• 44 results in Exploration of Drug Science
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    Original Article
    Subacute toxicity of isoliquiritigenin-zein phosphatidylcholine nanoparticles on biochemical, hematological, and histopathological parameters in Sprague-Dawley rats
    Aim: Isoliquiritigenin (ISL) is a natural flavonoid found in many natural plants, which exhibits numerous pharmacological properties including anti-inflammatory, antioxidant, antitumor, and antiv [...] Read more.
    Ke Yang ... Jianping Chen
    Published: April 29, 2024 Explor Drug Sci. 2024;2:234–253
    DOI: https://doi.org/10.37349/eds.2024.00044
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    Open Access
    Review
    Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens
    With the surge of antibiotic resistance in bacteria, the need for a larger arsenal of effective antibiotics and vaccines has drastically increased in the past decades. Antibiotics like vaccines can  [...] Read more.
    Chloé O. Sebilleau, Steven J. Sucheck
    Published: April 29, 2024 Explor Drug Sci. 2024;2:203–233
    DOI: https://doi.org/10.37349/eds.2024.00043
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:261
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    Times Cited: 0
    Open Access
    Perspective
    Daropeptide natural products
    Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post- [...] Read more.
    Suze Ma ... Qi Zhang
    Published: April 19, 2024 Explor Drug Sci. 2024;2:190–202
    DOI: https://doi.org/10.37349/eds.2024.00042
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:419
    Download:32
    Times Cited: 0
    Open Access
    Review
    Stapled peptides: targeting protein-protein interactions in drug development
    Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promis [...] Read more.
    Qian Zhang ... Chunqiu Zhang
    Published: April 18, 2024 Explor Drug Sci. 2024;2:154–189
    DOI: https://doi.org/10.37349/eds.2024.00041
    This article belongs to the special issue Bioactive Peptides discovery and development
    View:370
    Download:30
    Times Cited: 0
    Open Access
    Perspective
    Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives
    Five families of investigational products are in clinical investigation to slow or reverse normal aging processes [longevity candidates, mesenchymal stem cells, senolytics drugs, sirtuin activators, [...] Read more.
    Ricardo P. Garay
    Published: April 10, 2024 Explor Drug Sci. 2024;2:144–153
    DOI: https://doi.org/10.37349/eds.2024.00040
    This article belongs to the special issue Recent Advances with Investigational Compounds and Strategies to Delay or Reverse Normal Aging Processes
    View:226
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    Review
    Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonists for the treatment of obesity and diabetes mellitus
    Pharmaceutical interventions play a vital role in managing various conditions, including weight-related issues such as obesity. In this context, lifestyle changes are often challenging to maintain,  [...] Read more.
    Alexander C. Martins ... Fernando Albericio
    Published: April 03, 2024 Explor Drug Sci. 2024;2:126–143
    DOI: https://doi.org/10.37349/eds.2024.00039
    View:552
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    Times Cited: 0
    Open Access
    Mini Review
    Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses
    The search for novel therapeutic agents to combat the crisis of antimicrobial resistance has spanned from terrestrial to unique, marine environments. Currently, most of the drugs available for usage [...] Read more.
    Galana Siro, Atanas Pipite
    Published: February 29, 2024 Explor Drug Sci. 2024;2:117–125
    DOI: https://doi.org/10.37349/eds.2024.00038
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
    View:471
    Download:24
    Times Cited: 0
    Open Access
    Review
    Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery
    The influenza virus glycoprotein hemagglutinin (HA) participates in critical steps of the attachment of viral particles to the host cell membrane receptor and membrane fusion. Due to its crucial inv [...] Read more.
    Francisco Javier Hermoso-Pinilla ... Francisco Javier Luque
    Published: February 29, 2024 Explor Drug Sci. 2024;2:85–116
    DOI: https://doi.org/10.37349/eds.2024.00037
    View:503
    Download:32
    Times Cited: 0
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    Review
    Seaweed: a sustainable solution for greening drug manufacturing in the pursuit of sustainable healthcare
    The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to drug production is crucial. This review focuse [...] Read more.
    Leonel Pereira, João Cotas
    Published: February 27, 2024 Explor Drug Sci. 2024;2:50–84
    DOI: https://doi.org/10.37349/eds.2024.00036
    This article belongs to the special issue Greening Drug Manufacturing for a Sustainable Healthcare
    View:1290
    Download:42
    Open Access
    Review
    Effect of the size of nucleic acid delivery systems on their fate in cancer treatment
    Nucleic acid therapeutics are emerging as a promising class of medicines, offering unique therapeutic options for cancer at the gene level. However, the druggability of nucleic acid therapeutics is  [...] Read more.
    Mengyun Ye ... Dandan Zhu
    Published: February 01, 2024 Explor Drug Sci. 2024;2:38–49
    DOI: https://doi.org/10.37349/eds.2024.00035
    This article belongs to the special issue Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics
    View:415
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    Times Cited: 0