• 31 results in Exploration of Immunology
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    Pregnancy depends on a delicate balance of immune activation and regulation
    It is well recognized that immune tolerance is important to prevent semiallografted fetuses from rejection by maternal immunocompetent cells; however, immune activation also plays an important role  [...] Read more.
    Shigeru Saito ... Sayaka Tsuda
    Published: December 31, 2021 Explor Immunol. 2021;1:461-478
    DOI: https://doi.org/10.37349/ei.2021.00031
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
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    State-of-the-art preclinical evaluation of COVID-19 vaccine candidates
    The coronavirus disease 2019 (COVID-19) results from the infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and primarily affects the respiratory tissue. Since first reported  [...] Read more.
    Devlina Ghosh ... Abhishek Saxena
    Published: December 31, 2021 Explor Immunol. 2021;1:440-460
    DOI: https://doi.org/10.37349/ei.2021.00030
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
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    Times Cited: 0
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    New variants of SARS-CoV-2, vaccine immune response and the Brazilian reality
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly pathogenic β-coronavirus, is the etiologic agent of coronavirus disease 2019 (COVID-19), which gave rise to a diffi [...] Read more.
    Marileia Chaves Andrade ... Hellen Oliveira Rosa
    Published: December 31, 2021 Explor Immunol. 2021;1:432-439
    DOI: https://doi.org/10.37349/ei.2021.00029
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:103
    Download:17
    Times Cited: 0
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    Crosstalk between keratinocytes and immune cells in inflammatory skin diseases
    Cutaneous homeostasis is maintained by dynamic cellular communications between different cell types in the skin through interactions with various mediators, including cytokines, chemokines and antim [...] Read more.
    Xinhui Ni, Yuping Lai
    Published: December 31, 2021 Explor Immunol. 2021;1:418-431
    DOI: https://doi.org/10.37349/ei.2021.00028
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
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    Progesterone induced blocking factor in health and disease
    The foetus expressing paternal antigens ought to be “rejected” by the maternal immune system. However, the immunological relationship of the mother and the foetus does not follow the rules of transplantation immunology. Matern [...] Read more.
    Julia Szekeres-Bartho
    Published: December 31, 2021 Explor Immunol. 2021;1:406-417
    DOI: https://doi.org/10.37349/ei.2021.00027
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
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    A unique vaccine for birth control and treatment of advanced stage cancers secreting ectopically human chorionic gonadotropin
    This article is a tribute and homage to Gerard Chaouat who invited me to contribute this article. My years in France have remained very memorable to me. Reviewed briefly is the vaccine that was made [...] Read more.
    Gursaran P. Talwar ... Krishna M. Ella
    Published: December 31, 2021 Explor Immunol. 2021;1:398-405
    DOI: https://doi.org/10.37349/ei.2021.00026
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
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    Times Cited: 0
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    Activation of mucosal immunity and novel prophylactic and therapeutic strategy in combating COVID-19
    Coronavirus disease 2019 (COVID-19) emerges as an expeditiously growing pandemic, in the human population caused by the highly transmissible RNA virus severe acute respiratory syndrome of coronaviru [...] Read more.
    Swapan K. Chatterjee ... Maria Nilda M. Munoz
    Published: December 31, 2021 Explor Immunol. 2021;1:374-397
    DOI: https://doi.org/10.37349/ei.2021.00025
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:186
    Download:22
    Times Cited: 0
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    Vaccine-induced immune responses against SARS-CoV-2 infections
    Vaccination against coronavirus disease 2019 (COVID-19) is one of the most effective tools to curb the pandemic. Multiple vaccine candidates based on different platforms are available for emergency  [...] Read more.
    Mandeep Garg ... Suruchi Garg
    Published: December 31, 2021 Explor Immunol. 2021;1:356-373
    DOI: https://doi.org/10.37349/ei.2021.00024
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:159
    Download:14
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    COVID-19 vaccine and immune response
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; βCoV), the causative agent of coronavirus disease 2019 (COVID-19), causes severe lower respiratory tract infections and acute  [...] Read more.
    Sevilay Hintistan, Hatice Demirağ
    Published: December 31, 2021 Explor Immunol. 2021;1:341-355
    DOI: https://doi.org/10.37349/ei.2021.00023
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:192
    Download:22
    Times Cited: 0
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    Preeclampsia—an immune disease? An epidemiologic narrative
    The maternal syndrome preeclampsia is triggered by syncytiotrophoblast (STB) stress; the heterogeneity of the syndrome is caused by the different pathways leading to this STB stress. Inflammation pl [...] Read more.
    Gustaaf Albert Dekker, Pierre Yves Robillard
    Published: December 31, 2021 Explor Immunol. 2021;1:325-340
    DOI: https://doi.org/10.37349/ei.2021.00022
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
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    Times Cited: 0
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    Immunoregulation in the testis and its implication in fertility and infections
    The testis is designated as one of the immune previleged sites in the body and harbours a unique immunoregulatory environment, which is important for preventing an immune response against sperm anti [...] Read more.
    Kushaan Khambata ... Satish K. Gupta
    Published: December 31, 2021 Explor Immunol. 2021;1:309-324
    DOI: https://doi.org/10.37349/ei.2021.00021
    This article belongs to the special issue Human Reproduction: Involvement of the Immune System
    View:153
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    Times Cited: 0
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    Viral vector-based vaccines against SARS-CoV-2
    Viral vectors have been frequently applied for vaccine development. It has also been the case for vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to tackle the coronavi [...] Read more.
    Kenneth Lundstrom
    Published: October 31, 2021 Explor Immunol. 2021;1:295-308
    DOI: https://doi.org/10.37349/ei.2021.00020
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:538
    Download:48
    Times Cited: 0
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    Skin and immune cells crosstalk via circadian regulations
    Both innate and adaptive immune cells exist in the skin, predominantly in the dermis layer. Recent studies have focused on how and which circadian rhythms contribute to maintain good health. Over re [...] Read more.
    Kanami Orihara
    Published: October 31, 2021 Explor Immunol. 2021;1:285-294
    DOI: https://doi.org/10.37349/ei.2021.00019
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:275
    Download:52
    Times Cited: 0
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    Original Article
    The two faces of mast cells in vitiligo pathogenesis
    Aim: Previously, we reported increased number of T helper 17 (Th17) cells in vitiligo. However, in our recent study, tryptase and interleukin (IL)17 double positive cells which identified by polycl [...] Read more.
    Ichiro Katayama ... Mari Wataya-Kaneda
    Published: October 31, 2021 Explor Immunol. 2021;1:269-284
    DOI: https://doi.org/10.37349/ei.2021.00018
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:315
    Download:46
    Times Cited: 0
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    Original Article
    Serum profiles of tryptophan-kynurenine pathway metabolites in psoriasis
    Aim: Chronic inflammation is closely associated with tryptophan (TRP)-kynurenine (KYN) metabolic pathway. However, TRP-KYN pathway has not been fully elucidated in psoriasis, a systemic inflammator [...] Read more.
    Mariko Seishima ... Kuniaki Saito
    Published: October 31, 2021 Explor Immunol. 2021;1:258-268
    DOI: https://doi.org/10.37349/ei.2021.00017
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:266
    Download:27
    Times Cited: 0
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    Immune responses induced by different vaccine platforms against coronavirus disease-19
    There have been significant developments in the design of nanostructured scaffolds for eliciting robust immune responses named vaccine. The technique is to produce strong immune responses is to mani [...] Read more.
    Eknath D. Ahire, Sanjay J. Kshirsagar
    Published: October 31, 2021 Explor Immunol. 2021;1:243-257
    DOI: https://doi.org/10.37349/ei.2021.00016
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:529
    Download:40
    Times Cited: 0
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    Macrophages and fibroblasts underpin skin immune responses
    There are various types of skin immune responses including inflammatory skin diseases and skin malignancy. Macrophages and fibroblasts are skin resident cells that had been overlooked in terms of im [...] Read more.
    Makoto Sugaya
    Published: August 31, 2021 Explor Immunol. 2021;1:226-242
    DOI: https://doi.org/10.37349/ei.2021.00015
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:518
    Download:30
    Times Cited: 0
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    The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
    Understanding the interactions of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with humans is deeply grounded in immunology, from the diagnosis to pathogenesis, from the clinical pre [...] Read more.
    Eduardo Tosta
    Published: August 31, 2021 Explor Immunol. 2021;1:199-225
    DOI: https://doi.org/10.37349/ei.2021.00014
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
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    Review
    Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
    Head and neck squamous cell carcinoma (HNSCC) is a relatively widespread cancer with high mortality rates. Many patients with locally advanced disease are treated with combinations of surgery, radia [...] Read more.
    Shalini K. Sureshbabu ... Shubhada V. Chiplunkar
    Published: August 31, 2021 Explor Immunol. 2021;1:166-198
    DOI: https://doi.org/10.37349/ei.2021.00013
    View:620
    Download:40
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    Original Article
    Conserved envelope protein of nCoV2 as the possible target to design polytope vaccine
    Aim: The envelope protein of novel coronavirus 2 (nCoV2) was reported to be highly conserved compared to its spike (S) protein which was shown to undergo several alterations in their amino acid seq [...] Read more.
    Krupanidhi Sreerama
    Published: August 31, 2021 Explor Immunol. 2021;1:155-165
    DOI: https://doi.org/10.37349/ei.2021.00012
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:459
    Download:12
    Times Cited: 0
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    Severe acute respiratory syndrome coronavirus 2 targeted antibodies cocktail and B cell receptor interplay: interventions to trigger vaccine development
    Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 spread globally and creates an alarming situation. Following the SARS-CoV-2 paradigm, therape [...] Read more.
    Kabeer Haneef ... Zainab Fatima
    Published: August 31, 2021 Explor Immunol. 2021;1:140-154
    DOI: https://doi.org/10.37349/ei.2021.00011
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
    View:622
    Download:47
    Times Cited: 0
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    Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
    Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regene [...] Read more.
    Panagiotis Mallis ... Catherine Stavropoulos Giokas
    Published: June 30, 2021 Explor Immunol. 2021;1:112-139
    DOI: https://doi.org/10.37349/ei.2021.00010
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    Vitamin D and immunomodulation in the skin: a useful affirmative nexus
    Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune r [...] Read more.
    Saptadip Samanta
    Published: June 30, 2021 Explor Immunol. 2021;1:90-111
    DOI: https://doi.org/10.37349/ei.2021.00009
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:900
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    Times Cited: 0
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    L-arginine as a novel target for clinical intervention in inflammatory bowel disease
    Arginase-1 (Arg1) and the inducible nitric oxide synthase 2 (NOS2) compete for the common substrate L-arginine, semi-essential amino acid, and central intestinal metabolite. Both enzymes exhibit var [...] Read more.
    Björn Nüse, Jochen Mattner
    Published: June 30, 2021 Explor Immunol. 2021;1:80-89
    DOI: https://doi.org/10.37349/ei.2021.00008
    View:683
    Download:52
    Times Cited: 0
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    Immunopathogenesis of severe acute respiratory syndrome coronavirus-2: evolving knowledge and its current status
    As the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is a new virus, the current knowledge on the immunopathogenesis of this newly emerged SARS-CoV-2 is beginning to unravel with intens [...] Read more.
    Nitin Saksena ... Monica Miranda-Saksena
    Published: June 30, 2021 Explor Immunol. 2021;1:61-79
    DOI: https://doi.org/10.37349/ei.2021.00007
    View:796
    Download:55
    Times Cited: 0
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    Immunology of biodegradable nanoparticles: a brief overview on a wide growing field
    Immunity is continuously evolving by evolutionary mechanisms shaped by pathogenic stimuli of different kinds. Man-made nanomaterials (NMs) have been developed in the last decades and represent a nov [...] Read more.
    Anissa Pisani, Giuseppe Bardi
    Published: April 30, 2021 Explor Immunol. 2021;1:48-60
    DOI: https://doi.org/10.37349/ei.2021.00006
    View:1134
    Download:63
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    Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
    Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 rece [...] Read more.
    Masutaka Furue, Mihoko Furue
    Published: April 30, 2021 Explor Immunol. 2021;1:37-47
    DOI: https://doi.org/10.37349/ei.2021.00005
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
    View:1103
    Download:43
    Times Cited: 0
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    Original Article
    Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition
    Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect a [...] Read more.
    Buyong Ma
    Published: April 30, 2021 Explor Immunol. 2021;1:27-36
    DOI: https://doi.org/10.37349/ei.2021.00004
    View:661
    Download:16
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    Original Article
    In silico investigation of binding affinities between human leukocyte antigen class I molecules and SARS-CoV-2 virus spike and ORF1ab proteins
    Aim: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019, a global pandemic. There is hence an urgent need for effective approaches to [...] Read more.
    Spyros A. Charonis ... Apostolos P. Georgopoulos
    Published: April 30, 2021 Explor Immunol. 2021;1:16-26
    DOI: https://doi.org/10.37349/ei.2021.00003
    View:1163
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    The role of interleukin-24 in atopic dermatitis
    Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl  [...] Read more.
    Yen Hai Vu ... Gaku Tsuji
    Published: April 30, 2021 Explor Immunol. 2021;1:4-15
    DOI: https://doi.org/10.37349/ei.2021.00002
    This article belongs to the special issue Cross Talk Among Skin Cells and Immune Cells
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    Editorial
    Exploration of Immunology: challenging knowledge, developing curiosity and transforming passion into discovery
    Dominique J Charron, Reem Al-Daccak
    Published: April 30, 2021 Explor Immunol. 2021;1:1-3
    DOI: https://doi.org/10.37349/ei.2021.00001
    View:1726
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