• Special Issue Topic

    Spotlight on Cervical Cancer: Prevention, Early-Diagnosis, and Treatments

    Submission Deadline: February 29, 2024

    Guest Editors

    Dr. Andrea Giannini E-Mail

    Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy

    Research Keywords: cervical cancer; HPV; cervical dysplasia; radical hysterectomy; laproscopy; Robotic; surgery

    Dr. Giorgio Bogani E-Mail

    Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy

    Research Keywords: cervical cancer; HPV; cervical dysplasia; radical hysterectomy; laproscopy; Robotic; surgery

    About the Special Issue

    Cervical cancer (CC) represents one of the most common gynecological malignancies worldwide. Despite the strong implementation of prevention protocols, cervical cancer is still a source of concern, especially in developing countries. The HPV vaccine represents the crucial resource used in primary prevention, recommended with level A evidence. Available data show that the HPV vaccine is able to reduce the HPV infection prevalence by supporting the decrease in the development of precancerous and CC. By using the cervical smear and HPV-DNA test, there is an increase of cervical dysplasia, early-stage CC, and consequently its treatments. In the last decade, these data were confirmed in industrialized countries, with an increase of early-stage CC compared to women living in developing countries, where a large proportion of advanced or metastatic CC was diagnosed. CC treatment differs in accordance with the stage at diagnosis. In last years, various trials investigated the use of conservative treatment and minimally invasive surgery for CC. Its data highlighted the safety and effectiveness of this approach, and as a result, the 2018 ESGO/ESTRO/ESP guidelines, with level B evidence, stated that the minimally invasive approach is favored. However, the LACC trial questioned the oncological outcomes of this approach, proving an increased risk of recurrence and death. To date, the choice of an adequate surgical approach in CC is still debated. Considering the history of HPV infection and the development of CC, it’s crucial to implement prevention protocols with the aim to detect early diagnosis of precancerous lesions and CC. CC management is still a source of ongoing concern. Considering the involvement of this disease in young women, also looking for a pregnancy, early diagnosis and personalized treatment is essential. This special issue of Exploration of Medicine is dedicated to focusing on the most important advancements in the prevention, early diagnosis, and treatment of CC, providing an update that will contribute to establish CC tailored-management.

    Keywords: cervical cancer; early-diagnosis cervical cancer; cervical cancer prevention; cervical cancer screening; cervical cancer treatment

    Published Articles

    Open Access
    Original Article
    Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice
    Aim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. ci [...] Read more.
    Beatriz Medeiros-Fonseca ... Paula A. Oliveira
    Published: June 18, 2024 Explor Med. 2024;5:416–433
    DOI: https://doi.org/10.37349/emed.2024.00228
    Times Cited: 0
    Open Access
    The future of cervical cancer prevention: advances in research and technology
    This article provides an informative overview of the current situation and future trends in cervical cancer prevention. Cervical cancer remains a significant public health concern worldwide and is c [...] Read more.
    Praveen Kumar Chandra Sekar ... Ramakrishnan Veerabathiran
    Published: May 22, 2024 Explor Med. 2024;5:384–400
    DOI: https://doi.org/10.37349/emed.2024.00226
    Times Cited: 0
    Open Access
    Original Article
    Prevalence of specific human papillomavirus genotypes among Moroccan women with invasive cervical cancer
    Aim: The aim of this study is to investigate the prevalence of human papillomavirus (HPV) genotypes in Moroccan women diagnosed with invasive cervical cancer and to assess the association between [...] Read more.
    Kaoutar Anouar Tadlaoui ... Moulay Mustapha Ennaji
    Published: February 28, 2024 Explor Med. 2024;5:76–88
    DOI: https://doi.org/10.37349/emed.2024.00207
    Times Cited: 0