• 72 results in Exploration of Drug Science
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    Mini Review
    Lactoferrin: a secret weapon in the war against pathogenic bacteria
    The excessive use of antibiotics to treat bacterial infectious diseases in all living beings has caused a global epidemic of bacterial resistance to antibiotics, leading to the emergence of multidru [...] Read more.
    Lucero Ruiz-Mazón ... Mireya de la Garza
    Published: October 21, 2024 Explor Drug Sci. 2024;2:734–743
    DOI: https://doi.org/10.37349/eds.2024.00072
    This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research
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    Open Access
    Original Article
    Bicyclic peptide-enhanced covalent inhibitor of SARS-CoV-2 3CL protease
    Aim: Develop technology to apply bicyclic peptides for discovering covalent inhibitors of proteases and use this technology to create bicyclic peptide—warhead conjugates for targeting the sever [...] Read more.
    Qian Wang ... Shiyu Chen
    Published: October 17, 2024 Explor Drug Sci. 2024;2:719–733
    DOI: https://doi.org/10.37349/eds.2024.00071
    This article belongs to the special issue Bioactive Peptides discovery and development
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    Review
    Synthetic peptides as valuable and versatile tools for research: our 20 year journey in Chile
    According to the International Union of Pure and Applied Chemistry (IUPAC), peptides are small proteins with a size between 2 and 50 amino acids residues. They are ubiquitous across the evolutionary [...] Read more.
    Constanza Cárdenas ... Fanny Guzmán
    Published: October 15, 2024 Explor Drug Sci. 2024;2:701–718
    DOI: https://doi.org/10.37349/eds.2024.00070
    This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research
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    Times Cited: 0
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    Perspective
    Foundational contributions of Svetlana Mojsov to the GLP-1 field
    Biochemist Svetlana Mojsov, both as a graduate student at The Rockefeller University under the mentorship of Bruce Merrifield during the 1970s, and as an independent investigator at the Massachusett [...] Read more.
    George Barany, Michael J. Barany
    Published: October 3, 2024 Explor Drug Sci. 2024;2:688–700
    DOI: https://doi.org/10.37349/eds.2024.00069
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    Original Article
    Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults
    Aim: The objective of this study was to evaluate the predictive performance of a proposed method to predict absolute bioavailability of medicines in children (infants to adolescents). Method [...] Read more.
    Iftekhar Mahmood
    Published: September 30, 2024 Explor Drug Sci. 2024;2:677–687
    DOI: https://doi.org/10.37349/eds.2024.00068
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    Review
    Effect of combined oral contraceptives on menstrual migraine frequency and severity: a narrative review
    Migraine, a commonly occurring neurological disorder, disproportionately affects women during their reproductive years, and its symptoms are often intensified by hormonal fluctuations. This narrativ [...] Read more.
    Yethindra Vityala ... Krishna Chaitanya Meduri
    Published: September 30, 2024 Explor Drug Sci. 2024;2:666–676
    DOI: https://doi.org/10.37349/eds.2024.00067
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    Review
    21st century Latin American synthetic peptides for their application in antivenom production
    Envenomation caused by snakes, scorpions, and spiders represents a serious public health problem in Latin America. The antivenoms used for its treatment are produced by immunizing horses repeatedly  [...] Read more.
    Jésica A. Rodríguez ... Silvia A. Camperi
    Published: September 30, 2024 Explor Drug Sci. 2024;2:648–665
    DOI: https://doi.org/10.37349/eds.2024.00066
    This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research
    View:490
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    Times Cited: 0
    Open Access
    Original Article
    Properties of new polycationic bacteriochlorin photosensitizers: cytotoxicity and interaction with biofilms
    Aim: Biofilms of pathogenic bacteria are phenotypically resistant to antibiotics and other antimicrobial agents, host immune systems, and adverse environmental conditions, and are responsible for [...] Read more.
    Irina Tiganova ... Yulia Romanova
    Published: September 27, 2024 Explor Drug Sci. 2024;2:632–647
    DOI: https://doi.org/10.37349/eds.2024.00065
    This article belongs to the special issue Discovery and development of new antibacterial compounds
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    Original Article
    Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro
    Aim: The aim of this research was to generate new peptide molecules with cytotoxic activity against cervical cancer that can become effective in mitigating the impact of the disease and preventin [...] Read more.
    Natalia Ardila-Chantré ... Javier Eduardo García-Castañeda
    Published: September 27, 2024 Explor Drug Sci. 2024;2:614–631
    DOI: https://doi.org/10.37349/eds.2024.00064
    This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research
    View:454
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    Open Access
    Review
    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
    Cervical cancer (CaCx) is the fourth most prevalent cancer in women contributing to 341,831 annual deaths globally in 2020. Owing to its high mortality rate, the identification of novel inhibitors p [...] Read more.
    Tanya Tripathi ... Alok Chandra Bharti
    Published: September 24, 2024 Explor Drug Sci. 2024;2:583–613
    DOI: https://doi.org/10.37349/eds.2024.00063
    This article belongs to the special issue Remedial benefits of natural products in inflammation and cancer
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