• 28 results in Exploration of Medicine
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    Original Article
    Identification of digital voice biomarkers for cognitive health
    Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identif...
    Honghuang Lin ... Rhoda Au
    Published: December 31, 2020 Explor Med. 2020;1:406-417
    DOI: https://doi.org/10.37349/emed.2020.00028
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:126
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    Times Cited: 0
    Open Access
    Original Article
    Detection of mild traumatic brain injury in pediatric populations using BrainCheck, a tablet-based cognitive testing software: a preliminary study
    Aim: Despite its high frequency of occurrence, mild traumatic brain injury (mTBI), or concussion, is difficult to recognize and diagnose, particularly in pediatric populations. Conventional methods...
    Siao Ye ... Reza Hosseini Ghomi
    Published: December 31, 2020 Explor Med. 2020;1:396-405
    DOI: https://doi.org/10.37349/emed.2020.00027
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:94
    Download:7
    Times Cited: 0
    Open Access
    Original Article
    Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity
    Aim: Research suggests that Alzheimer’s disease (AD) is heterogeneous with numerous subtypes. Through a proprietary interactive ML system, several underlying biological mechanisms associa...
    Bessi Qorri ... Joseph Geraci
    Published: December 31, 2020 Explor Med. 2020;1:377-395
    DOI: https://doi.org/10.37349/emed.2020.00026
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:299
    Download:10
    Times Cited: 0
    Open Access
    Review
    The entero-insular axis: a journey in the physiopathology of diabetes
    Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role. The discovery of the hormone in...
    Roberta Malaguarnera ... Salvatore Piro
    Published: December 31, 2020 Explor Med. 2020;1:364-376
    DOI: https://doi.org/10.37349/emed.2020.00025
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:168
    Download:9
    Times Cited: 0
    Open Access
    Commentary
    The need for a harmonized speech dataset for Alzheimer’s disease biomarker development
    This commentary is the product of a concerted effort to understand the needs, barriers, and gaps in the field of speech and language biomarkers for Alzheimer’s disease (AD). It distills in...
    Nicole L. Bjorklund ... Lampros Kourtis
    Published: December 31, 2020 Explor Med. 2020;1:359-363
    DOI: https://doi.org/10.37349/emed.2020.00024
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:308
    Download:17
    Times Cited: 0
    Open Access
    Perspective
    High-performance computing will assist experiments in recovery from COVID-19
    Bhushan Dharmadhikari ... Prabir Patra
    Published: October 30, 2020 Explor Med. 2020;1:355-358
    DOI: https://doi.org/10.37349/emed.2020.00023
    View:705
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    Times Cited: 0
    Open Access
    Original Article
    Going against the norm: validation of a novel alternative to brain SPECT normative datasets
    Aim: Quantitative analysis of brain single photon emission computed tomography (SPECT) perfusion imaging is dependent on normative datasets that are challenging to produce. This study investigated ...
    Lindsay M. Quandt, Cyrus A. Raji
    Published: October 30, 2020 Explor Med. 2020;1:331-354
    DOI: https://doi.org/10.37349/emed.2020.00022
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:765
    Download:19
    Times Cited: 0
    Open Access
    Review
    Insulin pump therapy and continuous glucose monitoring in adults with type 2 diabetes: where are we now?
    Technology in diabetes is rapidly evolving, with the aim of helping affected people to safely optimize their blood glucose control. New technologies are now considered as an essential tool for manag...
    Erika Pedone ... Amelia Caretto
    Published: October 30, 2020 Explor Med. 2020;1:314-330
    DOI: https://doi.org/10.37349/emed.2020.00021
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:593
    Download:7
    Times Cited: 0
    Open Access
    Commentary
    Country rankings on the scientific production in endocrinology and diabetology
    Alessandro Mantovani ... Chiara Zusi
    Published: October 30, 2020 Explor Med. 2020;1:307-313
    DOI: https://doi.org/10.37349/emed.2020.00020
    View:629
    Download:3
    Times Cited: 0
    Open Access
    Review
    The diagnostic conundrum in non-alcoholic fatty liver disease
    Non-alcoholic fatty liver disease (NAFLD) has become the most common liver alteration worldwide. It encompasses a spectrum of disorders that range from simple steatosis to a progressive form, define...
    Valerio Rosato ... Marcello Persico
    Published: October 30, 2020 Explor Med. 2020;1:259-286
    DOI: https://doi.org/10.37349/emed.2020.00018
    This article belongs to the special issue Exploring NAFLD/NASH
    View:724
    Download:17
    Times Cited: 0
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially know...
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287-306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:919
    Download:16
    Open Access
    Review
    Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
    Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways...
    Fatiha Nassir
    Published: August 31, 2020 Explor Med. 2020;1:248-258
    DOI: https://doi.org/10.37349/emed.2020.00017
    This article belongs to the special issue Exploring NAFLD/NASH
    View:828
    Download:12
    Times Cited: 0
    Open Access
    Review
    Non-alcoholic fatty liver disease and transient elastography
    Nonalcoholic fatty liver disease (NAFLD) is a serious condition that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD is associated with metabolic syndrome (MetS) and all of its ...
    Ivana Mikolasevic ... Sandra Milic
    Published: August 31, 2020 Explor Med. 2020;1:205-217
    DOI: https://doi.org/10.37349/emed.2020.00014
    This article belongs to the special issue Exploring NAFLD/NASH
    View:963
    Download:12
    Times Cited: 0
    Open Access
    Review
    Genetic and metabolic factors: the perfect combination to treat metabolic associated fatty liver disease
    The prevalence of nonalcoholic or more recently re-defined metabolic associated fatty liver disease (MAFLD) is rapidly growing worldwide. It is characterized by hepatic fat accumulation exceeding 5&...
    Marica Meroni ... Paola Dongiovanni
    Published: August 31, 2020 Explor Med. 2020;1:218-243
    DOI: https://doi.org/10.37349/emed.2020.00015
    This article belongs to the special issue Exploring NAFLD/NASH
    View:929
    Download:28
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge no...
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184-204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1001
    Download:10
    Times Cited: 0
    Open Access
    Perspective
    Visual communication and learning from COVID-19 to advance preparedness for pandemics
    The currently ongoing coronavirus disease 19 (COVID-19) pandemic has affected globally human health and economy. Research in progress has shown facts associated with this disease and raised question...
    José de la Fuente ... Christian Gortázar
    Published: August 31, 2020 Explor Med. 2020;1:244-247
    DOI: https://doi.org/10.37349/emed.2020.00016
    View:990
    Download:18
    Times Cited: 0
    Open Access
    Review
    The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis
    Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity...
    Michael Doulberis ... Stergios A. Polyzos
    Published: August 31, 2020 Explor Med. 2020;1:170-183
    DOI: https://doi.org/10.37349/emed.2020.00012
    This article belongs to the special issue Exploring NAFLD/NASH
    View:888
    Download:11
    Times Cited: 0
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and...
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149-169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:1100
    Download:22
    Open Access
    Original Article
    Reduction of endoglin receptor impairs mononuclear cell-migration
    Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell su...
    Zhenying Han ... Hua Su
    Published: June 29, 2020 Explor Med. 2020;1:136-148
    DOI: https://doi.org/10.37349/emed.2020.00010
    View:901
    Download:17
    Open Access
    Original Article
    Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study
    Aim: Epigenetic variation of DNA methylation of the mu-opioid receptor gene (OPRM1) has been identified in the blood and saliva of individuals with opioid use disorder (OUD) and infants with neonat...
    Elisha M. Wachman ... Huiping Zhang
    Published: June 29, 2020 Explor Med. 2020;1:124-135
    DOI: https://doi.org/10.37349/emed.2020.00009
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:915
    Download:18
    Times Cited: 0
    Open Access
    Meta-Analysis
    GLP-1 receptor agonists for NAFLD treatment in patients with and without type 2 diabetes: an updated meta-analysis
    Aim: Recent randomized controlled trials (RCTs) have tested the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RA) to specifically treat non-alcoholic fatty liver disease (NAFLD). We ...
    Alessandro Mantovani ... Giovanni Targher
    Published: June 29, 2020 Explor Med. 2020;1:108-123
    DOI: https://doi.org/10.37349/emed.2020.00008
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:720
    Download:17
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of f...
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85-107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    View:1174
    Download:37
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a ...
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. 2020;1:75-84
    DOI: https://doi.org/10.37349/emed.2020.00006
    View:1110
    Download:38
    Times Cited: 0
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mech...
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51-74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2564
    Download:53
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause,...
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42-50
    DOI: https://doi.org/10.37349/emed.2020.00004
    View:942
    Download:12
    Open Access
    Original Article
    Identifying factors associated with opioid cessation in a biracial sample using machine learning
    Aim: Racial disparities in opioid use disorder (OUD) management exist, however, and there is limited research on factors that influence opioid cessation in different population groups. Methods: ...
    Jiayi W. Cox ... Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:27-41
    DOI: https://doi.org/10.37349/emed.2020.00003
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:1580
    Download:42
    Times Cited: 0
    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP dis...
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. 2020;1:4-26
    DOI: https://doi.org/10.37349/emed.2020.00002
    View:1207
    Download:39
    Open Access
    Editorial
    Welcome message from the Editor-in-Chief
    Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:1-3
    DOI: https://doi.org/10.37349/emed.2020.00001
    View:630
    Download:18
    Times Cited: 0