of pyogenic liver abscess (PLA) reflecting different evolutive stages and to assess th [...] Read more.
    Giampiero Francica
    Published: June 28, 2022 Explor Med. 2022;3:289–299
    DOI: https://doi.org/10.37349/emed.2022.00093
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:970
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    Open Access
    Review
    Involvement of retroelements in the autoimmune response in humans
    Retroelements are mobile genomic components requiring reverse transcription into an RNA intermediate and then synthesis of complementary DNA for transposition. Human genome contains a vast amount of retroelements including retrotr [...] Read more.
    Sezer Okay
    Published: June 24, 2022 Explor Med. 2022;3:280–288
    DOI: https://doi.org/10.37349/emed.2022.00092
    This article belongs to the special issue The Role of Repetitive DNA Elements in the Development and Progression of Human Disease
    View:841
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    Editorial
    Does our microbiota eat with or without gluten?
    Giuseppe Merra ... Marco Marchetti
    Published: June 24, 2022 Explor Med. 2022;3:275–279
    DOI: https://doi.org/10.37349/emed.2022.00091
    This article belongs to the special issue The Role of Gut Microbiota and its Metabolites in Gastrointestinal Diseases
    View:759
    Download:28
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    Open Access
    Review
    Recent advances of gut microbiota in chronic kidney disease patients
    Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of  [...] Read more.
    Ying-Yong Zhao
    Published: June 23, 2022 Explor Med. 2022;3:260–274
    DOI: https://doi.org/10.37349/emed.2022.00090
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    View:1153
    Download:59
    Open Access
    Meta-Analysis
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem [...] Read more.
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. 2022;3:249–259
    DOI: https://doi.org/10.37349/emed.2022.00089
    This article belongs to the special issue Disease Diagnosis, Molecular Mechanism and Therapeutic Strategies in Kidney Injury and Fibrosis
    Open Access
    Review
    Early taurine administration as a means for halting the cytokine storm progression in COVID-19 patients
    Around the world, more than 6.2 million individuals have died as a result of COVID-19. According to a recent survey conducted among immunologists, epidemiologists, and virologists, this disease is expected to become endemic. This  [...] Read more.
    Alberto Rubio-Casillas ... Raied Badierah
    Published: June 08, 2022 Explor Med. 2022;3:234–248
    DOI: https://doi.org/10.37349/emed.2022.00088
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1766
    Download:56
    Open Access
    Review
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects  [...] Read more.
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. 2022;3:219–233
    DOI: https://doi.org/10.37349/emed.2022.00087
    View:2071
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    Open Access
    Original Article
    High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney
    Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism  [...] Read more.
    Dewan S. A. Majid ... L. Gabriel Navar
    Published: April 26, 2022 Explor Med. 2022;3:205–218
    DOI: https://doi.org/10.37349/emed.2022.00086
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Review
    Reactive oxygen species in cardiovascular diseases: an update
    Cardiovascular diseases are among the leading causes of death worldwide, imposing major health threats. Reactive oxygen species (ROS) are one of the most important products from the process of redox [...] Read more.
    Juanjuan Fei ... Jun Ren
    Published: April 26, 2022 Explor Med. 2022;3:188–204
    DOI: https://doi.org/10.37349/emed.2022.00085
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:756
    Download:47
    Times Cited: 0
    Open Access
    Case Report
    Complex liver injury induced by combined Aloe Vera and vitamin A oral supplements, as assessed by histology and the updated RUCAM
    A case of combined acute and chronic liver injury related to consumption of multi-ingredient nutritional oral supplements containing Aloe Vera gel and vitamin A among other vitamins, minerals and di [...] Read more.
    Katerina Delladetsima ... Stratigoula Sakellariou
    Published: April 24, 2022 Explor Med. 2022;3:181–187
    DOI: https://doi.org/10.37349/emed.2022.00084
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1845
    Download:49
    Times Cited: 0
    Open Access
    Commentary
    Semaglutide: a game changer for metabolic diseases?
    Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1 RA) molecule approved for the treatment of both type 2 diabetes (T2D) and obesity. Semaglutide has a greater impact on glycated haemo [...] Read more.
    Agostino Milluzzo ... Laura Sciacca
    Published: April 19, 2022 Explor Med. 2022;3:173–180
    DOI: https://doi.org/10.37349/emed.2022.00083
    View:1753
    Download:69
    Open Access
    Original Article
    Development of systolic dysfunction unrelated to myocardial infarction in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: While it is commonly thought that left ventricular (LV) systolic function may insidiously deteriorate in hypertensive patients, few prospective data are available to support this notion.  [...] Read more.
    Marcello Chinali ... Richard B. Devereux
    Published: April 02, 2022 Explor Med. 2022;3:160–172
    DOI: https://doi.org/10.37349/emed.2022.00082
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Original Article
    Incident left bundle branch block predicts cardiovascular events and death in hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: Whether incident left bundle branch block (LBBB) is associated with increased cardiovascular (CV) morbidity and mortality in treated hypertensive patients with left ventricular hypertrophy ( [...] Read more.
    Casper N. Bang ... Peter M. Okin
    Published: March 29, 2022 Explor Med. 2022;3:149–159
    DOI: https://doi.org/10.37349/emed.2022.00081
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Original Article
    Incident atrial fibrillation and heart failure in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: The present study investigated the appearance and severity of atrial fibrillation (AF) and heart failure (HF) in 8,702 hypertensive patients with left ventricular hypertrophy (LVH) receiving [...] Read more.
    Casper N. Bang ... Peter M. Okin
    Published: March 23, 2022 Explor Med. 2022;3:139–148
    DOI: https://doi.org/10.37349/emed.2022.00080
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Original Article
    Time-varying serum uric acid predicts new-onset atrial fibrillation in treated hypertensive patients. The LIFE Study
    Aim: The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study showed less new-onset atrial fibrillation (AF) in hypertensive patients receiving losartan- vs. atenolol-based t [...] Read more.
    Eran S. Zacks ... Richard B. Devereux
    Published: March 17, 2022 Explor Med. 2022;3:128–138
    DOI: https://doi.org/10.37349/emed.2022.00079
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Review
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging,  [...] Read more.
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. 2022;3:112–127
    DOI: https://doi.org/10.37349/emed.2022.00078
    View:7724
    Download:156
    Open Access
    Original Article
    Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia
    Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously [...] Read more.
    Kristin E. Reeve ... Babbette LaMarca
    Published: February 25, 2022 Explor Med. 2022;3:99–111
    DOI: https://doi.org/10.37349/emed.2022.00077
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:1078
    Download:61
    Open Access
    Review
    Multi-faced roles of reactive oxygen species in anti-tumor T cell immune responses and combination immunotherapy
    T cells play a central role in anti-tumor immunity, and reactive oxygen species (ROS) lie at the crossroad on the anti-tumor T cell responses. To activate efficient T cell immunity, a moderate level [...] Read more.
    Tao Wang, Haiyan Xu
    Published: February 25, 2022 Explor Med. 2022;3:77–98
    DOI: https://doi.org/10.37349/emed.2022.00076
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1439
    Download:61
    Open Access
    Editorial
    Elimination of hepatitis C virus infection in Europe: targeting the obstacles
    Dante Romagnoli
    Published: February 24, 2022 Explor Med. 2022;3:71–76
    DOI: https://doi.org/10.37349/emed.2022.00075
    This article belongs to the special issue Exploring Chronic Liver Disease
    Open Access
    Review
    Oxidative stress in obesity and insulin resistance
    Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published lite [...] Read more.
    Anastasija Panic ... Esma R. Isenovic
    Published: February 23, 2022 Explor Med. 2022;3:58–70
    DOI: https://doi.org/10.37349/emed.2022.00074
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1816
    Download:103
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole [...] Read more.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:2998
    Download:151
    Open Access
    Review
    Nano-immunotherapeutics: targeting approach as strategic regulation at tumor microenvironment for cancer treatment
    Cancer is the leading cause of mortality worldwide, which necessitates our consideration related to novel treatment approach. Tumor cells at the tumor microenvironment (TME), regulate a plethora of  [...] Read more.
    Priyanka Singh ... Anita Kamra Verma
    Published: February 16, 2022 Explor Med. 2022;3:22–42
    DOI: https://doi.org/10.37349/emed.2022.00072
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:1350
    Download:46
    Open Access
    Original Article
    Preclinical toxicity test results of a new antiviral–immune-modulator compound consisting of flavonoid molecules (COVID-19 clinical trial preliminary data)
    Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of bioavailability and molecular concentrations. The specific formula is then tested [...] Read more.
    Gürer G. Budak ... Orkun Tarkun
    Published: January 18, 2022 Explor Med. 2022;3:1–21
    DOI: https://doi.org/10.37349/emed.2022.00071
    View:1015
    Download:57
    Times Cited: 0
    Open Access
    Review
    Antioxidant enzymes and vascular diseases
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in regulating endothelial function and vascular tone in the physiological conditions of a vascular system. However, oxidative stress has det [...] Read more.
    Jelena Radovanovic ... Esma R. Isenovic
    Published: December 31, 2021 Explor Med. 2021;2:544–555
    DOI: https://doi.org/10.37349/emed.2021.00070
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:1352
    Download:64
    Open Access
    Review
    A global genetic epidemiological review of pseudoexfoliation syndrome
    Pseudoexfoliation (PXF) syndrome is an important public health concern requiring individual population level analysis. Disease prevalence differs by geographic location and ethnicity, and has environmental, demographic, genetic, a [...] Read more.
    Patrice M. Hicks ... Margaret M. DeAngelis
    Published: December 31, 2021 Explor Med. 2021;2:527–543
    DOI: https://doi.org/10.37349/emed.2021.00069
    View:1310
    Download:58
    Times Cited: 0
    Open Access
    Review
    Key roles of CCCTC-binding factor in cancer evolution and development
    The processes of cancer and embryonic development have a partially overlapping effect. Several transcription factor families, which are highly conserved in the evolutionary history of biology, play a key role in the development of [...] Read more.
    Zishuai Li ... Guangwen Cao
    Published: December 31, 2021 Explor Med. 2021;2:516–526
    DOI: https://doi.org/10.37349/emed.2021.00068
    View:924
    Download:36
    Times Cited: 0
    Open Access
    Commentary
    Functions of two distinct Kupffer cells in the liver
    Tissue-resident macrophages play critically important roles in host homeostasis and pathogenesis of diseases, with the functions of phagocytosis, metabolism, and immune modulation. Recently, two research studies accomplished by a  [...] Read more.
    Chunye Zhang ... Ming Yang
    Published: December 31, 2021 Explor Med. 2021;2:511–515
    DOI: https://doi.org/10.37349/emed.2021.00067
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1709
    Download:99
    Open Access
    Review
    Molecular targets regulating endoplasmic reticulum-mitochondria crosstalk for NAFLD treatment
    Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease poses a significant impact on public healthcare and economic risk worldwide. As a multifactorial disease, NAFLD is usually associated with many com [...] Read more.
    Chunye Zhang, Ming Yang
    Published: December 31, 2021 Explor Med. 2021;2:494–510
    DOI: https://doi.org/10.37349/emed.2021.00066
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1100
    Download:60
    Times Cited: 0
    Open Access
    Original Article
    Cross-cultural adaptation of Delphi definitions of low back pain prevalence in French (Delphi DOLBaPP-F)
    Aim: The high heterogeneity in the definitions of low back pain encountered in the literature has led to the development of standardized definitions of this condition called “Delphi definitions of low back pain prevalence (D [...] Read more.
    Antarou Ly ... Clermont E. Dionne
    Published: December 31, 2021 Explor Med. 2021;2:483–493
    DOI: https://doi.org/10.37349/emed.2021.00065
    Open Access
    Review
    Obstetric implications of maternal chronic hepatitis B virus infection
    Antenatal screening for hepatitis B surface antigen seropositivity is widely adopted to identify pregnant women with chronic hepatitis B virus (HBV) infection in order to target their newborn infants for combined passive-active ne [...] Read more.
    Terence T. Lao
    Published: December 31, 2021 Explor Med. 2021;2:468–482
    DOI: https://doi.org/10.37349/emed.2021.00064
    View:888
    Download:38
    Times Cited: 0
    Open Access
    Review
    Future incidence and mortality of colorectal carcinoma in the United States: an updated overview of risk factors and preventative measures
    According to the Global Cancer Observatory (GLOBOCAN) 2020, colorectal carcinoma (CRC) was the second leading cause of cancer death globally. Current literature utilizes reported databases such as Surveillance, Epidemiology, and E [...] Read more.
    Hassam Ali
    Published: December 31, 2021 Explor Med. 2021;2:455–467
    DOI: https://doi.org/10.37349/emed.2021.00063
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is [...] Read more.
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443–454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
    View:3505
    Download:1429
    Open Access
    Commentary
    Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
    Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone  [...] Read more.
    Amedeo Lonardo
    Published: October 31, 2021 Explor Med. 2021;2:435–442
    DOI: https://doi.org/10.37349/emed.2021.00061
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1030
    Download:69
    Open Access
    Review
    Aortic complications in pregnancy: the less remembered chapter—a narrative review
    Pregnancy increases the risk of common vascular events and also the rarer events like aortic dissection (AD)/aortic rupture and this is even more pronounced in patients with predisposing aortopathies. AD was found to occur in 0.00 [...] Read more.
    Preetha Rajasekaran ... Bashi V. Velayudhan
    Published: October 31, 2021 Explor Med. 2021;2:423–434
    DOI: https://doi.org/10.37349/emed.2021.00060
    This article belongs to the special issue Exploring Aortic Disease
    View:998
    Download:57
    Times Cited: 0
    Open Access
    Meta-Analysis
    A review of aortic thrombosis in COVID-19 infection
    Aim: As the novel coronavirus disease 2019 (COVID-19) pandemic impacts the global healthcare system, evolving data show increased frequency of arterial and venous thromboembolism among patients with COVID-19 infection. Aortic t [...] Read more.
    Korin Karabulut ... James Morgan
    Published: October 31, 2021 Explor Med. 2021;2:410–422
    DOI: https://doi.org/10.37349/emed.2021.00059
    This article belongs to the special issue Exploring Aortic Disease
    View:1370
    Download:28
    Open Access
    Review
    Exploring evidence-based innovative therapy for the treatment of chronic HBV infection: experimental and clinical
    With the advent of various vaccines and antimicrobial agents during the 20th century, the control and containment of infectious diseases appeared to be a matter of time. However, studies unveiled the diverse natures of microbes, t [...] Read more.
    Sheikh Mohammad Fazle Akbar ... Yoichi Hiasa
    Published: October 31, 2021 Explor Med. 2021;2:392–409
    DOI: https://doi.org/10.37349/emed.2021.00058
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:971
    Download:26
    Times Cited: 0
    Open Access
    Original Article
    Objective measurement of sleep by smartphone application: comparison with actigraphy and relation to self-reported sleep
    Aim: Smartphone technology is increasingly used by the public to assess sleep. Specific features of some sleep-tracking applications are comparable to actigraphy in objectively monitoring sleep. The clinical utility of smartpho [...] Read more.
    Taylor Maynard ... Sandy Neargarder
    Published: October 31, 2021 Explor Med. 2021;2:382–391
    DOI: https://doi.org/10.37349/emed.2021.00057
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1447
    Download:37
    Open Access
    Commentary
    Breastfeeding duration and reduced risk of NAFLD in midlife of parous women
    Alessandro Mantovani ... Andrea Dalbeni
    Published: October 31, 2021 Explor Med. 2021;2:378–381
    DOI: https://doi.org/10.37349/emed.2021.00056
    This article belongs to the special issue Exploring Chronic Liver Disease
    Open Access
    Original Article
    High prevalence of false positive SARS-CoV2 serology in a cohort of patients with liver autoimmune diseases
    Aim: Monitoring the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) immunization in patients with autoimmune diseases is of particular concern to understand their response to the infection and to the v [...] Read more.
    Maria Giulia Cornacchia ... Gaetano Serviddio
    Published: August 31, 2021 Explor Med. 2021;2:372–377
    DOI: https://doi.org/10.37349/emed.2021.00055
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:1756
    Download:41
    Open Access
    Review
    Role of angiotensin II in the development of subcellular remodeling in heart failure
    The development of heart failure under various pathological conditions such as myocardial infarction (MI), hypertension and diabetes are accompanied by adverse cardiac remodeling and cardiac dysfunction. Since heart function is ma [...] Read more.
    Sukhwinder K. Bhullar ... Naranjan S. Dhalla
    Published: August 31, 2021 Explor Med. 2021;2:352–371
    DOI: https://doi.org/10.37349/emed.2021.00054
    This article belongs to the special issue Angiotensins—A Century of Progress
    Open Access
    Perspective
    Why the aortic dissection detection risk score is problematic in emergency departments
    Acute aortic syndromes, including aortic dissection (AD), are rare. The AD detection risk score (ADDRS) and associated investigation pathway were developed to reduce missed diagnosis of AD. The methodology for its development was  [...] Read more.
    Anne-Maree Kelly
    Published: August 31, 2021 Explor Med. 2021;2:348–351
    DOI: https://doi.org/10.37349/emed.2021.00053
    This article belongs to the special issue Exploring Aortic Disease