• 62 results in Exploration of Medicine
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    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful,...
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. 2021;2:443-454
    DOI: https://doi.org/10.37349/emed.2021.00062
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
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    Commentary
    Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
    Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421&a...
    Amedeo Lonardo
    Published: October 31, 2021 Explor Med. 2021;2:435-442
    DOI: https://doi.org/10.37349/emed.2021.00061
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:192
    Download:39
    Times Cited: 0
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    Review
    Aortic complications in pregnancy: the less remembered chapter—a narrative review
    Pregnancy increases the risk of common vascular events and also the rarer events like aortic dissection (AD)/aortic rupture and this is even more pronounced in patients with predisposing aortopathie...
    Preetha Rajasekaran ... Bashi V. Velayudhan
    Published: October 31, 2021 Explor Med. 2021;2:423-434
    DOI: https://doi.org/10.37349/emed.2021.00060
    This article belongs to the special issue Exploring Aortic Disease
    View:110
    Download:25
    Times Cited: 0
    Open Access
    Meta-Analysis
    A review of aortic thrombosis in COVID-19 infection
    Aim: As the novel coronavirus disease 2019 (COVID-19) pandemic impacts the global healthcare system, evolving data show increased frequency of arterial and venous thromboembolism among patients wit...
    Korin Karabulut ... James Morgan
    Published: October 31, 2021 Explor Med. 2021;2:410-422
    DOI: https://doi.org/10.37349/emed.2021.00059
    This article belongs to the special issue Exploring Aortic Disease
    View:310
    Download:9
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    Review
    Exploring evidence-based innovative therapy for the treatment of chronic HBV infection: experimental and clinical
    With the advent of various vaccines and antimicrobial agents during the 20th century, the control and containment of infectious diseases appeared to be a matter of time. However, studies unveiled th...
    Sheikh Mohammad Fazle Akbar ... Yoichi Hiasa
    Published: October 31, 2021 Explor Med. 2021;2:392-409
    DOI: https://doi.org/10.37349/emed.2021.00058
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:232
    Download:11
    Times Cited: 0
    Open Access
    Original Article
    Objective measurement of sleep by smartphone application: comparison with actigraphy and relation to self-reported sleep
    Aim: Smartphone technology is increasingly used by the public to assess sleep. Specific features of some sleep-tracking applications are comparable to actigraphy in objectively monitoring sleep. Th...
    Taylor Maynard ... Sandy Neargarder
    Published: October 31, 2021 Explor Med. 2021;2:382-391
    DOI: https://doi.org/10.37349/emed.2021.00057
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:262
    Download:18
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    Commentary
    Breastfeeding duration and reduced risk of NAFLD in midlife of parous women
    Alessandro Mantovani ... Andrea Dalbeni
    Published: October 31, 2021 Explor Med. 2021;2:378-381
    DOI: https://doi.org/10.37349/emed.2021.00056
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:276
    Download:8
    Times Cited: 0
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    Original Article
    High prevalence of false positive SARS-CoV2 serology in a cohort of patients with liver autoimmune diseases
    Aim: Monitoring the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) immunization in patients with autoimmune diseases is of particular concern to understand their respon...
    Maria Giulia Cornacchia ... Gaetano Serviddio
    Published: August 31, 2021 Explor Med. 2021;2:372-377
    DOI: https://doi.org/10.37349/emed.2021.00055
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:532
    Download:23
    Times Cited: 0
    Open Access
    Review
    Role of angiotensin II in the development of subcellular remodeling in heart failure
    The development of heart failure under various pathological conditions such as myocardial infarction (MI), hypertension and diabetes are accompanied by adverse cardiac remodeling and cardiac dysfunc...
    Sukhwinder K. Bhullar ... Naranjan S. Dhalla
    Published: August 31, 2021 Explor Med. 2021;2:352-371
    DOI: https://doi.org/10.37349/emed.2021.00054
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:321
    Download:24
    Times Cited: 0
    Open Access
    Perspective
    Why the aortic dissection detection risk score is problematic in emergency departments
    Acute aortic syndromes, including aortic dissection (AD), are rare. The AD detection risk score (ADDRS) and associated investigation pathway were developed to reduce missed diagnosis of AD. The meth...
    Anne-Maree Kelly
    Published: August 31, 2021 Explor Med. 2021;2:348-351
    DOI: https://doi.org/10.37349/emed.2021.00053
    This article belongs to the special issue Exploring Aortic Disease
    View:435
    Download:11
    Times Cited: 0
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    Case Report
    Submucosal esophageal hematomas in a critically ill patient on anticoagulation
    Submucosal esophageal hematoma is an uncommon clinical complication of anticoagulation. Current literature is scarce regarding presentation and management in acute submucosal hematomas in critically...
    Hassam Ali, Maliha Naseer
    Published: August 31, 2021 Explor Med. 2021;2:343-347
    DOI: https://doi.org/10.37349/emed.2021.00052
    View:266
    Download:17
    Times Cited: 0
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    Review
    Pediatric vs. adult NAFLD to MAFLD transition: a welcome but tangled path
    The term non-alcoholic fatty liver disease (NAFLD) appears unfitting both in adults and in children. As obesity and metabolic syndrome play a relevant pathogenic role, an international group of adul...
    Angelo Colucci ... Claudia Mandato
    Published: August 31, 2021 Explor Med. 2021;2:333-342
    DOI: https://doi.org/10.37349/emed.2021.00051
    This article belongs to the special issue Exploring NAFLD/NASH
    View:359
    Download:22
    Times Cited: 0
    Open Access
    Case Report
    Central pontine myelinolysis secondary to glycemic variability in type 1 diabetes: a case report and a systematic review of the literature
    Central pontine myelinolysis (CPM) is a rare manifestation of osmotic demyelination syndrome (ODS) which involves the pons and causes significant morbidity and mortality. CPM usually occurs in the s...
    Stefania Di Agostino ... Mauro Maurantonio
    Published: August 31, 2021 Explor Med. 2021;2:324-332
    DOI: https://doi.org/10.37349/emed.2021.00050
    View:283
    Download:21
    Times Cited: 0
    Open Access
    Review
    Sex hormones abnormalities in non-alcoholic fatty liver disease: pathophysiological and clinical implications
    Obesity and metabolic syndrome are conditions at high risk for the development of complications such as type 2 diabetes mellitus, atherosclerotic cardiovascular disease, and non-alcoholic fatty live...
    Angelo Di Vincenzo ... Marco Rossato
    Published: August 31, 2021 Explor Med. 2021;2:311-323
    DOI: https://doi.org/10.37349/emed.2021.00049
    This article belongs to the special issue Exploring NAFLD/NASH
    View:346
    Download:39
    Times Cited: 0
    Open Access
    Commentary
    An engineered mayhem: YAP/TAZ mechanosignaling and hepatocarcinogenesis in NAFLD
    Gyorgy Baffy
    Published: August 31, 2021 Explor Med. 2021;2:305-310
    DOI: https://doi.org/10.37349/emed.2021.00048
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:581
    Download:31
    Times Cited: 0
    Open Access
    Review
    Angiotensin peptides in the regulation of adrenal cortical function
    The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones. Evide...
    Gian Paolo Rossi ... Teresa Maria Seccia
    Published: June 30, 2021 Explor Med. 2021;2:294-304
    DOI: https://doi.org/10.37349/emed.2021.00047
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:638
    Download:83
    Times Cited: 0
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    Review
    Angiotensin-(1-7) and Mas receptor in the brain
    The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associa...
    Natalia L. Rukavina Mikusic ... Mariela M. Gironacci
    Published: June 30, 2021 Explor Med. 2021;2:268-293
    DOI: https://doi.org/10.37349/emed.2021.00046
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:718
    Download:102
    Times Cited: 0
    Open Access
    Original Article
    Digital sleep measures and white matter health in the Framingham Heart Study
    Aim: Impaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort. Me...
    Robert Joseph Thomas ... Rhoda Au
    Published: June 30, 2021 Explor Med. 2021;2:253-267
    DOI: https://doi.org/10.37349/emed.2021.00045
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:409
    Download:14
    Times Cited: 0
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    Original Article
    Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort
    Aim: Although clinicians primarily diagnose dementia based on a combination of metrics such as medical history and formal neuropsychological tests, recent work using linguistic analysis of narrative...
    Larry Zhang ... Reza Hosseini Ghomi
    Published: June 30, 2021 Explor Med. 2021;2:232-252
    DOI: https://doi.org/10.37349/emed.2021.00044
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:482
    Download:24
    Times Cited: 0
    Open Access
    Review
    Emerging nanomaterials for cancer immunotherapy
    Immunotherapy is a unique approach to treat cancer that targets tumours besides triggering the immune cells. It attempts to harness the supremacy and specificity of immune cells for the regression o...
    Sureshbabu Ram Kumar Pandian ... Krishnan Sundar
    Published: June 30, 2021 Explor Med. 2021;2:208-231
    DOI: https://doi.org/10.37349/emed.2021.00043
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:346
    Download:31
    Times Cited: 0
    Open Access
    Review
    Wave propagation and reflection in the aorta and implications of the aortic Windkessel
    Some have said that it is inappropriate and perhaps impossible to consider wave and Windkessel phenomena simultaneously. For 50 years, arterial hemodynamics has been dominated by the frequency-domai...
    John V. Tyberg
    Published: June 30, 2021 Explor Med. 2021;2:198-207
    DOI: https://doi.org/10.37349/emed.2021.00042
    This article belongs to the special issue Exploring Aortic Disease
    View:267
    Download:28
    Times Cited: 0
    Open Access
    Perspective
    Vascular aging, the vascular cytoskeleton and aortic stiffness
    Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the st...
    Lova Prasadareddy Kajuluri ... Kathleen G Morgan
    Published: June 30, 2021 Explor Med. 2021;2:186-197
    DOI: https://doi.org/10.37349/emed.2021.00041
    This article belongs to the special issue Exploring Aortic Disease
    View:498
    Download:29
    Times Cited: 0
    Open Access
    Review
    Nanomedicine in cancer therapy: promises and hurdles of polymeric nanoparticles
    The limitations of current cancer treatments have stimulated the application of nanotechnology to develop more effective and safer cancer therapies. Remarkable progress has been made in the developm...
    Carmen Paus ... Alessandra Cambi
    Published: April 30, 2021 Explor Med. 2021;2:167-185
    DOI: https://doi.org/10.37349/emed.2021.00040
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:678
    Download:20
    Open Access
    Review
    AS1411-functionalized delivery nanosystems for targeted cancer therapy
    Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications....
    Pooria Safarzadeh Kozani ... Mohammad Tariq Malik
    Published: April 30, 2021 Explor Med. 2021;2:146-166
    DOI: https://doi.org/10.37349/emed.2021.00039
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:664
    Download:30
    Times Cited: 0
    Open Access
    Original Article
    Angiotensin-(3-4) modulates the overweight- and undernutrition-induced ACE2 downregulation in renal proximal tubule cells: implications for COVID-19?
    Aim: The renal lesions–including severe acute kidney injury–are severe outcomes in severe acute respiratory syndrome coronavirus 2 infections. There are no reports regarding ...
    Rafael Luzes ... Adalberto Vieyra
    Published: April 30, 2021 Explor Med. 2021;2:135-145
    DOI: https://doi.org/10.37349/emed.2021.00038
    This article belongs to the special issue Angiotensins—A Century of Progress
    View:778
    Download:83
    Times Cited: 0
    Open Access
    Case Report
    Hepatic manifestations of drug reaction with eosinophilia and systemic symptoms syndrome
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening drug reaction, which can affect multiple organs. Patients with DRESS syndrome and hepatic man...
    Maria Gabriela Delgado ... Jean François Dufour
    Published: April 30, 2021 Explor Med. 2021;2:122-134
    DOI: https://doi.org/10.37349/emed.2021.00037
    This article belongs to the special issue Exploring Chronic Liver Disease
    View:865
    Download:13
    Times Cited: 0
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    Original Article
    Proof of concept: digital clock drawing behaviors prior to transcatheter aortic valve replacement may predict length of hospital stay and cost of care
    Aims: Reduced pre-operative cognitive functioning in older adults is a risk factor for postoperative complications, but it is unknown if preoperative digitally-acquired clock drawing test (CDT) cog...
    Margaret Ellenora Wiggins ... Catherine C. Price
    Published: April 30, 2021 Explor Med. 2021;2:110-121
    DOI: https://doi.org/10.37349/emed.2021.00036
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1139
    Download:20
    Times Cited: 0
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    Original Article
    Risk factors in acute diabetic foot syndrome: analysis of 75 consecutive patients referred to a tertiary center in Modena, Italy
    Aim: Diabetic foot syndrome (DFS) is a complication of diabetes in which the presence of infections, ulceration and/or destruction of deep tissue associated with neuropathy, peripheral atherosclero...
    Mauro Maurantonio ... Luca Roncucci
    Published: February 28, 2021 Explor Med. 2021;2:98-109
    DOI: https://doi.org/10.37349/emed.2021.00035
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:951
    Download:15
    Times Cited: 0
    Open Access
    Original Article
    Assessing the capacity for mental manipulation in patients with statically-determined mild cognitive impairment using digital technology
    Aims: Prior research employing a standard backward digit span test has been successful in operationally defining neurocognitive constructs associated with the Fuster's model of executiv...
    Sheina Emrani ... David J. Libon
    Published: February 28, 2021 Explor Med. 2021;2:86-97
    DOI: https://doi.org/10.37349/emed.2021.00034
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1036
    Download:16
    Times Cited: 0
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    Original Article
    A machine learning approach to identify correlates of current e-cigarette use in Canada
    Aim: Popularity of electronic cigarettes (i.e. e-cigarettes) is soaring in Canada. Understanding person-level correlates of current e-cigarette use (vaping) is crucial to guide tobacco policy, but ...
    Rui Fu ... Michael Chaiton
    Published: February 28, 2021 Explor Med. 2021;2:74-85
    DOI: https://doi.org/10.37349/emed.2021.00033
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:1161
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    Original Article
    Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes
    Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite ...
    Richard Sherva ... Lindsay A. Farrer
    Published: February 28, 2021 Explor Med. 2021;2:60-73
    DOI: https://doi.org/10.37349/emed.2021.00032
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:1306
    Download:20
    Times Cited: 0
    Open Access
    Review
    Cell-derived vesicles for delivery of cancer immunotherapy
    In recent years, cancer immunotherapy has received unprecedented attention due to the clinical achievements. The applications of biomedical engineering and materials science to cancer immunotherapy ...
    Jialu Xu, Chao Wang
    Published: February 28, 2021 Explor Med. 2021;2:39-59
    DOI: https://doi.org/10.37349/emed.2021.00031
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
    View:1006
    Download:35
    Times Cited: 0
    Open Access
    Review
    Cardiovascular involvement after liver transplantation: role of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    Patients submitted to liver transplantation (LT) are exposed to high risk of cardiovascular (CV) complications which are the main determinants of both short-term and long-term morbidity and mortalit...
    Rosa Lombardi ... Anna Ludovica Fracanzani
    Published: February 28, 2021 Explor Med 2021;2:20-38
    DOI: https://doi.org/10.37349/emed.2021.00030
    This article belongs to the special issue Exploring NAFLD/NASH
    View:702
    Download:15
    Times Cited: 0
    Open Access
    Review
    Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies
    Silent coronary artery disease (CAD) is one of the manifestations of heart disease that particularly affects subjects with type 2 diabetes mellitus (T2DM). From a clinical point of view, silent CAD ...
    Saula Vigili de Kreutzenberg
    Published: February 28, 2021 Explor Med. 2021;2:1-19
    DOI: https://doi.org/10.37349/emed.2021.00029
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1003
    Download:19
    Times Cited: 0
    Open Access
    Original Article
    Identification of digital voice biomarkers for cognitive health
    Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identif...
    Honghuang Lin ... Rhoda Au
    Published: December 31, 2020 Explor Med. 2020;1:406-417
    DOI: https://doi.org/10.37349/emed.2020.00028
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1153
    Download:35
    Open Access
    Original Article
    Detection of mild traumatic brain injury in pediatric populations using BrainCheck, a tablet-based cognitive testing software: a preliminary study
    Aim: Despite its high frequency of occurrence, mild traumatic brain injury (mTBI), or concussion, is difficult to recognize and diagnose, particularly in pediatric populations. Conventional methods...
    Siao Ye ... Reza Hosseini Ghomi
    Published: December 31, 2020 Explor Med. 2020;1:396-405
    DOI: https://doi.org/10.37349/emed.2020.00027
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:980
    Download:26
    Times Cited: 0
    Open Access
    Original Article
    Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity
    Aim: Research suggests that Alzheimer’s disease (AD) is heterogeneous with numerous subtypes. Through a proprietary interactive ML system, several underlying biological mechanisms associa...
    Bessi Qorri ... Joseph Geraci
    Published: December 31, 2020 Explor Med. 2020;1:377-395
    DOI: https://doi.org/10.37349/emed.2020.00026
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1335
    Download:30
    Open Access
    Review
    The entero-insular axis: a journey in the physiopathology of diabetes
    Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role. The discovery of the hormone in...
    Roberta Malaguarnera ... Salvatore Piro
    Published: December 31, 2020 Explor Med. 2020;1:364-376
    DOI: https://doi.org/10.37349/emed.2020.00025
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:908
    Download:24
    Times Cited: 0
    Open Access
    Commentary
    The need for a harmonized speech dataset for Alzheimer’s disease biomarker development
    This commentary is the product of a concerted effort to understand the needs, barriers, and gaps in the field of speech and language biomarkers for Alzheimer’s disease (AD). It distills in...
    Nicole L. Bjorklund ... Lampros Kourtis
    Published: December 31, 2020 Explor Med. 2020;1:359-363
    DOI: https://doi.org/10.37349/emed.2020.00024
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1439
    Download:63
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    Open Access
    Perspective
    High-performance computing will assist experiments in recovery from COVID-19
    Bhushan Dharmadhikari ... Prabir Patra
    Published: October 30, 2020 Explor Med. 2020;1:355-358
    DOI: https://doi.org/10.37349/emed.2020.00023
    View:1028
    Download:11
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    Original Article
    Going against the norm: validation of a novel alternative to brain SPECT normative datasets
    Aim: Quantitative analysis of brain single photon emission computed tomography (SPECT) perfusion imaging is dependent on normative datasets that are challenging to produce. This study investigated ...
    Lindsay M. Quandt, Cyrus A. Raji
    Published: October 30, 2020 Explor Med. 2020;1:331-354
    DOI: https://doi.org/10.37349/emed.2020.00022
    This article belongs to the special issue Digital Biomarkers: The New Frontier for Medicine and Research
    View:1554
    Download:30
    Times Cited: 0
    Open Access
    Review
    Insulin pump therapy and continuous glucose monitoring in adults with type 2 diabetes: where are we now?
    Technology in diabetes is rapidly evolving, with the aim of helping affected people to safely optimize their blood glucose control. New technologies are now considered as an essential tool for manag...
    Erika Pedone ... Amelia Caretto
    Published: October 30, 2020 Explor Med. 2020;1:314-330
    DOI: https://doi.org/10.37349/emed.2020.00021
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1659
    Download:23
    Times Cited: 0
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    Commentary
    Country rankings on the scientific production in endocrinology and diabetology
    Alessandro Mantovani ... Chiara Zusi
    Published: October 30, 2020 Explor Med. 2020;1:307-313
    DOI: https://doi.org/10.37349/emed.2020.00020
    View:913
    Download:10
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    Review
    The diagnostic conundrum in non-alcoholic fatty liver disease
    Non-alcoholic fatty liver disease (NAFLD) has become the most common liver alteration worldwide. It encompasses a spectrum of disorders that range from simple steatosis to a progressive form, define...
    Valerio Rosato ... Marcello Persico
    Published: October 30, 2020 Explor Med. 2020;1:259-286
    DOI: https://doi.org/10.37349/emed.2020.00018
    This article belongs to the special issue Exploring NAFLD/NASH
    View:1960
    Download:64
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially know...
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. 2020;1:287-306
    DOI: https://doi.org/10.37349/emed.2020.00019
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2079
    Download:51
    Open Access
    Review
    Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
    Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways...
    Fatiha Nassir
    Published: August 31, 2020 Explor Med. 2020;1:248-258
    DOI: https://doi.org/10.37349/emed.2020.00017
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2119
    Download:44
    Times Cited: 0
    Open Access
    Review
    Non-alcoholic fatty liver disease and transient elastography
    Nonalcoholic fatty liver disease (NAFLD) is a serious condition that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD is associated with metabolic syndrome (MetS) and all of its ...
    Ivana Mikolasevic ... Sandra Milic
    Published: August 31, 2020 Explor Med. 2020;1:205-217
    DOI: https://doi.org/10.37349/emed.2020.00014
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2654
    Download:26
    Open Access
    Review
    Genetic and metabolic factors: the perfect combination to treat metabolic associated fatty liver disease
    The prevalence of nonalcoholic or more recently re-defined metabolic associated fatty liver disease (MAFLD) is rapidly growing worldwide. It is characterized by hepatic fat accumulation exceeding 5&...
    Marica Meroni ... Paola Dongiovanni
    Published: August 31, 2020 Explor Med. 2020;1:218-243
    DOI: https://doi.org/10.37349/emed.2020.00015
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2263
    Download:49
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge no...
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. 2020;1:184-204
    DOI: https://doi.org/10.37349/emed.2020.00013
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:3063
    Download:62
    Open Access
    Perspective
    Visual communication and learning from COVID-19 to advance preparedness for pandemics
    The currently ongoing coronavirus disease 19 (COVID-19) pandemic has affected globally human health and economy. Research in progress has shown facts associated with this disease and raised question...
    José de la Fuente ... Christian Gortázar
    Published: August 31, 2020 Explor Med. 2020;1:244-247
    DOI: https://doi.org/10.37349/emed.2020.00016
    View:2423
    Download:39
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    Open Access
    Review
    The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis
    Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity...
    Michael Doulberis ... Stergios A. Polyzos
    Published: August 31, 2020 Explor Med. 2020;1:170-183
    DOI: https://doi.org/10.37349/emed.2020.00012
    This article belongs to the special issue Exploring NAFLD/NASH
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    Times Cited: 0
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and...
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. 2020;1:149-169
    DOI: https://doi.org/10.37349/emed.2020.00011
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2181
    Download:40
    Open Access
    Original Article
    Reduction of endoglin receptor impairs mononuclear cell-migration
    Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell su...
    Zhenying Han ... Hua Su
    Published: June 29, 2020 Explor Med. 2020;1:136-148
    DOI: https://doi.org/10.37349/emed.2020.00010
    View:1253
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    Open Access
    Original Article
    Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study
    Aim: Epigenetic variation of DNA methylation of the mu-opioid receptor gene (OPRM1) has been identified in the blood and saliva of individuals with opioid use disorder (OUD) and infants with neonat...
    Elisha M. Wachman ... Huiping Zhang
    Published: June 29, 2020 Explor Med. 2020;1:124-135
    DOI: https://doi.org/10.37349/emed.2020.00009
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:1870
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    Open Access
    Meta-Analysis
    GLP-1 receptor agonists for NAFLD treatment in patients with and without type 2 diabetes: an updated meta-analysis
    Aim: Recent randomized controlled trials (RCTs) have tested the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RA) to specifically treat non-alcoholic fatty liver disease (NAFLD). We ...
    Alessandro Mantovani ... Giovanni Targher
    Published: June 29, 2020 Explor Med. 2020;1:108-123
    DOI: https://doi.org/10.37349/emed.2020.00008
    This article belongs to the special issue Exploring Type 2 Diabetes Mellitus
    View:1269
    Download:43
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of f...
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. 2020;1:85-107
    DOI: https://doi.org/10.37349/emed.2020.00007
    This article belongs to the special issue Exploring NAFLD/NASH
    View:2485
    Download:63
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a ...
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. 2020;1:75-84
    DOI: https://doi.org/10.37349/emed.2020.00006
    View:2572
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    Times Cited: 0
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mech...
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. 2020;1:51-74
    DOI: https://doi.org/10.37349/emed.2020.00005
    This article belongs to the special issue Exploring NAFLD/NASH
    View:4936
    Download:108
    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause,...
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. 2020;1:42-50
    DOI: https://doi.org/10.37349/emed.2020.00004
    View:1284
    Download:21
    Open Access
    Original Article
    Identifying factors associated with opioid cessation in a biracial sample using machine learning
    Aim: Racial disparities in opioid use disorder (OUD) management exist, however, and there is limited research on factors that influence opioid cessation in different population groups. Methods: ...
    Jiayi W. Cox ... Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:27-41
    DOI: https://doi.org/10.37349/emed.2020.00003
    This article belongs to the special issue The Biological Basis of Substance Use Disorders
    View:2617
    Download:52
    Times Cited: 0
    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP dis...
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. 2020;1:4-26
    DOI: https://doi.org/10.37349/emed.2020.00002
    View:1880
    Download:63
    Open Access
    Editorial
    Welcome message from the Editor-in-Chief
    Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. 2020;1:1-3
    DOI: https://doi.org/10.37349/emed.2020.00001
    View:861
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    Times Cited: 0